Crystal nucleation, growth, and morphology of the synthetic malaria pigment β-hematin and the effect thereon by quinoline additives: The malaria pigment as a target of various antimalarial drugs

Journal of the American Chemical Society

Volumn 129, Issue 9, 2007, Pages 2615-2627

  Solomonov, Inna ^a   Osipova, Maria ^a   Feldman, Yishay ^a   Baehtz, Carsten ^b   Kjaer, Kristian ^c   Robinson, Ian K ^d   Webster, Grant T ^e   McNaughton, Don ^e   Wood, Bayden R ^e   Weissbuch, Isabelle ^a   Leiserowitz, Leslie ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b DESY   (Germany)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

HEMATIN CRYSTALS; NEEDLE-LIKE CRYSTALS; SYNCHROTRON X-RAY DIFFRACTION; VACUOLE'S MEMBRANOUS SURFACE;

BINDING ENERGY; CRYSTAL GROWTH; NUCLEATION; RAMAN SCATTERING; TRANSMISSION ELECTRON MICROSCOPY; X RAY DIFFRACTION;

CRYSTALS;

ANTIMALARIAL AGENT; ARTEMISININ; BETA HEMATIN; CHLOROQUINE; DIBEHENOYL PHOSPHATIDYLCHOLINE; HEMOZOIN; PHOSPHATIDYLCHOLINE; PIGMENT; PROPIONIC ACID; QUININE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; CRYSTAL STRUCTURE; DIFFRACTION; DRUG TARGETING; IMAGE ANALYSIS; MALARIA; MATHEMATICAL COMPUTING; NONHUMAN; PIGMENTATION; PRECIPITATION; RAMAN SPECTROMETRY; STEREOCHEMISTRY; STRUCTURE ANALYSIS; SYNCHROTRON RADIATION; TRANSMISSION ELECTRON MICROSCOPY; X RAY DIFFRACTION; X RAY POWDER DIFFRACTION;

ANIMALS; ANTIMALARIALS; BINDING SITES; CHLOROQUINE; DIMERIZATION; DRUG DELIVERY SYSTEMS; HEMEPROTEINS; MICROSCOPY, ELECTRON, TRANSMISSION; PRECIPITATION; PROPIONIC ACIDS; QUINOLINES; SPECTRUM ANALYSIS, RAMAN; STEREOISOMERISM; X-RAY DIFFRACTION;

EID: 33847631234     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0674183     Document Type: Article

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