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Volumn 661, Issue , 2010, Pages 299-308

Rho kinase-mediated vasoconstriction in pulmonary hypertension

Author keywords

Chronic hypoxia; Monocrotaline; Pulmonary hypertension; Pulmonary vascular remodeling; Pulmonary vasoconstriction; Rho kinase; RhoA

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; BLEOMYCIN; BONE MORPHOGENETIC PROTEIN RECEPTOR 2; FASUDIL; G PROTEIN COUPLED RECEPTOR; INTEGRIN; MONOCROTALINE; MYOSIN ADENOSINE TRIPHOSPHATASE; NIFEDIPINE; NITRIC OXIDE; PROSTACYCLIN; PROTEIN TYROSINE KINASE; RHO KINASE; RHO KINASE INHIBITOR; ROSIGLITAZONE; SEMAXANIB; SEROTONIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

EID: 77951239891     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-60761-500-2_19     Document Type: Conference Paper
Times cited : (61)

References (60)
  • 2
    • 77953666423 scopus 로고    scopus 로고
    • The effects of vasodilators in pulmonary hypertension. Pulmonary vascular or peripheral vascular?
    • Rich S (2009) The effects of vasodilators in pulmonary hypertension. Pulmonary vascular or peripheral vascular? Circ Heart Fail 2:145-150
    • (2009) Circ Heart Fail , vol.2 , pp. 145-150
    • Rich, S.1
  • 4
    • 46749142123 scopus 로고    scopus 로고
    • Molecular pathogenesis of pulmonary arterial hypertension
    • DOI 10.1172/JCI33452
    • Rabinovitch M (2008) Molecular pathogenesis of pulmonary arterial hypertension. J Clin Invest 118:2372-2379 (Pubitemid 351949764)
    • (2008) Journal of Clinical Investigation , vol.118 , Issue.7 , pp. 2372-2379
    • Rabinovitch, M.1
  • 5
    • 53849089211 scopus 로고    scopus 로고
    • Therapeutic potential of RhoA/Rho kinase inhibitors in pulmonary hypertension
    • Oka M, Fagan KA, Jones PL, McMurtry IF (2008) Therapeutic potential of RhoA/Rho kinase inhibitors in pulmonary hypertension. Br J Pharmacol 155:444-454
    • (2008) Br J Pharmacol , vol.155 , pp. 444-454
    • Oka, M.1    Fagan, K.A.2    Jones, P.L.3    McMurtry, I.F.4
  • 6
    • 45549086738 scopus 로고    scopus 로고
    • Rho kinase-mediated vasoconstriction in rat models of pulmonary hypertension
    • Oka M, Homma N, McMurtry IF (2008) Rho kinase-mediated vasoconstriction in rat models of pulmonary hypertension. Methods Enzymol 439:191-204
    • (2008) Methods Enzymol , vol.439 , pp. 191-204
    • Oka, M.1    Homma, N.2    McMurtry, I.F.3
  • 7
    • 53449100875 scopus 로고    scopus 로고
    • Actin cytoskeletal dynamics in smooth muscle: A new paradigm for the regulation of smooth muscle contraction
    • Gunst SJ, Zhang W (2008) Actin cytoskeletal dynamics in smooth muscle: a new paradigm for the regulation of smooth muscle contraction. Am J Physiol Cell Physiol 295:C576-C587
    • (2008) Am J Physiol Cell Physiol , vol.295
    • Gunst, S.J.1    Zhang, W.2
  • 10
    • 0141751697 scopus 로고    scopus 로고
    • 2+ sensitivity of smooth muscle and nonmuscle myosin II: Modulated by G proteins, kinases, and myosin phosphatase
    • Somlyo AP, Somlyo AV (2003) Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev 83:1325-1358 (Pubitemid 37222274)
    • (2003) Physiological Reviews , vol.83 , Issue.4 , pp. 1325-1358
    • Somlyo, A.P.1    Somlyo, A.V.2
  • 11
    • 43949104415 scopus 로고    scopus 로고
    • Physiologic properties and regulation of the actin cytoskeleton in vascular smooth muscle
