The role of vascular injury and hemodynamics in rat pulmonary artery remodeling

Journal of Clinical Investigation

Volumn 98, Issue 2, 1996, Pages 434-442

  Tanaka, Yoshihiro ^a   Schuster, Daniel P ^a   Davis, Elaine C ^a   Patterson, G Alexander ^a   Botney, Mitchell D ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BARNES JEWISH HOSPITAL   (United States)

Author keywords

extracellular matrix; monocrotaline; neointima; pulmonary hypertension; vascular injury

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE; MONOCROTALINE; PROCOLLAGEN; TRANSFORMING GROWTH FACTOR BETA; TROPOELASTIN;

ANIMAL MODEL; ARTERIOGRAPHY; ARTICLE; BLALOCK TAUSSIG ANASTOMOSIS; BLOOD VESSEL INJURY; CONTROLLED STUDY; ENDARTERECTOMY; EXTRACELLULAR MATRIX; HEART WEIGHT; HEMODYNAMICS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INTIMA; LUNG ARTERY; LUNG ARTERY PRESSURE; MALE; NONHUMAN; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RAT; SYSTOLIC BLOOD PRESSURE;

EID: 0030036720     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118809     Document Type: Article

References (42)

1. Heath, D., E. Wood, J. Dushane, and J. Edwards. 1959. The structure of the pulmonary trunk at different ages and in cases of pulmonary hypertension and pulmonary stenosis. J. Pathol. Bacteriol. 77:443.
2. Heath, D., E.H. Wood, J.W. DuShane, and J.E. Edwards. 1960. The relation of age and blood pressure to atheroma in the pulmonary arteries and thoracic aorta in congenital heart disease. Lab Invest. 9:259-272.
3. Botney, M.D., L.R. Kaiser, J.D. Cooper, R.P. Mecham, J. Roby and W.C. Parks. 1992. Extracellular matrix protein gene expression in atherosclerotic pulmonary arteries. Am. J. Pathol. 140:357-364.
4. Liptay, M.J., W.C. Parks, R.P. Mecham, J. Roby, L.R. Kaiser, J.D. Cooper and M.D. Botney. 1993. Neointimal macrophages co-localize with extracellular matrix gene expression in human atherosclerotic pulmonary arteries. J. Clin. Invest. 91:588-594.
5. Glagov, S., and A.K. Ozoa. 1968. Significance of the relatively low incidence of atherosclerosis in the pulmonary, renal, and mesenteric arteries. Ann. NY Acad. Sci. 149:940-955.
6. Wissler, R.W., and D. Vesselinovitch. 1990. Atherogenesis in the Pulmonary Artery. In The Pulmonary Circulation: Normal and Abnormal. A.P. Fishman, editor. U. Pennsylvania Press, Philadelphia. PA. 245-255.
7. Tanaka, Y., M.L. Bernstein, R.P. Mecham, G.A. Patterson, J.D. Cooper, and M.D. Botney. 1996. Site-specific responses to monocrotaline-induced vascular injury: evidence for two distinct mechanisms of remodeling. Am. J. Respir. Cell Mol. Biol. In Press.
8. Poiani, G.J., C.A. Tozzi, S.E. Yohn, R.A. Pierce, S.A. Belsky, R.A. Berg, S.Y. Yu, S.B. Deak, and D.J. Riley. 1990. Collagen and elastin metabolism in hypertensive pulmonary arteries of rats. Circ. Res. 66:968-978.
9. Stenmark, K.R., J. Fasules, D.M. Hyde, N.F. Voelkel, J. Henson, A. Tucker, H. Wilson, and J.T. Reeves. 1987. Severe pulmonary hypertension and arterial adventitial changes in newborn calves at 4,300 m. Am. J. Physiol. 62: 821-830.
