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Volumn 58, Issue 3, 2013, Pages 219-230

The regulation of vascular tetrahydrobiopterin bioavailability

Author keywords

Endothelial; GTP cyclohydrolase 1; Nitric oxide synthase; Tetrahydrobiopterin

Indexed keywords

ASCORBIC ACID; BIOMARIN; GCH1 FEEDBACK REGULATORY PROTEIN; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; REGULATOR PROTEIN; SAPROPTERIN; SEPIAPTERIN; SUPEROXIDE DISMUTASE; TETRAHYDROBIOPTERIN; UNCLASSIFIED DRUG;

EID: 84875367037     PISSN: 15371891     EISSN: 18793649     Source Type: Journal    
DOI: 10.1016/j.vph.2012.08.002     Document Type: Article
Times cited : (14)

References (196)
  • 1
    • 0035425503 scopus 로고    scopus 로고
    • Nitric oxide synthases: structure, function and inhibition
    • Alderton W.K., Cooper C.E., Knowles R.G. Nitric oxide synthases: structure, function and inhibition. Biochem. J. 2001, 357(Pt. 3):593-615.
    • (2001) Biochem. J. , vol.357 , Issue.PART. 3 , pp. 593-615
    • Alderton, W.K.1    Cooper, C.E.2    Knowles, R.G.3
  • 2
    • 1542344000 scopus 로고    scopus 로고
    • Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice
    • Alp N.J., et al. Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice. Arterioscler. Thromb. Vasc. Biol. 2004, 24(3):445-450.
    • (2004) Arterioscler. Thromb. Vasc. Biol. , vol.24 , Issue.3 , pp. 445-450
    • Alp, N.J.1
  • 3
    • 33748645122 scopus 로고    scopus 로고
    • 5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling
    • Antoniades C., et al. 5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling. Circulation 2006, 114(11):1193-1201.
    • (2006) Circulation , vol.114 , Issue.11 , pp. 1193-1201
    • Antoniades, C.1
  • 4
    • 45849101717 scopus 로고    scopus 로고
    • GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function
    • Antoniades C., et al. GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function. J. Am. Coll. Cardiol. 2008, 52(2):158-165.
    • (2008) J. Am. Coll. Cardiol. , vol.52 , Issue.2 , pp. 158-165
    • Antoniades, C.1
  • 5
    • 12944300456 scopus 로고    scopus 로고
    • Zinc plays a key role in human and bacterial GTP cyclohydrolase I
    • Auerbach G., et al. Zinc plays a key role in human and bacterial GTP cyclohydrolase I. Proc. Natl. Acad. Sci. U. S. A. 2000, 97(25):13567-13572.
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , Issue.25 , pp. 13567-13572
    • Auerbach, G.1
  • 6
    • 0027441142 scopus 로고
    • Macrophage nitric oxide synthase subunits. Purification, characterization, and role of prosthetic groups and substrate in regulating their association into a dimeric enzyme
    • Baek K.J., et al. Macrophage nitric oxide synthase subunits. Purification, characterization, and role of prosthetic groups and substrate in regulating their association into a dimeric enzyme. J. Biol. Chem. 1993, 268(28):21120-21129.
    • (1993) J. Biol. Chem. , vol.268 , Issue.28 , pp. 21120-21129
    • Baek, K.J.1
  • 7
    • 0034181284 scopus 로고    scopus 로고
    • Protection against endotoxemia in rats by a novel tetrahydrobiopterin analogue
    • Bahrami S., et al. Protection against endotoxemia in rats by a novel tetrahydrobiopterin analogue. Shock 2000, 13(5):386-391.
    • (2000) Shock , vol.13 , Issue.5 , pp. 386-391
    • Bahrami, S.1
  • 8
    • 0016404247 scopus 로고
    • Letter: a new molecular defect in phenylketonuria
    • Bartholome K. Letter: a new molecular defect in phenylketonuria. Lancet 1974, 2(7896):1580.
