Regression of chronic hypoxic pulmonary hypertension by simvastatin

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 292, Issue 5, 2007, Pages

  Girgis, Reda E ^a   Mozammel, Shehzin ^a   Champion, Hunter C ^a   Li, Dechun ^a,b   Peng, Xinqi ^a   Shimoda, Larissa ^a   Tuder, Rubin M ^a   Johns, Roger A ^a   Hassoun, Paul M ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Mevalonate; Rho kinase; Statins

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVALONIC ACID; MYOSIN; MYOSIN PHOSPHATASE; RHO KINASE; RHO KINASE 1; RHO KINASE 2; SIMVASTATIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC DISEASE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HEART LEFT VENTRICLE; HEART RIGHT VENTRICLE; HEART VENTRICLE WALL; HYPOXIA; LUNG ARTERY PRESSURE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; THICKNESS; TREATMENT DURATION; WESTERN BLOTTING;

ANIMALS; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERTENSION, PULMONARY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; PROTEIN-SERINE-THREONINE KINASES; PULMONARY ARTERY; PULMONARY CIRCULATION; RATS; RATS, SPRAGUE-DAWLEY; SIMVASTATIN;

EID: 34447576415     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00411.2006     Document Type: Article

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