메뉴 건너뛰기




Volumn 109, Issue 3, 2012, Pages 67-75

Animal models of pulmonary hypertension: Rho kinase inhibition

Author keywords

Pulmonary hypertension; RhoA Rho kinase

Indexed keywords

PROTEIN KINASE INHIBITOR; RHO KINASE;

EID: 84864566286     PISSN: 00796107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbiomolbio.2012.05.009     Document Type: Review
Times cited : (18)

References (100)
  • 1
    • 10744222390 scopus 로고    scopus 로고
    • Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats
    • Abe K., Shimokawa H., Morikawa K., et al. Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats. Circ. Res. 2004, 94:385-393.
    • (2004) Circ. Res. , vol.94 , pp. 385-393
    • Abe, K.1    Shimokawa, H.2    Morikawa, K.3
  • 2
    • 33846110312 scopus 로고    scopus 로고
    • Long-term inhibition of Rho-kinase ameliorates hypoxia-induced pulmonary hypertension in mice
    • Abe K., Tawara S., Oi K., et al. Long-term inhibition of Rho-kinase ameliorates hypoxia-induced pulmonary hypertension in mice. J. Cardiovasc. Pharmacol. 2006, 48:280-285.
    • (2006) J. Cardiovasc. Pharmacol. , vol.48 , pp. 280-285
    • Abe, K.1    Tawara, S.2    Oi, K.3
  • 3
    • 9444287592 scopus 로고    scopus 로고
    • Appetite-suppressant drugs and the risk of primary pulmonary hypertension. International primary pulmonary hypertension study Group
    • Abenhaim L., Moride Y., Brenot F., et al. Appetite-suppressant drugs and the risk of primary pulmonary hypertension. International primary pulmonary hypertension study Group. N. Engl. J. Med. 1996, 335:609-616.
    • (1996) N. Engl. J. Med. , vol.335 , pp. 609-616
    • Abenhaim, L.1    Moride, Y.2    Brenot, F.3
  • 4
    • 0025963441 scopus 로고
    • Loss of endothelium-dependent relaxant activity in the pulmonary circulation of rats exposed to chronic hypoxia
    • Adnot S., Raffestin B., Eddahibi S., Braquet P., Chabrier P.E. Loss of endothelium-dependent relaxant activity in the pulmonary circulation of rats exposed to chronic hypoxia. J. Clin. Invest. 1991, 87:155-162.
    • (1991) J. Clin. Invest. , vol.87 , pp. 155-162
    • Adnot, S.1    Raffestin, B.2    Eddahibi, S.3    Braquet, P.4    Chabrier, P.E.5
  • 5
    • 0027049145 scopus 로고
    • The control of protein phosphatase-1 by targetting subunits. The major myosin phosphatase in avian smooth muscle is a novel form of protein phosphatase-1
    • Alessi D., MacDougall L.K., Sola M.M., Ikebe M., Cohen P. The control of protein phosphatase-1 by targetting subunits. The major myosin phosphatase in avian smooth muscle is a novel form of protein phosphatase-1. Eur. J. Biochem. 1992, 210:1023-1035.
    • (1992) Eur. J. Biochem. , vol.210 , pp. 1023-1035
    • Alessi, D.1    MacDougall, L.K.2    Sola, M.M.3    Ikebe, M.4    Cohen, P.5
  • 6
    • 2642579001 scopus 로고    scopus 로고
    • RhoA activation by hypoxia in pulmonary arterial smooth muscle cells is age and site specific
    • Bailly K., Ridley A.J., Hall S.M., Haworth S.G. RhoA activation by hypoxia in pulmonary arterial smooth muscle cells is age and site specific. Circ. Res. 2004, 94:1383-1391.
    • (2004) Circ. Res. , vol.94 , pp. 1383-1391
    • Bailly, K.1    Ridley, A.J.2    Hall, S.M.3    Haworth, S.G.4
  • 7
    • 34547619198 scopus 로고    scopus 로고
    • Vasoconstrictor effect of endothelin-1 on hypertensive pulmonary arterial smooth muscle involves Rho-kinase and protein kinase C
    • Barman S.A. Vasoconstrictor effect of endothelin-1 on hypertensive pulmonary arterial smooth muscle involves Rho-kinase and protein kinase C. Am. J. Physiol. Lung Cell Mol. Physiol. 2007, 293:L472-L479.
    • (2007) Am. J. Physiol. Lung Cell Mol. Physiol. , vol.293
    • Barman, S.A.1
  • 9
    • 72449124776 scopus 로고    scopus 로고
    • Chronic pulmonary artery pressure elevation is insufficient to explain right heart failure
    • Bogaard H.J., Natarajan R., Henderson S.C., et al. Chronic pulmonary artery pressure elevation is insufficient to explain right heart failure. Circulation 2009, 120:1951-1960.
    • (2009) Circulation , vol.120 , pp. 1951-1960
    • Bogaard, H.J.1    Natarajan, R.2    Henderson, S.C.3
  • 10
    • 0020664110 scopus 로고
    • Effect of chronic hypoxia on angiotensin-induced pulmonary vasoconstriction and converting enzyme activity in the rat
    • Caldwell R.W., Blatteis C.M. Effect of chronic hypoxia on angiotensin-induced pulmonary vasoconstriction and converting enzyme activity in the rat. Proc. Soc. Exp. Biol. Med. 1983, 172:346-350.
    • (1983) Proc. Soc. Exp. Biol. Med. , vol.172 , pp. 346-350
    • Caldwell, R.W.1    Blatteis, C.M.2
  • 11
    • 77953786515 scopus 로고    scopus 로고
    • Analysis of responses to the Rho-kinase inhibitor Y-27632 in the pulmonary and systemic vascular bed of the rat
    • Casey D.B., Badejo A.M., Dhaliwal J.S., et al. Analysis of responses to the Rho-kinase inhibitor Y-27632 in the pulmonary and systemic vascular bed of the rat. Am. J. Physiol. Heart Circ. Physiol. 2010, 299:H184-H192.