    • (1974) Lancet , vol.2 , Issue.7896 , pp. 1580
    • Bartholome, K.1
  • 9
    • 0032577582 scopus 로고    scopus 로고
    • Reaction of neuronal nitric-oxide synthase with oxygen at low temperature. Evidence for reductive activation of the oxy-ferrous complex by tetrahydrobiopterin
    • Bec N., et al. Reaction of neuronal nitric-oxide synthase with oxygen at low temperature. Evidence for reductive activation of the oxy-ferrous complex by tetrahydrobiopterin. J. Biol. Chem. 1998, 273(22):13502-13508.
    • (1998) J. Biol. Chem. , vol.273 , Issue.22 , pp. 13502-13508
    • Bec, N.1
  • 10
    • 0031179265 scopus 로고    scopus 로고
    • Flow associated or flow mediated dilatation? More than just semantics
    • Bhagat K., Hingorani A., Vallance P. Flow associated or flow mediated dilatation? More than just semantics. Heart 1997, 78(1):7-8.
    • (1997) Heart , vol.78 , Issue.1 , pp. 7-8
    • Bhagat, K.1    Hingorani, A.2    Vallance, P.3
  • 11
    • 33750617640 scopus 로고    scopus 로고
    • Vitamin-mineral supplementation and the progression of atherosclerosis: a meta-analysis of randomized controlled trials
    • (quiz 954-5)
    • Bleys J., et al. Vitamin-mineral supplementation and the progression of atherosclerosis: a meta-analysis of randomized controlled trials. Am. J. Clin. Nutr. 2006, 84(4):880-887. (quiz 954-5).
    • (2006) Am. J. Clin. Nutr. , vol.84 , Issue.4 , pp. 880-887
    • Bleys, J.1
  • 13
    • 0027424664 scopus 로고
    • Altered synaptic plasticity and memory formation in nitric oxide synthase inhibitor-treated rats
    • Bohme G.A., et al. Altered synaptic plasticity and memory formation in nitric oxide synthase inhibitor-treated rats. Proc. Natl. Acad. Sci. U. S. A. 1993, 90(19):9191-9194.
    • (1993) Proc. Natl. Acad. Sci. U. S. A. , vol.90 , Issue.19 , pp. 9191-9194
    • Bohme, G.A.1
  • 14
    • 0032509360 scopus 로고    scopus 로고
    • Anti-pterins as tools to characterize the function of tetrahydrobiopterin in NO synthase
    • Bommel H.M., et al. Anti-pterins as tools to characterize the function of tetrahydrobiopterin in NO synthase. J. Biol. Chem. 1998, 273(50):33142-33149.
    • (1998) J. Biol. Chem. , vol.273 , Issue.50 , pp. 33142-33149
    • Bommel, H.M.1
  • 15
    • 35248882919 scopus 로고    scopus 로고
    • The response of patients with phenylketonuria and elevated serum phenylalanine to treatment with oral sapropterin dihydrochloride (6R-tetrahydrobiopterin): a phase II, multicentre, open-label, screening study
    • Burton B.K., et al. The response of patients with phenylketonuria and elevated serum phenylalanine to treatment with oral sapropterin dihydrochloride (6R-tetrahydrobiopterin): a phase II, multicentre, open-label, screening study. J. Inherit. Metab. Dis. 2007, 30(5):700-707.
    • (2007) J. Inherit. Metab. Dis. , vol.30 , Issue.5 , pp. 700-707
    • Burton, B.K.1
  • 16
    • 0036045827 scopus 로고    scopus 로고
    • GTP cyclohydrolase I gene transfer augments intracellular tetrahydrobiopterin in human endothelial cells: effects on nitric oxide synthase activity, protein levels and dimerisation
    • Cai S., et al. GTP cyclohydrolase I gene transfer augments intracellular tetrahydrobiopterin in human endothelial cells: effects on nitric oxide synthase activity, protein levels and dimerisation. Cardiovasc. Res. 2002, 55(4):838-849.
    • (2002) Cardiovasc. Res. , vol.55 , Issue.4 , pp. 838-849
    • Cai, S.1
  • 17
    • 21144435142 scopus 로고    scopus 로고
    • Endothelial dihydrofolate reductase: critical for nitric oxide bioavailability and role in angiotensin II uncoupling of endothelial nitric oxide synthase
    • Chalupsky K., Cai H. Endothelial dihydrofolate reductase: critical for nitric oxide bioavailability and role in angiotensin II uncoupling of endothelial nitric oxide synthase. Proc. Natl. Acad. Sci. U. S. A. 2005, 102(25):9056-9061.
