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Volumn 91, Issue 3, 2013, Pages 297-309

Vascular remodeling in pulmonary hypertension

Author keywords

Chronic obstructive pulmonary disease; Pulmonary arterial pressure; Pulmonary hypertension; Pulmonary vascular resistance; Vascular remodeling

Indexed keywords

BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN RECEPTOR 2; CALCIUM ION; ENDOTHELIN 1; HYPOXIA INDUCIBLE FACTOR 1; MONOCROTALINE; POTASSIUM CHANNEL; RHO KINASE; SEROTONIN; SEROTONIN TRANSPORTER; SILDENAFIL; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; SODIUM PROTON EXCHANGE PROTEIN; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN;

EID: 84875708891     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-013-0998-0     Document Type: Review
Times cited : (189)

References (160)
  • 1
    • 70049112901 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of pulmonary hypertension: The Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT)
    • 19713419 10.1093/eurheartj/ehp297
    • Galie N, Hoeper MM, Humbert M, Torbicki A, Vachiery JL, Barbera JA, Beghetti M, Corris P, Gaine S, Gibbs JS et al (2009) Guidelines for the diagnosis and treatment of pulmonary hypertension: the Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT). Eur Heart J 30:2493-2537
    • (2009) Eur Heart J , vol.30 , pp. 2493-2537
    • Galie, N.1    Hoeper, M.M.2    Humbert, M.3    Torbicki, A.4    Vachiery, J.L.5    Barbera, J.A.6    Beghetti, M.7    Corris, P.8    Gaine, S.9    Gibbs, J.S.10
  • 3
    • 0033795729 scopus 로고    scopus 로고
    • Hypoxia-induced pulmonary vascular remodeling: A model for what human disease?
    • 10995781 1:CAS:528:DC%2BD3cXms1CgsLY%3D 10.1172/JCI11144
    • Voelkel NF, Tuder RM (2000) Hypoxia-induced pulmonary vascular remodeling: a model for what human disease? J Clin Invest 106:733-738
    • (2000) J Clin Invest , vol.106 , pp. 733-738
    • Voelkel, N.F.1    Tuder, R.M.2
  • 4
    • 71949129187 scopus 로고    scopus 로고
    • Animal models of pulmonary arterial hypertension: The hope for etiological discovery and pharmacological cure
    • 19748998 1:CAS:528:DC%2BD1MXhsFOgtr%2FO 10.1152/ajplung.00217.2009
    • Stenmark KR, Meyrick B, Galie N, Mooi WJ, McMurtry IF (2009) Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure. Am J Physiol Lung Cell Mol Physiol 297:L1013-L1032
    • (2009) Am J Physiol Lung Cell Mol Physiol , vol.297
    • Stenmark, K.R.1    Meyrick, B.2    Galie, N.3    Mooi, W.J.4    McMurtry, I.F.5
  • 5
    • 68049102899 scopus 로고    scopus 로고
    • Pathology of pulmonary arterial hypertension
    • 19634077 10.1055/s-0029-1233307
    • Tuder RM (2009) Pathology of pulmonary arterial hypertension. Semin Respir Crit Care Med 30:376-385
    • (2009) Semin Respir Crit Care Med , vol.30 , pp. 376-385
    • Tuder, R.M.1
  • 6
    • 77949474595 scopus 로고    scopus 로고
    • Emerging therapies for the treatment of pulmonary hypertension
    • 20216170 10.1097/PCC.0b013e3181c76db3
    • Stenmark KR, Rabinovitch M (2010) Emerging therapies for the treatment of pulmonary hypertension. Pediatr Crit Care Med 11:S85-S90
    • (2010) Pediatr Crit Care Med , vol.11
    • Stenmark, K.R.1    Rabinovitch, M.2
  • 8
    • 32644435423 scopus 로고    scopus 로고
    • Relationship of pulmonary arterial capacitance and mortality in idiopathic pulmonary arterial hypertension
    • 16487848 10.1016/j.jacc.2005.09.054
    • Mahapatra S, Nishimura RA, Sorajja P, Cha S, McGoon MD (2006) Relationship of pulmonary arterial capacitance and mortality in idiopathic pulmonary arterial hypertension. J Am Coll Cardiol 47:799-803
    • (2006) J Am Coll Cardiol , vol.47 , pp. 799-803
    • Mahapatra, S.1    Nishimura, R.A.2    Sorajja, P.3    Cha, S.4    McGoon, M.D.5
  • 9
    • 79251509290 scopus 로고    scopus 로고
    • Effects of acute Rho kinase inhibition on chronic hypoxia-induced changes in proximal and distal pulmonary arterial structure and function
    • 21088209 10.1152/japplphysiol.00533.2010
    • Vanderpool RR, Kim AR, Molthen R, Chesler NC (2011) Effects of acute Rho kinase inhibition on chronic hypoxia-induced changes in proximal and distal pulmonary arterial structure and function. J Appl Physiol 110:188-198
    • (2011) J Appl Physiol , vol.110 , pp. 188-198
    • Vanderpool, R.R.1    Kim, A.R.2    Molthen, R.3    Chesler, N.C.4
  • 10
    • 22744455284 scopus 로고    scopus 로고
    • Inhibition of Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation
    • 15961717 1:CAS:528:DC%2BD2MXmtFSlt7g%3D 10.1161/01.RES.0000174287.17953. 83
    • Hyvelin J-M, Howell K, Nichol A, Costello CM, Preston RJ, McLoughlin P (2005) Inhibition of Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation. Circ Res 97:185-191
    • (2005) Circ Res , vol.97 , pp. 185-191
    • Hyvelin, J.-M.1    Howell, K.2    Nichol, A.3    Costello, C.M.4    Preston, R.J.5    McLoughlin, P.6
  • 11
    • 22744457972 scopus 로고    scopus 로고
    • Vascular remodeling versus vasoconstriction in chronic hypoxic pulmonary hypertension: A time for reappraisal?
    • 16037575 1:CAS:528:DC%2BD2MXos1Gms7Y%3D 10.1161/01.RES.00000175934.68087. 29
    • Stenmark KR, McMurtry IF (2005) Vascular remodeling versus vasoconstriction in chronic hypoxic pulmonary hypertension: a time for reappraisal? Circ Res 97:95-98
    • (2005) Circ Res , vol.97 , pp. 95-98
    • Stenmark, K.R.1    McMurtry, I.F.2
  • 12
    • 77951239891 scopus 로고    scopus 로고
    • Rho kinase-mediated vasoconstriction in pulmonary hypertension
    • 20204738 1:CAS:528:DC%2BC3cXhsFyjtrrK 10.1007/978-1-60761-500-2-19
    • McMurtry IV, Abe K, Ota H, Fagan KA, Oka M (2010) Rho kinase-mediated vasoconstriction in pulmonary hypertension. Adv Exp Med Biol 661:299-308
    • (2010) Adv Exp Med Biol , vol.661 , pp. 299-308
    • McMurtry, I.V.1    Abe, K.2    Ota, H.3    Fagan, K.A.4    Oka, M.5
  • 13
    • 0000399371 scopus 로고
    • The heart and pulmonary circulation in children at high altitudes: Physiological, anatomical, and clinical observations
    • 14212475 1:STN:280:DyaF2M%2Fhs1yltQ%3D%3D
    • Penaloza D, Arias-Stella J, Sime F, Recavarren S, Marticorena E (1964) The heart and pulmonary circulation in children at high altitudes: physiological, anatomical, and clinical observations. Pediatrics 34:568-582
    • (1964) Pediatrics , vol.34 , pp. 568-582
    • Penaloza, D.1    Arias-Stella, J.2    Sime, F.3    Recavarren, S.4    Marticorena, E.5
  • 15
    • 11744278432 scopus 로고
    • Electrocardiographic observation of 493 residents living at high altitude (10,150 feet)
    • 5834470 1:STN:280:DyaF28%2Fhs12mtA%3D%3D 10.1016/0002-9149(65)90025-1
    • Pryor R, Weaver WF, Blount SG (1965) Electrocardiographic observation of 493 residents living at high altitude (10,150 feet). Am J Cardiol 16:494-499
    • (1965) Am J Cardiol , vol.16 , pp. 494-499
    • Pryor, R.1    Weaver, W.F.2    Blount, S.G.3
  • 16
    • 0001644427 scopus 로고
    • Hypoxemia and pulmonary hypertension. A study of the pulmonary vasculature
    • 13727385 1:STN:280:DyaF3c%2FkslSjtw%3D%3D
    • Naeye RL (1961) Hypoxemia and pulmonary hypertension. A study of the pulmonary vasculature. Arch Pathol 71:447-452
    • (1961) Arch Pathol , vol.71 , pp. 447-452
    • Naeye, R.L.1
  • 17
    • 0007153930 scopus 로고
    • Children at high altitude: Pulmonary and renal abnormalities
    • 14252154 1:STN:280:DyaF2M%2Fls1Kmsw%3D%3D 10.1161/01.RES.16.1.33
    • Naeye RL (1965) Children at high altitude: pulmonary and renal abnormalities. Circ Res 16:33-38
    • (1965) Circ Res , vol.16 , pp. 33-38
    • Naeye, R.L.1
  • 18
    • 0001507064 scopus 로고
    • The terminal portion of the pulmonary arterial tree in people native to high altitudes
    • 14079195 1:STN:280:DyaF2c%2Fjs1ygtA%3D%3D 10.1161/01.CIR.28.5.915
    • Arias-Stella J, Saldana M (1963) The terminal portion of the pulmonary arterial tree in people native to high altitudes. Circulation 28:915-925
    • (1963) Circulation , vol.28 , pp. 915-925
    • Arias-Stella, J.1    Saldana, M.2
  • 19
    • 0019479960 scopus 로고
    • Small pulmonary arteries in some natives of la Paz, Bolivia
    • 7314035 1:STN:280:DyaL38%2FosFejsg%3D%3D 10.1136/thx.36.8.599
    • Heath D, Smith P, Rios Dalenz J, Williams D, Harris P (1981) Small pulmonary arteries in some natives of La Paz, Bolivia. Thorax 36:599-604
    • (1981) Thorax , vol.36 , pp. 599-604
    • Heath, D.1    Smith, P.2    Rios Dalenz, J.3    Williams, D.4    Harris, P.5
  • 21
    • 0026785650 scopus 로고
    • Lack of smooth muscle in the small pulmonary arteries of the native Ladakhi. Is the Himalayan highlander adapted?