    • (2010) Am. J. Physiol. Heart Circ. Physiol. , vol.299
    • Casey, D.B.1    Badejo, A.M.2    Dhaliwal, J.S.3
  • 12
    • 57049169732 scopus 로고    scopus 로고
    • Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, suppresses 5-hydroxytryptamine-induced pulmonary artery smooth muscle cell proliferation via JNK and ERK1/2 pathway
    • Chen X.Y., Dun J.N., Miao Q.F., Zhang Y.J. Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, suppresses 5-hydroxytryptamine-induced pulmonary artery smooth muscle cell proliferation via JNK and ERK1/2 pathway. Pharmacology 2009, 83:67-79.
    • (2009) Pharmacology , vol.83 , pp. 67-79
    • Chen, X.Y.1    Dun, J.N.2    Miao, Q.F.3    Zhang, Y.J.4
  • 13
    • 78349304473 scopus 로고    scopus 로고
    • KMUP-1 inhibits pulmonary artery proliferation by targeting serotonin receptors/transporter and NO synthase, inactivating RhoA and suppressing AKT/ERK phosphorylation
    • Chung H.H., Dai Z.K., Wu B.N., et al. KMUP-1 inhibits pulmonary artery proliferation by targeting serotonin receptors/transporter and NO synthase, inactivating RhoA and suppressing AKT/ERK phosphorylation. Vascul. Pharmacol. 2010, 53:239-249.
    • (2010) Vascul. Pharmacol. , vol.53 , pp. 239-249
    • Chung, H.H.1    Dai, Z.K.2    Wu, B.N.3
  • 14
    • 77952836879 scopus 로고    scopus 로고
    • The xanthine derivative KMUP-1 inhibits models of pulmonary artery hypertension via increased NO and cGMP-dependent inhibition of RhoA/Rho kinase
    • Chung H.H., Dai Z.K., Wu B.N., et al. The xanthine derivative KMUP-1 inhibits models of pulmonary artery hypertension via increased NO and cGMP-dependent inhibition of RhoA/Rho kinase. Br. J. Pharmacol. 2010, 160:971-986.
    • (2010) Br. J. Pharmacol. , vol.160 , pp. 971-986
    • Chung, H.H.1    Dai, Z.K.2    Wu, B.N.3
  • 17
    • 67649863502 scopus 로고    scopus 로고
    • Analysis of pulmonary vasodilator responses to SB-772077-B [4-(7-((3-amino-1-pyrrolidinyl)carbonyl)-1-ethyl-1H-imidazo(4,5-c)pyridin-2-yl)-1,2,5-oxadiazol-3-amine], a novel aminofurazan-based Rho kinase inhibitor
    • Dhaliwal J.S., Badejo A.M., Casey D.B., Murthy S.N., Kadowitz P.J. Analysis of pulmonary vasodilator responses to SB-772077-B [4-(7-((3-amino-1-pyrrolidinyl)carbonyl)-1-ethyl-1H-imidazo(4,5-c)pyridin-2-yl)-1,2,5-oxadiazol-3-amine], a novel aminofurazan-based Rho kinase inhibitor. J. Pharmacol. Exp. Ther. 2009, 330:334-341.
    • (2009) J. Pharmacol. Exp. Ther. , vol.330 , pp. 334-341
    • Dhaliwal, J.S.1    Badejo, A.M.2    Casey, D.B.3    Murthy, S.N.4    Kadowitz, P.J.5
  • 18
    • 0017851438 scopus 로고
    • Persistent pulmonary hypertension in the neonate: development of an animal model
    • Drummond W.H., Bissonnette J.M. Persistent pulmonary hypertension in the neonate: development of an animal model. Am. J. Obstet. Gynecol. 1978, 131:761-763.
    • (1978) Am. J. Obstet. Gynecol. , vol.131 , pp. 761-763
    • Drummond, W.H.1    Bissonnette, J.M.2
  • 19
    • 0026338522 scopus 로고
    • Pulmonary vascular reactivity to endothelin-1 in normal and chronically pulmonary hypertensive rats
    • Eddahibi S., Raffestin B., Braquet P., Chabrier P.E., Adnot S. Pulmonary vascular reactivity to endothelin-1 in normal and chronically pulmonary hypertensive rats. J. Cardiovasc. Pharmacol. 1991, 17(Suppl. 7):S358-S361.
    • (1991) J. Cardiovasc. Pharmacol. , vol.17 , Issue.SUPPL. 7
    • Eddahibi, S.1    Raffestin, B.2    Braquet, P.3    Chabrier, P.E.4    Adnot, S.5
  • 20
    • 0032896721 scopus 로고    scopus 로고
    • The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia
    • Fagan K.A., Fouty B.W., Tyler R.C., et al. The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia. J. Clin. Invest. 1999, 103:291-299.
    • (1999) J. Clin. Invest. , vol.103 , pp. 291-299
    • Fagan, K.A.1    Fouty, B.W.2    Tyler, R.C.3
  • 21
    • 4544388803 scopus 로고    scopus 로고
    • Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rho-kinase
    • Fagan K.A., Oka M., Bauer N.R., et al. Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rho-kinase. Am. J. Physiol. Lung Cell Mol. Physiol. 2004, 287:L656-L664.
    • (2004) Am. J. Physiol. Lung Cell Mol. Physiol. , vol.287
    • Fagan, K.A.1    Oka, M.2    Bauer, N.R.3
  • 22
    • 80051557093 scopus 로고    scopus 로고
    • Pulmonary hypertension and idiopathic pulmonary fibrosis: a tale of angiogenesis, apoptosis, and growth factors
    • Farkas L., Gauldie J., Voelkel N.F., Kolb M. Pulmonary hypertension and idiopathic pulmonary fibrosis: a tale of angiogenesis, apoptosis, and growth factors. Am. J. Respir. Cell Mol. Biol. 2011, 45:1-15.
    • (2011) Am. J. Respir. Cell Mol. Biol. , vol.45 , pp. 1-15
    • Farkas, L.1    Gauldie, J.2    Voelkel, N.F.3    Kolb, M.4
  • 23
    • 0032573607 scopus 로고    scopus 로고
    • The effects of the Rho-kinase inhibitor Y-27632 on arachidonic acid-, GTPgammaS-, and phorbol ester-induced Ca2+-sensitization of smooth muscle
    • Fu X., Gong M.C., Jia T., Somlyo A.V., Somlyo A.P. The effects of the Rho-kinase inhibitor Y-27632 on arachidonic acid-, GTPgammaS-, and phorbol ester-induced Ca2+-sensitization of smooth muscle. FEBS Lett. 1998, 440:183-187.
