The crystal structure of halofantrine-ferriprotoporphyrin IX and the mechanism of action of arylmethanol antimalarials

Journal of Inorganic Biochemistry

Volumn 102, Issue 8, 2008, Pages 1660-1667

  de Villiers, Katherine A ^a   Marques, Helder M ^b   Egan, Timothy J ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b UNIVERSITY OF THE WITWATERSRAND   (South Africa)

Author keywords

Antimalarials; Crystal structure; Halofantrine; Heme; Malaria; Quinidine; Quinine

Indexed keywords

9 EPIQUINIDINE; ACETONITRILE; ANTIMALARIAL AGENT; EPIQUININE; HALOFANTRINE; HEMATIN; IRON; METHANOL DERIVATIVE; OXIDE; OXYGEN; PHENANTHRENE; PORPHYRIN; QUINIDINE; QUININE;

ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG MECHANISM; DRUG STRUCTURE; MOLECULAR MECHANICS; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION; X RAY DIFFRACTION;

ALCOHOLS; ANTIMALARIALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HEMIN; MOLECULAR STRUCTURE; PHENANTHRENES;

EID: 46949083309     PISSN: 01620134     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jinorgbio.2008.04.001     Document Type: Article

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