High-resolution optical mapping of the right bundle branch in connexin40 knockout mice reveals slow conduction in the specialized conduction system

Circulation Research

Volumn 87, Issue 10, 2000, Pages 929-936

  Tamaddon, Houman S ^a   Vaidya, Dhananjay ^a   Simon, Alexander M ^b   Paul, David L ^c   Jalife, José ^a   Morley, Gregory E ^a  

^a State University of New York Upstate Medical University: College of Medicine   (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Connexin40; Knockout mice; Optical mapping; Specialized conduction system

Indexed keywords

CONNEXIN 40; CONNEXIN 45;

ANIMAL EXPERIMENT; ARTICLE; ELECTROCARDIOGRAPHY; HEART CONDUCTION; HEART LEFT VENTRICLE; HEART RIGHT VENTRICLE; HIS BUNDLE; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PURKINJE FIBER;

EID: 0034634288     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.87.10.929     Document Type: Article

References (42)

1. Continuous and discontinuous propagation
2. Altered pattern of connexin40 distribution in persistent atrial fibrillation in the goat
3. Conduction disturbances and increased atrial vulnerability in connexin40-deficient mice analyzed by transesophageal stimulation
4. Reduced cardiac conduction velocity and predisposition to arrhythmias in connexin40-deficient mice
5. Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block
6. Gap junction protein connexin40 is preferentially expressed in vascular endothelium and conductive bundles of rat myocardium and is increased under hypertensive conditions
7. 6) expression delineates an extended conduction system in the embryonic and mature rodent heart
8. Gap junction protein phenotypes of the human heart and conduction system
9. Impaired conduction of vasodilation along arterioles in connexin40-deficient mice
10. Expression pattern of connexin gene products at the early developmental stages of the mouse cardiovascular system
11. Spatial distribution of connexin43, the major cardiac gap junction protein, in the developing and adult rat heart
12. Connexins in mammalian heart function
13. The spatial distribution and relative abundance of gap-junctional connexin40 and connexin43 correlate to functional properties of components of the cardiac atrioventricular conduction system
14. The conduction system of the mouse heart
15. Development of the cardiac conduction system
16. Physiology of canine intraventricular conduction and endocardial excitation
17. Electrophysiological properties of the canine peripheral A-V conducting system
18. Total excitation of the isolated human heart
19. Cardiac conduction abnormalities in mice lacking the gap junction protein connexin40
20. Estimation of conduction velocity vector fields from epicardial mapping data
21. Characterization of conduction in the ventricles of normal and heterozygous connexin43 knockout mice using optical mapping
22. Purkinje-muscle reentry as a mechanism of polymorphic ventricular arrhythmias in a 3-dimensional model of the ventricles
23. Electrical uncoupling and impulse propagation in isolated sheep Purkinje fibers
24. Slow conduction in cardiac tissue, I: Effects of a reduction of excitability versus a reduction of electrical coupling on microconduction
25. Slow conduction in cardiac tissue, II: Effects of branching tissue geometry
26. Gap junction uncoupling and discontinuous propagation in the heart: A comparison of experimental data with computer simulations
27. Paradoxical improvement of impulse conduction in cardiac tissue by partial cellular uncoupling
28. Dynamics of intramural scroll waves in threedimensional continuous myocardium with rotational anisotropy
29. Conductances and selective permeability of connexin43 gap junction channels examined in neonatal rat heart cells
30. Conditional lineage ablation to model human diseases
31. Cardiac physiology in transgenic mice
32. Connexins and impulse propagation in the mouse heart
33. Cardiac malformation in neonatal mice lacking connexin43
34. Block of impulse propagation at an abrupt tissue expansion: Evaluation of the critical strand diameter in 2- and 3-dimensional computer models
35. Propagation of impulses across the Purkinje fiber-muscle junctions in the dog heart
36. A mechanism for reentry in canine ventricular tissue
37. Spread of the epicardial excitation in right bundle branch block pattern
38. The gating mechanism in the distal atrioventricular conducting system
39. Functional characteristics of the gating mechanism in the canine A-V conducting system
40. Cardiac tissue geometry as a determinant of unidirectional conduction block: Assessment of microscopic excitation spread by optical mapping in patterned cell cultures and in a computer model