Relative to quinine and quinidine, their 9-epimers exhibit decreased cytostatic activity and altered heme binding but similar cytocidal activity versus Plasmodium falciparum

Antimicrobial Agents and Chemotherapy

Volumn 57, Issue 1, 2013, Pages 365-374

  Gorka, Alexander P ^a,b   Sherlach, Katy S ^a,b   De Dios, Angel C ^b   Roepea, Paul D ^a,b  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GEORGETOWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEMATIN; HEME; PROTON; PROTOPORPHYRIN ZINC; QUINIDINE; QUININE;

ANTIMALARIAL ACTIVITY; ARTICLE; CELL KILLING; CONTROLLED STUDY; CYTOSTASIS; DRUG POTENCY; DRUG SYNTHESIS; ELECTROSPRAY; EPIMER; ESTERIFICATION; FLUORESCENCE SPECTROSCOPY; GEOMETRY; IC 50; MAGNETISM; MASS SPECTROMETRY; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; SAPONIFICATION; STOICHIOMETRY; ULTRAVIOLET SPECTROSCOPY;

ANTIMALARIALS; CELLS, CULTURED; CRYSTALLIZATION; CYTOSTATIC AGENTS; CYTOTOXINS; ERYTHROCYTES; HEME; HEMEPROTEINS; HUMANS; HYDROGEN-ION CONCENTRATION; INHIBITORY CONCENTRATION 50; KINETICS; MASS SPECTROMETRY; PLASMODIUM FALCIPARUM; QUINIDINE; QUININE; SPECTROMETRY, FLUORESCENCE;

EID: 84872019217     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01234-12     Document Type: Article

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