    • (1998) FEBS Lett. , vol.440 , pp. 183-187
    • Fu, X.1    Gong, M.C.2    Jia, T.3    Somlyo, A.V.4    Somlyo, A.P.5
  • 24
    • 77950921360 scopus 로고    scopus 로고
    • Acute vasodilator effects of inhaled fasudil, a specific Rho-kinase inhibitor, in patients with pulmonary arterial hypertension
    • Fujita H., Fukumoto Y., Saji K., et al. Acute vasodilator effects of inhaled fasudil, a specific Rho-kinase inhibitor, in patients with pulmonary arterial hypertension. Heart Vessels 2010, 25:144-149.
    • (2010) Heart Vessels , vol.25 , pp. 144-149
    • Fujita, H.1    Fukumoto, Y.2    Saji, K.3
  • 26
    • 33847713292 scopus 로고    scopus 로고
    • Role of Rho kinases in PKG-mediated relaxation of pulmonary arteries of fetal lambs exposed to chronic high altitude hypoxia
    • Gao Y., Portugal A.D., Negash S., Zhou W., Longo L.D., Usha Raj J. Role of Rho kinases in PKG-mediated relaxation of pulmonary arteries of fetal lambs exposed to chronic high altitude hypoxia. Am. J. Physiol. Lung Cell Mol. Physiol. 2007, 292:L678-L684.
    • (2007) Am. J. Physiol. Lung Cell Mol. Physiol. , vol.292
    • Gao, Y.1    Portugal, A.D.2    Negash, S.3    Zhou, W.4    Longo, L.D.5    Usha Raj, J.6
  • 27
    • 57049147058 scopus 로고    scopus 로고
    • Preservation of cGMP-induced relaxation of pulmonary veins of fetal lambs exposed to chronic high altitude hypoxia: role of PKG and Rho kinase
    • Gao Y., Portugal A.D., Liu J., et al. Preservation of cGMP-induced relaxation of pulmonary veins of fetal lambs exposed to chronic high altitude hypoxia: role of PKG and Rho kinase. Am. J. Physiol. Lung Cell Mol. Physiol. 2008, 295:L889-L896.
    • (2008) Am. J. Physiol. Lung Cell Mol. Physiol. , vol.295
    • Gao, Y.1    Portugal, A.D.2    Liu, J.3
  • 29
    • 41149115441 scopus 로고    scopus 로고
    • Enhancement of pulmonary vascular remodelling and inflammatory genes with VIP gene deletion
    • Hamidi S.A., Prabhakar S., Said S.I. Enhancement of pulmonary vascular remodelling and inflammatory genes with VIP gene deletion. Eur. Respir. J. 2008, 31:135-139.
    • (2008) Eur. Respir. J. , vol.31 , pp. 135-139
    • Hamidi, S.A.1    Prabhakar, S.2    Said, S.I.3
  • 31
    • 57049147057 scopus 로고    scopus 로고
    • Upregulation of vascular calcium channels in neonatal piglets with hypoxia-induced pulmonary hypertension
    • Hirenallur S.D., Haworth S.T., Leming J.T., et al. Upregulation of vascular calcium channels in neonatal piglets with hypoxia-induced pulmonary hypertension. Am. J. Physiol. Lung Cell Mol. Physiol. 2008, 295:L915-L924.
    • (2008) Am. J. Physiol. Lung Cell Mol. Physiol. , vol.295
    • Hirenallur, S.D.1    Haworth, S.T.2    Leming, J.T.3
  • 32
    • 79957999313 scopus 로고    scopus 로고
    • Mast cells promote lung vascular remodelling in pulmonary hypertension
    • Hoffmann J., Yin J., Kukucka M., et al. Mast cells promote lung vascular remodelling in pulmonary hypertension. Eur. Respir. J. 2011, 37:1400-1410.
    • (2011) Eur. Respir. J. , vol.37 , pp. 1400-1410
    • Hoffmann, J.1    Yin, J.2    Kukucka, M.3
  • 33
    • 37349071022 scopus 로고    scopus 로고
    • Endothelin-1 and serotonin are involved in activation of RhoA/Rho kinase signaling in the chronically hypoxic hypertensive rat pulmonary circulation
    • Homma N., Nagaoka T., Morio Y., et al. Endothelin-1 and serotonin are involved in activation of RhoA/Rho kinase signaling in the chronically hypoxic hypertensive rat pulmonary circulation. J. Cardiovasc. Pharmacol. 2007, 50:697-702.
    • (2007) J. Cardiovasc. Pharmacol. , vol.50 , pp. 697-702
    • Homma, N.1    Nagaoka, T.2    Morio, Y.3
  • 34
    • 0037440743 scopus 로고    scopus 로고
    • Chronic hypoxia causes angiogenesis in addition to remodelling in the adult rat pulmonary circulation
    • Howell K., Preston R.J., McLoughlin P. Chronic hypoxia causes angiogenesis in addition to remodelling in the adult rat pulmonary circulation. J. Physiol. 2003, 547:133-145.
    • (2003) J. Physiol. , vol.547 , pp. 133-145
    • Howell, K.1    Preston, R.J.2    McLoughlin, P.3
  • 35
    • 4544334528 scopus 로고    scopus 로고
    • Effect of changes in pH on wall tension in isolated rat pulmonary artery: role of the RhoA/Rho-kinase pathway
    • Hyvelin J.M., O'Connor C., McLoughlin P. Effect of changes in pH on wall tension in isolated rat pulmonary artery: role of the RhoA/Rho-kinase pathway. Am. J. Physiol. Lung Cell Mol. Physiol. 2004, 287:L673-L684.
    • (2004) Am. J. Physiol. Lung Cell Mol. Physiol. , vol.287
    • Hyvelin, J.M.1    O'Connor, C.2    McLoughlin, P.3
  • 36
    • 22744455284 scopus 로고    scopus 로고
    • Inhibition of Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation
    • Hyvelin J.M., Howell K., Nichol A., Costello C.M., Preston R.J., McLoughlin P. Inhibition of Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation. Circ. Res. 2005, 97:185-191.