    • 1586066 1:STN:280:DyaK383msVGqtA%3D%3D 10.1164/ajrccm/145.5.1201
    • Gupta ML, Rao KS, Anand IS, Banerjee AK, Boparai MS (1992) Lack of smooth muscle in the small pulmonary arteries of the native Ladakhi. Is the Himalayan highlander adapted? Am Rev Respir Dis 145:1201-1204
    • (1992) Am Rev Respir Dis , vol.145 , pp. 1201-1204
    • Gupta, M.L.1    Rao, K.S.2    Anand, I.S.3    Banerjee, A.K.4    Boparai, M.S.5
  • 22
    • 0023928253 scopus 로고
    • A pathophysiological study of 10 cases of hypoxic cor pulmonale
    • 3174923 1:STN:280:DyaL1M%2FhslOnsQ%3D%3D
    • Wilkinson M, Langhorne CA, Heath D, Barer GR, Howard P (1988) A pathophysiological study of 10 cases of hypoxic cor pulmonale. Q J Med 66:65-85
    • (1988) Q J Med , vol.66 , pp. 65-85
    • Wilkinson, M.1    Langhorne, C.A.2    Heath, D.3    Barer, G.R.4    Howard, P.5
  • 24
    • 0026573643 scopus 로고
    • Analysis of the structure of the muscular pulmonary arteries in patients with pulmonary hypertension and COPD: National Institutes of Health nocturnal oxygen therapy trial
    • 1501507 1:STN:280:DyaK38zmsFCisw%3D%3D 10.1007/BF00175982
    • Wright JL, Petty T, Thurlbeck WM (1992) Analysis of the structure of the muscular pulmonary arteries in patients with pulmonary hypertension and COPD: National Institutes of Health nocturnal oxygen therapy trial. Lung 170:109-124
    • (1992) Lung , vol.170 , pp. 109-124
    • Wright, J.L.1    Petty, T.2    Thurlbeck, W.M.3
  • 25
    • 0036212004 scopus 로고    scopus 로고
    • Characterization of pulmonary vascular remodelling in smokers and patients with mild COPD
    • 11998991 1:STN:280:DC%2BD383lvFGmug%3D%3D 10.1183/09031936.02.00245902
    • Santos S, Peinado VI, Ramírez J, Melgosa T, Roca J, Rodriguez-Roisin R, Barberà JA (2002) Characterization of pulmonary vascular remodelling in smokers and patients with mild COPD. Eur Respir J 19:632-638
    • (2002) Eur Respir J , vol.19 , pp. 632-638
    • Santos, S.1    Peinado, V.I.2    Ramírez, J.3    Melgosa, T.4    Roca, J.5    Rodriguez-Roisin, R.6    Barberà, J.A.7
  • 26
    • 84858330300 scopus 로고    scopus 로고
    • COPD/emphysema: The vascular story
    • 10.4103/2045-8932.87295
    • Voelkel N, Mizuno S, Gomez-Arroyo J (2011) COPD/emphysema: the vascular story. Pulm Circ 3:320
    • (2011) Pulm Circ , vol.3 , pp. 320
    • Voelkel, N.1    Mizuno, S.2    Gomez-Arroyo, J.3
  • 28
    • 14144255938 scopus 로고    scopus 로고
    • Comparative physiology of hypoxic pulmonary hypertension: Historical clues from brisket disease
    • 15703167 10.1152/japplphysiol.01017.2004
    • Rhodes J (2005) Comparative physiology of hypoxic pulmonary hypertension: historical clues from brisket disease. J Appl Physiol 98:1092-1100
    • (2005) J Appl Physiol , vol.98 , pp. 1092-1100
    • Rhodes, J.1
  • 30
    • 0018487516 scopus 로고
    • Rat pulmonary circulation after chronic hypoxia: Hemodynamic and structural features
    • 443445 1:CAS:528:DyaE1MXktlKktrg%3D
    • Rabinovitch M, Gamble WJ, Nadas AS, Miettinen OS, Reid L (1979) Rat pulmonary circulation after chronic hypoxia: hemodynamic and structural features. Am J Physiol 236:H818-H827
    • (1979) Am J Physiol , vol.236
    • Rabinovitch, M.1    Gamble, W.J.2    Nadas, A.S.3    Miettinen, O.S.4    Reid, L.5
  • 31
    • 35349028821 scopus 로고    scopus 로고
    • Point:counterpoint: Chronic hypoxia-induced pulmonary hypertension does/does not lead to loss of pulmonary vasculature
    • 17363624 10.1152/japplphysiol.00274.2007
    • Rabinovitch M, Chesler N, Molthen RC (2007) Point:counterpoint: chronic hypoxia-induced pulmonary hypertension does/does not lead to loss of pulmonary vasculature. J Appl Physiol 103:1449-1451
    • (2007) J Appl Physiol , vol.103 , pp. 1449-1451
    • Rabinovitch, M.1    Chesler, N.2    Molthen, R.C.3
  • 32
    • 0017099110 scopus 로고
    • New findings in pulmonary arteries of rats with hypoxia-induced pulmonary hypertension
    • 136978 1:STN:280:DyaE2s%2FmsFCruw%3D%3D
    • Hislop A, Reid L (1976) New findings in pulmonary arteries of rats with hypoxia-induced pulmonary hypertension. Br J Exp Pathol 57:542-554
    • (1976) Br J Exp Pathol , vol.57 , pp. 542-554
    • Hislop, A.1    Reid, L.2
  • 33
    • 35348961449 scopus 로고    scopus 로고
    • Chronic hypoxia-induced pulmonary hypertension does/does not lead to loss of pulmonary vasculature
    • 17916681 10.1152/japplphysiol.00739.2007
    • Berg JT (2007) Chronic hypoxia-induced pulmonary hypertension does/does not lead to loss of pulmonary vasculature. J Appl Physiol 103:1455
    • (2007) J Appl Physiol , vol.103 , pp. 1455
    • Berg, J.T.1
  • 34
    • 38449097957 scopus 로고    scopus 로고
    • Counterpoint: Chronic hypoxia-induced pulmonary hypertension does not lead to loss of pulmonary vasculature
    • 17916678 1:STN:280:DC%2BD2srpsV2qtA%3D%3D 10.1152/japplphysiol.00274. 2007a discussion 1453-1454
    • Mcloughlin P, Mcmurtry I (2007) Counterpoint: chronic hypoxia-induced pulmonary hypertension does not lead to loss of pulmonary vasculature. J Appl Physiol 103:1451-1453, discussion 1453-1454
    • (2007) J Appl Physiol , vol.103 , pp. 1451-1453
    • McLoughlin, P.1    McMurtry, I.2
  • 35
    • 0037440743 scopus 로고    scopus 로고
    • Chronic hypoxia causes angiogenesis in addition to remodelling in the adult rat pulmonary circulation
    • 12562951 1:CAS:528:DC%2BD3sXivFSkt7s%3D 10.1113/jphysiol.2002.030676
    • Howell K, Preston RJ, McLoughlin P (2003) Chronic hypoxia causes angiogenesis in addition to remodelling in the adult rat pulmonary circulation. J Physiol 547:133-145
    • (2003) J Physiol , vol.547 , pp. 133-145
    • Howell, K.1    Preston, R.J.2    McLoughlin, P.3
  • 38
    • 33749345684 scopus 로고    scopus 로고
    • Hypoxia-induced pulmonary vascular remodeling: Cellular and molecular mechanisms
    • 17008597 1:CAS:528:DC%2BD28XpvFertro%3D 10.1161/01.RES.0000243584.45145. 3f
    • Stenmark KR, Fagan KA, Frid MG (2006) Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms. Circ Res 99:675-691
    • (2006) Circ Res , vol.99 , pp. 675-691
    • Stenmark, K.R.1    Fagan, K.A.2    Frid, M.G.3
  • 39
    • 0015805208 scopus 로고
    • Fine structural alterations of bovine peripheral pulmonary arteries in hypoxia-induced hypertension
    • 4357176 1:STN:280:DyaE2c%2FksFegtA%3D%3D
    • Jaenke RS, Alexander AF (1973) Fine structural alterations of bovine peripheral pulmonary arteries in hypoxia-induced hypertension. Am J Pathol 73:377-398
    • (1973) Am J Pathol , vol.73 , pp. 377-398
