A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension

Circulation

Volumn 119, Issue 17, 2009, Pages 2313-2322

  Yu, Ying ^a,c,g   Keller, Steve H ^a   Remillard, Carmelle V ^a   Safrina, Olga ^c   Nicholson, Ann ^a   Zhang, Shenyuan L ^c   Jiang, Weihua ^c   Vangala, Nivruthi ^a   Landsberg, Judd W ^a   Wang, Jian Ying ^d   Thistlethwaite, Patricia A ^b   Channick, Richard N ^a   Robbins, Ivan M ^e   Loyd, James E ^e   Ghofrani, Hossein A ^f   Grimminger, Friedrich ^f   Schermuly, Ralph T ^f   Cahalan, Michael D ^c   Rubin, Lewis J ^a   Yuan, Jason X J ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^e VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f JUSTUS LIEBIG UNIVERSITY   (Germany)

^g ALCON RESEARCH LTD   (United States)

Author keywords

Calcium; Hypertension, pulmonary; Ion channels; Muscle, smooth; NF kappa B

Indexed keywords

CALCIUM ION; GENOMIC DNA; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SMALL INTERFERING RNA; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; TUMOR NECROSIS FACTOR ALPHA; TRANSIENT RECEPTOR POTENTIAL CHANNEL C; TRPC6 PROTEIN, HUMAN;

ARTICLE; BINDING SITE; BLOOD SAMPLING; CALCIUM TRANSPORT; CONTROLLED STUDY; DOWN REGULATION; GENE ACTIVITY; GENE CONTROL; GENE EXPRESSION; GENE FREQUENCY; GENE FUNCTION; GENETIC TRANSCRIPTION; GENOTYPE; HOMOZYGOTE; HUMAN; HUMAN TISSUE; IDIOPATHIC DISEASE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PULMONARY HYPERTENSION; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; CASE CONTROL STUDY; CELL PROLIFERATION; GENETIC PREDISPOSITION; GENETICS; HYPERTENSION; METABOLISM; PATHOPHYSIOLOGY; PROMOTER REGION; PULMONARY ARTERY; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

BINDING SITES; CASE-CONTROL STUDIES; CELL PROLIFERATION; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; HYPERTENSION; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NF-KAPPA B; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; PULMONARY ARTERY; TRPC CATION CHANNELS;

EID: 66349095797     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.108.782458     Document Type: Article

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