    • (2005) Circ. Res. , vol.97 , pp. 185-191
    • Hyvelin, J.M.1    Howell, K.2    Nichol, A.3    Costello, C.M.4    Preston, R.J.5    McLoughlin, P.6
  • 37
    • 31644431508 scopus 로고    scopus 로고
    • Beneficial acute effects of rho-kinase inhibitor in patients with pulmonary arterial hypertension
    • Ishikura K., Yamada N., Ito M., et al. Beneficial acute effects of rho-kinase inhibitor in patients with pulmonary arterial hypertension. Circ. J. 2006, 70:174-178.
    • (2006) Circ. J. , vol.70 , pp. 174-178
    • Ishikura, K.1    Yamada, N.2    Ito, M.3
  • 38
    • 0034017744 scopus 로고    scopus 로고
    • Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases
    • Ishizaki T., Uehata M., Tamechika I., et al. Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol. Pharmacol. 2000, 57:976-983.
    • (2000) Mol. Pharmacol. , vol.57 , pp. 976-983
    • Ishizaki, T.1    Uehata, M.2    Tamechika, I.3
  • 39
    • 0035006955 scopus 로고    scopus 로고
    • Excitation-contraction coupling in pulmonary vascular smooth muscle involves tyrosine kinase and Rho kinase
    • Janssen L.J., Lu-Chao H., Netherton S. Excitation-contraction coupling in pulmonary vascular smooth muscle involves tyrosine kinase and Rho kinase. Am. J. Physiol. Lung Cell Mol. Physiol. 2001, 280:L666-L674.
    • (2001) Am. J. Physiol. Lung Cell Mol. Physiol. , vol.280
    • Janssen, L.J.1    Lu-Chao, H.2    Netherton, S.3
  • 40
    • 33847191058 scopus 로고    scopus 로고
    • Acute vasodilator effect of fasudil, a Rho-kinase inhibitor, in monocrotaline-induced pulmonary hypertension in rats
    • Jiang B.H., Tawara S., Abe K., Takaki A., Fukumoto Y., Shimokawa H. Acute vasodilator effect of fasudil, a Rho-kinase inhibitor, in monocrotaline-induced pulmonary hypertension in rats. J. Cardiovasc. Pharmacol. 2007, 49:85-89.
    • (2007) J. Cardiovasc. Pharmacol. , vol.49 , pp. 85-89
    • Jiang, B.H.1    Tawara, S.2    Abe, K.3    Takaki, A.4    Fukumoto, Y.5    Shimokawa, H.6
  • 41
    • 0024787734 scopus 로고
    • Pulmonary neuroendocrine cells. Their secretory products and their potential roles in health and chronic lung disease in infancy
    • Johnson D.E., Georgieff M.K. Pulmonary neuroendocrine cells. Their secretory products and their potential roles in health and chronic lung disease in infancy. Am. Rev. Respir. Dis. 1989, 140:1807-1812.
    • (1989) Am. Rev. Respir. Dis. , vol.140 , pp. 1807-1812
    • Johnson, D.E.1    Georgieff, M.K.2
  • 42
    • 0035824915 scopus 로고    scopus 로고
    • Contribution of the 5-HT(1B) receptor to hypoxia-induced pulmonary hypertension: converging evidence using 5-HT(1B)-receptor knockout mice and the 5-HT(1B/1D)-receptor antagonist GR127935
    • Keegan A., Morecroft I., Smillie D., Hicks M.N., MacLean M.R. Contribution of the 5-HT(1B) receptor to hypoxia-induced pulmonary hypertension: converging evidence using 5-HT(1B)-receptor knockout mice and the 5-HT(1B/1D)-receptor antagonist GR127935. Circ. Res. 2001, 89:1231-1239.
    • (2001) Circ. Res. , vol.89 , pp. 1231-1239
    • Keegan, A.1    Morecroft, I.2    Smillie, D.3    Hicks, M.N.4    MacLean, M.R.5
  • 43
    • 84860710320 scopus 로고    scopus 로고
    • PAR-2 inhibition Reverses Experimental pulmonary hypertension
    • Kwapiszewska G., Markart P., Dahal B.K., et al. PAR-2 inhibition Reverses Experimental pulmonary hypertension. Circ. Res. 2012, 110:1179-1191.
    • (2012) Circ. Res. , vol.110 , pp. 1179-1191
    • Kwapiszewska, G.1    Markart, P.2    Dahal, B.K.3
  • 44
    • 79959945831 scopus 로고    scopus 로고
    • Lack of CCR7 induces pulmonary hypertension involving perivascular leukocyte infiltration and inflammation
    • Larsen K.O., Yndestad A., Sjaastad I., et al. Lack of CCR7 induces pulmonary hypertension involving perivascular leukocyte infiltration and inflammation. Am. J. Physiol. Lung Cell Mol. Physiol. 2011, 301:L50-L59.
    • (2011) Am. J. Physiol. Lung Cell Mol. Physiol. , vol.301
    • Larsen, K.O.1    Yndestad, A.2    Sjaastad, I.3
  • 45
    • 0028863142 scopus 로고
    • A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes
    • Leung T., Manser E., Tan L., Lim L. A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes. J. Biol. Chem. 1995, 270:29051-29054.
    • (1995) J. Biol. Chem. , vol.270 , pp. 29051-29054
    • Leung, T.1    Manser, E.2    Tan, L.3    Lim, L.4
  • 46
    • 64249097973 scopus 로고    scopus 로고
    • Acute inhibition of Rho-kinase attenuates pulmonary hypertension in patients with congenital heart disease
    • Li F., Xia W., Yuan S., Sun R. Acute inhibition of Rho-kinase attenuates pulmonary hypertension in patients with congenital heart disease. Pediatr. Cardiol. 2009, 30:363-366.
