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The reported cell constants are a = 12.20 Å, b = 14.68 Å, c = 8.04 Å, a = 90.2°, β = 96.8°, γ = 97.9°, space group P1.
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{h, k, l} denotes both (h, k, l) and (-h, -k, -l) faces.
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44
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0346973151
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To reduce errors due to the possibility that the specimen crystals may not lie exactly parallel to the plane of the {100} face we had made use of crystals with different azimuths, as well as the projected thickness of the {011} face.
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45
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0346343260
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Extended polymer chains would most likely lie parallel to the long axis of the crystal, in this case the c-axis, even though such a crystal would grow by side-to-side juxtaposition of the polymer chains. Since such chains will not be of the same length their ends cannot form a smooth obliquely oriented {011} face.
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2(carboxylate) hydrogen bond, which occurs in several zwitterionic α-amino acid crystal structures, must be no less than 6 kcal/mol.
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It is noteworthy that the γ-crystalline form of glycine, which is in a zwitterionic state, is obtained from an aqueous solution of glycine made acidic with acetic acid or basic with ammonium hydroxide (ref 76).
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58
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0346973148
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note
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50 (effective dose 50) is the amount of material required to produce a specified effect in 50% of an animal population.
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50 values (ref 58) for drug-mediated crystal inhibition in vitro experiments was usually higher than for in-vivo experiments (using chloroquine sensitive parasites). This difference may be attributed to the ability of the molecule to accumulate within the food vacuole, increasing its local concentration at the target site.
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61
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0346973147
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note
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Thermodynamic parameters for various quinolines were also calculated for neutral pH ∼ 7.5 by Egan et al. (refs 27 and 77) in 407% DMSO, while Dorn et al. (ref 22) measured at pH ∼ 6.5 in water, with similar results.
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63
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3 and H groups attached to the asymmetric C atom, does not appear to embody poor intramolecular contacts, nor introduce a noticeable change in intermolecular contacts.
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68
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0346973146
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