Connexin45 (α6) expression delineates an extended conduction system in the embryonic and mature rodent heart

Developmental Genetics

Volumn 24, Issue 1-2, 1999, Pages 82-90

  Coppen, Steven R ^a   Severs, Nicholas J ^a   Gourdie, Robert G ^b  

^a ROYAL BROMPTON HOSPITAL   (United Kingdom)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Conduction system; Development; Heart; Transgenic; 6 (Cx45)

Indexed keywords

CONNEXIN 45; GAP JUNCTION PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ATRIOVENTRICULAR CONDUCTION; CELL VIABILITY; CONTROLLED STUDY; EMBRYO; HEART MUSCLE CONDUCTION SYSTEM; HIS BUNDLE; HISTOLOGY; IMMUNOFLUORESCENCE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TISSUE DISTRIBUTION; TRANSGENIC MOUSE;

ANIMALIA; MAMMALIA; MUS MUSCULUS; RODENTIA;

EID: 0033041407     PISSN: 0192253X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-6408(1999)24:1/2<82::AID-DVG9>3.0.CO;2-1     Document Type: Article

References (30)

1. Beyer EC, Seul KH, Larson D. 1998. Cardiovascular gap junction proteins: Molecular characterization and biochemical regulation. In: DeMello WC, Janse M, editors. Cardiac gap junctions: Aspects in health and disease. Boston, Dordrecht, London: Kluwer, pp 45-72.
2. Chan-Thomas PS, Thompson RP, Robert B, Yacoub MH, Barton PJ. 1993. Expression of homeobox genes Msx-1 (Hox-7) and Msx-2 (Hox-8) during cardiac development in the chick. Dev Dyn 197:203-216.
3. Cheng G, Thompson RP, Mikawa T, Gourdie RG. 1998. Retroviral cell lineage tracing of the developmental origin of the cardiac conduction system. FASEB J 12:A324.
4. Coppen SR, Dupont E, Rothery S, Severs NJ. 1998. Connexin45 expression is preferentially associated with the ventricular conduction system in mouse and rat heart. Circ Res 82:232-243.
5. Davis LM, Kanter HL, Beyer EC, Saffitz JE. 1994. Distinct gap junction protein phenotypes in cardiac tissues with disparate conduction properties. J Am Coll Cardiol 24:1124-1132.
6. Davis LM, Rodefeld ME, Green K, Beyer EC, Saffitz JE. 1995. Gap junction protein phenotypes of the human heart and conduction system. J Cardiovasc Electrophysiol 6:813-822.
7. Gittenberger-de Groot AC, Vrancken Peeters M-PFM, Mentink MMT, Gourdie RG, Poelmann RE. 1998. Epicardial derived cells contribute a novel population to the myocardial wall and the atrioventricular cushions. Circ Res 82:1043-1052.
8. Gourdie RG, Green CR, Severs NJ, Thompson RP. 1992. Immunolabelling patterns of gap junction connexins in the developing and mature rat heart. Anat Embryol 185:363-378.
9. Gourdie RG, Green CR, Severs NJ, Anderson RH, Thompson RP. 1993a. Evidence for a distinct gap-junctional phenotype in ventricular conduction tissues of the developing and mature avian heart. Circ Res 72:278-289.
10. Gourdie RG, Severs NJ, Green CR, Rothery S, Germroth P, Thompson RP. 1993b. The spatial distribution and relative abundance of gap-junctional connexin40 and connexin43 correlate to functional properties of components of the cardiac atrioventricular conduction system. J Cell Sci 105:985-991.
11. Gourdie RG, Mima T, Thompson RP, Mikawa T. 1995. Terminal diversification of the myocyte lineage generates Purkinje fibers of the cardiac conduction system. Development 121:1423-1431.
12. Gourdie RG, Kubalak S, Mikawa T. 1998a. Conducting the embryonic heart: Orchestrating development of cardiac specialized tissues. Trends Cardiovasc Med, 9:in press.
