Downregulation of connexin 45 gene products during mouse heart development

Circulation Research

Volumn 84, Issue 12, 1999, Pages 1365-1379

  Alcoléa, Sébastien ^a   Théveniau Ruissy, Magali ^a   Jarry Guichard, Thérèse ^a   Marics, Irène ^a   Tzouanacou, Elena ^a   Chauvin, Jean Paul ^a   Briand, Jean Paul ^c   Moorman, Antoon F M ^b   Lamers, Wouter H ^b   Gros, Daniel B ^a  

^a AIX MARSEILLE UNIVERSITÉ   (France)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c INSTITUT DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

Connexin 45; Development; Heart

Indexed keywords

CONNEXIN 45; GAP JUNCTION PROTEIN; GENE PRODUCT; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; DOWN REGULATION; GAP JUNCTION; GENE EXPRESSION; HEART CONDUCTION; HEART CONTRACTION; HEART DEVELOPMENT; HEART LEFT VENTRICLE OUTFLOW TRACT; HEART MUSCLE CELL; HEART VENTRICLE; HEART VENTRICLE SEPTUM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINUS NODE; TISSUE DISTRIBUTION; TISSUE SPECIFICITY;

EID: 18244411722     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.84.12.1365     Document Type: Article

References (59)

1. Bruzzone R, White TW, Paul DL. Connections with connexins: the molecular basis of direct intercellular signaling. Eur J Biochem. 1996; 238:1-27.
2. Bruzzone R, White TW, Goodenough DA. The cellular Internet: on-line with connexins. BioEssays. 1996;18:709-718.
3. Sosinski GE. Molecular organization of gap junction membrane channels. J Bioenerg Biomembr. 1996;28:297-309.
4. White TW, Bruzzone R. Multiple connexin proteins in single intercellular channels: connexin compatibility and functional consequences. J Bioenerg Biomembr. 1996;28:339-350.
5. Kumar NM, Gilula N B. The gap junction communication channel. Cell. 1996;84:381-388.
6. Goodenough DA, Goliger JA, Paul DL. Connexins, connexons, and intercellular communication. Annu Rev Biochem. 1996;65:475-502.
7. Yeager A, Nicholson BJ. Structure of gap junction intercellular channels. Curr Opin Struct Biol. 1996;6:183-192.
8. Nicholson SM, Bruzzone R. Gap junctions: getting the message through. Curr Biol. 1997;7:R340-R344.
9. Jongsma HJ, Rook MB. Morphology and electrophysiology of cardiac gap junction channels. In: Zipes DP, Jalife J, eds. Cardiac Electrophysiology: From Cell to Bedside. Philadelphia, Pa: WB Saunders Co; 1996: 115-126.
10. Gros D, Jongsma HJ. Connexins in mammalian heart function. BioEssays. 1996;18:719-730.
11. Gourdie RG, Green CR, Severs NJ, Thompson RP. Immunolabeling patterns of gap junction connexins in the developing and mature rat heart. Anat Embryol. 1992;185:363-378.
12. Van Kempen MA, Ten Velde I, Wessels A, Oosthoek PW, Gros D, Jongsma HJ, Moorman AFM, Lamers WH. Differential connexin distribution accommodates cardiac function in different species. Microsc Res Tech. 1995;31:420-436.
13. Delorme B, Dahl E, Jarry-Guichard T, Briand JP, Willecke K, Gros D, Théveniau-Ruissy M. Expression pattern of connexin genes products at the early developmental stages of the mouse cardiovascular system. Circ Res. 1997;81:423-437.
14. Fromaget C, El Aoumari A, Dupont E, Briand JP, Gros D. Changes in the expression of connexin 43, a gap junctional protein, during mouse heart development. J Mol Cell Cardiol. 1990;22:1245-1248.
15. Réaume AG, de Sousa PA, Kulkarni S, Langille BL, Zhu D, Davies TC, Juneja SC, Kidder GM, Rossant J. Cardiac malformation in mice lacking connexin 43. Science. 1995;267:1831-1834.
16. Guerrero PA, Schuessler RB, Beyer EC, Saffitz JE. Mice heterozygous for a Cx43 null mutation exhibit a cardiac conduction defect. J Clin Invest. 1997;97:1991-1998.
17. Ya J, Erdtsieck-Emste EBHW, De Boer PAJ, Van Kempen MJA, Jongsma HJ, Gros D, Moorman AFM, Lamers WH. Heart defect in connexin43-deficient mice. Circ Res. 1998;82:360-366.
