Mutation in the Plasmodium falciparum CRT protein determines the stereospecific activity of antimalarial Cinchona alkaloids

Antimicrobial Agents and Chemotherapy

Volumn 56, Issue 10, 2012, Pages 5356-5364

  Griffin, Carol E ^a,f   Hoke, Jonathan M ^a   Samarakoon, Upeka ^b   Duan, Junhui ^c   Mu, Jianbing ^c   Ferdig, Michael T ^b   Warhurst, David C ^d   Cooper, Roland A ^a,e  

^a OLD DOMINION UNIVERSITY   (United States)

^b UNIVERSITY OF NOTRE DAME   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^e DOMINICAN UNIVERSITY OF CALIFORNIA   (United States)

^f EDWARD VIA COLLEGE OF OSTEOPATHIC MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CINCHONA ALKALOID; CINCHONIDINE; CINCHONINE; QUINIDINE; QUININE;

ANTIMALARIAL ACTIVITY; ARTICLE; GENE MUTATION; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALARIA; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL;

ANTIMALARIALS; CINCHONA ALKALOIDS; MEMBRANE TRANSPORT PROTEINS; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; QUINIDINE; QUINOLINES;

EID: 84866340548     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.05667-11     Document Type: Article

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