Pulmonary hemodynamics modify the rat pulmonary artery response to injury: A neointimal model of pulmonary hypertension

American Journal of Pathology

Volumn 151, Issue 4, 1997, Pages 1019-1025

  Okada, Kazushige ^a   Tanaka, Yoshihiro ^a   Bernstein, Matthew ^a   Zhang, Wei ^a   Patterson, G Alexander ^a   Botney, Mitchell D ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BARNES JEWISH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCROTALINE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTERY INTIMA PROLIFERATION; ARTICLE; CONTROLLED STUDY; HISTOPATHOLOGY; LUNG HEMODYNAMICS; LUNG RESECTION; MALE; NONHUMAN; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RAT; SEQUENCE ANALYSIS; VASCULAR DISEASE;

ACTINS; ANIMALS; DISEASE MODELS, ANIMAL; HEMODYNAMIC PROCESSES; HYPERPLASIA; HYPERTENSION, PULMONARY; HYPERTROPHY, RIGHT VENTRICULAR; IMMUNOHISTOCHEMISTRY; LUNG; MALE; MONOCROTALINE; PNEUMONECTOMY; PULMONARY ARTERY; PULMONARY CIRCULATION; RATS; RATS, SPRAGUE-DAWLEY; SPECIFIC PATHOGEN-FREE ORGANISMS; TUNICA INTIMA;

