Role of connexin 43 in ischemic preconditioning does not involve intercellular communication through gap junctions

Journal of Molecular and Cellular Cardiology

Volumn 36, Issue 1, 2004, Pages 161-163

  Li, X ^a   Heinzel, F R ^a   Boengler, K ^a   Schulz, R ^a   Heusch, G ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

Cardioprotection; Connexin 43; Ischemic preconditioning; Myocardial ischemia

Indexed keywords

CONNEXIN 43;

ANIMAL CELL; ARTICLE; CELL COMMUNICATION; CELL ISOLATION; CELL VIABILITY; CONTROLLED STUDY; GAP JUNCTION; HEART INFARCTION PREVENTION; HEART MUSCLE CELL; HEART VOLUME; HETEROZYGOTE; HOMEOSTASIS; ISCHEMIA; KNOCKOUT MOUSE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REOXYGENATION; SIMULATION; STRAIN DIFFERENCE; WILD TYPE;

EID: 0347635344     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2003.10.019     Document Type: Article

References (20)

1. Ping P., Zhang J., Pierce W.M., Bolli R. Functional proteomic analysis of protein kinase Cε signaling complexes in the normal heart and during cardioprotection. Circ Res. 88:2001;59-62.
2. Schulz R., Gres P., Skyschally A., Duschin A., Belosjorow S., Konietzka I., et al. Ischemic preconditioning preserves connexin 43 phosphorylation during sustained ischemia in pig hearts in vivo. FASEB J. 17:2003;1355-1357.
3. Jain S.K., Schuessler R.B., Saffitz J.E. Mechanisms of delayed electrical uncoupling induced by ischemic preconditioning. Circ Res. 92:2003;1138-1144.
4. Miura T., Ohnuma Y., Kuno A., Tanno M., Ichikawa Y., Nakamura Y., et al. Protective role of gap junctions in preconditioning against myocardial infarction. Am J Physiol Heart Circ Physiol. 2003;. 10.1152/ajpheart.00441.2003.
5. Li G., Whittaker P., Yao M., Kloner R.A., Przyklenk K. The gap junction uncoupler heptanol abrogates infarct size reduction with preconditioning in mouse hearts. Cardiovasc Pathol. 11:2002;158-165.
6. Schwanke U., Konietzka I., Duschin A., Li X., Schulz R., Heusch G. No ischemic preconditioning in heterozygous connexin43-deficient mice. Am J Physiol Heart Circ Physiol. 283:2002;H1740-H1742.
7. Schwanke U., Li X., Schulz R., Heusch G. No ischemic preconditioning in heterozygous connexin 43-deficient mice: a further in vivo study. Basic Res Cardiol. 98:2003;181-182.
8. Padilla F., Garcia-Dorado D., Rodriguez-Sinovas A., Ruiz-Meana M., Inserte J., Soler-Soler J. Protection afforded by ischemic preconditioning is not mediated by effects on cell-to-cell electrical coupling during myocardial ischemia-reperfusion. Am J Physiol Heart Circ Physiol. 285:2003;H1909-H1916.
9. Quist A.P., Rhee S.K., Lin H., Lal R. Physiological role of gap-junctional hemichannels. Extracellular calcium-dependent isosmotic volume regulation. J Cell Biol. 148:2000;1063-1074.
10. Schulz R., Cohen M.V., Behrends M., Downey J.M., Heusch G. Signal transduction of ischemic preconditioning. Cardiovasc Res. 52:2001;181-198.
11. Armstrong S., Downey J.M., Ganote C.E. Preconditioning of isolated rabbit cardiomyocytes: induction by metabolic stress and blockade by the adenosine antagonist SPT and calphostin C, a protein kinase C inhibitor. Cardiovasc Res. 28:1994;72-77.
12. Kirchhoff S., Kim J.-S., Hagendorff A., Thönissen E., Krüger O., Lamers W.H., et al. Abnormal cardiac conduction and morphogenesis in connexin40 and connexin43 double-deficient mice. Circ Res. 87:2000;399-405.
13. Wolska B.M., Solaro R.J. Method for isolation of adult mouse cardiac myocytes for studies of contraction and microfluorimetry. Am J Physiol Heart Circ Physiol. 40:1996;H1250-H1255.
14. Hilal-Dandan R., Kanter J.R., Brunton L.L. Characterization of G-protein signaling in ventricular myocytes from the adult mouse heart: differences from the rat. J Mol Cell Cardiol. 32:2000;1211-1221.
15. Lim C.C., Apstein C.S., Colucci W.S., Liao R. Impaired cell shortening and relengthening with increased pacing frequency are intrinsic to the senescent mouse cardiomyocyte. J Mol Cell Cardiol. 32:2000;2075-2082.
16. Armstrong S.C., Kao R., Gao W., Shivell L.C., Downey J.M., Honkanen R.E., et al. Comparison of in vitro preconditioning responses of isolated pig and rabbit cardiomyocytes: effects of a protein phosphatase inhibitor, fostriecin. J Mol Cell Cardiol. 29:1997;3009-3024.
17. Ikonomidis J.S., Tumiati L.C., Weisel R.D., Mickle D.A.G., Li R.K. Preconditioning human ventricular cardiomyocytes with brief periods of simulated ischaemia. Cardiovasc Res. 28:1994;1285-1291.
18. ATP channels. Naunyn-Schmiedeberg's Arch Pharmacol. 367:2003;219-226.
19. Li H., Brodsky S., Kumari S., Valiunas V., Brink P., Kaide J.-I., et al. Paradoxical overexpression and translocation of connexin 43 in homocysteine-treated endothelial cells. Am J Physiol Heart Circ Physiol. 282:2001;H2124-H2133.
20. Krieg T., Cohen M.V., Downey J.M. Mitochondria and their role in preconditioning's trigger phase. Basic Res Cardiol. 98:2003;228-234.