    • DOI 10.1177/1074248407313737
    • Tang DD, Anfinogenova Y (2008) Physiologic properties and regulation of the actin cytoskeleton in vascular smooth muscle. J Cardiovasc Pharmacol Ther 13:130-140 (Pubitemid 351704167)
    • (2008) Journal of Cardiovascular Pharmacology and Therapeutics , vol.13 , Issue.2 , pp. 130-140
    • Tang, D.D.1    Anfinogenova, Y.2
  • 13
    • 52649126946 scopus 로고    scopus 로고
    • Reactive oxygen species mediate RhoA/Rho kinase-induced Ca2+ sensitization in pulmonary vascular smooth muscle following chronic hypoxia
    • Jernigan NL, Walker BR, Resta TC (2008) Reactive oxygen species mediate RhoA/Rho kinase-induced Ca2+ sensitization in pulmonary vascular smooth muscle following chronic hypoxia. Am J Physiol Lung Cell Mol Physiol 295:L515-L529
    • (2008) Am J Physiol Lung Cell Mol Physiol , vol.295
    • Jernigan, N.L.1    Walker, B.R.2    Resta, T.C.3
  • 14
    • 33644837177 scopus 로고    scopus 로고
    • Mechanisms of endothelin-1-induced contraction in pulmonary arteries from chronically hypoxic rats
    • Weigand L, Sylvester JT, Shimoda LA (2006) Mechanisms of endothelin-1-induced contraction in pulmonary arteries from chronically hypoxic rats. Am J Physiol Lung Cell Mol Physiol 290:L284-L290
    • (2006) Am J Physiol Lung Cell Mol Physiol , vol.290
    • Weigand, L.1    Sylvester, J.T.2    Shimoda, L.A.3
  • 19
    • 0033822011 scopus 로고    scopus 로고
    • Inhibition of sustained hypoxic vasoconstriction by Y-27632 in isolated intrapulmonary arteries and perfused lung of the rat
    • Robertson TP, Dipp M, Ward JPT, Aaronson PI, Evans AM (2000) Inhibition of sustained hypoxic vasoconstriction by Y-27632 in isolated intrapulmonary arteries and perfused lung of the rat. Br J Pharmacol 131:5-9
    • (2000) Br J Pharmacol , vol.131 , pp. 5-9
    • Robertson, T.P.1    Dipp, M.2    Jpt, W.3    Aaronson, P.I.4    Evans, A.M.5
  • 20
    • 59249090538 scopus 로고    scopus 로고
    • Superoxide constricts rat pulmonary arteries via Rho-kinase-mediated Ca2+ sensitization
    • Knock GA, Snetkov VA, Shaifta Y et al (2009) Superoxide constricts rat pulmonary arteries via Rho-kinase-mediated Ca2+ sensitization. Free Radic Biol Med 46:633-642
    • (2009) Free Radic Biol Med , vol.46 , pp. 633-642
    • Knock, G.A.1    Snetkov, V.A.2    Shaifta, Y.3
  • 21
    • 37349071022 scopus 로고    scopus 로고
    • Endothelin-1 and serotonin are involved in activation of RhoA/Rho kinase signaling in the chronically hypoxic hypertensive rat pulmonary circulation
    • DOI 10.1097/FJC.0b013e3181593774, PII 0000534420071200000014
    • Homma N, Nagaoka T, Morio Y et al (2007) Endothelin-1 and serotonin are involved in activation of RhoA/Rho kinase signaling in the chronically hypoxic hypertensive rat pulmonary circulation. J Cardiovasc Pharmacol 50:697-702 (Pubitemid 350307041)
    • (2007) Journal of Cardiovascular Pharmacology , vol.50 , Issue.6 , pp. 697-702
    • Homma, N.1    Nagaoka, T.2    Morio, Y.3    Ota, H.4    Gebb, S.A.5    Karoor, V.6    McMurtry, I.F.7    Oka, M.8
  • 22
    • 34547619198 scopus 로고    scopus 로고
    • Vasoconstrictor effect of endothelin-1 on hypertensive pulmonary arterial smooth muscle involves Rho-kinase and protein kinase C
    • DOI 10.1152/ajplung.00101.2006
