Dynamic model for ventricular junctional conductance during the cardiac action potential

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 288, Issue 3 57-3, 2005, Pages

  Lin, Xianming ^a   Gemel, Joanna ^b   Beyer, Eric C ^b   Veenstra, Richard D ^a,c  

^a SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c State University of New York Upstate Medical University: College of Medicine   (United States)

Author keywords

Connexin43; Gap junctions; Inactivation; Kinetics; Repolarization; Voltage gating

Indexed keywords

ACCURACY; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ATRIOVENTRICULAR CONDUCTION; CONTROLLED STUDY; DYNAMICS; ELECTRIC POTENTIAL; FLUORESCENCE MICROSCOPY; GAP JUNCTION; HEART ARRHYTHMIA; HEART MUSCLE CONDUCTION SYSTEM; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; HEART VENTRICLE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MATHEMATICAL MODEL; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; TIME;

ACTION POTENTIALS; ANIMALS; CONNEXIN 43; CONNEXINS; GAP JUNCTIONS; HEART; HEART VENTRICLES; KINETICS; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MODELS, CARDIOVASCULAR; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC;

EID: 13944261228     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00882.2004     Document Type: Article

References (43)

1. Alcoléa S, Théveniau-Ruissy M, Jarry-Ruchard T, Marics I, Tzouanacou E, Chauvin JP, Briand JP, Moorman AF, Lamers WH, and Gros DB. Downregulation of connexin 45 gene products during mouse heart development. Circ Res 84: 1365-1379, 1999.
2. Bastide B, Neyses L, Ganten D, Paul M, Willecke K, and Traub O. Gap junction protein connexin40 is preferentially expressed in vascular endothelium and conductive bundles of rat myocardium and is increased under hypertensive conditions. Circ Res 73: 1138-1149, 1993.
3. Beyer EC. Molecular cloning and developmental expression of two chick embryo gap junction proteins. J Biol Chem 265: 14439-14443, 1990.
4. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein using the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
5. Cooklin M, Wallis WRJ, Sheridan DJ, and Fry CH. Changes in cell-to-cell electrical coupling associated with left ventricular hypertrophy. Circ Res 80: 765-771, 1997.
6. Coppen SR, Dupont E, Rothery S, and Severs NJ. Connexin45 expression is preferentially associated with the ventricular conduction system in the embryonic and mature rodent heart. Circ Res 82: 232-243, 1998.
7. Coppen SR, Severs NJ, and Gourdie RG. Connexin 45 (a6) expression delineates an extended conduction system in the embryonic and mature rodent heart. Dev Genet 24: 82-90, 1999.
8. Gemel J, Valiunas V, Brink PR, and Beyer EC. Connexin43 and connexin26 form gap junctions, but not heteromeric channels in co-expressing cells. J Cell Sci 117: 2469-2480, 2004.
9. Giepmans BN and Moolenar WH. The gap junction protein connexin43 interacts with the second PDZ domain of the zona occludens-1 protein. Curr Biol 8: 931-934, 1998.
10. Gourdie RG, Severs NJ, Green CR, Rothery S, Germroth P, and Thompson RP. The spatial distribution and relative abundance of gap-junctional connexin40 and connexin43 correlate to functional properties of components of the cardiac atrioventricular conduction system. J Cell Sci 105: 985-991, 1993.
11. Gros D, Jarry-Guichard T, Ten Velde I, de Maziere A, van Kempen MJ, Davoust J, Briand JP, Moorman AF, and Jongsma HJ. Restricted distribution of connexin40, a gap junction protein, in mammalian heart. Circ Res 74: 839-851, 1994.
12. Hennemann H, Suchyna T, Lichten-Fraté H, Jungbluth S, Dahl E, Schwarz J, Nicholson BJ, and Willecke K. Molecular cloning and functional expression of mouse connexin40, a second gap junction gene preferentially expressed in lung. J Cell Biol 117: 1299-1310, 1992.
13. Henriquez AP, Vogel R, Muller-Borer BJ, Henriquez CS, Weingart R, and Cascio W. Influence of dynamic gap junction resistance on impulse propagation in ventricular myocardium: a computer simulation study. Biophys J 81: 2112-2121, 2001.
14. Johnson CM, Kanter EM, Green KG, Laing JG, Betsuyaku T, Beyer EC, Steinberg TH, Saffitz JE, and Yamada KA. Redistribution of connexin45 in gap junctions of connexin43-deficient hearts. Cardiovasc Res 53: 921-935, 2002.
15. Kanter EM, Laing JG, Beau SL, Beyer EC, and Saffitz JE. Distinct patterns of connexin expression in canine Purkinje fibers and ventricular muscle. Circ Res 72: 1124-1131, 1993.
16. Kanter HL, Saffitz JE, and Beyer EC. Cardiac myocytes express multiple gap junction proteins. Circ Res 70: 438-444, 1992.
17. Kléber AG, Riegger CB, and Janse MJ. Electrical uncoupling and increase of extracellular resistance after induction of ischemia in isolated, arterially perfused rabbit papillary muscle. Circ Res 67: 271-279, 1987.