    • (2009) Pediatr. Cardiol. , vol.30 , pp. 363-366
    • Li, F.1    Xia, W.2    Yuan, S.3    Sun, R.4
  • 47
    • 4644248958 scopus 로고    scopus 로고
    • Rho kinase-induced nuclear translocation of ERK1/ERK2 in smooth muscle cell mitogenesis caused by serotonin
    • Liu Y., Suzuki Y.J., Day R.M., Fanburg B.L. Rho kinase-induced nuclear translocation of ERK1/ERK2 in smooth muscle cell mitogenesis caused by serotonin. Circ. Res. 2004, 95:579-586.
    • (2004) Circ. Res. , vol.95 , pp. 579-586
    • Liu, Y.1    Suzuki, Y.J.2    Day, R.M.3    Fanburg, B.L.4
  • 48
    • 68549098152 scopus 로고    scopus 로고
    • Serotonin induces Rho/ROCK-dependent activation of Smads 1/5/8 in pulmonary artery smooth muscle cells
    • Liu Y., Ren W., Warburton R., Toksoz D., Fanburg B.L. Serotonin induces Rho/ROCK-dependent activation of Smads 1/5/8 in pulmonary artery smooth muscle cells. FASEB J. 2009, 23:2299-2306.
    • (2009) FASEB J. , vol.23 , pp. 2299-2306
    • Liu, Y.1    Ren, W.2    Warburton, R.3    Toksoz, D.4    Fanburg, B.L.5
  • 49
    • 76649099163 scopus 로고    scopus 로고
    • Attenuation of pulmonary arterial smooth muscle cell proliferation following hypoxic pulmonary hypertension by the Na+/H+ exchange inhibitor amiloride
    • Liu Y., Zhang B., Dong M.Q., et al. Attenuation of pulmonary arterial smooth muscle cell proliferation following hypoxic pulmonary hypertension by the Na+/H+ exchange inhibitor amiloride. Chin. J. Physiol. 2010, 53:36-44.
    • (2010) Chin. J. Physiol. , vol.53 , pp. 36-44
    • Liu, Y.1    Zhang, B.2    Dong, M.Q.3
  • 50
    • 33645751955 scopus 로고    scopus 로고
    • Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficient mice
    • Long L., MacLean M.R., Jeffery T.K., et al. Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficient mice. Circ. Res. 2006, 98:818-827.
    • (2006) Circ. Res. , vol.98 , pp. 818-827
    • Long, L.1    MacLean, M.R.2    Jeffery, T.K.3
  • 51
    • 32544458797 scopus 로고    scopus 로고
    • Mutations of the TGF-beta type II receptor BMPR2 in pulmonary arterial hypertension
    • Machado R.D., Aldred M.A., James V., et al. Mutations of the TGF-beta type II receptor BMPR2 in pulmonary arterial hypertension. Hum. Mutat. 2006, 27:121-132.
    • (2006) Hum. Mutat. , vol.27 , pp. 121-132
    • Machado, R.D.1    Aldred, M.A.2    James, V.3
  • 52
    • 0034779893 scopus 로고    scopus 로고
    • Increased contractile response to 5-hydroxytryptamine1-receptor stimulation in pulmonary arteries from chronic hypoxic rats: role of pharmacological synergy
    • MacLean M.R., Morecroft I. Increased contractile response to 5-hydroxytryptamine1-receptor stimulation in pulmonary arteries from chronic hypoxic rats: role of pharmacological synergy. Br. J. Pharmacol. 2001, 134:614-620.
    • (2001) Br. J. Pharmacol. , vol.134 , pp. 614-620
    • MacLean, M.R.1    Morecroft, I.2
  • 53
    • 0033774752 scopus 로고    scopus 로고
    • 5-hydroxytryptamine and the pulmonary circulation: receptors, transporters and relevance to pulmonary arterial hypertension
    • MacLean M.R., Herve P., Eddahibi S., Adnot S. 5-hydroxytryptamine and the pulmonary circulation: receptors, transporters and relevance to pulmonary arterial hypertension. Br. J. Pharmacol. 2000, 131:161-168.
    • (2000) Br. J. Pharmacol. , vol.131 , pp. 161-168
    • MacLean, M.R.1    Herve, P.2    Eddahibi, S.3    Adnot, S.4
  • 54
    • 2442519344 scopus 로고    scopus 로고
    • Overexpression of the 5-hydroxytryptamine transporter gene: effect on pulmonary hemodynamics and hypoxia-induced pulmonary hypertension
    • MacLean M.R., Deuchar G.A., Hicks M.N., et al. Overexpression of the 5-hydroxytryptamine transporter gene: effect on pulmonary hemodynamics and hypoxia-induced pulmonary hypertension. Circulation 2004, 109:2150-2155.
    • (2004) Circulation , vol.109 , pp. 2150-2155
    • MacLean, M.R.1    Deuchar, G.A.2    Hicks, M.N.3
  • 55
    • 53849083055 scopus 로고    scopus 로고
    • Novel interactions between the 5-HT transporter, 5-HT1B receptors and Rho kinase in vivo and in pulmonary fibroblasts
    • Mair K.M., MacLean M.R., Morecroft I., Dempsie Y., Palmer T.M. Novel interactions between the 5-HT transporter, 5-HT1B receptors and Rho kinase in vivo and in pulmonary fibroblasts. Br. J. Pharmacol. 2008, 155:606-616.
    • (2008) Br. J. Pharmacol. , vol.155 , pp. 606-616
    • Mair, K.M.1    MacLean, M.R.2    Morecroft, I.3    Dempsie, Y.4    Palmer, T.M.5
  • 56
    • 0842313242 scopus 로고    scopus 로고
    • Hypoxia and Rho/Rho-kinase signaling. Lung development versus hypoxic pulmonary hypertension
    • McMurtry I.F., Bauer N.R., Fagan K.A., Nagaoka T., Gebb S.A., Oka M. Hypoxia and Rho/Rho-kinase signaling. Lung development versus hypoxic pulmonary hypertension. Adv. Exp. Med. Biol. 2003, 543:127-137.