13. Gourdie RG, Litchenberg WH, Eisenberg LM. 1998b. Gap junctions and heart development. In: DeMello WC, Janse M, editors. Cardiac gap junctions: Aspects in health and disease. Boston: Kluwer, pp 19-44.
14. Gourdie RG, Wei Y, Kim D, Klatt S, Mikawa T. 1998c. Endothelin-induced conversion of embryonic heart muscle cells into impulse conducting cardiac Purkinje fibers. Proc Natl Acad Sci USA 95:6815-6818.
15. Gros DB, Jongsma HJ. 1996. Connexins in mammalian heart function. Bioessays 18:719-730.
16. Guerrero PA, Schuessler RB, Davis LM, Beyer EC, Johnson CM, Yamada KA, Saffitz JE. 1997. Slow ventricular conduction in mice heterozygous for a connexin43 null mutation. J Clin Invest 99:1991-1998.
17. Kanter HL, Saffitz JE, Beyer EC. 1992. Cardiac myocytes express multiple gap junction proteins. Circ Res 70:438-444.
18. Kanter HL, Laing JG, Beyer EC, Green KG, Saffitz JE. 1993. Multiple connexins colocalize in canine ventricular myocyte gap junctions. Circ Res 73:344-350.
19. Kirchhoff S, Nelles E, Hagendorff A, Kruger O, Traub O, Willecke K. 1998. Reduced cardiac conduction velocity and predisposition to arrhythmias in connexin40-deficient mice. Curr Biol 8:299-302.
20. Masaki T, Kimura S, Yanagisawa M, Goto K. 1991. Molecular and cellular mechanism of endothelin regulation. Implications for vascular function. Circulation 84:1457-1468.
21. McGuire MA, Debakker JMT, Vermeulen JT, Moorman AFM, Loh P, Thibault B, Vermeulen JLM, Becker AE, Janse MJ. 1996. Atrioventricular junctional tissue - Discrepancy between histological and electrophysiological characteristics. Circulation 94:571-577.
22. Moorman AF, de Jong F, Lamers WH. 1997. Development of the conduction system of the heart. Pacing Clin Electrophysiol 20:2087-2092.
23. Schott JJ, Benson DW, Basson CT, Pease W, Silberbach GM, Moak JP, Maron BJ, Seidman CE, Seidman JG. 1998. Congenital heart disease caused by mutations in the transcription factor Nkx2-5. Science 281:108-111.
24. Severs NJ, Dupont E, Kaprielian R, Yeh HI, Rothery S. 1996. Gap junctions and connexins in the cardiovascular system. In: Annual of Cardiac Surgery. London: Rapid Science Publishers, pp 31-44.
25. Simon AM, Goodenough DA, Paul DL. 1998. Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block. Curr Biol 8:295-298.
26. Thomas SA, Schuessler RB, Berul CI, Beardslee MA, Beyer EC, Mendelsohn ME, Saffitz JE. 1998. Disparate effects of deficient expression of connexin43 on atrial and ventricular conduction. Evidence for chamber-specific molecular determinants of conduction. Circulation 97:686-691.
27. Van Kempen MJ, Vermeulen JL, Moorman AF, Gros D, Paul DL, Lamers WH. 1996. Developmental changes of connexin40 and connexin43 mRNA distribution patterns in the rat heart. Cardiovasc Res 32:886-900.
28. Walsh EP, Saul JP. 1991. Cardiac arrhythmias. In: Fyler D, Nadas AS, editors. Congenital heart disease. Philadelphia: Hanley & Belfus, pp 377-433.
29. Wessels A, Vermeulen JL, Verbeek FJ, Viragh S, Kalman F, Lamers WH, Moorman AF. 1992. Spatial distribution of "tissue-specific" antigens in the developing human heart and skeletal muscle. III. An immunohistochemical analysis of the distribution of the neural tissue antigen G1N2 in the embryonic heart; implications for the development of the atrioventricular conduction system. Anat Rec 232:97-111.
30. Yeh HI, Dupont E, Coppen S, Rothery S, Severs NJ. 1997. Gap junction localization and connexin expression in cytochemically identified endothelial cells of arterial tissue. J Histochem Cytochem 45: 539-550.