Relationship between antimalarial drug activity, accumulation, and inhibition of heme polymerization in Plasmodium falciparum in vitro

Antimicrobial Agents and Chemotherapy

Volumn 42, Issue 3, 1998, Pages 682-686

  Hawley, Shaun R ^a   Bray, Patrick G ^a   Mungthin, Mathirut ^a   Atkinson, Jill D ^a   O'Neill, Paul M ^a   Ward, Stephen A ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

7 CHLORO 4 (4' PYROLLIDINO 1' METHYLBUTAMINO)QUINOLINE; AMODIAQUINE; AMOPYROQUINE; ARTEETHER; ARTEMETHER; BIDESETHYLAMODIAQUINE; CHLOROQUINE; CINCHONINE; DEETHYLAMODIAQUINE; DEETHYLCHLOROQUINE; HALOFANTRINE; HEMATIN; HEME; MEFLOQUINE; MEPACRINE; PRIMAQUINE; PYRONARIDINE; QUINIDINE; QUININE; QUINOLINE DERIVATIVE; TEBUQUINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; DRUG ACCUMULATION; DRUG POTENCY; DRUG SENSITIVITY; DRUG STRUCTURE; NONHUMAN; PHYSICAL CHEMISTRY; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN POLYMERIZATION;

EID: 0031916653     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.42.3.682     Document Type: Article

References (28)

1. Bray, P. G., M. K. Boulter, G. Y. Ritchie, and S. A. Ward. 1994. Relationship of global chloroquine transport and reversal of chloroquine resistance in P. falciparum. Mol. Biochem. Parasitol. 63:87-94.
2. Bray, P. G., S. R. Hawley, M. Mungthin, and S. A. Ward. 1996. Physicochemical properties correlated with drug resistance and the reversal of drug resistance in Plasmodium falciparum. Mol. Pharmacol. 50:1559-1566.
3. Bray, P. G., S. R. Hawley, and S. A. Ward. 1996. 4-Aminoquinoline resistance of Plasmodium falciparum: insights from the study of amodiaquine uptake. Mol. Pharmacol. 50:1551-1558.
4. Bray, P. G., M. Mungthin, R. Ridley, and S. A. Ward. Submitted for publication.
5. Chou, A. C., and C. D. Fitch. 1980. Haemolysis of mouse erythrocytes by ferriprotoporphyrin IX and chloroquine. Chemotherapeutic implications. J. Clin. Invest. 66:856-858.
6. Cohen, S. N., K. O. Phifer, and K. L. Yielding. 1964. Complex formation between chloroquine and ferrihaemic acid in vitro and its effect on the antimalarial action of chloroquine. Nature 202:805-806.
7. Desjardins, R. E., J. Canfield, D. Haynes, and J. D. Chulay. 1979. Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique. Antimicrob. Agents Chemother. 16:710-718.
8. Dorn, A., R. Stoffel, H. Matile, A. Bubendorf, and R. Ridley. 1995. Malarial haemozoin/β-haematin supports the polymerisation of haem in the absence of protein. Nature 374:269-271.
9. Foley, M., and L. Tilley. 1997. Quinoline antimalarials: mechanisms of action and resistance. Int. J. Parasitol. 27:231-240.
10. Geary, T. G., A. D. Divo, J. B. Jensen, M. Zangwill, and H. Ginsburg. 1990. Kinetic modelling of the response of Plasmodium falciparum to chloroquine and its experimental testing in vitro. Implications for mechanism of action and resistance to the drug. Biochem. Pharmacol. 40:685-691.
11. 3H chloroquine by drug-sensitive and -resistant strains of the human malarial parasite Plasmodium falciparum. Biochem. Pharmacol. 35:3805-3812.
12. Goldberg, D. E., and A. F. G. Slater. 1992. The pathway of hemoglobin degradation in malaria parasites. Parasitol. Today 8:280-283.
13. Hawley, S. R., P. G. Bray, P. M. O'Neill, D. J. Naisbitt, B. K. Park, and S. A. Ward. 1996. Manipulation of the N-alkyl substituent in amodiaquine to overcome the verapamil-sensitive chloroquine resistance component. Antimicrob. Agents Chemother. 40:2345-2349.
14. Hawley, S. R., P. G. Bray, P. M. O'Neill, B. K. Park, and S. A. Ward. 1996. The role of drug accumulation in 4-aminoquinoline antimalarial potency -the influence of structural substitution and physicochemical properties. Biochem. Pharmacol. 52:723-733.
15. Hawley, S. R., P. G. Bray, B. K. Park, and S. A. Ward. 1996. Amodiaquine accumulation in Plasmodium falciparum as a possible explanation for its superior antimalarial activity over chloroquine. Mol. Biochem. Parasitol. 80:15-25.
16. Jensen, J. B., and W. Trager. 1977. Plasmodium falciparum in culture: use of outdated erythrocytes and description of the candle-jar method. J. Parasitol. 63:883-886.
17. Lambros, C., and J. P. Vandenburg. 1979. Synchronisation of Plasmodium falciparum erythrocytic stages in culture. J. Parasitol. 65:418-420.
18. Macomber, P. B., H. Sprinz, and A. J. Tousimis. 1967. Morphological effects of chloroquine on Plasmodium berghei in mice. Nature 214:937-939.
19. Martiney, J. A., A. Cerami, and A. F. G. Slater. 1995. Verapamil reversal of chloroquine resistance in the malaria parasite Plasmodium falciparum is specific for resistant parasites and independent of the weak base effect. J. Biol. Chem. 270:22393-22398.
20. O'Neill, P. M., D. J. Willock, S. R. Hawley, P. G. Bray, R. C. Storr, S. A. Ward, and B. K. Park. 1997. Synthesis, antimalarial activity, and molecular modeling of tebuquine analogues. J. Med. Chem. 40:437-448.
21. Raynes, K., M. Foley, L. Tilley, and L. W. Deady. 1996. Novel bisquinoline antimalarials. Synthesis, antimalarial activity, and inhibition of haem polymerisation. Biochem. Pharmacol. 52:551-559.
22. Rosenthal, P. J., and S. R. Meshnick. 1996. Hemoglobin catabolism and iron utilisation by malaria parasites. Mol. Biochem. Parasitol. 83:131-139.
23. Schueler, F. W., and W. F. Cantrell. 1964. Antagonism of the antimalarial action of chloroquine by ferrihaemate and a hypothesis for the mechanism of chloroquine resistance. J. Pharmacol. Exp. Ther. 143:278-281.
24. Sherman, I. W. 1977. Amino acid metabolism and protein synthesis in malarial parasites. Bull. W. H. O. 55:265-276.
25. 14C-amino acids by malaria (Plasmodium lophurae). Int. J. Biochem. 1:635-637.
26. Slater, A. F. G., and A. Cerami. 1992. Inhibition by chloroquine of a novel haeme polymerase enzyme activity in malaria trophozoites. Nature 355:167-169.
27. Ward, S. A., P. G. Bray, and S. R. Hawley. 1997. Quinoline resistance mechanisms in Plasmodium falciparum: the debate goes on. Parasitology 114:5125-5136.
28. Zarchin, S., M. Krugliak, and H. Ginsburg. 1986. Digestion of the host erythrocyte by malarial parasites is the primary target for quinoline-containing antimalarials. Biochem. Pharmacol. 35:2435-2442.