Digestive vacuolar pH of intact intraerythrocytic P. falciparum either sensitive or resistant to chloroquine

Molecular and Biochemical Parasitology

Volumn 110, Issue 1, 2000, Pages 107-124

  Dzekunov, Sergey M ^a   Ursos, Lyann May B ^a   Roepe, Paul D ^a  

^a GEORGETOWN UNIVERSITY   (United States)

Author keywords

Acridine orange; Antimalarial drug resistance; Single cell photometry; Vacuolar pH

Indexed keywords

CHLOROQUINE; HEMATIN; HEME; HEMOZOIN; VERAPAMIL;

ANIMAL CELL; ANTIBIOTIC RESISTANCE; ARTICLE; CELL PH; CELL VACUOLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG EFFICACY; DRUG TARGETING; ERYTHROCYTE; HUMAN; HUMAN CELL; ION TRANSPORT; NONHUMAN; PHOTOMETRY; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN POLYMERIZATION; STRAIN DIFFERENCE; TITRIMETRY;

ACRIDINE ORANGE; ANIMALS; ANTIMALARIALS; CHLOROQUINE; DRUG RESISTANCE; ERYTHROCYTES; FLUORESCENCE; HUMANS; HYDROGEN-ION CONCENTRATION; MICROSCOPY, CONFOCAL; PARASITIC SENSITIVITY TESTS; PHOTOMETRY; PLASMODIUM FALCIPARUM; VACUOLES;

ANIMALIA; PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 0033827908     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(00)00261-9     Document Type: Article

References (26)

1. Sullivan D.J., Gluzman I.Y., Russell D.G., Goldberg D.E. On the molecular mechanism of chloroquine's antimalarial action. Proc. Natl. Acad. Sci. 93:1996;11865-11870.
2. Dorn A., Vippagunta S.R., Matile H., Jaquet C., Vennerstrom J.L., Ridley R.G. An assessment of drug-haematin binding as a mechanism for inhibition of haematin polymerisation by quinoline antimalarials. Biochem. Pharm. 55:1998;727-736.
3. Wadkins R.M., Roepe P.D. The biophysics of multidrug resistance. Int. Rev. Cyt. 171:1997;121-165.
4. Martiney J.A., Cerami A., Slater A.F.G. Verapamil reversal of chloroquine resistance in the malaria parasite Plasmodium falciparum is specific for resistant parasites and independent of the weak base effect. J. Biol. Chem. 270:1995;22393-22398.
5. O'Neill P.M., Bray P.G., Hawley S.R., Ward S.A., Park B.K. 4-Aminoquinolines-past, present and future: a chemical perspective. Pharmacol. Ther. 77:1998;29-58.
6. Reed M.B., Saliba K.J., Caruana S.R., Kirk K., Cowman A.F. Pgh 1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum. Nature. 403:2000;906-909.
7. Barnes D.A., Foote S.J., Galatis D., Kemp D.J., Cowman A.F. Selection for high-level chloroquine resistance results in deamplification of the pfmdr1 gene and increased sensitivity to mefloquine in Plasmodium falciparum. EMBO J. 11:1992;3067-3076.
8. Ritchie G.Y., Mungthin M., Green J.E., Bray P.G., Hawley S.R., Ward S.A. In vitro selection of halofantrine resistance in Plasmodium falciparum is not associated with increased expression of Pgh 1. Mol. Biochem. Parasitol. 83:1996;35-46.
9. Hoffman M.M., Roepe P.D. Analysis of ion transport perturbations caused by hu MDR 1 protein overexpression. Biochemistry. 36:1997;11153-11168.
10. Roepe P.D., Wei L.Y., Cruz J., Carlson D. Lower electrical membrane potential and altered pHi homeostasis in multidrug-resistant (MDR) cells: further characterization of a series of MDR cell lines expressing different levels of P-glycoprotein. Biochemistry. 32:1993;11042-11056.
11. Martiney J.A., Roepe P.D. Are ion exchange processes central to understanding drug-resistance phenomena? Trends Pharmacol. Sci. 20:1999;62-65.
12. Yayon A., Cabantchick Z.I., Ginsburg H. Identification of the acidic compartment of Plasmodium falciparum-infected human erythrocytes as the target of the antimalarial drug chloroquine. EMBO J. 3:1984;2695-2700.
13. Krogstad D.J., Schlesinger P.H., Gluzman I.Y. Antimalarials increase vesicle pH in Plasmodium falciparum. J. Cell Biol. 101:1985;2302-2309.
14. Krogstad D.J., Schlesinger P.H. The basis of antimalarial action: non-weak base effects of chloroquine on acid vesicle pH. Am. J. Trop. Med. Hyg. 36:1987;213-230.
15. Ginsburg H., Nissani E., Krugliak M. Alkalinization of the food vacuole of malaria parasites by quinoline drugs and alkylamines is not correlated with their antimalarial activity. Biochem. Pharmacol. 38:1989;2645-2654.
16. - exchange in Chinese hamster ovary cells. Biochemistry. 33:1994;7239-7249.
17. Wei L.Y., Hoffman M.M., Roepe P.D. Altered pHi regulation in 3T3/CFTR clones and their chemotherapeutic drug selected derivatives. Am. J. Physiol. 272:1997;C1642-C1653.
18. Su X.-z., Kirkman L.A., Fujioka H., Wellems T.E. Complex polymorphisms on an ≈330 kDa protein are linked to chloroquine-resistant P. falciparum in Southeast Asia and Africa. Cell. 91:1997;593-603.
19. Hoffman M.M., Wei L.Y., Roepe P.D. Are altered pHi and membrane potential in hu MDR 1 transfectants sufficient to cause MDR protein-mediated multidrug resistance? J. Gen. Physiol. 108:1996;295-313.
20. Gamage S.A., Tepsiri N., Wilairat P., Wojcik S.J., Figgit D.P., Ralph R.K., et al. Synthesis and in vitro evaluation of 9-anilino-3,6-diaminoacridines active against a multidrug-resistant strain of the malaria parasite Plasmodium falciparum. J. Med. Chem. 37:1994;1486-1494.
21. Goodyear I., Pouvelle B., Schneider E.G., Trelka D.P., Taraschi T.F. Characterization of macromolecular transport pathways in malaria infected erythrocytes. Mol. Biochem. Parasitol. 87:1997;13-28.
22. + exchangers. Cell. 94:1998;285-286.
23. Bray P.G., Mungthin M., Ridley R.G., Ward S.A. Access to hematin: the basis of chloroquine resistance. Mol. Pharmacol. 54:1998;170-179.
24. Fitch C.D. Plasmodium falciparum in owl monkeys: drug resistance and chloroquine binding capacity. Science. 169:1970;289-290.
25. Bornmann W.G., Roepe P.D. Analysis of drug transport kinetics in multidrug-resistant cells using a novel coumarin-vinblastine compound. Biochemistry. 33:1994;12655-12675.
26. + exchanger determines chloroquine uptake in Plasmodium falciparum. J. Cell Biol. 140:1998;335-345.