10. Prosser, I.W., K.R. Stenmark, M. Suthar, E.C. Crouch, R.P. Mecham, and W.C. Parks. 1989. Regional heterogeneity of elastin and collagen gene expression in intralobar arteries in response to hypoxic pulmonary hypertension as demonstrated by in situ hybridization. Am. J. Pathol. 135:1073-1087.
11. Todorovich-Hunter, L., D.J. Johnson, P. Ranger, F.W. Keeley, and M. Rabinovitch. 1988. Altered elastin and collagen synthesis associated with progressive pulmonary hypertension induced by monocrotaline: a biochemical and ultrastructural study. Lab. Invest. 58:184-195.
12. Perkett, E.A., J.M. Davidson, and B. Meyrick. 1991. Sequence of structural changes and elastin peptide release during vascular remodeling in sheep with chronic pulmonary hypertension induced by air embolization. Am. J. Pathol. 139:1319-1332.
13. Ross, R. 1993. Atherosclerosis: a defense mechanism gone awry. Am. J. Pathol. 143:987-1002.
14. Gibbons, G.H., and V.J. Dzau. 1994. The emerging concept of vascular remodeling. N. Engl. J. Med. 330:1431-1438.
15. Stenmark, K.R., M.L. Morganroth, L.K. Remigio, N.F. Voelkel, R.C. Murphy, P.M. Henson, M.M. Mathias, and J.T. Reeves. 1985. Alveolar inflammation and arachidonate metabolism in monocrotaline-induced pulmonary hypertension. Am. J. Physiol. 248:H859-H866.
16. Wilson, D.W., H.J. Segall, L.C.W. Pan, and S.K. Dunston. 1989. Progressive inflammatory and structural changes in the pulmonary vasculature of monocrotaline-trealed rats. Microvasc. Res. 38:57-80.
17. Todorovich-Hunter, L., H. Dodo, C. Ye, L. McCready, F. Keeley, and M. Rabinovitch. 1992. Increased pulmonary artery elastolytic activity in adult rats with monocrotaline-induced progressive hypertensive pulmonary vascular disease compared with infant rats with nonprogressive disease. Am. Rev. Resp. Dis. 146:213-223.
18. Rosenberg, H.C., and M. Rabinovitch. 1988. Endothelial injury and vascular reactivity in monocrotaline pulmonary hypertension. Am. J. Physiol. 255: H1484-1491.
19. Guzowski, D.E., and E.D. Salgado. 1987. Changes in main pulmonary artery in rats with monocrotaline-induced pulmonary hypertension. Arch. Pathol. Lab. Med. 111:741-745.
20. Kameji, K., H. Otsuka, and Y. Hayashi. 1980. Increase of collagen synthesis in pulmonary arteries of monocrotaline-treated rats. Experientia. 36:441-442.
21. Lipke, D.W., S.S. Arcot, M.N. Gillepsie, and J.W. Olson. 1993. Temporal alterations in specific basement membrane components in lungs from monocrotaline-treated rats. Am. J. Respir. Cell Mol. Biol. 9:418-428.
22. Clowes, A.W., M.A. Reidy, and M.M. Clowes. 1983. Mechanisms of stenosis after arterial injury. Lab. Invest. 49:208-215.
23. Nikkari, S.T., H.T. Jarvelainen, T.N. Wight, M. Ferguson, and A.W. Clowes. 1994. Smooth muscle cells expression of extracellular matrix genes after arterial injury. Am. J. Pathol. 144:1348-1356.
24. Mizuta, T., A. Kawaguchi, K. Nakahara, and Y. Kawashima. 1989. Simplified rat lung transplantation using a cuff technique. J. Thorac. Cardiovasc. Surg. 97:578-581.
25. Bahadori, L., J. Milder, L.I. Gold, and M.D. Botney. 1995. Active macrophage-associated TGF-β colocalizes with type I procollagen gene expression in atherosclerotic human hypertensive pulmonary arteries. Am. J. Pathol. 146: 1140-1149.
