Cardiomyocyte-restricted deletion of connexin43 during mouse development

Journal of Molecular and Cellular Cardiology

Volumn 41, Issue 6, 2006, Pages 963-971

  Eckardt, Dominik ^a   Kirchhoff, Susanne ^b,d   Kim, Jung Sun ^b   Degen, Joachim ^a   Theis, Martin ^a   Ott, Thomas ^a   Wiesmann, Frank ^c   Doevendans, Pieter A ^d   Lamers, Wouter H ^b   de Bakker, Jacques M T ^e   van Rijen, Harold V M ^f   Schneider, Michael D ^g   Willecke, Klaus ^a  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c UNIVERSITY OF WÜRZBURG   (Germany)

^d MAASTRICHT UNIVERSITY   (Netherlands)

^e ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCES   (Netherlands)

^f UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^g BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Cardiac development; Conditional gene targeting; Connexin43; Gap junctions; Surface ECG

Indexed keywords

CONNEXIN 43;

AMPLITUDE MODULATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE DELETION; GENE INACTIVATION; HEART DEVELOPMENT; HEART MUSCLE; HETEROZYGOSITY; HOMOZYGOSITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; QRS COMPLEX;

AGE FACTORS; ANIMALS; CONNEXIN 43; ELECTROCARDIOGRAPHY; FEMALE; FETAL HEART; GENE TARGETING; GESTATIONAL AGE; HEART; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCARDIUM; MYOCYTES, CARDIAC; PREGNANCY;

EID: 33751202968     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2006.07.017     Document Type: Article

References (20)

1. Willecke K., Eiberger J., Degen J., Eckardt D., Romualdi A., Güldenagel M., et al. Structural and functional diversity of connexin genes in the mouse and human genome. Biol. Chem. 383 (2002) 725-737
2. van Veen A.A., van Rijen H.V., and Opthof T. Cardiac gap junction channels: Modulation of expression and channel properties. Cardiovasc. Res. 51 (2001) 217-229
3. Gros D., Dupays L., Alcolea S., Meysen S., Miquerol L., and Theveniau-Ruissy M. Genetically modified mice: tools to decode the functions of connexins in the heart-new models for cardiovascular research. Cardiovasc. Res. 69 (2004) 299-308
4. Yancey S.B., Biswal S., and Revel J.P. Spatial and temporal patterns of distribution of the gap junction protein connexin43 during mouse gastrulation and organogenesis. Development 114 (1992) 203-212
5. Ruangvoravat C.P., and Lo C.W. Connexin 43 expression in the mouse embryo: localization of transcripts within developmentally significant domains. Dev. Dyn. 194 (1992) 261-281
6. Reaume A.G., de Sousa P.A., Kulkarni S., Langille B.L., Zhu D., Davies T.C., et al. Cardiac malformation in neonatal mice lacking connexin43. Science 267 (1995) 1831-1834
7. Ya J., Erdtsieck-Ernste E.B., de Boer P.A., van Kempen M.J., Jongsma H., Gros D., et al. Heart defects in connexin43-deficient mice. Circ. Res. 82 (1998) 360-366
8. Wei C.J., Xu X., and Lo C.W. Connexins and cell signaling in development and disease. Annu. Rev. Cell Dev. Biol. 20 (2004) 811-838
9. Gutstein D.E., Morley G.E., Tamaddon H., Vaidya D., Schneider M.D., Chen J., et al. Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43. Circ. Res. 88 (2001) 333-339
10. Danik S.B., Liu F., Zhang J., Suk H.J., Morley G.E., and Fishman D.E. Modulation of cardiac gap junction expression and arrhythmic susceptibility. Circ. Res. 95 (2004) 1035-1041
11. Eckardt D., Theis M., Degen J., Ott T., van Rijen H.V.M., Kirchhoff S., et al. Functional role of connexin43 gap junction channels in adult mouse heart assessed by inducible gene deletion. J. Mol. Cell. Cardiol. 36 (2004) 101-110
12. van Rijen H.V.M., Eckardt D., Degen J., Theis M., Ott T., Willecke K., et al. Slow conduction and enhanced anisotropy increase the propensity for ventricular tachyarrhythmias in adult mice with induced deletion of connexin43. Circulation 109 (2004) 1048-1055
13. Theis M., de Wit C., Schlaeger T.M., Eckardt D., Kruger O., Doring B., et al. Endothelium-specific replacement of the connexin43 coding region by a lacZ reporter gene. Genesis 29 (2001) 1-13
14. Agah R., Frenkel P.A., French B.A., Michael L.H., Overbeek P.A., and Schneider M.D. Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo. J. Clin. Invest. 100 (1997) 169-179
15. Wiesmann F., Ruff J., Hiller K.H., Rommel E., Haase A., and Neubauer S. Developmental changes of cardiac function and mass assessed with MRI in neonatal, juvenile, and adult mice. Am. J. Physiol.: Heart Circ. Physiol. 278 (2000) H652-H657
16. Delorme B., Dahl E., Jarry-Guichard T., Briand J.P., Willecke K., Gros D., et al. Expression pattern of connexin gene products at the early developmental stages of the mouse cardiovascular system. Circ. Res. 81 (1997) 423-437
17. Vaidya D., Tamaddon H.S., Lo C.W., Taffet S.M., Delmar M., Morley G.E., et al. Null mutation of connexin43 causes slow propagation of ventricular activation in the late stages of mouse embryonic development. Circ. Res. 88 (2001) 1196-1202
18. Leu M., Ehler E., and Perriard J.C. Characterisation of postnatal growth of the murine heart. Anat. Embryol. 204 (2001) 217-224
19. Wakimoto H., Kasahara H., Maguire C.T., Izumo S., and Berul C.I. Developmentally modulated cardiac conduction failure in transgenic mice with fetal or postnatal overexpression of DNA nonbinding mutant Nkx2.5. J. Cardiovasc. Electrophysiol. 13 (2002) 682-688
20. Vooijs M., Jonkers J., and Berns A. A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent. EMBO Rep. 2 (2001) 292-297