18. Kléber AG and Rudy Y. Basic mechanisms of cardiac impulse propagation and associated arrhythmias. Physiol Rev 84: 431-488, 2004.
19. Kumar R and Joyner RW. An experimental model of the production of early after depolarizations by injury current from an ischemic region. Pflügers Arch 428: 425-32, 1994.
20. Kwong KF, Schuessler RB, Green KG, Laing JG, Beyer EC, Boineau JP, and Saffitz JE. Differential expression of gap junction proteins in the canine sinus node. Circ Res 82: 604-612, 1998.
21. Lin X, Crye M, and Veenstra RD. Regulation of connexin43 gap junctional conductance by ventricular action potentials. Circ Res 93: e63-e73, 2003.
22. Lin X and Veenstra RD. Action potential modulation of connexin40 gap junctional condutance. Am J Physiol Heart Circ Physiol 286: H1726-H1735, 2004.
23. Luke RA and Saffitz JE. Remodeling of ventricular conduction pathways in healed canine infarct border zones. J Clin Invest 87: 736-754, 1991.
24. Luo CH and Rudy Y. A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circ Res 74: 1071-1096, 1994.
25. Moreno AP, Fishman GI, and Spray DC. Phosphorylation shifts the unitary conductance and modifies voltage-dependent kinetics of human connexin43 gap junction protein channels. Biophys J 62: 51-53, 1992.
26. Peters NS, Coromilas J, Severs NJ, and Wit AL. Disturbed connexin43 gap junction distribution correlates with the location of reentrant circuits in the epicardial border zone of healing canine infarcts that cause ventricular tachycardia. Circulation 95: 988-996, 1997.
27. Peters NS, Green CR, Poole-Wilson PA, and Severs NJ. Reduced content of connexin43 in ventricular myocardium from hypertrophied and ischemic human hearts. Circulation 88: 864-875, 1993.
28. Petrecca K, Amellal F, Laird DW, Cohen SA, and Shrier A. Sodium channel distribution within the rabbit atrioventricular node as analyzed by confocal microscopy. J Physiol 501: 263-274, 1997.
29. Poelzing S, Akar FG, Baron E, and Rosenbaum DS. Heterogeneous connexin43 expression produces electrophysiological heterogeneities across ventricular wall. Am J Physiol Heart Circ Physiol 286: H2001-H2009, 2004.
30. Rudy Y. The cardiac ventricular action potential. In: The Handbook of Physiology. The Cardiovascular System. The Heart. Bethesda, MD: Am. Physiol. Soc., 2002, sect. 2, vol. I, Chap. 13, p. 531-547.
31. Sáez JC, Berthoud VM, Brañes MC, Martínez AD, and Beyer EC. Plasma membrane channels formed by connexins: their regulation and function. Physiol Rev 83: 1359-1400, 2003.
32. Saiz J, Ferrero JM Jr, Monserrat M, Ferraro JM, and Thakor NV. Influence of electrical coupling on early afterdepolarizations in ventricular myocytes. IEEE Trans Biomed Eng 46: 138-147, 1999.
33. Schram G, Fourrier M, Melnyk P, and Nattel S. Differential distribution of cardiac ion channel expression as a basis for regional specialization in electrical function. Circ Res 90: 939-950, 2002.
34. Shaw RM and Rudy Y. The vulnerable window for unidirectional block in cardiac tissue: characterization and dependence on membrane excitability and intercellular coupling. J Cardiovasc Electrophysiol 6: 115-131, 1995.
35. Takens-Kwak BR and Jongsma IU. Three distinct channel conductances and their modulation by phosphorylation treatment. Pflügers Arch 422: 198-200, 1992.
36. Toyofuku T, Yabuki M, Otsu K, Kuzuya T, Tada T, and Hori M. Direct association of the gap junction protein connexin-43 with ZO-1 in cardiac myocytes. J Biol Chem 273: 12725-12731, 1998.
37. Traub O, Eckert R, Lichten-Fraté H, Elfgang C, Bastide B, Scheidtmann KH, Hülser DF, and Willecke K. Immunochemical and electrophysiological characterization of murine connexin40 and -43 in mouse tissues and transfected human cells. Eur J Cell Biol 64: 101-112, 1994.
38. Van Veen TAB, van Rigen HVM, and Opthof T. Cardiac gap junction channels: modulation of expression and channel properties. Cardiovasc Res 51: 217-229, 2001.
39. Veenstra RD. Developmental changes in regulation of embryonic chick heart gap junctions. J Membr Biol 119: 253-265, 1991.
40. Veenstra RD. Voltage clamp limitations of dual whole cell recordings of gap junction current and voltage recordings. I. Conductance measurements. Biophys J 80: 2231-2247, 2001.
41. Vogel R and Weingart R. Mathematical model of vertebrate gap junctions derived from electrical measurements of homotypic and heterotypic channels. J Physiol 501: 177-189, 1998.
42. Yao JA, Gutstein DE, Liu F, Fishman GI, and Wit AL. Cell coupling between ventricular myocyte pairs from connexin43-deficient murine hearts. Circ Res 93: 736-743, 2003a.
43. Yao JA, Hussein W, Patel P, Peters NS, Boyden PA, and Wit AL. Remodeling of gap junctional channel function in epicardial border zone of healing canine infarcts. Circ Res 92: 437-443, 2003b.