Electrophysiological abnormalities precede overt structural changes in arrhythmogenic right ventricular cardiomyopathy due to mutations in desmoplakin-A combined murine and human study

European Heart Journal

Volumn 33, Issue 15, 2012, Pages 1942-1953

  Gomes, John ^a   Finlay, Malcolm ^a   Ahmed, Akbar K ^a   Ciaccio, Edward J ^b   Asimaki, Angeliki ^c   Saffitz, Jeffrey E ^c   Quarta, Giovanni ^a   Nobles, Muriel ^a,d   Syrris, Petros ^a   Chaubey, Sanjay ^e   McKenna, William J ^a   Tinker, Andrew ^a,d   Lambiase, Pier D ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^d QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^e KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Arrhythmia; ARVC; Conduction; Desmoplakin; Desmosome; Repolarization

Indexed keywords

DESMOPLAKIN; DESMOPLAKIN A; SODIUM CHANNEL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; FEMALE; GENE EXPRESSION; GENE MUTATION; HEART ELECTROPHYSIOLOGY; HEART REPOLARIZATION; HEART RIGHT VENTRICLE DYSPLASIA; HEART VENTRICLE TACHYCARDIA; HETEROZYGOSITY; HISTOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUPRAVENTRICULAR TACHYCARDIA;

ADULT; AGED; ANIMALS; ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA; CASE-CONTROL STUDIES; DESMOPLAKINS; ELECTROCARDIOGRAPHY; FEMALE; GENE DELETION; HEART CONDUCTION SYSTEM; HETEROZYGOTE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MIDDLE AGED; MUTATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SODIUM CHANNELS; YOUNG ADULT;

EID: 84862760898     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehr472     Document Type: Article

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