    • Jaenke, R.S.1    Alexander, A.F.2
  • 40
    • 0034943184 scopus 로고    scopus 로고
    • Mild hypoxia causes severe pulmonary hypertension in fawn-hooded but not in Tester Moriyama rats
    • 11445200 1:STN:280:DC%2BD3MzptFCgtg%3D%3D 10.1016/S0034-5687(01)00217-1
    • Nagaoka T, Muramatsu M, Sato K, McMurtry I, Oka M, Fukuchi Y (2001) Mild hypoxia causes severe pulmonary hypertension in fawn-hooded but not in Tester Moriyama rats. Respir Physiol 127:53-60
    • (2001) Respir Physiol , vol.127 , pp. 53-60
    • Nagaoka, T.1    Muramatsu, M.2    Sato, K.3    McMurtry, I.4    Oka, M.5    Fukuchi, Y.6
  • 41
  • 42
    • 0035130107 scopus 로고    scopus 로고
    • Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension
    • 11156958 1:CAS:528:DC%2BD3MXhsFemsrw%3D 10.1096/fj.00-0343com
    • Taraseviciene-Stewart L, Kasahara Y, Alger L, Hirth P, Mc Mahon G, Waltenberger J, Voelkel NF, Tuder RM (2001) Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension. FASEB J 15:427-438
    • (2001) FASEB J , vol.15 , pp. 427-438
    • Taraseviciene-Stewart, L.1    Kasahara, Y.2    Alger, L.3    Hirth, P.4    Mc Mahon, G.5    Waltenberger, J.6    Voelkel, N.F.7    Tuder, R.M.8
  • 45
    • 0014061764 scopus 로고
    • Pulmonary hypertension produced in rats by ingestion of Crotalaria spectabilis seeds
    • 6033385 1:STN:280:DyaF2s3gvVeltg%3D%3D 10.1136/thx.22.2.176
    • Kay JM, Harris P, Heath D (1967) Pulmonary hypertension produced in rats by ingestion of Crotalaria spectabilis seeds. Thorax 22:176-179
    • (1967) Thorax , vol.22 , pp. 176-179
    • Kay, J.M.1    Harris, P.2    Heath, D.3
  • 47
    • 0019082316 scopus 로고
    • Development of Crotalaria pulmonary hypertension: Hemodynamic and structural study
    • 6449154 1:STN:280:DyaL3M%2FlvFymuw%3D%3D
    • Meyrick B, Gamble W, Reid L (1980) Development of Crotalaria pulmonary hypertension: hemodynamic and structural study. Am J Physiol 239:H692-H702
    • (1980) Am J Physiol , vol.239
    • Meyrick, B.1    Gamble, W.2    Reid, L.3
  • 48
    • 0030036720 scopus 로고    scopus 로고
    • The role of vascular injury and hemodynamics in rat pulmonary artery remodeling
    • 8755654 1:CAS:528:DyaK28XksFCltrw%3D 10.1172/JCI118809
    • Tanaka Y, Schuster DP, Davis EC, Patterson GA, Botney MD (1996) The role of vascular injury and hemodynamics in rat pulmonary artery remodeling. J Clin Invest 98:434-442
    • (1996) J Clin Invest , vol.98 , pp. 434-442
    • Tanaka, Y.1    Schuster, D.P.2    Davis, E.C.3    Patterson, G.A.4    Botney, M.D.5
  • 49
    • 0030828893 scopus 로고    scopus 로고
    • Pulmonary hemodynamics modify the rat pulmonary artery response to injury. A neointimal model of pulmonary hypertension
    • 9327735 1:STN:280:DyaK2svmvVKksg%3D%3D
    • Okada K, Tanaka Y, Bernstein M, Zhang W, Patterson GA, Botney MD (1997) Pulmonary hemodynamics modify the rat pulmonary artery response to injury. A neointimal model of pulmonary hypertension. Am J Pathol 151:1019-1025
    • (1997) Am J Pathol , vol.151 , pp. 1019-1025
    • Okada, K.1    Tanaka, Y.2    Bernstein, M.3    Zhang, W.4    Patterson, G.A.5    Botney, M.D.6
  • 50
    • 77951227152 scopus 로고    scopus 로고
    • The serotonin hypothesis of pulmonary hypertension revisited
    • 20204739 1:CAS:528:DC%2BC3cXhsFyjtrrE 10.1007/978-1-60761-500-2-20
    • Maclean MR, Dempsie Y (2010) The serotonin hypothesis of pulmonary hypertension revisited. Adv Exp Med Biol 661:309-322
    • (2010) Adv Exp Med Biol , vol.661 , pp. 309-322
    • Maclean, M.R.1    Dempsie, Y.2
  • 51
    • 0013023197 scopus 로고    scopus 로고
    • Contractile responses to human urotensin-II in rat and human pulmonary arteries: Effect of endothelial factors and chronic hypoxia in the rat
    • 10807654 1:CAS:528:DC%2BD3cXjsl2mtLg%3D 10.1038/sj.bjp.0703314
    • MacLean MR, Alexander D, Stirrat A, Gallagher M, Douglas SA, Ohlstein EH, Morecroft I, Polland K (2000) Contractile responses to human urotensin-II in rat and human pulmonary arteries: effect of endothelial factors and chronic hypoxia in the rat. Br J Pharmacol 130:201-204
    • (2000) Br J Pharmacol , vol.130 , pp. 201-204
    • Maclean, M.R.1    Alexander, D.2    Stirrat, A.3    Gallagher, M.4    Douglas, S.A.5    Ohlstein, E.H.6    Morecroft, I.7    Polland, K.8
  • 52
    • 0032971293 scopus 로고    scopus 로고
    • Induction of serotonin transporter by hypoxia in pulmonary vascular smooth muscle cells. Relationship with the mitogenic action of serotonin
    • 10024307 1:CAS:528:DyaK1MXhsVaksb0%3D 10.1161/01.RES.84.3.329
    • Eddahibi S, Fabre V, Boni C, Martres MP, Raffestin B, Hamon M, Adnot S (1999) Induction of serotonin transporter by hypoxia in pulmonary vascular smooth muscle cells. Relationship with the mitogenic action of serotonin. Circ Res 84:329-336
    • (1999) Circ Res , vol.84 , pp. 329-336
    • Eddahibi, S.1    Fabre, V.2    Boni, C.3    Martres, M.P.4    Raffestin, B.5    Hamon, M.6    Adnot, S.7
  • 53
    • 79955369537 scopus 로고    scopus 로고
    • The serotonin transporter, gender, and 17β oestradiol in the development of pulmonary arterial hypertension
    • 21177701 1:CAS:528:DC%2BC3MXlt1Glsbg%3D 10.1093/cvr/cvq408
    • White K, Dempsie Y, Nilsen M, Wright AF, Loughlin L, MacLean MR (2011) The serotonin transporter, gender, and 17β oestradiol in the development of pulmonary arterial hypertension. Cardiovasc Res 90:373-382
    • (2011) Cardiovasc Res , vol.90 , pp. 373-382
    • White, K.1    Dempsie, Y.2    Nilsen, M.3    Wright, A.F.4    Loughlin, L.5    Maclean, M.R.6
  • 54
    • 77956404810 scopus 로고    scopus 로고
    • BMP signaling in vascular development and disease
    • 20674464 1:CAS:528:DC%2BC3cXhtFGjsbfP 10.1016/j.cytogfr.2010.06.001
    • Lowery JW, de Caestecker MP (2010) BMP signaling in vascular development and disease. Cytokine Growth Factor Rev 21:287-298
    • (2010) Cytokine Growth Factor Rev , vol.21 , pp. 287-298
    • Lowery, J.W.1    De Caestecker, M.P.2
  • 55
    • 70649083092 scopus 로고    scopus 로고
    • Recent advances in BMP receptor signaling
    • 19897402 1:CAS:528:DC%2BD1MXhsV2ms7fK 10.1016/j.cytogfr.2009.10.007
    • Sieber C, Kopf J, Hiepen C, Knaus P (2009) Recent advances in BMP receptor signaling. Cytokine Growth Factor Rev 20:343-355
    • (2009) Cytokine Growth Factor Rev , vol.20 , pp. 343-355
    • Sieber, C.1    Kopf, J.2    Hiepen, C.3    Knaus, P.4
  • 56
  • 57
    • 24644441189 scopus 로고    scopus 로고
    • Genetics of pulmonary arterial hypertension: Current and future implications
