Ionic mechanisms of propagation in cardiac tissue: Roles of the sodium and L-type calcium currents during reduced excitability and decreased gap junction coupling

Circulation Research

Volumn 81, Issue 5, 1997, Pages 727-741

  Shaw, Robin M ^a   Rudy, Yoram ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Cardiac excitation; Cardiac ion channels; Gap junction

Indexed keywords

CALCIUM ION; ION CHANNEL; SODIUM ION;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM CURRENT; CELL JUNCTION; HEART ARRHYTHMIA; HEART CONDUCTION; HEART INFARCTION; HEART MUSCLE EXCITABILITY; HEART MUSCLE POTENTIAL; PRIORITY JOURNAL; SODIUM CURRENT;

EID: 0030665763     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.81.5.727     Document Type: Article

References (49)

1. Gettes LS, Reuter H. Slow recovery from inactivation of inward currents in mammalian myocardial fibres. J Physiol Lond. 1974;240:703-724.
2. Kodama I, Wilde A, Janse MJ, Durrer D, Yamada K. Combined effects of hypoxia, hyperkalemia and acidosis on membrane action potential and excitability of guinea-pig ventricular muscle. J Mol Cell Cardiol. 1984;16:247-259.
3. Veenstra RD, Joyner RW, Wiedmann RT, Young ML, Tan RC. Effects of hypoxia, hyperkalemia, and metabolic acidosis on canine subendocardial action potential conduction. Circ Res. 1987;60:93-101.
4. Bigger JT Jr, Hoffman BF. Antiarrhythmic drugs. In: Gilmam AG, Rall TW, Nies AS, Taylor P, eds. The Pharmacological Basis of Therapeutics. New York, NY: Pergamon Press; 1990:840-873.
5. Rudy Y, Quan WL. A model study of the effects of the discrete cellular structure on electrical propagation in cardiac tissue. Circ Res. 1987;61:815-823.
6. Henriquez CS, Plonsey R. Effect of restrictive discontinuities on waveshape and velocity in a single cardiac fibre. Med Biol Eng Comput. 1987;25:428-438.
7. Joyner RW. Effects of the discrete pattern of electrical coupling on propagation through and electrical syncytium. Circ Res. 1982;50:192-200.
8. Spach MS, Miller WT III, Geselowitz DB, Barr RC, Kootsey JM, Johnson EA. The discontinuous nature of propagation in normal canine cardiac muscle: evidence for recurrent discontinuities of intracellular resistance that affect membrane currents. Circ Res. 1981;48:39-54.
9. Delgado C, Steinhaus B, Delmar M, Chialvo DR, Jalife J. Directional differences in excitability and margin of safety for propagation in sheep ventricular epicardial muscle. Circ Res. 1990;67:97-110.
10. de Bakker JM, van Capelle FJ, Janse MJ, Wilde AA, Coronel R, Becker AE, Dingemans KP, van Hemel NM, Hauer RN. Reentry as a cause of ventricular tachycardia in patients with chronic ischemic heart disease: electrophysiologic and anatomic correlation. Circulation 1988;77:589-606.
11. max, tau foot, and the propagation safety factor. Circ Res. 1987;60:206-219.
12. Leon LJ, Roberge FA. Directional characteristics of action potential propagation in cardiac muscle: a model study. Circ Res. 1991;69:378-395.
13. Joyner RW, Kumar R, Wilders R, Jongsma HJ, Verheijck EE, Golod DA, van Ginneken ACG, Wagner MB, Goolsby WN. Modulating L-type calcium current affects discontinuous cardiac action potential conduction. Biophys J. 1996;71:237-245.
14. Rohr S, Kucera JP. Involvement of the calcium inward current in cardiac impulse propagation: induction of unidirectional conduction block by nifedipine and reversal by Bay K 8644. Biophys J. 1997;72:754-766.
15. 2+ in cultured rat dorsal root ganglion cells. J Physiol. 1996;490.2:319-324.
16. Luo CH, Rudy Y. A dynamic model of the cardiac ventricular action potential, I: simulations of ionic currents and concentration changes. Circ Res. 1994;74:1071-1096.
17. Luo CH, Rudy Y. A dynamic model of the cardiac ventricular action potential, II: afterdepolarizations, triggered activity, and potentiation. Circ Res. 1994;74:1097-1113.
18. + current in ventricular myocytes of the guinea pig type: theoretical formulation and their role in repolarization. Circ Res. 1995;77:140-152.
19. Beeler GW, Reuter H. Reconstruction of the action potential of ventricular myocardial fibres. J Physiol (Lond). 1977;268:177-210.
20. Shaw RM, Rudy Y. Electrophysiologic effects of acute myocardial ischemia: a mechanistic investigation of action potential conduction and conduction failure. Circ Res. 1997;80:124-138.
21. Weidmann S. The electrical constants of Purkinje fibers. J Physiol Lond. 1952;118:348-360.
22. Hodgkin AL, Rushton WAH. The electrical constants of a crustacean nerve fibre. Proc R Soc B. 1946;133:444-479.
23. Jack JJB, Noble D, Tsien RW. Electric Current Flow in Excitable Cells. Oxford, UK: Clarendon Press; 1975:502.
