Simvastatin enhances bone morphogenetic protein receptor type II expression

Biochemical and Biophysical Research Communications

Volumn 339, Issue 1, 2006, Pages 59-64

  Hu, Hong ^a   Sung, Arthur ^a   Zhao, Guohua ^a   Shi, Lingfang ^a   Qiu, Daoming ^a   Nishimura, Toshihiko ^a   Kao, Peter N ^a  

^a STANFORD UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Mevalonate; Posttranscriptional RNA stabilization; Pulmonary hypertension; Statins; Transcription

Indexed keywords

BONE MORPHOGENETIC PROTEIN RECEPTOR; PROCOLLAGEN C PROTEINASE; SIMVASTATIN;

ARTICLE; CARDIOVASCULAR SYSTEM; CELL DIFFERENTIATION; CELL SURVIVAL; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE ACTIVATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LIGAND BINDING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PULMONARY ARTERY; RECEPTOR BINDING; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

BASE SEQUENCE; BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE II; CELL LINE; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MOLECULAR SEQUENCE DATA; MYOCYTES, SMOOTH MUSCLE; PROMOTER REGIONS (GENETICS); RNA PROCESSING, POST-TRANSCRIPTIONAL; SIMVASTATIN; UP-REGULATION;

EID: 28144440031     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.10.187     Document Type: Article

References (40)