    • Barman SA (2007) Vasoconstrictor effect of endothelin-1 on hypertensive pulmonary arterial smooth muscle involves Rho-kinase and protein kinase C. Am J Physiol Lung Cell Mol Physiol 293:L472-L479 (Pubitemid 47205028)
    • (2007) American Journal of Physiology - Lung Cellular and Molecular Physiology , vol.293 , Issue.2
    • Barman, S.A.1
  • 23
    • 34547890621 scopus 로고    scopus 로고
    • Mechanisms of U46619- and 5-HT-induced contraction of bovine pulmonary arteries: Role of chloride ions
    • DOI 10.1038/sj.bjp.0707338, PII 0707338
    • Alapati VR, McKenzie C, Blair A, Kenny D, MacDonald A, Shaw AM (2007) Mechanisms of U46619- and 5-HT-induced contraction of bovine pulmonary arteries: role of chloride ions. Br J Pharmacol 151:1224-1234 (Pubitemid 47255905)
    • (2007) British Journal of Pharmacology , vol.151 , Issue.8 , pp. 1224-1234
    • Alapati, V.R.1    McKenzie, C.2    Blair, A.3    Kenny, D.4    MacDonald, A.5    Shaw, A.M.6
  • 24
    • 0035141402 scopus 로고    scopus 로고
    • Vasoconstrictor actions of isoprostanes via tyrosine kinase and Rho kinase in human and canine pulmonary vascular smooth muscles
    • Janssen LJ, Premji M, Netherton S, Coruzzi J, Lu-Chao H, Cox PG (2001) Vasoconstrictor actions of isoprostanes via tyrosine kinase and Rho kinase in human and canine pulmonary vascular smooth muscles. Br J Pharmacol 132:127-134 (Pubitemid 32128441)
    • (2001) British Journal of Pharmacology , vol.132 , Issue.1 , pp. 127-134
    • Janssen, L.J.1    Premji, M.2    Netherton, S.3    Coruzzi, J.4    Lu-Chao, H.5    Cox, P.G.6
  • 27
    • 42149175480 scopus 로고    scopus 로고
    • Heterogeneity in 5-HT-induced contractile and proliferative responses in rat pulmonary arterial bed
    • DOI 10.1159/000111071
    • Rodat-Despoix L, Crevel H, Marthan R, Savineau JP, Guibert C (2008) Heterogeneity in 5-HT-induced contractile and proliferative responses in rat pulmonary arterial bed. J Vasc Res 45:181-192 (Pubitemid 351543142)
    • (2008) Journal of Vascular Research , vol.45 , Issue.3 , pp. 181-192
    • Rodat-Despoix, L.1    Crevel, H.2    Marthan, R.3    Savineau, J.-P.4    Guibert, C.5
  • 31
    • 29544450461 scopus 로고    scopus 로고
    • 5,6-EET-induced contraction of intralobar pulmonary arteries depends on the activation of Rho-kinase
    • DOI 10.1152/japplphysiol.00473.2005
    • Losapio JL, Sprague RS, Lonigro AJ, Stephenson AH (2005) 5,6-EET-induced contraction of intralobar pulmonary arteries depends on the activation of Rho-kinase. J Appl Physiol 99:1391-1396 (Pubitemid 43014345)
    • (2005) Journal of Applied Physiology , vol.99 , Issue.4 , pp. 1391-1396
    • Losapio, J.L.1    Sprague, R.S.2    Lonigro, A.J.3    Stephenson, A.H.4
  • 33
  • 34
    • 22744455284 scopus 로고    scopus 로고
    • Inhibition of Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation
    • DOI 10.1161/01.RES.0000174287.17953.83
    • Hyvelin JM, Howell K, Nichol A, Costello CM, Preston RJ, McLoughlin P (2005) Inhibition of Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation. Circ Res 97:185-191 (Pubitemid 41033475)
    • (2005) Circulation Research , vol.97 , Issue.2 , pp. 185-191
    • Hyvelin, J.-M.1    Howell, K.2    Nichol, A.3    Costello, C.M.4    Preston, R.J.5    McLoughlin, P.6
  • 36
    • 22744457972 scopus 로고    scopus 로고
    • Vascular remodeling versus vasoconstriction in chronic hypoxic pulmonary hypertension: A time for reappraisal?
