Structure - Activity relationships in 4-aminoquinoline antiplasmodials. The role of the group at the 7-position

Journal of Medicinal Chemistry

Volumn 45, Issue 16, 2002, Pages 3531-3539

  Kaschula, Catherine H ^a   Egan, Timothy J ^a   Hunter, Roger ^a   Basilico, Nicoletta ^b   Parapini, Silvia ^b   Taramelli, Donatella ^b   Pasini, Erica ^b   Monti, Diego ^b  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOQUINOLINE; 4 AMINOQUINOLINE; ANTIMALARIAL AGENT; HEMATIN; N 2 (7 AMINO 4 QUINOLINYL) N 1,N 1 DIETHYL 1,2 ETHANEDIAMINE; N 2 (7 BROMO 4 QUINOLINYL) N1,N1 DIETHYL 1,2 ETHANEDIAMINE; N1,N1 DIETHYL N 2 (7 FLUORO 4 QUINOLINYL) 1,2 ETHANEDIAMINE; N1,N1 DIETHYL N 2 (7 HYDROXY 4 QUINOLINYL) 1,2 ETHANEDIAMINE; N1,N1 DIETHYL N 2 (7 IODO 4 QUINOLINYL) 1,2 ETHANEDIAMINE; N1,N1 DIETHYL N 2 (7 METHOXY 4 QUINOLINYL) 1,2 ETHANEDIAMINE; N1,N1 DIETHYL N 2 (7 METHYL 4 QUINOLINYL) 1,2 ETHANEDIAMINE; N1,N1 DIETHYL N 2 (7 NITRO 4 QUINOLINYL) 1,2 ETHANEDIEMINE; N1,N1 DIETHYL N 2 (7 TRIFLUOROMETHYL 4 QUINOLINYL) 1,2 ETHANEDIAMINE; NITROGEN; UNCLASSIFIED DRUG;

ANTIBIOTIC SENSITIVITY; ARTICLE; ASSOCIATION; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CORRELATION ANALYSIS; IC 50; INHIBITION KINETICS; LIPOPHILICITY; MELTING POINT; NONHUMAN; PH; PLASMODIUM FALCIPARUM; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

AMINOQUINOLINES; ANIMALS; ANTIMALARIALS; HEMIN; INHIBITORY CONCENTRATION 50; PLASMODIUM FALCIPARUM; POLYMERS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036681979     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020858u     Document Type: Article

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