Heterotypic docking of Cx43 and Cx45 connexons blocks fast voltage gating of Cx43

Biophysical Journal

Volumn 81, Issue 3, 2001, Pages 1406-1418

  Elenes, Sergio ^a   Martinez, Agustin D ^b   Delmar, Mario ^c   Beyer, Eric C ^b   Moreno, Alonso P ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c State University of New York Upstate Medical University: College of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONNEXIN 43; CONNEXIN 45;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE DEPOLARIZATION; CHANNEL GATING; CONFORMATIONAL TRANSITION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; PROTEIN LOCALIZATION;

EID: 0034859346     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(01)75796-7     Document Type: Article

References (49)

1. The carboxyl terminal domain regulates the unitary conductance and voltage-dependence of connexin40 gap junction channels
2. Species-specific voltage-gating properties of connexin-45 junctions expressed in Xenopus oocytes
3. Structure-function studies of voltage sensitivity of connexins, the family of gap junction forming proteins
4. Connexin and gap junction degradation
5. Molecular cloning and developmental expression of two chick embryo gap junction proteins
6. Connexin43: A protein from rat heart homologous to a gap junction protein from liver
7. A rapid and sensitive method for the quantitation of microgram quantities of protein using the principle of protein-dye binding
8. Clustering of connexin 43-enhanced green fluorescent protein gap junction channels and functional coupling in living cells
9. Electrical coupling between cells of the insect Aedes albopictus
10. 2-sensitive and voltage-sensitive
11. Volatile anesthetics block intercellular communication between neonatal rat myocardial cells
12. A two opposing gates model for the asymmetric voltage gating of gap junction channels
13. Connexin45 expression is preferentially associated with the ventricular conduction system in mouse and rat heart
14. Phosphorylation of connexin43 gap junction protein in uninfected and Rous sarcoma virus-transformed mammalian fibroblasts
15. pH regulation of connexin43: Molecular analysis of the gating particle
16. The carboxyl-terminal of connexin43 modulates channels unitary conductance distribution and their voltage gating kinetics
17. Junctional communication between isolated pairs of canine atrial cells is mediated by homogeneous and heterogeneous gap junction channels
18. Murine Cx45: Voltage dependence characterization at physiological conditions
19. Connexins in mammalian heart function
20. Connexin37 in normal and pathological development of mouse heart and great arteries
21. Characterization of gap junction genes expressed in F9 embryonic carcinoma cells: Molecular cloning of mouse connexin31 and -45 cDNAs
22. pH sensitivity of the cardiac gap junction proteins, connexin 45 and 43
23. Multiple connexins colocalize in canine ventricular myocyte gap junctions
24. Transfected connexin45 alters gap junction permeability in cells expressing endogenous connexin43
25. Differential regulation of distinct types of gap junction channels by similar phosphorylating conditions
26. Gap junctions between human corpus cavernosum smooth muscle cells: Gating properties and unitary conductance
27. Connexin32 gap junction channel in stably transfected cells: Equilibrium and kinetic properties
28. Voltage dependent gating and single channel analysis of heterotypic gap junction channels formed of Cx45 and Cx43
29. Unmasking electrophysiological properties of connexins32 and 43: Transfection of communication-deficient cells with wild type and mutant connexins
30. Phosphorylation shift unitary conductance and modifies voltage dependent kinetics of human connexin43 gap junction channels
31. Properties of gap junction channels formed of connexin 45 endogenously expressed in human hepatoma (SKHep1) cells
32. Gap junction channels: Distinct voltage-sensitive and -insensitive conductance states
33. Human connexin43 gap junction channels: Regulation of unitary conductances by phosphorylation
34. Expression of the gap junction protein connexin43 in embryonic chick lens: Molecular cloning, ultrastructural localization, and post-translational phosphorylation
35. Connexin46, a novel lens gap junction protein, induces voltage - Gated currents in nonjunctional plasma membrane of Xenopus oocytes
36. Characterization of gap junctions between pairs of Leydig cells from mouse testis
37. Molecular cloning and functional expression of human connexin37, an endothelial cell gap junction protein
38. Molecular dissection of transjunctional voltage dependence in the connexin-32 and connexin-43 junctions
39. Connexin43 and connexin45 form gap junctions with different molecular permeabilities in osteoblastic cells
40. Functional characterization of canine connexin45
41. Immunochemical and electrophysiological characterization of murine connexin40 and -43 in mouse tissues and transfected human cells
42. Voltage gating and permeation in a gap junction hemichannel
43. Conductances and selective permeability of connexin43 gap junction channels examined in neonatal rat heart cells
44. Human connexin40 gap junction channels are modulated by cAMP
45. Electrical conductance of mouse connexin45 gap junction channels is modulated by phosphorylation
46. Selectivity of connexin-specific gap junctions does not correlate with channel conductance
47. Multiple connexins confer distinct regulatory and conductance properties of gap junctions in developing heart
48. Chemical gating of heteromeric and heterotypic gap junction channels
49. Formation of hybrid cell-cell channels