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , Issue.25 , pp. 9056-9061
    • Chalupsky, K.1    Cai, H.2
  • 18
    • 13444262357 scopus 로고    scopus 로고
    • Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease
    • Channon K.M. Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease. Trends Cardiovasc. Med. 2004, 14(8):323-327.
    • (2004) Trends Cardiovasc. Med. , vol.14 , Issue.8 , pp. 323-327
    • Channon, K.M.1
  • 19
    • 33750066689 scopus 로고    scopus 로고
    • GTP cyclohydrolase feedback regulatory protein controls cofactor 6-tetrahydrobiopterin synthesis in the cytosol and in the nucleus of epidermal keratinocytes and melanocytes
    • Chavan B., et al. GTP cyclohydrolase feedback regulatory protein controls cofactor 6-tetrahydrobiopterin synthesis in the cytosol and in the nucleus of epidermal keratinocytes and melanocytes. J. Invest. Dermatol. 2006, 126(11):2481-2489.
    • (2006) J. Invest. Dermatol. , vol.126 , Issue.11 , pp. 2481-2489
    • Chavan, B.1
  • 20
    • 33644807156 scopus 로고    scopus 로고
    • High-dose oral vitamin C partially replenishes vitamin C levels in patients with type 2 diabetes and low vitamin C levels but does not improve endothelial dysfunction or insulin resistance
    • Chen H., et al. High-dose oral vitamin C partially replenishes vitamin C levels in patients with type 2 diabetes and low vitamin C levels but does not improve endothelial dysfunction or insulin resistance. Am. J. Physiol. Heart Circ. Physiol. 2006, 290(1):H137-H145.
    • (2006) Am. J. Physiol. Heart Circ. Physiol. , vol.290 , Issue.1
    • Chen, H.1
  • 21
    • 0026669343 scopus 로고
    • Antiatherogenic effects of l-arginine in the hypercholesterolemic rabbit
    • Cooke J.P., et al. Antiatherogenic effects of l-arginine in the hypercholesterolemic rabbit. J. Clin. Invest. 1992, 90(3):1168-1172.
    • (1992) J. Clin. Invest. , vol.90 , Issue.3 , pp. 1168-1172
    • Cooke, J.P.1
  • 22
    • 0028813306 scopus 로고
    • Tetrahydrobiopterin and dysfunction of endothelial nitric oxide synthase in coronary arteries
    • Cosentino F., Katusic Z.S. Tetrahydrobiopterin and dysfunction of endothelial nitric oxide synthase in coronary arteries. Circulation 1995, 91(1):139-144.
    • (1995) Circulation , vol.91 , Issue.1 , pp. 139-144
    • Cosentino, F.1    Katusic, Z.S.2
  • 23
    • 41149105370 scopus 로고    scopus 로고
    • Chronic treatment with tetrahydrobiopterin reverses endothelial dysfunction and oxidative stress in hypercholesterolaemia
    • Cosentino F., et al. Chronic treatment with tetrahydrobiopterin reverses endothelial dysfunction and oxidative stress in hypercholesterolaemia. Heart 2008, 94(4):487-492.
    • (2008) Heart , vol.94 , Issue.4 , pp. 487-492
    • Cosentino, F.1
  • 24
  • 25
    • 84875372219 scopus 로고    scopus 로고
    • in press, Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease. Nitric Oxide, Corrected Proof.
    • Crabtree, M.J. and Channon, K.M., in press, Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease. Nitric Oxide, Corrected Proof.
    • Crabtree, M.J.1    Channon, K.M.2
  • 26
    • 41849144894 scopus 로고    scopus 로고
    • Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS
    • Crabtree M.J., et al. Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS. Am. J. Physiol. Heart Circ. Physiol. 2008, 294(4):H1530-H1540.
    • (2008) Am. J. Physiol. Heart Circ. Physiol. , vol.294 , Issue.4
    • Crabtree, M.J.1
  • 27
    • 70350496588 scopus 로고    scopus 로고
    • Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways
    • Crabtree M.J., et al. Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways. J. Biol. Chem. 2009, 284(41):28128-28136.
