Structure-function relationships in aminoquinolines: Effect of amino and chloro groups on quinoline-hematin complex formation, inhibition of β- hematin formation, and antiplasmodial activity

Journal of Medicinal Chemistry

Volumn 43, Issue 2, 2000, Pages 283-291

  Egan, Timothy J ^a   Hunter, Roger ^a   Kaschula, Catherine H ^a   Marques, Helder M ^b   Misplon, Ashley ^a   Walden, Jason ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b UNIVERSITY OF THE WITWATERSRAND   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOQUINOLINE; 4 AMINOQUINOLINE; 4 AMINOQUINOLINE DERIVATIVE; AMINOQUINOLINE DERIVATIVE; CHLOROQUINE; HEMATIN; HEMOZOIN; QUINOLINE;

ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; DRUG STRUCTURE; STRUCTURE ACTIVITY RELATION;

AMINOQUINOLINES; ANIMALS; ANTIMALARIALS; HEMIN; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034719487     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990437l     Document Type: Article

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