    • (2003) Adv. Exp. Med. Biol. , vol.543 , pp. 127-137
    • McMurtry, I.F.1    Bauer, N.R.2    Fagan, K.A.3    Nagaoka, T.4    Gebb, S.A.5    Oka, M.6
  • 57
    • 39149145493 scopus 로고    scopus 로고
    • Acute vasodilator effects of Rho-kinase inhibitors in neonatal rats with pulmonary hypertension unresponsive to nitric oxide
    • McNamara P.J., Murthy P., Kantores C., et al. Acute vasodilator effects of Rho-kinase inhibitors in neonatal rats with pulmonary hypertension unresponsive to nitric oxide. Am. J. Physiol. Lung Cell Mol. Physiol. 2008, 294:L205-L213.
    • (2008) Am. J. Physiol. Lung Cell Mol. Physiol. , vol.294
    • McNamara, P.J.1    Murthy, P.2    Kantores, C.3
  • 58
    • 0032751507 scopus 로고    scopus 로고
    • 5-Hydroxytryptamine receptors mediating contraction in human small muscular pulmonary arteries: importance of the 5-HT1B receptor
    • Morecroft I., Heeley R.P., Prentice H.M., Kirk A., MacLean M.R. 5-Hydroxytryptamine receptors mediating contraction in human small muscular pulmonary arteries: importance of the 5-HT1B receptor. Br. J. Pharmacol. 1999, 128:730-734.
    • (1999) Br. J. Pharmacol. , vol.128 , pp. 730-734
    • Morecroft, I.1    Heeley, R.P.2    Prentice, H.M.3    Kirk, A.4    MacLean, M.R.5
  • 59
    • 77957832881 scopus 로고    scopus 로고
    • Fasudil reduces monocrotaline-induced pulmonary arterial hypertension: comparison with bosentan and sildenafil
    • Mouchaers K.T., Schalij I., de Boer M.A., et al. Fasudil reduces monocrotaline-induced pulmonary arterial hypertension: comparison with bosentan and sildenafil. Eur. Respir. J. 2010, 36:800-807.
    • (2010) Eur. Respir. J. , vol.36 , pp. 800-807
    • Mouchaers, K.T.1    Schalij, I.2    de Boer, M.A.3
  • 60
    • 4544244944 scopus 로고    scopus 로고
    • Rho/Rho kinase signaling mediates increased basal pulmonary vascular tone in chronically hypoxic rats
    • Nagaoka T., Morio Y., Casanova N., et al. Rho/Rho kinase signaling mediates increased basal pulmonary vascular tone in chronically hypoxic rats. Am. J. Physiol. Lung Cell Mol. Physiol. 2004, 287:L665-L672.
    • (2004) Am. J. Physiol. Lung Cell Mol. Physiol. , vol.287
    • Nagaoka, T.1    Morio, Y.2    Casanova, N.3
  • 61
    • 15944403568 scopus 로고    scopus 로고
    • Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension
    • Nagaoka T., Fagan K.A., Gebb S.A., et al. Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension. Am. J. Respir. Crit. Care Med. 2005, 171:494-499.
    • (2005) Am. J. Respir. Crit. Care Med. , vol.171 , pp. 494-499
    • Nagaoka, T.1    Fagan, K.A.2    Gebb, S.A.3
  • 62
    • 33645816773 scopus 로고    scopus 로고
    • Involvement of RhoA/Rho kinase signaling in pulmonary hypertension of the fawn-hooded rat
    • Nagaoka T., Gebb S.A., Karoor V., et al. Involvement of RhoA/Rho kinase signaling in pulmonary hypertension of the fawn-hooded rat. J. Appl. Physiol. 2006, 100:996-1002.
    • (2006) J. Appl. Physiol. , vol.100 , pp. 996-1002
    • Nagaoka, T.1    Gebb, S.A.2    Karoor, V.3
  • 63
    • 0030603119 scopus 로고    scopus 로고
    • ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice
    • Nakagawa O., Fujisawa K., Ishizaki T., Saito Y., Nakao K., Narumiya S. ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice. FEBS Lett. 1996, 392:189-193.
    • (1996) FEBS Lett. , vol.392 , pp. 189-193
    • Nakagawa, O.1    Fujisawa, K.2    Ishizaki, T.3    Saito, Y.4    Nakao, K.5    Narumiya, S.6
  • 64
    • 33750895543 scopus 로고    scopus 로고
    • Influence of hypoxia on endothelin-1 binding sites in neonatal porcine pulmonary vasculature
    • Noguchi Y., Hislop A.A., Haworth S.G. Influence of hypoxia on endothelin-1 binding sites in neonatal porcine pulmonary vasculature. Am. J. Physiol. 1997, 272:H669-H678.
    • (1997) Am. J. Physiol. , vol.272
    • Noguchi, Y.1    Hislop, A.A.2    Haworth, S.G.3
  • 65
    • 0021504896 scopus 로고
    • Polyamines and the development of monocrotaline-induced pulmonary hypertension
    • Olson J.W., Hacker A.D., Altiere R.J., Gillespie M.N. Polyamines and the development of monocrotaline-induced pulmonary hypertension. Am. J. Physiol. 1984, 247:H682-H685.
    • (1984) Am. J. Physiol. , vol.247
    • Olson, J.W.1    Hacker, A.D.2    Altiere, R.J.3    Gillespie, M.N.4
  • 67
    • 0037461359 scopus 로고    scopus 로고
    • 2-sensitive potassium channel Kv1.5 reduces pulmonary hypertension and restores hypoxic pulmonary vasoconstriction in chronically hypoxic rats
    • 2-sensitive potassium channel Kv1.5 reduces pulmonary hypertension and restores hypoxic pulmonary vasoconstriction in chronically hypoxic rats. Circulation 2003, 107:2037-2044.
    • (2003) Circulation , vol.107 , pp. 2037-2044
    • Pozeg, Z.I.1    Michelakis, E.D.2    McMurtry, M.S.3
  • 68
    • 84855467311 scopus 로고    scopus 로고
    • Inflammation in pulmonary arterial hypertension
    • Price L.C., Wort S.J., Perros F., et al. Inflammation in pulmonary arterial hypertension. Chest 2012, 141:210-221.
    • (2012) Chest , vol.141 , pp. 210-221
    • Price, L.C.1    Wort, S.J.2    Perros, F.3
  • 70
    • 0034778907 scopus 로고    scopus 로고
    • Linking a serotonin transporter polymorphism to vascular smooth muscle proliferation in patients with primary pulmonary hypertension
    • Rabinovitch M. Linking a serotonin transporter polymorphism to vascular smooth muscle proliferation in patients with primary pulmonary hypertension. J. Clin. Invest. 2001, 108:1109-1111.