    • (2009) J. Biol. Chem. , vol.284 , Issue.41 , pp. 28128-28136
    • Crabtree, M.J.1
  • 28
    • 79955613244 scopus 로고    scopus 로고
    • Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency
    • Crabtree M.J., Hale A.B., Channon K.M. Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency. Free Radic. Biol. Med. 2011, 50(11):1639-1646.
    • (2011) Free Radic. Biol. Med. , vol.50 , Issue.11 , pp. 1639-1646
    • Crabtree, M.J.1    Hale, A.B.2    Channon, K.M.3
  • 29
    • 79955613244 scopus 로고    scopus 로고
    • Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency
    • Crabtree M.J., Hale A.B., Channon K.M. Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency. Free Radic. Biol. Med. 2011, 50(11):1639-1646.
    • (2011) Free Radic. Biol. Med. , vol.50 , Issue.11 , pp. 1639-1646
    • Crabtree, M.J.1    Hale, A.B.2    Channon, K.M.3
  • 30
    • 79955613244 scopus 로고    scopus 로고
    • Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency
    • Crabtree, M.J., A.B. Hale, and K.M. Channon, Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency. Free Radic. Biol. Med. 50(11): p. 1639-46.
    • Free Radic. Biol. Med. , vol.50 , Issue.11 , pp. 1639-1646
    • Crabtree, M.J.1    Hale, A.B.2    Channon, K.M.3
  • 31
    • 0032571411 scopus 로고    scopus 로고
    • Structure of nitric oxide synthase oxygenase dimer with pterin and substrate
    • Crane B.R., et al. Structure of nitric oxide synthase oxygenase dimer with pterin and substrate. Science 1998, 279(5359):2121-2126.
    • (1998) Science , vol.279 , Issue.5359 , pp. 2121-2126
    • Crane, B.R.1
  • 32
    • 78649908061 scopus 로고    scopus 로고
    • Tetrahydrobiopterin: pleiotropic roles in cardiovascular pathophysiology
    • Cunnington C., Channon K.M. Tetrahydrobiopterin: pleiotropic roles in cardiovascular pathophysiology. Heart 2010, 96(23):1872-1877.
    • (2010) Heart , vol.96 , Issue.23 , pp. 1872-1877
    • Cunnington, C.1    Channon, K.M.2
  • 33
    • 84862794123 scopus 로고    scopus 로고
    • Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease
    • Cunnington C., et al. Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease. Circulation 2012, 125(11):1356-1366.
    • (2012) Circulation , vol.125 , Issue.11 , pp. 1356-1366
    • Cunnington, C.1
  • 34
    • 66949115572 scopus 로고    scopus 로고
    • Nitrate tolerance as a model of vascular dysfunction: roles for mitochondrial aldehyde dehydrogenase and mitochondrial oxidative stress
    • Daiber A., et al. Nitrate tolerance as a model of vascular dysfunction: roles for mitochondrial aldehyde dehydrogenase and mitochondrial oxidative stress. Pharmacol. Rep. 2009, 61(1):33-48.
    • (2009) Pharmacol. Rep. , vol.61 , Issue.1 , pp. 33-48
    • Daiber, A.1
  • 35
    • 0032780775 scopus 로고    scopus 로고
    • Safety of withdrawing inhaled nitric oxide therapy in persistent pulmonary hypertension of the newborn
    • Davidson D., et al. Safety of withdrawing inhaled nitric oxide therapy in persistent pulmonary hypertension of the newborn. Pediatrics 1999, 104(2 Pt. 1):231-236.
    • (1999) Pediatrics , vol.104 , Issue.2 PART. 1 , pp. 231-236
    • Davidson, D.1
  • 37
    • 49849084603 scopus 로고    scopus 로고
    • Clinical genetics of functionally mild non-coding GTP cyclohydrolase 1 (GCH1) polymorphisms modulating pain and cardiovascular risk
    • Doehring A., et al. Clinical genetics of functionally mild non-coding GTP cyclohydrolase 1 (GCH1) polymorphisms modulating pain and cardiovascular risk. Mutat. Res. 2008, 659(3):195-201.