24. Crank J, Nicolson P. A practical method for numerical evaluation of solutions of partial differential equations of the heat conduction type. Proc Cambridge Phil Soc. 1947;43:50-67.
25. Sewall G. The numerical solution of ordinary and partial differential equations. Boston, Mass: Academic Press/Harcourt Brace Jovanovich; 1988:271.
26. Harris AS, Bisteni A, Russel RA, Brigham JC, Firestone JE. Excitatory factors in ventricular tachycardia resulting from myocardial ischemia: potassium a major excitant. Science. 1954;119:200-203.
27. + concentration on cable properties and excitability of sheep cardiac Purkinje fibers. Circ Res. 1970;26:565-574.
28. Gettes LS, Buchanan JW Jr, Saito T, Kagiyama Y, Oshita S, Fujino T. Studies concerned with slow conduction. In: Zipes DP, Jalife J, eds. Cardiac Electrophysiology and Arrhythmias. Orlando, Fla: Grune & Stratton; 1985:81-87.
29. Page E. Cardiac gap junctions. In: Fozzard HA, Jennings RB, Haber E, Katz AM, Morgan HE, eds. The Heart and Cardiovascular System. New York, NY: Raven Press, Publishers; 1992:1003-1047.
30. Wilders R, Kumar R, Joyner RW, Jongsma HJ, Verheijck EE, Golod DA, van Ginneken ACG, Goolsby WN. Action potential conduction between a ventricular cell model and an isolated ventricular cell. Biophys J. 1996;70:281-295.
31. Spach MS, Heidlage JF. The stochastic nature of cardiac propagation at a microscopic level: electrical description of myocardial architecture and its application to conduction. Circ Res. 1995;76:366-380.
32. Spach MS, Heidlage JF. A multidimensional model of cellular effects on the spread of electrotonic currents and on propagation action potential potentials. Crit Rev Biomed Eng. 1992;20:141-169.
33. Rohr S, Kucera JP. The calcium inward current can play a critical role for the success of impulse propagation across abrupt expansions of cardiac tissue in the presence of the sodium inward current. Circulation 1995;92(suppl 1):1-432. Abstract.
34. Rohr S, Kucera JP, Fast VG, Kleber AG. Paradoxical improvement of impulse conduction in cardiac tissue by partial cellular uncoupling. Science. 1997;275:841-844.
35. Fast VG, Darrow BJ, Saffitz JE, Kléber AG. Anisotropic activation spread in heart cell monolayers assessed by high resolution optical mapping: role of tissue discontinuities. Circ Res. 1996;79:115-127.
36. Fast VG, Kleber AG. Microscopic conduction in cultured strands of neonatal rat heart cells measured with voltage-sensitive dyes. Circ Res. 1993;73:914-925.
37. Fast VG, Kleber AG. Anisotropic conduction in monolayers of neonatal rat heart cells cultured on collagen substrate. Circ Res. 1994;75:591-595.
38. Ursell PC, Gardner PI, Albala A, Fenoglio JJ Jr, Wit AL. Structural and electrophysiological changes in the epicardial border zone of canine myocardial infarcts during infarct healing. Circ Res. 1985;56:436-451.
39. Gardner PI, Ursell PC, Fenoglio JJ Jr, Wit AL. Electrophysiologic and anatomic basis for fractionated electrograms recorded from healed myocardial infarcts. Circulation. 1985;72:596-611.
40. El-Sherif N, Scherlag BJ, Lazzara R, Hope RR. Reentrant ventricular arrhythmias in the late myocardial infarction period, I: conduction characteristics in the infarction zone. Circulation. 1977;55:686-702.
41. Wit AL, Allessie MA, Bonke FI, Lammers W, Smeets J, Fenoglio JJ Jr. Electrophysiologic mapping to determine the mechanism of experimental ventricular tachycardia initiated by premature impulses, experimental approach and initial results demonstrating reentrant excitation. Am J Cardiol. 1982;49:166-185.
42. Mehra R, Zeiler RH, Gough WB, El-Sherif N. Reentrant ventricular arrhythmias in the late myocardial infarction period, IX: electrophysiologic-anatomic correlation of reentrant circuits. Circulation. 1983;67:11-24.
43. Dillon SM, Allessie MA, Ursell PC, Wit AL. Influences of anisotropic tissue structure on reentrant circuits in the epicardial border zone of subacute canine infarcts. Circ Res. 1988;63:182-206.
44. 2+ channels. Prog Biophys Mol Biol. 1984;44:215-267.
45. 2+ release from sarcoplasmic reticulum in guinea pig ventricular myocytes. Circ Res. 1995;76:102-109.
46. 2+ influx during the cardiac action potential in guinea pig ventricular myocytes. Circ Res. 1996;79:194-200.
47. Lüscher C, Streit J, Quadroni R, Lüscher HR. Action potential propagation through embryonic dorsal root ganglion cells in culture, I: influence of cell morphology. J Neurophys. 1994;72:622-633.
48. Weingart R. Electrical properties of the nexal membrane studied in rat ventricular cell pairs. J Physiol. 1986;370:267-284.
49. White RL, Spray DC, Campos de Carvalho AC, Wittenberg BA, Bennett MVL. Some electrical and pharmacological properties of gap junctions between adult ventricular myocytes. Am J Physiol. 1985;249:C447-C455.