    • (2001) J. Clin. Invest. , vol.108 , pp. 1109-1111
    • Rabinovitch, M.1
  • 71
    • 0033822011 scopus 로고    scopus 로고
    • Inhibition of sustained hypoxic vasoconstriction by Y-27632 in isolated intrapulmonary arteries and perfused lung of the rat
    • Robertson T.P., Dipp M., Ward J.P., Aaronson P.I., Evans A.M. Inhibition of sustained hypoxic vasoconstriction by Y-27632 in isolated intrapulmonary arteries and perfused lung of the rat. Br. J. Pharmacol. 2000, 131:5-9.
    • (2000) Br. J. Pharmacol. , vol.131 , pp. 5-9
    • Robertson, T.P.1    Dipp, M.2    Ward, J.P.3    Aaronson, P.I.4    Evans, A.M.5
  • 73
    • 0141529785 scopus 로고    scopus 로고
    • Sildenafil prevents change in RhoA expression induced by chronic hypoxia in rat pulmonary artery
    • Sauzeau V., Rolli-Derkinderen M., Lehoux S., Loirand G., Pacaud P. Sildenafil prevents change in RhoA expression induced by chronic hypoxia in rat pulmonary artery. Circ. Res. 2003, 93:630-637.
    • (2003) Circ. Res. , vol.93 , pp. 630-637
    • Sauzeau, V.1    Rolli-Derkinderen, M.2    Lehoux, S.3    Loirand, G.4    Pacaud, P.5
  • 75
    • 79954596642 scopus 로고    scopus 로고
    • Role of Rho-kinase signaling and endothelial dysfunction in modulating blood flow distribution in pulmonary hypertension
    • Schwenke D.O., Pearson J.T., Sonobe T., et al. Role of Rho-kinase signaling and endothelial dysfunction in modulating blood flow distribution in pulmonary hypertension. J. Appl. Physiol. 2011, 110:901-908.
    • (2011) J. Appl. Physiol. , vol.110 , pp. 901-908
    • Schwenke, D.O.1    Pearson, J.T.2    Sonobe, T.3
  • 76
    • 84863393164 scopus 로고    scopus 로고
    • TASK1 (K(2P)3.1) K(+) channel inhibition by endothelin-1 is mediated through Rho kinase-dependent phosphorylation
    • Seyler C., Duthil-Straub E., Zitron E., et al. TASK1 (K(2P)3.1) K(+) channel inhibition by endothelin-1 is mediated through Rho kinase-dependent phosphorylation. Br. J. Pharmacol. 2012, 165:1467-1475.
    • (2012) Br. J. Pharmacol. , vol.165 , pp. 1467-1475
    • Seyler, C.1    Duthil-Straub, E.2    Zitron, E.3
  • 77
    • 33751117499 scopus 로고    scopus 로고
    • HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes
    • Shimoda L.A., Fallon M., Pisarcik S., Wang J., Semenza G.L. HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes. Am. J. Physiol. Lung Cell Mol. Physiol. 2006, 291:L941-L949.
    • (2006) Am. J. Physiol. Lung Cell Mol. Physiol. , vol.291
    • Shimoda, L.A.1    Fallon, M.2    Pisarcik, S.3    Wang, J.4    Semenza, G.L.5
  • 81
    • 33749345684 scopus 로고    scopus 로고
    • Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms
    • Stenmark K.R., Fagan K.A., Frid M.G. Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms. Circ. Res. 2006, 99:675-691.
    • (2006) Circ. Res. , vol.99 , pp. 675-691
    • Stenmark, K.R.1    Fagan, K.A.2    Frid, M.G.3
  • 82
    • 0032102283 scopus 로고    scopus 로고
    • Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3
    • Steudel W., Scherrer-Crosbie M., Bloch K.D., et al. Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3. J. Clin. Invest. 1998, 101:2468-2477.
    • (1998) J. Clin. Invest. , vol.101 , pp. 2468-2477
    • Steudel, W.1    Scherrer-Crosbie, M.2    Bloch, K.D.3
  • 83
    • 34447542025 scopus 로고    scopus 로고
    • Molecular effects of loss of BMPR2 signaling in smooth muscle in a transgenic mouse model of PAH
    • Tada Y., Majka S., Carr M., et al. Molecular effects of loss of BMPR2 signaling in smooth muscle in a transgenic mouse model of PAH. Am. J. Physiol. Lung Cell Mol. Physiol. 2007, 292:L1556-L1563.
    • (2007) Am. J. Physiol. Lung Cell Mol. Physiol. , vol.292
    • Tada, Y.1    Majka, S.2    Carr, M.3
  • 84
    • 34547941265 scopus 로고    scopus 로고
    • Effects of combined therapy with a Rho-kinase inhibitor and prostacyclin on monocrotaline-induced pulmonary hypertension in rats
    • Tawara S., Fukumoto Y., Shimokawa H. Effects of combined therapy with a Rho-kinase inhibitor and prostacyclin on monocrotaline-induced pulmonary hypertension in rats. J. Cardiovasc. Pharmacol. 2007, 50:195-200.
    • (2007) J. Cardiovasc. Pharmacol. , vol.50 , pp. 195-200
    • Tawara, S.1    Fukumoto, Y.2    Shimokawa, H.3
  • 85
    • 0030656619 scopus 로고    scopus 로고
    • Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
    • Uehata M., Ishizaki T., Satoh H., et al. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 1997, 389:990-994.
    • (1997) Nature , vol.389 , pp. 990-994
    • Uehata, M.1    Ishizaki, T.2    Satoh, H.3
  • 86
    • 0031747165 scopus 로고    scopus 로고
    • Pulmonary artery remodeling differs in hypoxia- and monocrotaline-induced pulmonary hypertension
    • van Suylen R.J., Smits J.F., Daemen M.J. Pulmonary artery remodeling differs in hypoxia- and monocrotaline-induced pulmonary hypertension. Am. J. Respir. Crit. Care Med. 1998, 157:1423-1428.
