Hematin polymerization assay as a high-throughput screen for identification of new antimalarial pharmacophores

Antimicrobial Agents and Chemotherapy

Volumn 44, Issue 10, 2000, Pages 2638-2644

  Kurosawa, Y ^a   Dorn, A ^a   Kitsuji Shirane, M ^a   Shimada, H ^a   Satoh, T ^a   Matile, H ^a   Hofheinz, W ^a   Masciadri, R ^a   Kansy, M ^a   Ridley, R G ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; CHLOROQUINE; HEMATIN; HEMOZOIN; RO 01 6014; RO 04 4410; RO 06 8463; RO 06 9075; RO 10 3428; RO 10 8995; RO 14 3955; RO 20 1120; RO 22 8014; RO 47 3191; RO 90 0987; RO 90 2341; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; ASSAY; CONTROLLED STUDY; DRUG SCREENING; FOLLOW UP; GROWTH INHIBITION; MALARIA; MALE; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PHARMACOPHORE; PLASMODIUM BERGHEI; POLYMERIZATION; PRIORITY JOURNAL;

ANIMAL; ANTIMALARIALS; CATALYSIS; CELL SURVIVAL; DRUG EVALUATION, PRECLINICAL; FALSE POSITIVE REACTIONS; HELA CELLS; HEMIN; HUMAN; MALE; MICE; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; POLYMERS;

EID: 0033806991     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.44.10.2638-2644.2000     Document Type: Article

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