    • 16121312 10.1055/s-2005-916150
    • Elliott CG (2005) Genetics of pulmonary arterial hypertension: current and future implications. Semin Respir Crit Care Med 26:365-371
    • (2005) Semin Respir Crit Care Med , vol.26 , pp. 365-371
    • Elliott, C.G.1
  • 58
    • 40049100690 scopus 로고    scopus 로고
    • Narrative review: The enigma of pulmonary arterial hypertension: New insights from genetic studies
    • 18283205
    • Newman JH, Phillips JA, Loyd JE (2008) Narrative review: the enigma of pulmonary arterial hypertension: new insights from genetic studies. Ann Intern Med 148:278-283
    • (2008) Ann Intern Med , vol.148 , pp. 278-283
    • Newman, J.H.1    Phillips, J.A.2    Loyd, J.E.3
  • 59
    • 57349188499 scopus 로고    scopus 로고
    • Molecular mechanisms of pulmonary arterial hypertension: Role of mutations in the bone morphogenetic protein type II receptor
    • 19059957 1:CAS:528:DC%2BD1MXps1elsA%3D%3D 10.1378/chest.08-1341
    • Davies RJ, Morrell NW (2008) Molecular mechanisms of pulmonary arterial hypertension: role of mutations in the bone morphogenetic protein type II receptor. Chest 134:1271-1277
    • (2008) Chest , vol.134 , pp. 1271-1277
    • Davies, R.J.1    Morrell, N.W.2
  • 60
    • 8644256840 scopus 로고    scopus 로고
    • BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia
    • 15286002 1:CAS:528:DC%2BD2cXhtFShsLfK 10.1152/ajplung.00239.2004
    • Beppu H, Ichinose F, Kawai N, Jones RC, Yu PB, Zapol WM, Miyazono K, Li E, Bloch KD (2004) BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia. Am J Physiol Lung Cell Mol Physiol 287:L1241-L1247
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.287
    • Beppu, H.1    Ichinose, F.2    Kawai, N.3    Jones, R.C.4    Yu, P.B.5    Zapol, W.M.6    Miyazono, K.7    Li, E.8    Bloch, K.D.9
  • 61
    • 23044504042 scopus 로고    scopus 로고
    • Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice
    • 16027259 1:CAS:528:DC%2BD2MXmt1yht7k%3D 10.1161/CIRCULATIONAHA.104.492488
    • Song Y, Jones JE, Beppu H, Keaney JF, Loscalzo J, Zhang Y-Y (2005) Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice. Circulation 112:553-562
    • (2005) Circulation , vol.112 , pp. 553-562
    • Song, Y.1    Jones, J.E.2    Beppu, H.3    Keaney, J.F.4    Loscalzo, J.5    Zhang, Y.-Y.6
  • 62
    • 40749102181 scopus 로고    scopus 로고
    • Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature
    • 18024717 1:CAS:528:DC%2BD1cXhtVWrtbk%3D 10.1152/ajplung.00034.2007
    • Frank DB, Lowery J, Anderson L, Brink M, Reese J, de Caestecker M (2008) Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature. Am J Physiol Lung Cell Mol Physiol 294:L98-L109
    • (2008) Am J Physiol Lung Cell Mol Physiol , vol.294
    • Frank, D.B.1    Lowery, J.2    Anderson, L.3    Brink, M.4    Reese, J.5    De Caestecker, M.6
  • 63
    • 2342486700 scopus 로고    scopus 로고
    • Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle
    • 15031260 1:CAS:528:DC%2BD2cXjt1ylu7w%3D 10.1161/01.RES.0000126047.82846. 20
    • West J, Fagan K, Steudel W, Fouty B, Lane K, Harral J, Hoedt-Miller M, Tada Y, Ozimek J, Tuder R et al (2004) Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle. Circ Res 94:1109-1114
    • (2004) Circ Res , vol.94 , pp. 1109-1114
    • West, J.1    Fagan, K.2    Steudel, W.3    Fouty, B.4    Lane, K.5    Harral, J.6    Hoedt-Miller, M.7    Tada, Y.8    Ozimek, J.9    Tuder, R.10
  • 64
    • 0020135694 scopus 로고
    • Membrane properties of smooth muscle cells in pulmonary hypertensive rats
    • 6805338 1:CAS:528:DyaL38XhvFOnt7g%3D
    • Suzuki H, Twarog BM (1982) Membrane properties of smooth muscle cells in pulmonary hypertensive rats. Am J Physiol 242:H907-H915
    • (1982) Am J Physiol , vol.242
    • Suzuki, H.1    Twarog, B.M.2
  • 65
    • 79955558300 scopus 로고    scopus 로고
    • Theme: Hypoxia. Hypoxia and ion channel function
    • 21178108 1:CAS:528:DC%2BC3MXmsFCmurc%3D 10.1152/ajpcell.00512.2010
    • Shimoda LA, Polak J (2011) Theme: Hypoxia. Hypoxia and ion channel function. Am J Physiol Cell Physiol 300(5):C951-C967
    • (2011) Am J Physiol Cell Physiol , vol.300 , Issue.5
    • Shimoda, L.A.1    Polak, J.2
  • 67
    • 40349110969 scopus 로고    scopus 로고
    • Potassium channels in the regulation of pulmonary artery smooth muscle cell proliferation and apoptosis: Pharmacotherapeutic implications
    • 18084317 1:CAS:528:DC%2BD1cXislSjtbs%3D
    • Burg ED, Remillard CV, Yuan JX (2008) Potassium channels in the regulation of pulmonary artery smooth muscle cell proliferation and apoptosis: pharmacotherapeutic implications. Br J Pharmacol 153(Suppl 1):S99-S111
    • (2008) Br J Pharmacol , vol.153 , Issue.SUPPL. 1
    • Burg, E.D.1    Remillard, C.V.2    Yuan, J.X.3
  • 68
    • 0037080541 scopus 로고    scopus 로고
    • Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: Role of increased expression and activity of voltage-gated potassium channels
    • 11790708 1:CAS:528:DC%2BD38XhsFeksL0%3D 10.1161/hc0202.101974
    • Michelakis ED, McMurtry MS, Wu XC, Dyck JR, Moudgil R, Hopkins TA, Lopaschuk GD, Puttagunta L, Waite R, Archer SL (2002) Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels. Circulation 105:244-250
    • (2002) Circulation , vol.105 , pp. 244-250
    • Michelakis, E.D.1    McMurtry, M.S.2    Wu, X.C.3    Dyck, J.R.4    Moudgil, R.5    Hopkins, T.A.6    Lopaschuk, G.D.7    Puttagunta, L.8    Waite, R.9    Archer, S.L.10
  • 69
    • 33745155785 scopus 로고    scopus 로고
    • An abnormal mitochondrial-hypoxia inducible factor-1a-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: Similarities to human pulmonary arterial hypertension
    • 16735674 1:CAS:528:DC%2BD28XltFWgtbk%3D 10.1161/CIRCULATIONAHA.105.609008
    • Bonnet S, Michelakis ED, Porter CJ, Andrade-Navarro MA, Thebaud B, Bonnet S, Haromy A, Harry G, Moudgil R, McMurtry MS et al (2006) An abnormal mitochondrial-hypoxia inducible factor-1a-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension. Circulation 113:2630-2641
    • (2006) Circulation , vol.113 , pp. 2630-2641
    • Bonnet, S.1    Michelakis, E.D.2    Porter, C.J.3    Andrade-Navarro, M.A.4    Thebaud, B.5    Bonnet, S.6    Haromy, A.7    Harry, G.8    Moudgil, R.9    McMurtry, M.S.10
  • 70
    • 0032492407 scopus 로고    scopus 로고
    • + channel gene transcription in primary pulmonary hypertension
    • 9504523 1:STN:280:DyaK1c7mtlSmsw%3D%3D 10.1016/S0140-6736(05)78495-6
