Interference with hemozoin formation represents an important mechanism of schistosomicidal action of antimalarial quinoline methanols

PLoS Neglected Tropical Diseases

Volumn 3, Issue 7, 2009, Pages

  Corrêa Soares, Juliana B R ^a   Menezes, Diego ^b   Vannier Santos, Marcos A ^b   Ferreira Pereira, Antonio ^a   Almeida, Giulliana T ^c   Venancio, Thiago M ^c,e   Verjovski Almeida, Sergio ^c   Zishiri, Vincent K ^d   Kuter, David ^d   Hunter, Roger ^d   Egan, Timothy J ^d   Oliveira, Marcus F ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d UNIVERSITY OF CAPE TOWN   (South Africa)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMISININ; CLOTRIMAZOLE; HEME; HEMOZOIN; MEPACRINE; PRAZIQUANTEL; QUINIDINE; QUININE; QUINOLINE DERIVATIVE; ANTHELMINTIC AGENT; HEMOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTHELMINTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CRYSTALLIZATION; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; FEMALE; GENE EXPRESSION; IC 50; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; GASTROINTESTINAL TRACT; GENE EXPRESSION PROFILING; INTESTINE MUCOSA; LIVER; MALE; METABOLISM; PARASITE IDENTIFICATION; PARASITOLOGY; ULTRASTRUCTURE;

ANIMALS; ANTHELMINTICS; FEMALE; GASTROINTESTINAL TRACT; GENE EXPRESSION PROFILING; HEMEPROTEINS; INTESTINAL MUCOSA; LIVER; MALE; MICE; PARASITE EGG COUNT; QUINACRINE; QUINIDINE; QUININE; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI;

EID: 70449558126     PISSN: None     EISSN: None     Source Type: Journal    
DOI: 10.1371/journal.pntd.0000477     Document Type: Article

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