EID: 0030828893     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Wagenvoort CA, Wagenvoort N: Primary pulmonary hypertension: a pathologic study of the lung vessels in 156 clinically diagnosed cases. Circulation 1970, 42:1163-1184
2. Bjornsson J, Edwards WD: Primary pulmonary hypertension: a histopathologic study of 80 cases. Mayo Clin Proc 1985, 60:16-25
3. Pietra GG, Edwards WD, Kay JM, Rich S, Kernis J, Schloo B, Ayres SM, Bergofsky EH, Brundage BH, Detre KM, Fishman AP, Goldring RM, Groves BM, Levy PS, Reid LM, Vreim CE, Williams GW: Histopathology of primary pulmonary hypertension: a qualitative and quantitative study of pulmonary blood vessels from 58 patients in the National Heart, Lung and Blood Institute, primary pulmonary hypertension registry. Circulation 1989, 80:1198-1206
4. Botney MD, Kaiser LR, Cooper JD, Mecham RP, Roby J, Parks WC: Extracellular matrix protein gene expression in atherosclerotic pulmonary arteries. Am J Pathol 1992, 140:357-364
5. Botney MD, Liptay MJ, Kaiser LR, Cooper JD, Parks WC, Mecham RP: Active collagen synthesis by pulmonary arteries in human primary pulmonary hypertension. Am J Pathol 1993, 143:121-129
6. Poiani GJ, Tozzi CA, Yohn SE, Pierce RA, Belsky SA, Berg RA, Yu SY, Deak SB, Riley DJ: Collagen and elastin metabolism in hypertensive pulmonary arteries of rats. Circ Res 1990. 66:968-978
7. Stenmark KR, Fasules J, Hyde DM, Voelkel NF, Henson J, Tucker A, Wilson H, Reeves JT: Severe pulmonary hypertension and arterial adventitial changes in newborn calves at 4,300 m. Am J Physiol 1987, 62:821-830
8. Prosser IW, Stenmark KR, Suthar M, Crouch EC, Mecham RP, Parks RP: Regional heterogeneity of elastin and collagen gene expression in intralobar arteries in response to hypoxic pulmonary hypertension as demonstrated by in situ hybridization. Am J Pathol 1989, 135:1073-1087
9. Perkett EA, Brigham KL, Meyrick B: Continuous air embolization into sheep causes sustained pulmonary hypertension and increased pulmonary vasoreactivity. Am J Pathol 1988, 132:444-54
10. Todorovich-Hunter L, Johnson DJ, Ranger P, Keeley FW, Rabinovitch M: Altered elastin and collagen synthesis associated with progressive pulmonary hypertension induced by monocrotaline: a biochemical and ultrastructural study. Lab Invest 1988, 58:184-195
11. Hayashi Y, Lalich JJ: Production of cor pulmonale in rats by single injection of monocrotaline. Am J Pathol 1967, 48:35
12. Hayashi Y, Hussa JF, Lalich JJ: Cor pulmonale in rats. Lab Invest 1967, 16:875-881
13. Stenmark KR, Morganroth ML, Remigio LK, Voelkel NF, Murphy RC, Henson PM, Mathias MM, Reeves JT: Alveolar inflammation and arachidonate metabolism in monocrotaline-induced pulmonary hypertension. Am J Physiol 1985, 248:H859-H866
14. Wilson DW, Segall HJ, Pan LCW, Dunston SK: Progressive inflammatory and structural changes in the pulmonary vasculature of monocrotaline-treated rats. Microvasc Res 1989, 38:57-80
15. Kameji K, Otsuka H, Hayashi Y: Increase of collagen synthesis in pulmonary arteries of monocrotaline-treated rats. Experientia 1980, 36:441-442
16. Tanaka Y, Bernstein ML, Mecham RP, Patterson GA, Cooper JD, Botney MD: Site-specific responses to monocrotaline-induced vascular injury: evidence for two distinct mechanisms of remodeling. Am J Respir Cell Mol Biol 1996, 15:390-397
17. Tanaka Y, Schuster DP, Davis EC, Patterson GA, Botney MD: The role of vascular injury and hemodynamics in pulmonary artery remodeling. J Clin Invest 1996, 98:434-442
18. Schoental R, Head MA: Pathological changes in rats as a result of treatment with monocrotaline. Br J Cancer 1955, 9:229-237
19. Sugita T, Stenmark KR, Wagner JWW, Henson PM, Henson JE, Hyers TM, Reeves JT: Abnormal alveolar cells in monocrotaline induced pulmonary hypertension. Exp Lung Res 1983, 5:201-215
20. Mizuta T, Kawaguchi A, Nakahara K, Kawashima Y: Simplified rat lung transplantation using a cuff technique. J Thorac Cardiovasc Surg 1989, 97:578-581
21. Holmes C, Thurlbeck WM: Normal lung growth and response after penumonectomy in rats at various ages. Am Rev Respir Dis 1979, 120:1125-1136
22. Rannels DE, White DM, Watkins CA: Rapidity of compensatory lung growth following pneumonectomy in adult rats. J Appl Physiol 1979, 46:326-333
23. Koh DW, Roby JD, Starcher B, Senior RM, Pierce RA: Postpneumonectomy lung growth: a model of reinitiation of tropoelastin and type I collagen production in a normal pattern in adult rat lung. Am J Respir Cell Mol Biol 1996, 15:611-623
24. Heath D, Wood EH, DuShane JW, Edwards JE: The relation of age and blood pressure to atheroma in the pulmonary arteries and thoracic aorta in congenital heart disease. Lab Invest 1960, 9:259-272
25. Wissler RW, Vesselinovitch D: Atherogenesis in the pulmonary artery. The Pulmonary Circulation: Normal and Abnormal. Edited by AP Fishman. Philadelphia, University of Pennsylvania Press, 1990, pp 245-255