18. Thomas SA, Schuessler RB, Berul CI, Beardslee MA, Beyer EC, Mendelsohn ME, Saffitz JE. Disparate effects of deficient expression of connexin43 on atrial and ventricular conduction: evidence for chamber-specific molecular determinants of conduction. Circulation. 1998;97: 686-691.
19. Gourdie RG, Severs NJ, Green CR, Rothery S, Germroth P, Thompson RP. The spatial distribution and relative abundance of gap-junctional connexin40 and connexin43 correlate to functional properties of components of the cardiac atrioventricular conduction system. J Cell Sci. 1993;105:985-991.
20. Delorme B, Dahl E, Jarry-Guichard T, Marics I, Briand JP, Willecke K, Gros D, Théveniau-Ruissy M. Developmental regulation of connexin 40 gene expression in mouse heart correlates with the differentiation of the conduction system. Dev Dyn. 1995;20:358-371.
21. Simon AM, Goodenough DA, Paul DL. Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block. Curr Biol. 1998;8:295-298.
22. Kirchhoff S, Nelles E, Hagendorff A, Krüger O, Traub O, Willecke K. Reduced cardiac conduction velocity and predisposition to arrhythmias in connexin40-deficient mice. Curr Biol. 1998;8:299-302.
23. Eckert R, Dunina-Barkovskaya A, Hülser DF. Biophysical characterization of gap junction channels in HeLa cells. Pflügers Arch. 1993;424: 335-342.
24. Moreno A P, Laing JG, Beyer EC, Spray DC. Properties of gap junction channels formed of connexin 45 endogenously expressed in human hepatoma (SKHep1) cells. Am J Physiol. 1995;268:C356-C365.
25. Kwak BR, Hermans MMP, De Jonge HR, Lohman SM, Jongsma HJ, Chanson M. Differential regulation of distinct types of gap junction channels by similar phosphorylating conditions. Mol Biol Cell. 1995;6: 1707-1719.
26. Hennemann H, Schwarz H-J, Willecke K. Characterization of gap junction genes expressed in F9 embryonic carcinoma cells: molecular cloning of mouse connexin 31 and -45 cDNAs. Eur J Cell Biol. 1992; 57:51-58.
27. Davis LM, Kanter LH, Beyer EC, Saffitz JE. Distinct gap junction protein phenotypes in cardiac tissues with disparate conduction system. J Am Coll Cardiol. 1994;24:1124-1132.
28. Saffitz JE, Kanter HL, Green KG, Tolley TK, Beyer EC. Tissue-specific determinants of anisotropic conduction velocity in canine atrial and ventricular myocardium. Circ Res. 1994;74:1065-1070.
29. Coppen SR, Dupond E, Rothery S, Severs NJ. Connexin45 expression is preferentially associated with the ventricular conduction system in mouse and rat heart. Circ Res. 1998;82:232-243.
30. Butterweck A, Gergs U, Elfgang C, Willecke K, Traub O. Immunochemical characterization of the gap junction protein connexin45 in mouse kidney and transfected human HeLa cells. J Membr Biol. 1994; 141:247-256.
31. Darrow BJ, Laing JG, Lampe PD, Saffitz JE, Beyer EC. Expression of multiple connexins in cultured neonatal rat ventricular myocytes. Circ Res. 1995;76:381-387.
32. Hertlein B, Butterweck A, Haubrich K, Willecke W, Traub O. Phosphorylated carboxy-terminal serine residues stabilize the mouse gap junction protein connexin45 against degradation. J Membr Biol. 1998;162: 247-257.
33. Kanter LH, Saffitz JE, Beyer EC. Cardiac myocytes express multiple gap junction proteins. Circ Res. 1992;70:438-444.
34. Kanter HL, Laing JG, Beyer EC, Green KG, Saffitz JE. Multiple connexins colocalize in canine ventricular myocyte gap junctions. Circ Res. 1993;73:344-350.
35. Kanter LH, Saffitz JE, Beyer EC. Molecular cloning of two novel human cardiac gap junction proteins, connexin 40 and connexin 45. J Mol Cell Cardiol. 1994;26:861-868.
36. Chen SC, Davis LM, Westphale EM, Beyer EC, Saffitz JE. Expression of multiple gap junction proteins in human fetal and infant hearts. Pediatr Res. 1994;36:561-566.
37. Darrow BJ, Fast VG, Kléber AG, Beyer EC, Saffitz JE. Functional and structural assessment of intercellular communication: increased conduction velocity and enhanced connexin expression in dibutyryl cAMP-treated cultured cardiac myocytes. Circ Res. 1996;79:174-183.