    • DOI 10.1161/01.RES.00000175934.68087.29
    • Stenmark KR, McMurtry IF (2005) Vascular remodeling versus vasoconstriction in chronic hypoxic pulmonary hypertension: a time for reappraisal? Circ Res 97:95-98 (Pubitemid 41033463)
    • (2005) Circulation Research , vol.97 , Issue.2 , pp. 95-98
    • Stenmark, K.R.1    McMurtry, I.F.2
  • 37
    • 0037440743 scopus 로고    scopus 로고
    • Chronic hypoxia causes angiogenesis in addition to remodelling in the adult rat pulmonary circulation
    • DOI 10.1113/jphysiol.2002.030676
    • Howell K, Preston RJ, McLoughlin P (2003) Chronic hypoxia causes angiogenesis in addition to remodelling in the adult rat pulmonary circulation. J Physiol 547:133-145 (Pubitemid 36285169)
    • (2003) Journal of Physiology , vol.547 , Issue.1 , pp. 133-145
    • Howell, K.1    Preston, R.J.2    McLoughlin, P.3
  • 38
    • 0031747165 scopus 로고    scopus 로고
    • Pulmonary artery remodeling differs in hypoxia- and monocrotaline-induced pulmonary hypertension
    • van Suylen RJ, Smits JF, Daemen MJ (1998) Pulmonary artery remodeling differs in hypoxia- and monocrotaline-induced pulmonary hypertension. Am J Respir Crit Care Med 157:1423-1428
    • (1998) Am J Respir Crit Care Med , vol.157 , pp. 1423-1428
    • Van Suylen, R.J.1    Smits, J.F.2    Daemen, M.J.3
  • 41
    • 0034925219 scopus 로고    scopus 로고
    • Chronic airway infection leads to angiogenesis in the pulmonary circulation
    • Hopkins N, Cadogan E, Giles S, McLoughlin P (2001) Chronic airway infection leads to angiogenesis in the pulmonary circulation. J Appl Physiol 91:919-928 (Pubitemid 32681128)
    • (2001) Journal of Applied Physiology , vol.91 , Issue.2 , pp. 919-928
    • Hopkins, N.1    Cadogan, E.2    Giles, S.3    McLoughlin, P.4
  • 43
    • 49049100968 scopus 로고    scopus 로고
    • Involvement of RhoA/Rho kinase signaling in protection against monocrotaline-induced pulmonary hypertension in pneumonectomized rats by dehydroepiandrosterone
    • Homma N, Nagaoka T, Karoor V et al (2008) Involvement of RhoA/Rho kinase signaling in protection against monocrotaline-induced pulmonary hypertension in pneumonectomized rats by dehydroepiandrosterone. Am J Physiol Lung Cell Mol Physiol 295:L71-L78
    • (2008) Am J Physiol Lung Cell Mol Physiol , vol.295
    • Homma, N.1    Nagaoka, T.2    Karoor, V.3
  • 46
    • 33847191058 scopus 로고    scopus 로고
    • Acute vasodilator effect of fasudil, a Rho-kinase inhibitor, in monocrotaline-induced pulmonary hypertension in rats
    • Jiang BH, Tawara S, Abe K, Takaki A, Fukumoto Y, Shimokawa H (2007) Acute vasodilator effect of fasudil, a Rho-kinase inhibitor, in monocrotaline-induced pulmonary hypertension in rats. J Cardiovasc Pharmacol 49:85-89
    • (2007) J Cardiovasc Pharmacol , vol.49 , pp. 85-89
    • Jiang, B.H.1    Tawara, S.2    Abe, K.3    Takaki, A.4    Fukumoto, Y.5    Shimokawa, H.6
  • 49
    • 33645751955 scopus 로고    scopus 로고
    • Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficient mice
    • Long L, MacLean MR, Jeffery TK et al (2006) Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficient mice. Circ Res 98:818-827
    • (2006) Circ Res , vol.98 , pp. 818-827
    • Long, L.1    MacLean, M.R.2    Jeffery, T.K.3
  • 51
    • 52449108680 scopus 로고    scopus 로고
    • Inflammation, endothelial injury, and persistent pulmonary hypertension in heterozygous BMPR2-mutant mice
    • Song Y, Coleman L, Shi J et al (2008) Inflammation, endothelial injury, and persistent pulmonary hypertension in heterozygous BMPR2-mutant mice. Am J Physiol Heart Circ Physiol 295:H677-H690
