The single crystal X-ray structure of β-hematin DMSO solvate grown in the presence of chloroquine, a β-hematin growth-rate inhibitor

Journal of the American Chemical Society

Volumn 135, Issue 3, 2013, Pages 1037-1047

  Gildenhuys, Johandie ^a   Roex, Tanya Le ^a   Egan, Timothy J ^b   De Villiers, Katherine A ^a  

^a STELLENBOSCH UNIVERSITY   (South Africa)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL COMPOUNDS; ANTIMALARIAL DRUG; AVRAMI CONSTANTS; AVRAMI EQUATIONS; CARBOXYLIC ACID DIMERS; DMSO MOLECULES; EQUILIBRIUM ADSORPTION CONSTANT; EXPONENTIAL KINETICS; HEMOZOIN; IRONPROTOPORPHYRIN; KINETICS STUDIES; LANGMUIR ISOTHERM; LOW CONCENTRATIONS; MECHANISM OF ACTION; PROPIONIC ACIDS; SINGLE CRYSTAL X-RAY DIFFRACTION; SINGLE CRYSTAL X-RAY STRUCTURES;

ADSORPTION; BIOMIMETICS; CARBOXYLIC ACIDS; EMULSIFICATION; FUNCTIONAL GROUPS; HYDROGEN BONDS; IRON COMPOUNDS; SCANNING ELECTRON MICROSCOPY; X RAY DIFFRACTION;

SINGLE CRYSTALS;

BETA HEMATIN; CARBOXYLIC ACID; CHLOROQUINE; DIMER; DIMETHYL SULFOXIDE; FUNCTIONAL GROUP; HEMATIN; HEMOZOIN; LIPID; LIPID EMULSION; PROPIONIC ACID; PROTOPORPHYRIN; QUINIDINE; UNCLASSIFIED DRUG; WATER;

ADSORPTION; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG ADSORPTION; DRUG BINDING SITE; DRUG MECHANISM; HYDROGEN BOND; IC 50; KINETICS; MOLECULAR DYNAMICS; NONHUMAN; PLASMODIUM FALCIPARUM; PRECIPITATION; SCANNING ELECTRON MICROSCOPY; SOLVATION; THEORETICAL MODEL;

ANIMALS; CHLOROQUINE; CRYSTALLOGRAPHY, X-RAY; DIMETHYL SULFOXIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; HEMEPROTEINS; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; SOLUTIONS; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

EID: 84872817411     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja308741e     Document Type: Article

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