Synthesis, Structure-activity relationship, and mode-of-action studies of antimalarial reversed chloroquine compounds

Journal of Medicinal Chemistry

Volumn 53, Issue 17, 2010, Pages 6477-6489

  Burgess, Steven J ^a,b   Kelly, Jane X ^a,c   Shomloo, Shawheen ^a,b   Wittlin, Sergio ^d,e   Brun, Reto ^d,e   Liebmann, Katherine ^a   Peyton, David H ^a,b  

^a PORTLAND STATE UNIVERSITY   (United States)

^b DesignMedix Inc   (United States)

^c PORTLAND VA MEDICAL CENTER   (United States)

^d SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^e UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 BENZHYDRYLPIPERAZIN 1 YL)ETHANOL; 7 CHLORO N [2 (4 [(4 CHLOROPHENYL)(PHENYL)METHYL]PIPERAZIN 1 YL]ETHYL]QUINOLIN 4 AMINE; 7 CHLORO N [2 [4 (DIPYRIDIN 2 YLMETHYLENEAMINO)PIPERIDIN 1 YL]ETHYL]QUINOLIN 4 AMINE; 7 CHLORO N [3 (4 [(4 CHLOROPHENYL)(PHENYL)METHYL] 1,4 DIAZEPAN 1 YL]PROPYL]QUINOLIN 4 AMINE; 7 CHLORO N [3 (4 [(4 CHLOROPHENYL)(PHENYL)METHYL]PIPERAZIN 1 YL]PROPYL]QUINOLIN 4 AMINE; 7 CHLORO N [3 (4 TRITYLPIPERAZIN 1 YL)PROPYL]QUINOLIN 4 AMINE; 7 CHLORO N [3 (PIPERAZIN 1 YL)PROPYL]QUINOLIN 4 AMINE; 7 CHLORO N [3 [4 (2,2 DIPHENYLETHYL)PIPERAZIN 1 YL)PROPYL]QUINOLIN 4 AMINE; 7 CHLORO N [3 [4 (DIPYRIDIN 2 YLMETHYLAMINO)PIPERIDIN 1 YL)PROPYL]QUINOLIN 4 AMINE; 7 CHLORO N [3 [4 (DIPYRIDIN 2 YLMETHYLENEAMINO)PIPERIDIN 1 YL]PROPYL]QUINOLIN 4 AMINE; CHLOROQUINE; HEMOZOIN; N (DIPYRIDIN 2 YLMETHYLENE)PIPERIDIN 4 AMINE; N 1 (7 CHLOROQUINOLIN 4 YL) N2 [3 (10,11 DIHYDRO 5H DIBENZO [B,F]AZEPIN-5-YL]PROPYL] N 2 METHYLETHANE 1,2 DIAMINE; N [2 (4 BENZHYDRYLPIPERAZIN 1 YL)ETHYL] 7 CHLOROQUINOLIN 4 AMINE; N [2 [4 (9H FLUOREN 9 YL) 1,4 DIAZEPAN 1 YL]ETHYL] 7 CHLOROQUINOLIN 4 AMINE; N [3 (4 BENZHYDRYL 1,4 DIAZEPAN 1 YL)PROPYL] 7 CHLOROQUINOLIN 4 AMINE; N [3 (4 BENZHYDRYLPIPERAZIN 1 YL)PROPYL] 7 CHLOROQUINOLIN 4 AMINE; N [3 [4 (9H FLUOREN 9 YL) 1,4 DIAZEPAN 1 YL)PROPYL] 7 CHLOROQUINOLIN 4 AMINE; N [3 [4 (ADAMANT 2 YL)PIPERAZIN 1 YL]PROPYL] 7 CHLOROQUINOLIN 4 AMINE; N [3 [4 (BIS(4 FLUOROPHENYL)METHYL]PIPERAZIN 1 YL]PROPYL] 7 CHLOROQUINOLIN 4 AMINE; N [4 (4 BENZHYDRYLPIPERAZIN 1 YL)BUTYL] 7 CHLOROQUINOLIN 4; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; CELL VACUOLE; CONTROLLED STUDY; DRUG SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; MALARIA FALCIPARUM; MOUSE; NONHUMAN; PLASMODIUM BERGHEI INFECTION; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIMALARIALS; CHLOROQUINE; DRUG RESISTANCE; HEME; HEMEPROTEINS; LYMPHOCYTES; MALARIA; MICE; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PROTEIN BINDING; PYRIDINES; SPLEEN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77956319522     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm1006484     Document Type: Article

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