A targeted disruption in Connexin40 leads to distinct atrioventricular conduction defects

Journal of Interventional Cardiac Electrophysiology

Volumn 4, Issue 3, 2000, Pages 459-567

  Bevilacqua, Laura M ^a   Simon, Alexander M ^a   Maguire, Colin T ^a   Gehrmann, Josef ^a   Wakimoto, Hiroko ^a   Paul, David L ^a   Berul, Charles I ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Animal models; Arrhythmias; Connexin; Electrophysiology; Gap junction

Indexed keywords

CONNEXIN 40;

AMBULATORY MONITORING; ANIMAL EXPERIMENT; ARTICLE; ATRIOVENTRICULAR BLOCK; ATRIOVENTRICULAR CONDUCTION; CONTROLLED STUDY; ELECTROCARDIOGRAM; GAP JUNCTION; GENE DELETION; HEART MUSCLE REFRACTORY PERIOD; HEART RATE; HEART RATE VARIABILITY; HEART VENTRICLE TACHYCARDIA; HOMOZYGOSITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TELEMETRY; WENCKEBACH PERIOD;

EID: 0033710745     PISSN: 1383875X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1009800328836     Document Type: Article

References (19)

1. Mice lacking connexin40 have cardiac conduction abnormalities characteristic of first degree atrioventricular block and bundle branch block
2. Reduced cardiac conduction velocity and predisposition to arrhythmias in connexin40 deficient mice
3. Restricted distribution of Connexin40, a gap junctional protein, in mammalian heart
4. Distinct gap junction protein phenotypes in cardiac tissues with disparate conduction properties
5. Expression of multiple connexins in cultured neonatal rat ventricular myocytes
6. Altered pattern of connexin40 distribution in persistent atrial fibrillation in the goat
7. The molecular basis of anisotropy: Role of gap junctions
8. Disparate effects of deficient connexin43 on a trial and ventricular conduction
9. Connexins, conduction, and atrial fibrillation
10. Connexin45 (alpha 6) expression delineates an extended conduction system in the embryonic and mature rodent heart
11. In vivo cardiac electrophysiology studies in the mouse
12. Familial hypertrophic cardiomyopathy mice display gender differences in electrophysiological abnormalities
13. Molecular biology and genetics of cardiac disease associated with sudden death: Electrophysiologic studies in mouse models of inherited human diseases
14. HRV standards of measurement, Task Force of ESC and NASPE
15. Measurement of heart rate and Q-T interval in the conscious mouse
16. Conduction disturbances and increased atrial vulnerability in connexin40-deficient mice analyzed by transesophageal stimulation
17. Asymmetry of retrograde conduction and reentry within the His-Purkinje system: A comparative analysis of left and right ventricular stimulation
18. Differential expression of gap junction proteins in the canine sinus node
19. Impaired conduction of vasodilation along arterioles in connexin40-deficient mice