    • + channel gene transcription in primary pulmonary hypertension. Lancet 351:726-727
    • (1998) Lancet , vol.351 , pp. 726-727
    • Yuan, X.J.1    Wang, J.2    Juhaszova, M.3    Gaine, S.P.4    Rubin, L.J.5
  • 75
    • 4444352981 scopus 로고    scopus 로고
    • 2+ channels in pulmonary arterial smooth muscle cells: A novel mechanism of hypoxic pulmonary hypertension
    • 15256480 1:CAS:528:DC%2BD2cXntVCrtLw%3D 10.1161/01.RES.0000138952.16382. ad
    • 2+ channels in pulmonary arterial smooth muscle cells: a novel mechanism of hypoxic pulmonary hypertension. Circ Res 95:496-505
    • (2004) Circ Res , vol.95 , pp. 496-505
    • Lin, M.J.1    Leung, G.P.2    Zhang, W.M.3    Yang, X.R.4    Yip, K.P.5    Tse, C.M.6    Sham, J.S.7
  • 76
    • 0026632785 scopus 로고
    • The effect of high doses of calcium-channel blockers on survival in primary pulmonary hypertension
    • 1603139 1:STN:280:DyaK383ptlaksQ%3D%3D 10.1056/NEJM199207093270203
    • Rich S, Kaufmann E, Levy PS (1992) The effect of high doses of calcium-channel blockers on survival in primary pulmonary hypertension. N Engl J Med 327:76-81
    • (1992) N Engl J Med , vol.327 , pp. 76-81
    • Rich, S.1    Kaufmann, E.2    Levy, P.S.3
  • 79
    • 6344257102 scopus 로고    scopus 로고
    • Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis
    • 15375007 1:CAS:528:DC%2BD2cXot1aitr8%3D 10.1161/01.RES.0000145360.16770. 9f
    • McMurtry MS, Bonnet S, Wu X, Dyck JR, Haromy A, Hashimoto K, Michelakis ED (2004) Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis. Circ Res 95:830-840
    • (2004) Circ Res , vol.95 , pp. 830-840
    • McMurtry, M.S.1    Bonnet, S.2    Wu, X.3    Dyck, J.R.4    Haromy, A.5    Hashimoto, K.6    Michelakis, E.D.7
  • 81
    • 2342483718 scopus 로고    scopus 로고
    • Calcium and TRP channels in pulmonary vascular smooth muscle cell proliferation
    • 15016901 1:CAS:528:DC%2BD2cXjslyktbg%3D
    • Landsberg JW, Yuan JX (2004) Calcium and TRP channels in pulmonary vascular smooth muscle cell proliferation. News Physiol Sci 19:44-50
    • (2004) News Physiol Sci , vol.19 , pp. 44-50
    • Landsberg, J.W.1    Yuan, J.X.2
  • 84
    • 84855317520 scopus 로고    scopus 로고
    • STIM2 contributes to enhanced store-operated Ca entry in pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension
    • 21709766 1:CAS:528:DC%2BC3MXpsVantb0%3D
    • Song MY, Makino A, Yuan JX (2011) STIM2 contributes to enhanced store-operated Ca entry in pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension. Pulm Circ 1:84-94
    • (2011) Pulm Circ , vol.1 , pp. 84-94
    • Song, M.Y.1    Makino, A.2    Yuan, J.X.3
  • 87
    • 20944438626 scopus 로고    scopus 로고
    • Low-voltage-activated (T-type) calcium channels control proliferation of human pulmonary artery myocytes
    • 15774856 1:CAS:528:DC%2BD2MXjsFagsLo%3D 10.1161/01.RES.0000163066.07472. ff
    • Rodman DM, Reese K, Harral J, Fouty B, Wu S, West J, Hoedt-Miller M, Tada Y, Li KX, Cool C et al (2005) Low-voltage-activated (T-type) calcium channels control proliferation of human pulmonary artery myocytes. Circ Res 96:864-872
    • (2005) Circ Res , vol.96 , pp. 864-872
    • Rodman, D.M.1    Reese, K.2    Harral, J.3    Fouty, B.4    Wu, S.5    West, J.6    Hoedt-Miller, M.7    Tada, Y.8    Li, K.X.9    Cool, C.10
  • 89
    • 27844586833 scopus 로고    scopus 로고
    • EGF induces tyrosine phosphorylation, membrane insertion and activation of transient receptor potential channel 4
    • 16144838 1:CAS:528:DC%2BD2MXhtF2is7%2FI 10.1074/jbc.M503646200
    • Odell AF, Scott JL, Van Helden DF (2005) EGF induces tyrosine phosphorylation, membrane insertion and activation of transient receptor potential channel 4. J Biol Chem 280:37974-37987
    • (2005) J Biol Chem , vol.280 , pp. 37974-37987
    • Odell, A.F.1    Scott, J.L.2    Van Helden, D.F.3
  • 90
    • 34548409544 scopus 로고    scopus 로고
    • 2+ signaling in hypoxic pulmonary vasoconstriction: Effects of myosin light chain and Rho kinase antagonists
    • 17575009 1:CAS:528:DC%2BD2sXhtVOqsbbP 10.1152/ajplung.00141.2007
    • 2+ signaling in hypoxic pulmonary vasoconstriction: effects of myosin light chain and Rho kinase antagonists. Am J Physiol Lung Cell Mol Physiol 293:L674-L685
    • (2007) Am J Physiol Lung Cell Mol Physiol , vol.293
    • Wang, J.1    Weigand, L.2    Foxson, J.3    Shimoda, L.A.4    Sylvester, J.T.5
  • 93
    • 66349095797 scopus 로고    scopus 로고
    • A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension
    • 19380626 1:CAS:528:DC%2BD1MXltV2jsrk%3D 10.1161/CIRCULATIONAHA.108.782458
    • Yu Y, Keller SH, Remillard CV, Safrina O, Nicholson A, Zhang SL, Jiang W, Vangala N, Landsberg JW, Wang JY et al (2009) A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension. Circulation 119:2313-2322
    • (2009) Circulation , vol.119 , pp. 2313-2322
    • Yu, Y.1    Keller, S.H.2    Remillard, C.V.3    Safrina, O.4    Nicholson, A.5    Zhang, S.L.6    Jiang, W.7    Vangala, N.8    Landsberg, J.W.9    Wang, J.Y.10
  • 94
    • 73649120970 scopus 로고    scopus 로고
    • Sildenafil inhibits chronically hypoxic upregulation of canonical transient receptor potential expression in rat pulmonary arterial smooth muscle
    • 19889962 1:CAS:528:DC%2BC3cXhsFKmtrg%3D 10.1152/ajpcell.00629.2008
    • Lu W, Ran P, Zhang D, Peng G, Li B, Zhong N, Wang J (2010) Sildenafil inhibits chronically hypoxic upregulation of canonical transient receptor potential expression in rat pulmonary arterial smooth muscle. Am J Physiol Cell Physiol 298:C114-C123
    • (2010) Am J Physiol Cell Physiol , vol.298
    • Lu, W.1    Ran, P.2    Zhang, D.3    Peng, G.4    Li, B.5    Zhong, N.6    Wang, J.7
  • 96
    • 84871788547 scopus 로고    scopus 로고
    • Sildenafil potentiates bone morphogenetic protein signaling in pulmonary arterial smooth muscle cells and in experimental pulmonary hypertension
    • 23139294 1:CAS:528:DC%2BC38XhvVeltrbN 10.1161/ATVBAHA.112.300121
    • Yang J, Li X, Al-Lamki R, Wu C, Weiss A, Berk J, Schermuly RT, Morrell NW (2013) Sildenafil potentiates bone morphogenetic protein signaling in pulmonary arterial smooth muscle cells and in experimental pulmonary hypertension. Arterioscler Thromb Vasc Biol 33:34-42
    • (2013) Arterioscler Thromb Vasc Biol , vol.33 , pp. 34-42
    • Yang, J.1    Li, X.2    Al-Lamki, R.3    Wu, C.4    Weiss, A.5    Berk, J.6    Schermuly, R.T.7    Morrell, N.W.8
  • 97
    • 28444461454 scopus 로고    scopus 로고
    • Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension
    • 16205723 1:CAS:528:DC%2BD2MXht1Ghu7vP 10.1038/sj.bjp.0706408
    • Guilluy C, Sauzeau V, Rolli-Derkinderen M, Guerin P, Sagan C, Pacaud P, Loirand G (2005) Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension. Br J Pharmacol 146:1010-1018
    • (2005) Br J Pharmacol , vol.146 , pp. 1010-1018
    • Guilluy, C.1    Sauzeau, V.2    Rolli-Derkinderen, M.3    Guerin, P.4    Sagan, C.5    Pacaud, P.6    Loirand, G.7
  • 99
    • 78649892620 scopus 로고    scopus 로고
    • MicroRNA-21 plays a role in hypoxia-mediated pulmonary artery smooth muscle cell proliferation and migration
    • 20693317 1:CAS:528:DC%2BC3cXhs1aitrrJ 10.1152/ajplung.00201.2010
    • Sarkar J, Gou D, Turaka P, Viktorova E, Ramchandran R, Raj JU (2010) MicroRNA-21 plays a role in hypoxia-mediated pulmonary artery smooth muscle cell proliferation and migration. Am J Physiol Lung Cell Mol Physiol 299:L861-L871
    • (2010) Am J Physiol Lung Cell Mol Physiol , vol.299
    • Sarkar, J.1    Gou, D.2    Turaka, P.3    Viktorova, E.4    Ramchandran, R.5    Raj, J.U.6
  • 101
    • 84866739116 scopus 로고    scopus 로고
    • Involvement of TRPV1 and TRPV4 channels in migration of rat pulmonary arterial smooth muscle cells
    • 22820913 1:CAS:528:DC%2BC38Xht1aisbbN 10.1007/s00424-012-1136-5
    • Martin E, Dahan D, Cardouat G, Gillibert-Duplantier J, Marthan R, Savineau JP, Ducret T (2012) Involvement of TRPV1 and TRPV4 channels in migration of rat pulmonary arterial smooth muscle cells. Pflugers Arch 464:261-272
    • (2012) Pflugers Arch , vol.464 , pp. 261-272
    • Martin, E.1    Dahan, D.2    Cardouat, G.3    Gillibert-Duplantier, J.4    Marthan, R.5    Savineau, J.P.6    Ducret, T.7
  • 102
    • 17144379334 scopus 로고    scopus 로고
    • Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption
    • 15815633 1:CAS:528:DC%2BD2MXivFCgurs%3D 10.1038/nature03460
    • Saadoun S, Papadopoulos MC, Hara-Chikuma M, Verkman AS (2005) Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption. Nature 434:786-792
    • (2005) Nature , vol.434 , pp. 786-792
    • Saadoun, S.1    Papadopoulos, M.C.2    Hara-Chikuma, M.3    Verkman, A.S.4
  • 103
    • 67650230936 scopus 로고    scopus 로고
    • AQP1 is not only a water channel: It contributes to cell migration through Lin7/beta-catenin
    • 19584911 10.1371/journal.pone.0006167 1:CAS:528:DC%2BD1MXosFOmtr8%3D
    • Monzani E, Bazzotti R, Perego C, La Porta CA (2009) AQP1 is not only a water channel: it contributes to cell migration through Lin7/beta-catenin. PLoS One 4:e6167
    • (2009) PLoS One , vol.4 , pp. 6167
    • Monzani, E.1    Bazzotti, R.2    Perego, C.3    La Porta, C.A.4
  • 106
    • 0035024643 scopus 로고    scopus 로고
    • Ion exchange activity in pulmonary artery smooth muscle cells: The response to hypoxia
    • 11159005 1:CAS:528:DC%2BD3MXjtVajtrk%3D
    • Madden JA, Ray DE, Keller PA, Kleinman JG (2001) Ion exchange activity in pulmonary artery smooth muscle cells: the response to hypoxia. Am J Physiol Lung Cell Mol Physiol 280:L264-L271
    • (2001) Am J Physiol Lung Cell Mol Physiol , vol.280
    • Madden, J.A.1    Ray, D.E.2    Keller, P.A.3    Kleinman, J.G.4
  • 110
    • 33751117499 scopus 로고    scopus 로고
    • HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes
    • 16766575 1:CAS:528:DC%2BD28Xht1GnsLrJ 10.1152/ajplung.00528.2005
    • Shimoda LA, Fallon M, Pisarcik S, Wang J, Semenza GL (2006) HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes. Am J Physiol Lung Cell Mol Physiol 291:L941-L949
    • (2006) Am J Physiol Lung Cell Mol Physiol , vol.291
    • Shimoda, L.A.1    Fallon, M.2    Pisarcik, S.3    Wang, J.4    Semenza, G.L.5
  • 111
    • 0031956840 scopus 로고    scopus 로고
    • Amiloride analogs inhibit chronic hypoxic pulmonary hypertension
    • 9563749 1:STN:280:DyaK1c3itlagug%3D%3D
    • Quinn DA, Du HK, Thompson BT, Hales CA (1998) Amiloride analogs inhibit chronic hypoxic pulmonary hypertension. Am J Respir Crit Care Med 157:1263-1268
    • (1998) Am J Respir Crit Care Med , vol.157 , pp. 1263-1268
    • Quinn, D.A.1    Du, H.K.2    Thompson, B.T.3    Hales, C.A.4
  • 112
    • 44449095608 scopus 로고    scopus 로고
    • Deficiency of the NHE1 gene prevents hypoxia-induced pulmonary hypertension and vascular remodeling
    • 18310478 1:CAS:528:DC%2BD1cXns1KgsL0%3D 10.1164/rccm.200710-1522OC
    • Yu L, Quinn DA, Garg HG, Hales CA (2008) Deficiency of the NHE1 gene prevents hypoxia-induced pulmonary hypertension and vascular remodeling. Am J Respir Crit Care Med 177:1276-1284
    • (2008) Am J Respir Crit Care Med , vol.177 , pp. 1276-1284
    • Yu, L.1    Quinn, D.A.2    Garg, H.G.3    Hales, C.A.4
  • 113
    • 80555143052 scopus 로고    scopus 로고
    • Silencing of NHE1 attenuates PASMC proliferation, hypertrophy and migration via E2F1
    • 21454803 1:CAS:528:DC%2BC3MXhsV2nsbjO 10.1165/rcmb.2011-0032OC
    • Yu L, Hales CA (2011) Silencing of NHE1 attenuates PASMC proliferation, hypertrophy and migration via E2F1. Am J Respir Cell Mol Biol 45:923-930
    • (2011) Am J Respir Cell Mol Biol , vol.45 , pp. 923-930
    • Yu, L.1    Hales, C.A.2
  • 115
    • 0029034799 scopus 로고
    • Hypoxia induces capillary network formation in cultured bovine pulmonary microvessel endothelial cells
    • 7539223 1:CAS:528:DyaK2MXlvVaisbc%3D
    • Phillips PG, Birnby LM, Narendran A (1995) Hypoxia induces capillary network formation in cultured bovine pulmonary microvessel endothelial cells. Am J Physiol 268:L789-L800
    • (1995) Am J Physiol , vol.268
    • Phillips, P.G.1    Birnby, L.M.2    Narendran, A.3
  • 118
    • 40749126460 scopus 로고    scopus 로고
    • Sodium-hydrogen exchange inhibition by cariporide to reduce the risk of ischemic cardiac events in patients undergoing coronary artery bypass grafting: Results of the EXPEDITION study
    • 18355507 10.1016/j.athoracsur.2007.10.054
    • Mentzer RM Jr, Bartels C, Bolli R, Boyce S, Buckberg GD, Chaitman B, Haverich A, Knight J, Menasche P, Myers ML et al (2008) Sodium-hydrogen exchange inhibition by cariporide to reduce the risk of ischemic cardiac events in patients undergoing coronary artery bypass grafting: results of the EXPEDITION study. Ann Thorac Surg 85:1261-1270
    • (2008) Ann Thorac Surg , vol.85 , pp. 1261-1270
    • Mentzer, Jr.R.M.1    Bartels, C.2    Bolli, R.3    Boyce, S.4    Buckberg, G.D.5    Chaitman, B.6    Haverich, A.7    Knight, J.8    Menasche, P.9    Myers, M.L.10
  • 119
    • 58149291690 scopus 로고    scopus 로고
    • Why did the NHE inhibitor clinical trials fail?