26. Botney, M.D., M.J. Liptay, L.R. Kaiser, J.D. Cooper, W.C. Parks, and R.P. Mecham. 1993. Active collagen synthesis by pulmonary arteries in human primary pulmonary hypertension. Am. J. Pathol. 143:121-129.
27. Schuster, D.P., E.C. Crouch, W.C. Parks, T. Johnson, and M.D. Botney. Angiotensin converting enzyme expression in primary pulmonary hypertension. Am. J. Resp. Crit. Care Med. In Press.
28. Davis, E.C. 1993. Smooth muscle cell to elastic lamina connecitons in developing mouse aorta - role in aortic medial organization. Lab. Invest. 68: 89-99.
29. Botney, M.D., W.C. Parks, E.C. Crouch, K. Stenmark, and R.P. Mecham. 1992. TGF-β1 is decreased in remodeling hypertensive bovine pulmonary arteries. J. Clin. Invest. 89:1629-1635.
30. Botney, M.D., L. Bahadori, and L.I. Gold. 1994. Vascular remodeling in primary pulmonary hypertension: potential role for transforming growth factor-β. Am. J. Pathol. 144:286-295.
31. Tuder, R.M., B.E. Flook, and N.F. Voelkel. 1995. Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide. J. Clin. Invest. 95:1798-1807.
32. Giaid, A., M. Yanagisawa, and D. Langleben. 1993. Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. N. Engl. J. Med. 328:1732-1739.
33. Giaid, A., and D. Saleh. 1995. Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension. N. Engl. J. Med. 333:214-221.
34. Bruner, L.H., L.J. Carpenter, P. Hamlow, and R.A. Roth. 1986. Effect of a mixed function oxidase inducer and inhibitor on monocrotaline pyrrole pneumotoxicity. Toxicol. Appl. Pharmacol. 85:416-427.
35. Schoental, R., and M.A. Head. 1955. Pathological changes in rats as a result of treatment with monocrotaline. Br. J. Cancer 9:229-237.
36. Jones, R., W.M. Zapol, and L. Reid. 1985. Oxygen toxicity and restructuring of pulmonary arteries - a morphometric study. The response to 4 weeks' exposure to hyperoxia and return to breathing air. Am. J. Pathol. 121: 212-223.
37. Leung, D.Y.M., S. Glagov, and M.B. Mathews. 1977. A new in vitro system for studying cell response to mechanical stimulation. Exp. Cell Res. 109: 285-298.
38. Tozzi, C.A., G.J. Poiani, A.M. Harangozo, C.D. Boyd, and D.J. Riley. 1989. Pressure-induced connective tissue synthesis in pulmonary artery segments is dependent on intact endothelium. J. Clin. Invest. 84:1005-1012.
39. Kolpakov, V., M.D. Rekhter, D. Gordon, W.H. Wang, and T.J. Kulik. 1995. Effect of mechanical forces on growth and matrix protein synthesis in the in vitro pulmonary artery. Circ. Res. 77:823-831.
40. Ku, D.N., and C. Zhu. 1993. The mechanical environment of the artery. In Hemodynamic Forces and Vascular Cell Biology. B. Sumpio, editor. R.G. Landes, Austin, TX. 1-23.
41. Fingerle, J., Y.P.T. Au, A.W. Clowes, and M.A. Reidy. 1990. Intimal lesion formation in rat carotid arteries after endothelial denudation in absence of medial injury. Arteriosclerosis. 10:1082-1087.
42. Pietra, G.G., W.D. Edwards, J.M. Kay, S. Rich, J. Kernis, B. Schloo, S.M. Ayres, E.H. Bergofsky, B.H. Brundage, K.M. Detre et al. 1989. Histopathology of primary pulmonary hypertension: a qualitative and quantitative study of pulmonary blood vessels from 58 patients in the National Heart, Lung and Blood Institute, primary pulmonary hypertension registry. Circulation. 80: 1198-1206.