    • (2008) Mutat. Res. , vol.659 , Issue.3 , pp. 195-201
    • Doehring, A.1
  • 38
    • 40749139448 scopus 로고    scopus 로고
    • Endothelium-specific GTP cyclohydrolase I overexpression attenuates blood pressure progression in salt-sensitive low-renin hypertension
    • Du Y.H., et al. Endothelium-specific GTP cyclohydrolase I overexpression attenuates blood pressure progression in salt-sensitive low-renin hypertension. Circulation 2008, 117(8):1045-1054.
    • (2008) Circulation , vol.117 , Issue.8 , pp. 1045-1054
    • Du, Y.H.1
  • 39
    • 84858983701 scopus 로고    scopus 로고
    • The protein partners of GTP cyclohydrolase I in rat organs
    • Du J., et al. The protein partners of GTP cyclohydrolase I in rat organs. PLoS One 2012, 7(3):e33991.
    • (2012) PLoS One , vol.7 , Issue.3
    • Du, J.1
  • 40
    • 35448929005 scopus 로고    scopus 로고
    • Myocardial ischemia results in tetrahydrobiopterin (BH4) oxidation with impaired endothelial function ameliorated by BH4
    • Dumitrescu C., et al. Myocardial ischemia results in tetrahydrobiopterin (BH4) oxidation with impaired endothelial function ameliorated by BH4. Proc. Natl. Acad. Sci. U. S. A. 2007, 104(38):15081-15086.
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , Issue.38 , pp. 15081-15086
    • Dumitrescu, C.1
  • 41
    • 0037428209 scopus 로고    scopus 로고
    • Long-term vitamin C treatment increases vascular tetrahydrobiopterin levels and nitric oxide synthase activity
    • d'Uscio L.V., et al. Long-term vitamin C treatment increases vascular tetrahydrobiopterin levels and nitric oxide synthase activity. Circ. Res. 2003, 92(1):88-95.
    • (2003) Circ. Res. , vol.92 , Issue.1 , pp. 88-95
    • d'Uscio, L.V.1
  • 42
    • 27844587829 scopus 로고    scopus 로고
    • Tetrahydrobiopterin augments endothelium-dependent dilatation in sedentary but not in habitually exercising older adults
    • Eskurza I., et al. Tetrahydrobiopterin augments endothelium-dependent dilatation in sedentary but not in habitually exercising older adults. J. Physiol. 2005, 568(Pt. 3):1057-1065.
    • (2005) J. Physiol. , vol.568 , Issue.PART. 3 , pp. 1057-1065
    • Eskurza, I.1
  • 43
    • 0347086140 scopus 로고    scopus 로고
    • Plasma tetrahydrobiopterin and its pharmacokinetic following oral administration
    • Fiege B., et al. Plasma tetrahydrobiopterin and its pharmacokinetic following oral administration. Mol. Genet. Metab. 2004, 81(1):45-51.
    • (2004) Mol. Genet. Metab. , vol.81 , Issue.1 , pp. 45-51
    • Fiege, B.1
  • 44
    • 77955607922 scopus 로고    scopus 로고
    • Tetrahydrobiopterin and the regulation of hypoxic pulmonary vasoconstriction
    • Francis B.N., Wilkins M.R., Zhao L. Tetrahydrobiopterin and the regulation of hypoxic pulmonary vasoconstriction. Eur. Respir. J. 2010, 36(2):323-330.
    • (2010) Eur. Respir. J. , vol.36 , Issue.2 , pp. 323-330
    • Francis, B.N.1    Wilkins, M.R.2    Zhao, L.3
  • 45
    • 4043080518 scopus 로고    scopus 로고
    • Tetrahydrobiopterin improves endothelial dysfunction and vascular oxidative stress in microvessels of intrauterine undernourished rats
    • Franco Mdo C., et al. Tetrahydrobiopterin improves endothelial dysfunction and vascular oxidative stress in microvessels of intrauterine undernourished rats. J. Physiol. 2004, 558(Pt. 1):239-248.
    • (2004) J. Physiol. , vol.558 , Issue.PART. 1 , pp. 239-248
    • Franco Mdo, C.1
  • 46
    • 0036182797 scopus 로고    scopus 로고
    • Tetrahydrobiopterin restores endothelial function of coronary arteries in patients with hypercholesterolaemia
    • Fukuda Y., et al. Tetrahydrobiopterin restores endothelial function of coronary arteries in patients with hypercholesterolaemia. Heart 2002, 87(3):264-269.