    • (1998) Am. J. Respir. Crit. Care Med. , vol.157 , pp. 1423-1428
    • van Suylen, R.J.1    Smits, J.F.2    Daemen, M.J.3
  • 88
    • 0025105088 scopus 로고
    • Endothelin and 5-hydroxytryptamine on rat pulmonary artery in pulmonary hypertension
    • Wanstall J.C., O'Donnell S.R. Endothelin and 5-hydroxytryptamine on rat pulmonary artery in pulmonary hypertension. Eur. J. Pharmacol. 1990, 176:159-168.
    • (1990) Eur. J. Pharmacol. , vol.176 , pp. 159-168
    • Wanstall, J.C.1    O'Donnell, S.R.2
  • 89
    • 66049112085 scopus 로고    scopus 로고
    • Mechanisms of hypoxic pulmonary vasoconstriction and their roles in pulmonary hypertension: new findings for an old problem
    • Ward J.P., McMurtry I.F. Mechanisms of hypoxic pulmonary vasoconstriction and their roles in pulmonary hypertension: new findings for an old problem. Curr. Opin. Pharmacol. 2009, 9:287-296.
    • (2009) Curr. Opin. Pharmacol. , vol.9 , pp. 287-296
    • Ward, J.P.1    McMurtry, I.F.2
  • 90
    • 77951215757 scopus 로고    scopus 로고
    • Cross talk between Smad, MAPK, and actin in the etiology of pulmonary arterial hypertension
    • West J. Cross talk between Smad, MAPK, and actin in the etiology of pulmonary arterial hypertension. Adv. Exp. Med. Biol. 2010, 661:265-278.
    • (2010) Adv. Exp. Med. Biol. , vol.661 , pp. 265-278
    • West, J.1
  • 91
    • 57049159708 scopus 로고    scopus 로고
    • Mice expressing BMPR2R899X transgene in smooth muscle develop pulmonary vascular lesions
    • West J., Harral J., Lane K., et al. Mice expressing BMPR2R899X transgene in smooth muscle develop pulmonary vascular lesions. Am. J. Physiol. Lung Cell Mol. Physiol. 2008, 295:L744-L755.
    • (2008) Am. J. Physiol. Lung Cell Mol. Physiol. , vol.295
    • West, J.1    Harral, J.2    Lane, K.3
  • 94
    • 24644479674 scopus 로고    scopus 로고
    • Calcium signalling in smooth muscle
    • Wray S., Burdyga T., Noble K. Calcium signalling in smooth muscle. Cell Calcium 2005, 38:397-407.
    • (2005) Cell Calcium , vol.38 , pp. 397-407
    • Wray, S.1    Burdyga, T.2    Noble, K.3
  • 95
    • 80055117501 scopus 로고    scopus 로고
    • Rho-kinase inhibition alleviates pulmonary hypertension in transgenic mice expressing a dominant-negative type II bone morphogenetic protein receptor gene
    • Yasuda T., Tada Y., Tanabe N., Tatsumi K., West J. Rho-kinase inhibition alleviates pulmonary hypertension in transgenic mice expressing a dominant-negative type II bone morphogenetic protein receptor gene. Am. J. Physiol. Lung Cell Mol. Physiol. 2011, 301:L667-L674.
    • (2011) Am. J. Physiol. Lung Cell Mol. Physiol. , vol.301
    • Yasuda, T.1    Tada, Y.2    Tanabe, N.3    Tatsumi, K.4    West, J.5
  • 96
    • 4644290321 scopus 로고    scopus 로고
    • Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension
    • Yu Y., Fantozzi I., Remillard C.V., et al. Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:13861-13866.
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 13861-13866
    • Yu, Y.1    Fantozzi, I.2    Remillard, C.V.3
  • 97
    • 44449095608 scopus 로고    scopus 로고
    • Deficiency of the NHE1 gene prevents hypoxia-induced pulmonary hypertension and vascular remodeling
    • Yu L., Quinn D.A., Garg H.G., Hales C.A. Deficiency of the NHE1 gene prevents hypoxia-induced pulmonary hypertension and vascular remodeling. Am. J. Respir. Crit. Care Med. 2008, 177:1276-1284.
    • (2008) Am. J. Respir. Crit. Care Med. , vol.177 , pp. 1276-1284
    • Yu, L.1    Quinn, D.A.2    Garg, H.G.3    Hales, C.A.4
  • 98
    • 79953746692 scopus 로고    scopus 로고
    • Heparin inhibits pulmonary artery smooth muscle cell proliferation through guanine nucleotide exchange factor-H1/RhoA/Rho kinase/p27
    • Yu L., Quinn D.A., Garg H.G., Hales C.A. Heparin inhibits pulmonary artery smooth muscle cell proliferation through guanine nucleotide exchange factor-H1/RhoA/Rho kinase/p27. Am. J. Respir. Cell Mol. Biol. 2011, 44:524-530.
    • (2011) Am. J. Respir. Cell Mol. Biol. , vol.44 , pp. 524-530
    • Yu, L.1    Quinn, D.A.2    Garg, H.G.3    Hales, C.A.4
  • 99
    • 0032491187 scopus 로고    scopus 로고
    • + channels in pulmonary artery smooth muscle cells of patients with primary pulmonary hypertension
    • + channels in pulmonary artery smooth muscle cells of patients with primary pulmonary hypertension. Circulation 1998, 98:1400-1406.
    • (1998) Circulation , vol.98 , pp. 1400-1406
    • Yuan, J.X.1    Aldinger, A.M.2    Juhaszova, M.3
  • 100
    • 77449104770 scopus 로고    scopus 로고
    • Effects of rho-kinase inhibition on pulmonary hypertension, lung growth, and structure in neonatal rats chronically exposed to hypoxia
    • Ziino A.J., Ivanovska J., Belcastro R., et al. Effects of rho-kinase inhibition on pulmonary hypertension, lung growth, and structure in neonatal rats chronically exposed to hypoxia. Pediatr. Res. 2010, 67:177-182.
    • (2010) Pediatr. Res. , vol.67 , pp. 177-182
    • Ziino, A.J.1    Ivanovska, J.2    Belcastro, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.