26. Botney MD, Parks WC, Crouch EC, Stenmark K, Mecham RP: TGF-β1 is decreased in remodeling hypertensive bovine pulmonary arteries. J Clin Invest 1992, 89:1629-1635
27. Botney MD, Bahadori L, Gold LI: Vascular remodeling in primary pulmonary hypertension: potential role for transforming growth factor-β. Am J Pathol 1994, 144:286-295
28. Bahadori L, Milder J, Gold LI, Botney MD: Active macrophage-associated TGF-β colocalizes with type I procollagen gene expression in atherosclerotic human hypertensive pulmonary arteries. Am J Pathol 1995, 146:1140-1149
29. Schuster DP, Crouch EC, Parks WC, Johnson T, Botney MD: Angiotensin converting enzyme expression in primary pulmonary hypertension. Am J Respir Crit Care Med 1996, 154:1087-1091
30. Tuder RM, Flook BE, Voelkel NF: Increased gene expression for VEGF and the VEGF receptors KDR/FIk and FIt in lungs exposed to acute or to chronic hypoxia: modulation of gene expression by nitric oxide. J Clin Invest 1995, 95:1798-1807
31. Giaid A, Yanagisawa M, Langleben D: Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. N Engl J Med 1993, 328:1732-1739
32. Giaid A, Saleh D: Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension. N Engl J Med 1995, 333:214-221
33. Ross R: Atherosclerosis: a defense mechanism gone awry. Am J Pathol 1993, 143:987-1002
34. Gibbons GH, Dzau VJ: The emerging concept of vascular remodeling. N Engl J Med 1994, 330:1431-1438
35. Glagov S, Ozoa AK: Significance of the relatively low incidence of atherosclerosis in the pulmonary, renal, and mesenteric arteries. Ann NY Acad Sci 1968, 149:940-955
36. Ku DN, Zhu C: The mechanical environment of the artery. Hemodynamic Forces and Vascular Cell Biology. Edited by B Sumpio. Austin, TX, RG Landes, 1993, pp 1-23
37. Shen, J, Luscinskas FW, Connolly A, Dewey CJ, Gimbrone MJ: Fluid shear stress modulates cytosolic free calcium in vascular endothelial cells. Am J Physiol 1992, 262:C384-C390
38. Tseng H, Peterson TE, Berk BC: Fluid shear stress stimulates mitogen-activated protein kinase in endothelial cells. Circ Res 1995, 77:869-878
39. Ranjan V, Diamond SL: Fluid shear stress induces synthesis and nuclear localization of c-fos in cultured human endothelial cells. Biochem Biophys Res Commun 1993, 196:79-84
40. Takahashi M, Berk BC: Mitogen-activated protein kinase (ERK 1/2) activation by shear stress and adhesion in endothelial cells: essential role for a herbimycin-sensitive kinase. J Clin Invest 1996, 98:2623-2631
41. Lan Q, Mercurius KO, Davies PF: Stimulation of transcription factors NF kappa B and AP1 in endothelial cells subjected to shear stress. Biochem Biophys Res Commun 1994, 201:950-956
42. Resnick N, Collins T, Atkinson W, Bonthron DT, Dewey JCF, Gimbrone MA: Platelet-derived growth factor B chain promoter contains a cis-acting fluid shear-stress-responsive element. Proc Natl Acad Sci USA 1993, 90:7908-7912
43. Ohno M, Cooke JP, Dzau VJ, Gibbons GH: Fluid shear stress induces endothelial transforming growth factor β-1 transcription and production: modulation by potassium channel blockade. J Clin Invest 1995, 95:1363-1369
44. Malek A, Izumo S: Physiological fluid shear stress causes downregulation of endothelin-1 mRNA in bovine aortic endothelium. Am J Physiol 1992, 263:C389-C396
45. Uematsu M, Ohara Y, Navas JP, Nishida N, Murphy TJ, Alexander RW, Nerem RM, Harrison DG: Regulation of endothelial cell nitric oxide synthase mRNA expression by shear stress. Am J Physiol 1995, 269:C1371-C1378
46. Rudolph AM, Neuhauser EBD, Golinko RJ, Auld PAM: Effects of pneumonectomy on pulmonary circulation in adult and young animals. Circ Res 1961, 9:856-861
47. Davies P, McBride J, Murray GF, Wilcox BR, Shallal JA, Reid L: Structural changes in the canine lung and pulmonary arteries after pneumonectomy. J Appl Physiol 1982, 53:859-864
48. Cournand A, Riley RL, Himmelstein A, Austrian R: Pulmonary circulation and alveolar ventilation-perfusion relationships after pneumonectomy. J Thorac Surg 1950, 19:80-116
49. Burrows B, Harrison RW, Adams WE, Humphreys EM, Long ET, Reiman AF: The postpneumonectomy state: clinical and physiologic observations in thirty-six cases. Am J Med 1960, 28:281-297
50. Besterman E: Atrial septal defect with pulmonary hypertension. Br Heart J 1961, 23:587-598
51. John-Sutton M, Tajik A, McGoon D: Atrial septal defect in patients ages 60 years or older: operative results and long-term postoperative follow-up. Circulation 1981, 64:402-409
52. Liptay MJ, Parks WC, Mecham RP, Roby J, Kaiser LR, Cooper JD, Botney MD: Neointimal macrophages co-localize with extracellular matrix gene expression in human atherosclerotic pulmonary arteries. J Clin Invest 1993, 91:588-594