    • (2002) Heart , vol.87 , Issue.3 , pp. 264-269
    • Fukuda, Y.1
  • 47
    • 0036234279 scopus 로고    scopus 로고
    • Tetrahydrobiopterin improves coronary endothelial function, but does not prevent coronary spasm in patients with vasospastic angina
    • Fukuda Y., et al. Tetrahydrobiopterin improves coronary endothelial function, but does not prevent coronary spasm in patients with vasospastic angina. Circ. J. 2002, 66(1):58-62.
    • (2002) Circ. J. , vol.66 , Issue.1 , pp. 58-62
    • Fukuda, Y.1
  • 48
    • 0019195506 scopus 로고
    • The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
    • Furchgott R.F., Zawadzki J.V. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980, 288(5789):373-376.
    • (1980) Nature , vol.288 , Issue.5789 , pp. 373-376
    • Furchgott, R.F.1    Zawadzki, J.V.2
  • 49
    • 70350610765 scopus 로고    scopus 로고
    • Mechanistic insights into folic acid-dependent vascular protection: dihydrofolate reductase (DHFR)-mediated reduction in oxidant stress in endothelial cells and angiotensin II-infused mice: a novel HPLC-based fluorescent assay for DHFR activity
    • Gao L., et al. Mechanistic insights into folic acid-dependent vascular protection: dihydrofolate reductase (DHFR)-mediated reduction in oxidant stress in endothelial cells and angiotensin II-infused mice: a novel HPLC-based fluorescent assay for DHFR activity. J. Mol. Cell. Cardiol. 2009, 47(6):752-760.
    • (2009) J. Mol. Cell. Cardiol. , vol.47 , Issue.6 , pp. 752-760
    • Gao, L.1
  • 50
    • 0009621605 scopus 로고    scopus 로고
    • Dynamic activation of endothelial nitric oxide synthase by Hsp90
    • Garcia-Cardena G., et al. Dynamic activation of endothelial nitric oxide synthase by Hsp90. Nature 1998, 392(6678):821-824.
    • (1998) Nature , vol.392 , Issue.6678 , pp. 821-824
    • Garcia-Cardena, G.1
  • 51
    • 71549142865 scopus 로고    scopus 로고
    • Ascorbic acid and tetrahydrobiopterin potentiate the EDHF phenomenon by generating hydrogen peroxide
    • Garry A., et al. Ascorbic acid and tetrahydrobiopterin potentiate the EDHF phenomenon by generating hydrogen peroxide. Cardiovasc. Res. 2009, 84(2):218-226.
    • (2009) Cardiovasc. Res. , vol.84 , Issue.2 , pp. 218-226
    • Garry, A.1
  • 52
    • 0030464496 scopus 로고    scopus 로고
    • Tetrahydrobiopterin-free neuronal nitric oxide synthase: evidence for two identical highly anticooperative pteridine binding sites
    • Gorren A.C., et al. Tetrahydrobiopterin-free neuronal nitric oxide synthase: evidence for two identical highly anticooperative pteridine binding sites. Biochemistry 1996, 35(51):16735-16745.
    • (1996) Biochemistry , vol.35 , Issue.51 , pp. 16735-16745
    • Gorren, A.C.1
  • 53
    • 0034718572 scopus 로고    scopus 로고
    • Low-temperature optical absorption spectra suggest a redox role for tetrahydrobiopterin in both steps of nitric oxide synthase catalysis
    • Gorren A.C., et al. Low-temperature optical absorption spectra suggest a redox role for tetrahydrobiopterin in both steps of nitric oxide synthase catalysis. Biochemistry 2000, 39(38):11763-11770.
    • (2000) Biochemistry , vol.39 , Issue.38 , pp. 11763-11770
    • Gorren, A.C.1
  • 54
    • 18744416561 scopus 로고    scopus 로고
    • 5-Methyltetrahydrofolate and tetrahydrobiopterin can modulate electrotonically mediated endothelium-dependent vascular relaxation
    • Griffith T.M., et al. 5-Methyltetrahydrofolate and tetrahydrobiopterin can modulate electrotonically mediated endothelium-dependent vascular relaxation. Proc. Natl. Acad. Sci. U. S. A. 2005, 102(19):7008-7013.
