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Volumn 9, Issue 3, 2009, Pages 287-296

Mechanisms of hypoxic pulmonary vasoconstriction and their roles in pulmonary hypertension: new findings for an old problem

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; REACTIVE OXYGEN METABOLITE; RHO KINASE; RYANODINE; VOLTAGE GATED POTASSIUM CHANNEL;

EID: 66049112085     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coph.2009.02.006     Document Type: Review
Times cited : (127)

References (61)
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    • i and was abolished by ROCK but not PKC inhibition. The mechanism by which chronic hypoxia augments the stretch-induced activation of ROCK is unknown, but this myogenicity likely contributes to the sustained ROCK-dependent vasoconstriction in hypoxic PH.
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    • The non-canonical WNT-pathway is operative in idiopathic pulmonary arterial hypertension
    • This study found upregulation in IPAH PA of several mediators of the canonical and non-canonical, the planar cell polarity, WNT pathways, the latter of which included wingless member 11, disheveled associated activator of morphogenesis-1, disheveled, Rac1, RhoA and ROCK. Immunohistochemical staining confirmed the enhanced expression of the planar cell polarity pathway mediators in both large and small PA. Functional studies are required to identify the contributions of the canonical and non-canonical WNT pathways to the pathogenesis of IPAH. At least two other reports of increased RhoA/ROCK activity in human hypertensive PA are currently under review.
    • Laumanns I.P., Fink L., Wilhelm J., Wolff J.C., Mitnacht-Kraus R., Graef-Hoechst S., Stein M.M., Bohle R.M., Klepetko W., Hoda M.A.R., Schermuly R.T., et al. The non-canonical WNT-pathway is operative in idiopathic pulmonary arterial hypertension. Am J Respir Cell Mol Biol 40 (2009) 683-691. This study found upregulation in IPAH PA of several mediators of the canonical and non-canonical, the planar cell polarity, WNT pathways, the latter of which included wingless member 11, disheveled associated activator of morphogenesis-1, disheveled, Rac1, RhoA and ROCK. Immunohistochemical staining confirmed the enhanced expression of the planar cell polarity pathway mediators in both large and small PA. Functional studies are required to identify the contributions of the canonical and non-canonical WNT pathways to the pathogenesis of IPAH. At least two other reports of increased RhoA/ROCK activity in human hypertensive PA are currently under review.
    • (2009) Am J Respir Cell Mol Biol , vol.40 , pp. 683-691
    • Laumanns, I.P.1    Fink, L.2    Wilhelm, J.3    Wolff, J.C.4    Mitnacht-Kraus, R.5    Graef-Hoechst, S.6    Stein, M.M.7    Bohle, R.M.8    Klepetko, W.9    Hoda, M.A.R.10    Schermuly, R.T.11


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.