    • 19027021 1:CAS:528:DC%2BD1MXntVGmtA%3D%3D 10.1016/j.yjmcc.2008.09.715
    • Murphy E, Allen DG (2009) Why did the NHE inhibitor clinical trials fail? J Mol Cell Cardiol 46:137-141
    • (2009) J Mol Cell Cardiol , vol.46 , pp. 137-141
    • Murphy, E.1    Allen, D.G.2
  • 120
    • 34147189502 scopus 로고    scopus 로고
    • Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats
    • 17332430 1:CAS:528:DC%2BD2sXjtlWmsLg%3D 10.1161/01.RES.0000261658.12024. 18
    • Oka M, Homma N, Taraseviciene-Stewart L, Morris KG, Kraskauskas D, Burns N, Voelkel NF, McMurtry IF (2007) Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats. Circ Res 100:923-929
    • (2007) Circ Res , vol.100 , pp. 923-929
    • Oka, M.1    Homma, N.2    Taraseviciene-Stewart, L.3    Morris, K.G.4    Kraskauskas, D.5    Burns, N.6    Voelkel, N.F.7    McMurtry, I.F.8
  • 121
    • 66049112085 scopus 로고    scopus 로고
    • Mechanisms of hypoxic pulmonary vasoconstriction and their roles in pulmonary hypertension: New findings for an old problem
    • 19297247 1:CAS:528:DC%2BD1MXms1OgsrY%3D 10.1016/j.coph.2009.02.006
    • Ward JPT, Mcmurtry IF (2009) Mechanisms of hypoxic pulmonary vasoconstriction and their roles in pulmonary hypertension: new findings for an old problem. Curr Opin Pharmacol 9:287-296
    • (2009) Curr Opin Pharmacol , vol.9 , pp. 287-296
    • Ward, J.P.T.1    McMurtry, I.F.2
  • 122
    • 84864566286 scopus 로고    scopus 로고
    • Animal models of pulmonary hypertension: Rho kinase inhibition
    • 22713173 1:CAS:528:DC%2BC38XhtFKnsrbO 10.1016/j.pbiomolbio.2012.05.009
    • Firth AL, Choi I-W, Park WS (2012) Animal models of pulmonary hypertension: Rho kinase inhibition. Prog Biophys Mol Biol 109:67-75
    • (2012) Prog Biophys Mol Biol , vol.109 , pp. 67-75
    • Firth, A.L.1    Choi, I.-W.2    Park, W.S.3
  • 123
    • 53849089211 scopus 로고    scopus 로고
    • Therapeutic potential of RhoA/Rho kinase inhibitors in pulmonary hypertension
    • 18536743 1:CAS:528:DC%2BD1cXht1emurzK 10.1038/bjp.2008.239
    • Oka M, Fagan KA, Jones PL, McMurtry IF (2008) Therapeutic potential of RhoA/Rho kinase inhibitors in pulmonary hypertension. Br J Pharmacol 155:444-454
    • (2008) Br J Pharmacol , vol.155 , pp. 444-454
    • Oka, M.1    Fagan, K.A.2    Jones, P.L.3    McMurtry, I.F.4
  • 124
    • 35348967735 scopus 로고    scopus 로고
    • BMP4 induces HO-1 via a Smad-independent, p38MAPK-dependent pathway in pulmonary artery myocytes
    • 17600318 1:CAS:528:DC%2BD2sXhtlWhsr3N 10.1165/rcmb.2006-0360OC
    • Yang X, Lee PJ, Long L, Trembath RC, Morrell NW (2007) BMP4 induces HO-1 via a Smad-independent, p38MAPK-dependent pathway in pulmonary artery myocytes. Am J Respir Cell Mol Biol 37:598-605
    • (2007) Am J Respir Cell Mol Biol , vol.37 , pp. 598-605
    • Yang, X.1    Lee, P.J.2    Long, L.3    Trembath, R.C.4    Morrell, N.W.5
  • 125
    • 33947715935 scopus 로고    scopus 로고
    • Mechanisms of vascular smooth muscle cell migration
    • 17363707 1:CAS:528:DC%2BD2sXisFyntL8%3D 10.1161/01.RES.0000258492.96097. 47
    • Gerthoffer WT (2007) Mechanisms of vascular smooth muscle cell migration. Circ Res 100:607-621
    • (2007) Circ Res , vol.100 , pp. 607-621
    • Gerthoffer, W.T.1
  • 126
    • 4644248958 scopus 로고    scopus 로고
    • Rho kinase-induced nuclear translocation of ERK1/ERK2 in smooth muscle cell mitogenesis caused by serotonin
    • 15297378 1:CAS:528:DC%2BD2cXntlyjtLc%3D 10.1161/01.RES.0000141428.53262. a4
    • Liu Y, Suzuki YJ, Day RM, Fanburg BL (2004) Rho kinase-induced nuclear translocation of ERK1/ERK2 in smooth muscle cell mitogenesis caused by serotonin. Circ Res 95:579-586
    • (2004) Circ Res , vol.95 , pp. 579-586
    • Liu, Y.1    Suzuki, Y.J.2    Day, R.M.3    Fanburg, B.L.4
  • 127
    • 84866995187 scopus 로고    scopus 로고
    • + exchange activity in murine pulmonary arterial smooth muscle cells via Rho kinase
    • 23029469 1:CAS:528:DC%2BC38XhsFShsL%2FJ 10.1371/journal.pone.0046303
    • + exchange activity in murine pulmonary arterial smooth muscle cells via Rho kinase. PLoS One 7:e46303
    • (2012) PLoS One , vol.7 , pp. 46303
    • Undem, C.1    Rios, E.J.2    Maylor, J.3    Shimoda, L.A.4
  • 128
    • 14244260105 scopus 로고    scopus 로고
    • Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension
    • 15710736 1:STN:280:DC%2BD2M%2FotFOhtw%3D%3D 10.1136/hrt.2003.029470
    • Fukumoto Y, Matoba T, Ito A, Tanaka H, Kishi T, Hayashidani S, Abe K, Takeshita A, Shimokawa H (2005) Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension. Heart 91:391-392
    • (2005) Heart , vol.91 , pp. 391-392
    • Fukumoto, Y.1    Matoba, T.2    Ito, A.3    Tanaka, H.4    Kishi, T.5    Hayashidani, S.6    Abe, K.7    Takeshita, A.8    Shimokawa, H.9
  • 129
    • 31644431508 scopus 로고    scopus 로고
    • Beneficial acute effects of Rho-kinase inhibitor in patients with pulmonary arterial hypertension
    • 16434811 1:CAS:528:DC%2BD28XhsFyqurY%3D 10.1253/circj.70.174
    • Ishikura K, Yamada N, Ito M, Ota S, Nakamura M, Isaka N, Nakano T (2006) Beneficial acute effects of Rho-kinase inhibitor in patients with pulmonary arterial hypertension. Circ J 70:174-178
    • (2006) Circ J , vol.70 , pp. 174-178
    • Ishikura, K.1    Yamada, N.2    Ito, M.3    Ota, S.4    Nakamura, M.5    Isaka, N.6    Nakano, T.7
  • 131
    • 77950921360 scopus 로고    scopus 로고
    • Acute vasodilator effects of inhaled fasudil, a specific Rho-kinase inhibitor, in patients with pulmonary arterial hypertension
    • 10.1007/s00380-009-1176-8
    • Fujita H, Fukumoto Y, Saji K, Sugimura K, Demachi J, Nawata J, Shimokawa H (2010) Acute vasodilator effects of inhaled fasudil, a specific Rho-kinase inhibitor, in patients with pulmonary arterial hypertension. Hear Vessel 25:144-149
    • (2010) Hear Vessel , vol.25 , pp. 144-149
    • Fujita, H.1    Fukumoto, Y.2    Saji, K.3    Sugimura, K.4    Demachi, J.5    Nawata, J.6    Shimokawa, H.7
  • 132
    • 4544388803 scopus 로고    scopus 로고
    • Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rho-kinase
    • 14977625 1:CAS:528:DC%2BD2cXptVyhs7k%3D 10.1152/ajplung.00090.2003
    • Fagan KA, Oka M, Bauer NR, Gebb SA, Ivy DD, Morris KG, McMurtry IF (2004) Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rho-kinase. Am J Physiol Lung Cell Mol Physiol 287:L656-L664
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.287
    • Fagan, K.A.1    Oka, M.2    Bauer, N.R.3    Gebb, S.A.4    Ivy, D.D.5    Morris, K.G.6    McMurtry, I.F.7
  • 133
    • 10744222390 scopus 로고    scopus 로고
    • Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats
    • 14670839 1:CAS:528:DC%2BD2cXhtFWlu7o%3D 10.1161/01.RES.0000111804.34509. 94
    • Abe K, Shimokawa H, Morikawa K, Uwatoku T, Oi K, Matsumoto Y, Hattori T, Nakashima Y, Kaibuchi K, Sueishi K et al (2004) Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats. Circ Res 94:385-393
    • (2004) Circ Res , vol.94 , pp. 385-393
    • Abe, K.1    Shimokawa, H.2    Morikawa, K.3    Uwatoku, T.4    Oi, K.5    Matsumoto, Y.6    Hattori, T.7    Nakashima, Y.8    Kaibuchi, K.9    Sueishi, K.10
  • 135
    • 0035859940 scopus 로고    scopus 로고
    • Altered growth responses of pulmonary artery smooth muscle cells from
    • 11502704 1:CAS:528:DC%2BD3MXmsVOgur8%3D 10.1161/hc3201.094152
    • Morrell NW, Yang X, Upton PD, Jourdan KB, Morgan N, Sheares KK, Trembath RC (2001) Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-β1 and bone morphogenetic proteins. Circulation 104:790-795
    • (2001) Circulation , vol.104 , pp. 790-795
    • Morrell, N.W.1    Yang, X.2    Upton, P.D.3    Jourdan, K.B.4    Morgan, N.5    Sheares, K.K.6    Trembath, R.C.7
  • 137
    • 20344362689 scopus 로고    scopus 로고
    • Dysfunctional Smad signaling contributes to abnormal smooth muscle cell proliferation in familial pulmonary arterial hypertension
    • 15845886 1:CAS:528:DC%2BD2MXktlKku78%3D 10.1161/01.RES.0000166926.54293. 68
