Quinoline drug-heme interactions and implications for antimalarial cytostatic versus cytocidal activities

Journal of Medicinal Chemistry

Volumn 56, Issue 13, 2013, Pages 5231-5246

  Gorka, Alexander P ^a   De Dios, Angel ^a   Roepe, Paul D ^a  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMODIAQUINE; ANTIMALARIAL AGENT; ARTEMETHER; ARTEMISININ; ARTESUNATE; ATOVAQUONE; BENFLUMETOL; CHLOROQUINE; DIHYDROARTEMISININ; HALOFANTRINE; HEME; HEMOGLOBIN; HEMOZOIN; MEFLOQUINE; PIPERAQUINE; PRIMAQUINE; PYRIMETHAMINE; QUINIDINE; QUININE; QUINOLINE; SULFADOXINE;

ANTIMALARIAL ACTIVITY; ANTIMALARIAL DRUG RESISTANCE; ARTICLE; BIOMINERALIZATION; CATABOLISM; CELL VACUOLE; CRYSTALLIZATION; DRUG DESIGN; DRUG PROTEIN BINDING; ERYTHROCYTE; HUMAN; MOLECULAR INTERACTION; NONHUMAN; PARASITE;

ANTIMALARIALS; CRYSTALLIZATION; DRUG RESISTANCE; HEME; HEMEPROTEINS; HUMANS; MALARIA, FALCIPARUM; MOLECULAR STRUCTURE; PLASMODIUM FALCIPARUM; QUINOLINES;

EID: 84880161070     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400282d     Document Type: Article

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