Amiloride analogs inhibit chronic hypoxic pulmonary hypertension

American Journal of Respiratory and Critical Care Medicine

Volumn 157, Issue 4 PART I, 1998, Pages 1263-1268

  Quinn, Deborah A ^a   Du, Hong Kai ^a   Thompson, B Taylor ^a   Hales, Charles A ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMILORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PH; CELL PROLIFERATION; DRUG EFFECT; HYPOXIA; LUNG ARTERY; LUNG ARTERY PRESSURE; LUNG VASCULAR RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; PULMONARY HYPERTENSION; RAT; VASCULAR SMOOTH MUSCLE;

AMILORIDE; ANIMALS; ANOXIA; BLOOD PRESSURE; CELL DIVISION; CHRONIC DISEASE; HEMATOCRIT; HYPERTENSION, PULMONARY; HYPERTROPHY, RIGHT VENTRICULAR; MUSCLE, SMOOTH, VASCULAR; PULMONARY ARTERY; RATS; RATS, SPRAGUE-DAWLEY; SODIUM-HYDROGEN ANTIPORTER; VASCULAR RESISTANCE;

EID: 0031956840     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.157.4.9704106     Document Type: Article

References (12)

1. Meyrick, B., and L. Reid. 1983. Pulmonary hypertension: anatomic and physiologic correlates. Clin. Chest Med. 4:199-217.
2. + exchange and growth factor-induced cytosolic pH changes: role in cellular proliferation. Biochim. Biophys. Acta 988:73-97.
3. Counilion, L., and J. Pouyssegur. 1995. Structure function studies and molecular regulation of the growth factor activatable sodium-hydrogen exchanger (NHE-1). Cardiovasc. Res. 29:147-154.
4. Lucchesi, P. A., and B. C. Berk. 1995. Regulation of sodium-hydrogen exchange in vascular smooth muscle. Cardiovasc. Res. 29:172-177.
5. + exchange to pH regulation in pulmonary artery smooth muscle cells. Am. J. Respir. Cell Mol. Biol. 5:586-591.
6. + exchange in pulmonary artery smooth muscle from spontaneously hypertensive and Wistar-Kyoto rats. Am. J. Physiol. 13:L673-L680.
7. + exchange and growth of PASMC. Am. J. Physiol. 14:L260-L265.
8. Kleyman, T. R., and E. J. Cragoe. 1988. Amiloride and its analogs as tools in study of ion transport. J. Membrane Biol. 105:1-21.
9. + exchange and growth factors in pulmonary artery smooth muscle cell proliferation. Am. J. Respir. Cell Mol. Biol. 14:139-145.
10. Bobik, A., A. Grooms, P. J. Little, E. J. Cragoe, and S. Grinpukel. 1991. Ethylisopropylamiloride-sensitive pH control mechanism mediate vascular smooth cell growth. Am. J. Physiol. 260:C581-C588.
11. Janssens, S. P., B. T. Thompson, C. R. Spence, and C. A. Hales. 1994. Functional and structural changes with hypoxia in pulmonary circulation of spontaneously hypertensive rats. J. Appl. Physiol. 77:1101-1107.
12. Du, H. K., Y. J. Lee, G. L. Colice, J. C. Leiter, and L. C. Ou. 1996. Pathophysiological effects of hemodilution in chronic mountain sickness in rats. J. Appl. Physiol. 80:574-582.