    • (2008) Am J Physiol Heart Circ Physiol , vol.295
    • Song, Y.1    Coleman, L.2    Shi, J.3
  • 52
    • 79959541600 scopus 로고    scopus 로고
    • Evidence for Rho-kinase activation in patients with pulmonary hypertension
    • Doe Z, Fukumoto Y, Takaki A et al (2008) Evidence for Rho-kinase activation in patients with pulmonary hypertension. Circulation 118:S-446
    • (2008) Circulation , vol.118
    • Doe, Z.1    Fukumoto, Y.2    Takaki, A.3
  • 53
    • 67449105737 scopus 로고    scopus 로고
    • Rhoa and Rho kinase activation in human pulmonary hypertension - Role of 5-HT signaling
    • Guilluy C, Eddahibi S, Agard C et al (2009) Rhoa and Rho kinase activation in human pulmonary hypertension - role of 5-HT signaling. Am J Respir Crit Care Med 179(12):1151-1158
    • (2009) Am J Respir Crit Care Med , vol.179 , Issue.12 , pp. 1151-1158
    • Guilluy, C.1    Eddahibi, S.2    Agard, C.3
  • 54
    • 34147175367 scopus 로고    scopus 로고
    • Pulmonary hypertension is associated with increased expression and activity of phosphodiesterase type 5a
    • Hemnes AR, Wigley F, Rodrigues FW, Girgis RE, Yang SC, Conte JV (2005) Pulmonary hypertension is associated with increased expression and activity of phosphodiesterase type 5a. Circulation 112:II-221-II-222
    • (2005) Circulation , vol.112
    • Hemnes, A.R.1    Wigley, F.2    Rodrigues, F.W.3    Girgis, R.E.4    Yang, S.C.5    Conte, J.V.6
  • 55
    • 66049144587 scopus 로고    scopus 로고
    • The non-canonical WNT-pathway is operative in idiopathic pulmonary arterial hypertension
    • Laumanns IP, Fink L, Wilhelm J et al (2009) The non-canonical WNT-pathway is operative in idiopathic pulmonary arterial hypertension. Am J Respir Cell Mol Biol 40(6):683-691
    • (2009) Am J Respir Cell Mol Biol , vol.40 , Issue.6 , pp. 683-691
    • Laumanns, I.P.1    Fink, L.2    Wilhelm, J.3
  • 57
    • 31644431508 scopus 로고    scopus 로고
    • Beneficial acute effects of Rho-kinase inhibitor in patients with pulmonary arterial hypertension
    • DOI 10.1253/circj.70.174
    • Ishikura K, Yamada N, Ito M et al (2006) Beneficial acute effects of Rho-kinase inhibitor in patients with pulmonary arterial hypertension. Circ J 70:174-178 (Pubitemid 43170128)
    • (2006) Circulation Journal , vol.70 , Issue.2 , pp. 174-178
    • Ishikura, K.1    Yamada, N.2    Ito, M.3    Ota, S.4    Nakamura, M.5    Isaka, N.6    Nakano, T.7
  • 58
    • 64249097973 scopus 로고    scopus 로고
    • Acute inhibition of Rho-kinase attenuates pulmonary hypertension in patients with congenital heart disease
    • Li F, Xia W, Yuan S, Sun R (2009) Acute inhibition of Rho-kinase attenuates pulmonary hypertension in patients with congenital heart disease. Pediatr Cardiol 30(3):363-366
    • (2009) Pediatr Cardiol , vol.30 , Issue.3 , pp. 363-366
    • Li, F.1    Xia, W.2    Yuan, S.3    Sun, R.4
  • 60
    • 17644405456 scopus 로고    scopus 로고
    • Effects of Rho kinase inhibition on cerebral artery myogenic tone and reactivity
    • DOI 10.1152/japplphysiol.01104.2004
    • Gokina NI, Park KM, McElroy-Yaggy K, Osol G (2005) Effects of Rho kinase inhibition on cerebral artery myogenic tone and reactivity. J Appl Physiol 98:1940-1948 (Pubitemid 40570810)
    • (2005) Journal of Applied Physiology , vol.98 , Issue.5 , pp. 1940-1948
    • Gokina, N.I.1    Park, K.M.2    McElroy-Yaggy, K.3    Osol, G.4


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