Dysfunctional Smad signaling contributes to abnormal smooth muscle cell proliferation in familial pulmonary arterial hypertension

Circulation Research

Volumn 96, Issue 10, 2005, Pages 1053-1063

  Yang, Xudong ^a   Long, Lu ^a   Southwood, Mark ^b   Rudarakanchana, Nung ^a   Upton, Paul D ^a   Jeffery, Trina K ^a   Atkinson, Carl ^b   Chen, Hailan ^a   Trembath, Richard C ^c   Morrell, Nicholas W ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b PAPWORTH HOSPITAL   (United Kingdom)

^c UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Cell signaling; Pulmonary hypertension; Smooth muscle cells; Transforming growth factor ; Vascular remodeling

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN RECEPTOR; BONE MORPHOGENETIC PROTEIN RECEPTOR 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; SMAD PROTEIN; SMAD1 PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BMPR2 GENE; CELL PROLIFERATION; CELL TYPE; CONTROLLED STUDY; GENE MUTATION; HEREDITARY HYPERTENSION; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; RECEPTOR GENE; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER;

APOPTOSIS; BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE II; BONE MORPHOGENETIC PROTEINS; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; DNA-BINDING PROTEINS; HUMANS; HYPERTENSION, PULMONARY; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MUSCLE, SMOOTH, VASCULAR; MUTATION; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PULMONARY ARTERY; SIGNAL TRANSDUCTION; SMAD PROTEINS; SMAD1 PROTEIN; TRANS-ACTIVATORS;

EID: 20344362689     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000166926.54293.68     Document Type: Article

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