    • Yang X, Long L, Southwood M, Rudarakanchana N, Upton PD, Jeffery TK, Atkinson C, Chen H, Trembath RC, Morrell NW (2005) Dysfunctional Smad signaling contributes to abnormal smooth muscle cell proliferation in familial pulmonary arterial hypertension. Circ Res 96:1053-1063
    • (2005) Circ Res , vol.96 , pp. 1053-1063
    • Yang, X.1    Long, L.2    Southwood, M.3    Rudarakanchana, N.4    Upton, P.D.5    Jeffery, T.K.6    Atkinson, C.7    Chen, H.8    Trembath, R.C.9    Morrell, N.W.10
  • 139
  • 141
  • 142
    • 33644865928 scopus 로고    scopus 로고
    • Bone morphogenetic protein receptor-2 signaling promotes pulmonary arterial endothelial cell survival: Implications for loss-of-function mutations in the pathogenesis of pulmonary hypertension
    • 16357305 1:CAS:528:DC%2BD28Xnt1CqsA%3D%3D 10.1161/01.RES.0000200180. 01710.e6
    • Teichert-Kuliszewska K, Kutryk MJ, Kuliszewski MA, Karoubi G, Courtman DW, Zucco L, Granton J, Stewart DJ (2006) Bone morphogenetic protein receptor-2 signaling promotes pulmonary arterial endothelial cell survival: implications for loss-of-function mutations in the pathogenesis of pulmonary hypertension. Circ Res 98:209-217
    • (2006) Circ Res , vol.98 , pp. 209-217
    • Teichert-Kuliszewska, K.1    Kutryk, M.J.2    Kuliszewski, M.A.3    Karoubi, G.4    Courtman, D.W.5    Zucco, L.6    Granton, J.7    Stewart, D.J.8
  • 143
    • 80053020850 scopus 로고    scopus 로고
    • Bone morphogenetic protein receptor II is a novel mediator of endothelial nitric-oxide synthase activation
    • 21808054 1:CAS:528:DC%2BC3MXhtFOit77P 10.1074/jbc.M111.274100
    • Gangopahyay A, Oran M, Bauer EM, Wertz JW, Comhair SA, Erzurum SC, Bauer PM (2011) Bone morphogenetic protein receptor II is a novel mediator of endothelial nitric-oxide synthase activation. J Biol Chem 286:33134-33140
    • (2011) J Biol Chem , vol.286 , pp. 33134-33140
    • Gangopahyay, A.1    Oran, M.2    Bauer, E.M.3    Wertz, J.W.4    Comhair, S.A.5    Erzurum, S.C.6    Bauer, P.M.7
  • 144
    • 28144440031 scopus 로고    scopus 로고
    • Simvastatin enhances bone morphogenetic protein receptor type II expression
    • 16297860 1:CAS:528:DC%2BD2MXht1OrtrzL 10.1016/j.bbrc.2005.10.187
    • Hu H, Sung A, Zhao G, Shi L, Qiu D, Nishimura T, Kao PN (2006) Simvastatin enhances bone morphogenetic protein receptor type II expression. Biochem Biophys Res Commun 339:59-64
    • (2006) Biochem Biophys Res Commun , vol.339 , pp. 59-64
    • Hu, H.1    Sung, A.2    Zhao, G.3    Shi, L.4    Qiu, D.5    Nishimura, T.6    Kao, P.N.7
  • 146
    • 79958069658 scopus 로고    scopus 로고
    • The role of endothelin-1 in the pathogenesis of pulmonary arterial hypertension
    • 21419223 1:CAS:528:DC%2BC3MXnt1Krs7g%3D 10.1016/j.phrs.2011.03.003
    • Shao D, Park JE, Wort SJ (2011) The role of endothelin-1 in the pathogenesis of pulmonary arterial hypertension. Pharmacol Res 63:504-511
    • (2011) Pharmacol Res , vol.63 , pp. 504-511
    • Shao, D.1    Park, J.E.2    Wort, S.J.3
  • 147
    • 0037158630 scopus 로고    scopus 로고
    • Acute and chronic hypoxic pulmonary vasoconstriction: A central role for endothelin-1?
    • 12126698 1:CAS:528:DC%2BD38XntVKjtbY%3D 10.1016/S1569-9048(02)00052-6
    • Shimoda LA, Sham JS, Liu Q, Sylvester JT (2002) Acute and chronic hypoxic pulmonary vasoconstriction: a central role for endothelin-1? Respir Physiol Neurobiol 132:93-106
    • (2002) Respir Physiol Neurobiol , vol.132 , pp. 93-106
    • Shimoda, L.A.1    Sham, J.S.2    Liu, Q.3    Sylvester, J.T.4
  • 149
    • 68849115556 scopus 로고    scopus 로고
    • The science of endothelin-1 and endothelin receptor antagonists in the management of pulmonary arterial hypertension: Current understanding and future studies
    • 1:CAS:528:DC%2BD1MXmvVyiur0%3D 10.1111/j.1365-2362.2009.02120.x
    • Davie NJ, Schermuly RT, Weissmann N, Grimminger F, Ghofrani HA (2009) The science of endothelin-1 and endothelin receptor antagonists in the management of pulmonary arterial hypertension: current understanding and future studies. Eur J Clin Investig 39(Suppl 2):38-49
    • (2009) Eur J Clin Investig , vol.39 , Issue.SUPPL. 2 , pp. 38-49
    • Davie, N.J.1    Schermuly, R.T.2    Weissmann, N.3    Grimminger, F.4    Ghofrani, H.A.5
  • 150
    • 53849083055 scopus 로고    scopus 로고
    • Novel interactions between the 5-HT transporter, 5-HT1B receptors and Rho kinase in vivo and in pulmonary fibroblasts
    • 18695640 1:CAS:528:DC%2BD1cXht1emurvF 10.1038/bjp.2008.310
    • Mair KM, MacLean MR, Morecroft I, Dempsie Y, Palmer TM (2008) Novel interactions between the 5-HT transporter, 5-HT1B receptors and Rho kinase in vivo and in pulmonary fibroblasts. Br J Pharmacol 155:606-616
    • (2008) Br J Pharmacol , vol.155 , pp. 606-616
    • Mair, K.M.1    Maclean, M.R.2    Morecroft, I.3    Dempsie, Y.4    Palmer, T.M.5
  • 151
    • 0026468180 scopus 로고
    • A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
    • 1448077 1:CAS:528:DyaK3sXltFShsr0%3D
    • Semenza GL, Wang GL (1992) A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 12:5447-5454
    • (1992) Mol Cell Biol , vol.12 , pp. 5447-5454
    • Semenza, G.L.1    Wang, G.L.2
  • 152
    • 17644423994 scopus 로고    scopus 로고
    • Pulmonary vascular responses to chronic hypoxia mediated by hypoxia-inducible factor 1
    • 16113471 1:CAS:528:DC%2BD28XhsFGitro%3D 10.1513/pats.200404-029MS
    • Semenza GL (2005) Pulmonary vascular responses to chronic hypoxia mediated by hypoxia-inducible factor 1. Proc Am Thorac Soc 2:68-70
    • (2005) Proc Am Thorac Soc , vol.2 , pp. 68-70
    • Semenza, G.L.1
  • 153
    • 84864131464 scopus 로고    scopus 로고
    • Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2
    • 22811423 1:CAS:528:DC%2BC38Xht1KmtbvF 10.1152/physrev.00030.2011
    • Prabhakar NR, Semenza GL (2012) Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2. Physiol Rev 92:967-1003
    • (2012) Physiol Rev , vol.92 , pp. 967-1003
    • Prabhakar, N.R.1    Semenza, G.L.2
  • 155
    • 78751690547 scopus 로고    scopus 로고
    • HIF and the lung: Role of hypoxia-inducible factors in pulmonary development and disease
    • 21242594 1:CAS:528:DC%2BC3MXis1Cqsbo%3D 10.1164/rccm.201009-1393PP
    • Shimoda LA, Semenza GL (2011) HIF and the lung: role of hypoxia-inducible factors in pulmonary development and disease. Am J Respir Crit Care Med 183:152-156
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. 152-156
    • Shimoda, L.A.1    Semenza, G.L.2
  • 156
    • 84875741389 scopus 로고    scopus 로고
    • 55th Bowditch lecture: Effects of chronic hypoxia on the pulmonary circulation: Role of HIF-1
    • 22923506 1:CAS:528:DC%2BC3sXhsVGjsQ%3D%3D 10.1152/japplphysiol.00843.2012
    • Shimoda LA (2012) 55th Bowditch lecture: effects of chronic hypoxia on the pulmonary circulation: role of HIF-1. J Appl Physiol 113:1343-1352
    • (2012) J Appl Physiol , vol.113 , pp. 1343-1352
    • Shimoda, L.A.1
  • 158
    • 85047691081 scopus 로고    scopus 로고
    • Heterozygous deficiency of hypoxia-inducible factor-2α protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia
    • 12750401 1:CAS:528:DC%2BD3sXktVGisLs%3D
    • Brusselmans K, Compernolle V, Tjwa M, Wiesener MS, Maxwell PH, Collen D, Carmeliet P (2003) Heterozygous deficiency of hypoxia-inducible factor-2α protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia. J Clin Invest 111:1519-1527
    • (2003) J Clin Invest , vol.111 , pp. 1519-1527
    • Brusselmans, K.1    Compernolle, V.2    Tjwa, M.3    Wiesener, M.S.4    Maxwell, P.H.5    Collen, D.6    Carmeliet, P.7
  • 159
    • 77951216444 scopus 로고    scopus 로고
    • Hypoxic regulation of ion channels and transporters in pulmonary vascular smooth muscle
    • 20204733 1:CAS:528:DC%2BC3cXhsFyjtr3L 10.1007/978-1-60761-500-2-14
    • Shimoda LA (2010) Hypoxic regulation of ion channels and transporters in pulmonary vascular smooth muscle. Adv Exp Med Biol 661:221-235
    • (2010) Adv Exp Med Biol , vol.661 , pp. 221-235
    • Shimoda, L.A.1


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