38. Verheule S, Van Kempen MJA, te Welscher PHJA, Kwak BR, Jongsma HJ. Characterization of gap junction channels in adult rabbit atrial and ventricular myocardium. Circ Res. 1997;80:673-681.
39. Coppen SR, Severs NJ, Gourdie RG. Connexin 45 (α6) expression delineates an extended conduction system in the embryonic and mature rodent heart. Dev Genet. 1999;24:82-90.
40. Steinberg TH, Civitelli R, Geist ST, Robertson AJ, Hick E, Veenstra RD, Wang H-Z, Warlow PM, Westphale EM, Laing JG, Beyer EC. Connexin43 and connexin45 form gap junctions with different molecular properties in osteoblastic cells. EMBO J. 1994;13:744-750.
41. Hülser DF, Rehkopf B, Traub O. Dispersed and aggregated gap junction channels identified by immunogold labeling of freeze-fractured membranes. Exp Cell Res. 1997;233:240-251.
42. Kaufman MH. The Atlas of Mouse Development. London, UK: Academic Press Ltd; 1992.
43. Chomczynski P, Sacchi N. Single-step method of RNA isolation by guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162:156-159.
44. 2+-ATPase mRNA. FEBS Lett. 1989;249:35-41.
45. 2+-ATPase and phospholamban mRNAs during rat heart development. Circ Res. 1995;76:616-625.
46. Sabath DE, Broome HE, Prystowsky MB. Glyceraldhehyde-3-phosphate dehydrogenase mRNA is a major interleukin 2-induced transcript in a cloned T-helper lymphocyte. Gene. 1990;91:185-191.
47. Li H, Choudhary SK, Milner DJ, Munir MI, Kusik IR, Capetanaki Y. Inhibition of desmin expression blocks fusion and interferes with the myogenic regulator MyoD and myogenin. J Cell Biol. 1994;124: 827-841.
48. Beyer EC. Molecular cloning and developmental expression of two chick embryo gap junction proteins. J Biol Chem. 1990;265:14439-14443.
49. Dupont E, El Aoumari A, Fromaget C, Briand JP, Gros D. Immunological characterization of rat cardiac gap junctions: presence of common antigenic determinant in heart of other vertebrate species and in various organs. J Membr Biol. 1988;104:119-128.
50. Bastide B, Jarry-Guichard T, Briand JP, Délèze J, Gros D. Effect of antipeptide directed against three domains of connexin 43 on the gap junctional permeability of cultured heart cells. J Membr Biol. 1996;150: 243-253.
51. Debus E, Weber K, Osborn M. Monoclonal antibodies to desmin, the muscle-specific intermediate filament protein. EMBO J. 1983;2: 2305-2312.
52. Berryman MA, Rodewald RD. An enhanced method for post-embedding immuno-cytochemical staining which preserves cell membranes. J Histochem Cytochem. 1990;38:159-170.
53. Gros D, Jarry-Guichard T, Ten Velde I, De Maziere A, Van Kempen MJA, Davoust J, Briand JP, Moorman AFM, Jongsma HJ. Restricted distribution of connexin 40, a gap junctional protein, in mammalian heart. Circ Res. 1994;74:839-851.
54. Rugh R. The Mouse: Its Reproduction and Development. Oxford, UK: Oxford Science Publications; 1990.
55. Hirota A, Kamino K, Komuro H, Sakai T, Yada T. Early events in development of electrical activity and contraction in embryonic rat heart assessed by optical recording. J Physiol (Lond). 1985;369:209-227.
56. Van Kempen MA, Vermeulen JLM, Moorman AFM, Gros D, Paul DL, Lamers WH. Developmental changes in the connexin40 and connexin43 mRNA-distribution pattern in the rat heart. Cardiovasc Res. 1996;32: 886-900.
57. Okuma A, Kuraoka A, Iida H, Wasano K, Shibata Y. Colocalization of connexin43 and connexin45 but absence of connexin40 in granulosa cell gap junctions of rat ovary. J Reprod Fertil. 1996;107:255-264.
58. Schaart G, Viebahn C, Langmann W, Ramaekers F. Desmin and titin expression in early postimplantation mouse embryos. Development. 1989; 107:585-596.
59. de Jong F, Opt'Hof T, Wilde AAM, Janse MJ, Charles R, Lamers WH, Moorman AFM. Persisting zones of slow impulse conduction in developing chicken heart. Circ Res. 1992;71:240-250.