1. M.R. Soma, E. Donetti, C. Parolini, G. Mazzini, C. Ferrari, R. Fumagalli, and R. Paoletti HMG CoA reductase inhibitors. In vivo effects on carotid intimal thickening in normocholesterolemic rabbits Arterioscler. Thromb. 13 1993 571 578
2. C. Bustos, M.A. Hernandez-Presa, M. Ortego, J. Tunon, L. Ortega, F. Perez, C. Diaz, G. Hernandez, and J. Egido HMG-CoA reductase inhibition by atorvastatin reduces neointimal inflammation in a rabbit model of atherosclerosis J. Am. Coll. Cardiol. 32 1998 2057 2064
3. J. Kreuzer, L. Watson, T. Herdegen, M. Loebe, P. Wende, and K. Kubler Effects of HMG-CoA reductase inhibition on PDGF- and angiotensin II-mediated signal transduction: suppression of c-Jun and c-Fos in human smooth muscle cells in vitro Eur. J. Med. Res. 4 1999 135 143
4. T. Nishimura, J.L. Faul, G.J. Berry, L.T. Vaszar, D. Qiu, R.G. Pearl, and P.N. Kao Simvastatin attenuates smooth muscle neointimal proliferation and pulmonary hypertension in rats Am. J. Respir. Crit. Care Med. 166 2002 1403 1408
5. U. Laufs, V.L. Fata, and J.K. Liao Inhibition of 3-hydroxy-3- methylglutaryl (HMG)-CoA reductase blocks hypoxia-mediated down-regulation of endothelial nitric oxide synthase J. Biol. Chem. 272 1997 31725 31729
6. A. Undas, K.E. Brummel, J. Musial, K.G. Mann, and A. Szczeklik Simvastatin depresses blood clotting by inhibiting activation of prothrombin, factor V, and factor XIII and by enhancing factor Va inactivation Circulation 103 2001 2248 2253
7. J. Llevadot, S. Murasawa, Y. Kureishi, S. Uchida, H. Masuda, A. Kawamoto, K. Walsh, J.M. Isner, and T. Asahara HMG-CoA reductase inhibitor mobilizes bone marrow-derived endothelial progenitor cells J. Clin. Invest. 108 2001 399 405
8. D.H. Walter, K. Rittig, F.H. Bahlmann, R. Kirchmair, M. Silver, T. Murayama, H. Nishimura, D.W. Losordo, T. Asahara, and J.M. Isner Statin therapy accelerates reendothelialization: a novel effect involving mobilization and incorporation of bone marrow-derived endothelial progenitor cells Circulation 105 2002 3017 3024
9. C. Urbich, and S. Dimmeler Endothelial progenitor cells: characterization and role in vascular biology Circ. Res. 95 2004 343 353
10. T. Nishimura, L.T. Vaszar, J.L. Faul, G. Zhao, G.J. Berry, L. Shi, D. Qiu, G. Benson, R.G. Pearl, and P.N. Kao Simvastatin rescues rats from fatal pulmonary hypertension by inducing apoptosis of neointimal smooth muscle cells Circulation 108 2003 1640 1645
11. W. Dichtl, J. Dulak, M. Frick, H.F. Alber, S.P. Schwarzacher, M.P. Ares, J. Nilsson, O. Pachinger, and F. Weidinger HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells Arterioscler. Thromb. Vasc. Biol. 23 2003 58 63
12. Y. Kureishi, Z. Luo, I. Shiojima, A. Bialik, D. Fulton, D.J. Lefer, W.C. Sessa, and K. Walsh The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals Nat. Med. 6 2000 1004 1010
13. M. Weis, C. Heeschen, A.J. Glassford, and J.P. Cooke Statins have biphasic effects on angiogenesis Circulation 105 2002 739 745
14. J. Pammer, C. Reinisch, C. Kaun, E. Tschachler, and J. Wojta Inhibitors of differentiation/DNA binding proteins Id1 and Id3 are regulated by statins in endothelial cells Endothelium 11 2004 175 180
15. U. Laufs, and J.K. Liao Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase J. Biol. Chem. 273 1998 24266 24271
16. G. Mundy, R. Garrett, S. Harris, J. Chan, D. Chen, G. Rossini, B. Boyce, M. Zhao, and G. Gutierrez Stimulation of bone formation in vitro and in rodents by statins Science 286 1999 1946 1949
17. M. Sugiyama, T. Kodama, K. Konishi, K. Abe, S. Asami, and S. Oikawa Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells Biochem. Biophys. Res. Commun. 271 2000 688 692
18. T. Maeda, T. Kawane, and N. Horiuchi Statins augment vascular endothelial growth factor expression in osteoblastic cells via inhibition of protein prenylation Endocrinology 144 2003 681 692
19. F. Liu, F. Ventura, J. Doody, and J. Massague Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs Mol. Cell. Biol. 15 1995 3479 3486
20. H. Beppu, M. Kawabata, T. Hamamoto, A. Chytil, O. Minowa, T. Noda, and K. Miyazono BMP type II receptor is required for gastrulation and early development of mouse embryos Dev. Biol. 221 2000 249 258
21. K. Miyazono, K. Kusanagi, and H. Inoue Divergence and convergence of TGF-beta/BMP signaling J. Cell Physiol. 187 2001 265 276
22. P. ten Dijke, O. Korchynskyi, G. Valdimarsdottir, and M.J. Goumans Controlling cell fate by bone morphogenetic protein receptors Mol. Cell. Endocrinol. 211 2003 105 113
23. M. Kretzschmar, F. Liu, A. Hata, J. Doody, and J. Massague The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase Genes Dev. 11 1997 984 995
24. A. Nohe, S. Hassel, M. Ehrlich, F. Neubauer, W. Sebald, Y.I. Henis, and P. Knaus The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways J. Biol. Chem. 277 2002 5330 5338
25. Z. Deng, J.H. Morse, S.L. Slager, N. Cuervo, K.J. Moore, G. Venetos, S. Kalachikov, E. Cayanis, S.G. Fischer, R.J. Barst, S.E. Hodge, and J.A. Knowles Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene Am. J. Hum. Genet. 67 2000 737 744
26. K.B. Lane, R.D. Machado, M.W. Pauciulo, J.R. Thomson, J.A. Phillips 3rd, J.E. Loyd, W.C. Nichols, and R.C. Trembath Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension. The International PPH Consortium Nat. Genet. 26 2000 81 84
27. C. Atkinson, S. Stewart, P.D. Upton, R. Machado, J.R. Thomson, R.C. Trembath, and N.W. Morrell Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor Circulation 105 2002 1672 1678
28. C.J. Favre, M. Mancuso, K. Maas, J.W. McLean, P. Baluk, and D.M. McDonald Expression of genes involved in vascular development and angiogenesis in endothelial cells of adult lung Am. J. Physiol. Heart Circ. Physiol. 285 2003 H1917 H1938
29. E.C. Delot, M.E. Bahamonde, M. Zhao, and K.M. Lyons BMP signaling is required for septation of the outflow tract of the mammalian heart Development 130 2003 209 220
30. P.N. Kao Simvastatin treatment of pulmonary hypertension: an observational case series Chest 127 2005 1446 1452
31. P.N. Kao, and J.L. Faul Emerging therapies for pulmonary hypertension: striving for efficacy and safety J. Am. Coll. Cardiol. 41 2003 2126 2129
32. G. Valdimarsdottir, M.J. Goumans, A. Rosendahl, M. Brugman, S. Itoh, F. Lebrin, P. Sideras, and P. ten Dijke Stimulation of Id1 expression by bone morphogenetic protein is sufficient and necessary for bone morphogenetic protein-induced activation of endothelial cells Circulation 106 2002 2263 2270
33. A.W. Alberts Lovastatin and simvastatin-inhibitors of HMG CoA reductase and cholesterol biosynthesis Cardiology 77 Suppl. 4 1990 14 21
34. L. Shi, G. Zhao, D. Qiu, W.R. Godfrey, H. Vogel, T.A. Rando, H. Hu, and P.N. Kao NF90 regulates cell cycle exit and terminal myogenic differentiation by direct binding to the 3′-untranslated region of MyoD and p21WAF1/CIP1 mRNAs J. Biol. Chem. 2005
35. P.J. Wilder, C.T. Bernadt, J.H. Kim, and A. Rizzino Stimulation of the murine type II transforming growth factor-beta receptor promoter by the transcription factor Egr-1 Mol. Reprod. Dev. 63 2002 282 290
36. J.D. Molkentin, and E.N. Olson Combinatorial control of muscle development by basic helix-loop-helix and MADS-box transcription factors Proc. Natl. Acad. Sci. USA 93 1996 9366 9373
37. F. Gonzalez-Fernandez, A. Jimenez, A. Lopez-Blaya, S. Velasco, M.M. Arriero, A. Celdran, L. Rico, J. Farre, S. Casado, and A. Lopez-Farre Cerivastatin prevents tumor necrosis factor-alpha-induced downregulation of endothelial nitric oxide synthase: role of endothelial cytosolic proteins Atherosclerosis 155 2001 61 70
38. G.B. Robb, A.R. Carson, S.C. Tai, J.E. Fish, S. Singh, T. Yamada, S.W. Scherer, K. Nakabayashi, and P.A. Marsden Post-transcriptional regulation of endothelial nitric-oxide synthase by an overlapping antisense mRNA transcript J. Biol. Chem. 279 2004 37982 37996
39. B. Lehner, G. Williams, R.D. Campbell, and C.M. Sanderson Antisense transcripts in the human genome Trends Genet. 18 2002 63 65
40. T. Nishimura, J.L. Faul, G.J. Berry, P.N. Kao, and R.G. Pearl Effect of a surgical aortocaval fistula on monocrotaline-induced pulmonary hypertension Crit. Care Med. 31 2003 1213 1218