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , Issue.19 , pp. 7008-7013
    • Griffith, T.M.1
  • 55
    • 0027251094 scopus 로고
    • Feedback regulation mechanisms for the control of GTP cyclohydrolase I activity
    • Harada T., Kagamiyama H., Hatakeyama K. Feedback regulation mechanisms for the control of GTP cyclohydrolase I activity. Science 1993, 260(5113):1507-1510.
    • (1993) Science , vol.260 , Issue.5113 , pp. 1507-1510
    • Harada, T.1    Kagamiyama, H.2    Hatakeyama, K.3
  • 56
    • 0029759279 scopus 로고    scopus 로고
    • Tetrahydrobiopterin and GTP cyclohydrolase I in a rat model of endotoxic shock: relation to nitric oxide synthesis
    • Hattori Y., et al. Tetrahydrobiopterin and GTP cyclohydrolase I in a rat model of endotoxic shock: relation to nitric oxide synthesis. Exp. Physiol. 1996, 81(4):665-671.
    • (1996) Exp. Physiol. , vol.81 , Issue.4 , pp. 665-671
    • Hattori, Y.1
  • 57
    • 0345532411 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitor increases GTP cyclohydrolase I mRNA and tetrahydrobiopterin in vascular endothelial cells
    • Hattori Y., et al. HMG-CoA reductase inhibitor increases GTP cyclohydrolase I mRNA and tetrahydrobiopterin in vascular endothelial cells. Arterioscler. Thromb. Vasc. Biol. 2003, 23(2):176-182.
    • (2003) Arterioscler. Thromb. Vasc. Biol. , vol.23 , Issue.2 , pp. 176-182
    • Hattori, Y.1
  • 58
    • 34247220499 scopus 로고    scopus 로고
    • Oral administration of tetrahydrobiopterin slows the progression of atherosclerosis in apolipoprotein E-knockout mice
    • Hattori Y., et al. Oral administration of tetrahydrobiopterin slows the progression of atherosclerosis in apolipoprotein E-knockout mice. Arterioscler. Thromb. Vasc. Biol. 2007, 27(4):865-870.
    • (2007) Arterioscler. Thromb. Vasc. Biol. , vol.27 , Issue.4 , pp. 865-870
    • Hattori, Y.1
  • 60
    • 0033752910 scopus 로고    scopus 로고
    • Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with type II diabetes mellitus
    • Heitzer T., et al. Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with type II diabetes mellitus. Diabetologia 2000, 43(11):1435-1438.
    • (2000) Diabetologia , vol.43 , Issue.11 , pp. 1435-1438
    • Heitzer, T.1
  • 61
    • 0034602878 scopus 로고    scopus 로고
    • Tetrahydrobiopterin improves endothelium-dependent vasodilation in chronic smokers: evidence for a dysfunctional nitric oxide synthase
    • Heitzer T., et al. Tetrahydrobiopterin improves endothelium-dependent vasodilation in chronic smokers: evidence for a dysfunctional nitric oxide synthase. Circ. Res. 2000, 86(2):E36-E41.
    • (2000) Circ. Res. , vol.86 , Issue.2
    • Heitzer, T.1
  • 62
    • 0032555598 scopus 로고    scopus 로고
    • Phosphorylation of GTP cyclohydrolase I and modulation of its activity in rodent mast cells. GTP cyclohydrolase I hyperphosphorylation is coupled to high affinity IgE receptor signaling and involves protein kinase C
    • Hesslinger C., et al. Phosphorylation of GTP cyclohydrolase I and modulation of its activity in rodent mast cells. GTP cyclohydrolase I hyperphosphorylation is coupled to high affinity IgE receptor signaling and involves protein kinase C. J. Biol. Chem. 1998, 273(34):21616-21622.
    • (1998) J. Biol. Chem. , vol.273 , Issue.34 , pp. 21616-21622
    • Hesslinger, C.1
  • 63
    • 0036100972 scopus 로고    scopus 로고
    • Tetrahydrobiopterin enhances forearm vascular response to acetylcholine in both normotensive and hypertensive individuals
    • Higashi Y., et al. Tetrahydrobiopterin enhances forearm vascular response to acetylcholine in both normotensive and hypertensive individuals. Am. J. Hypertens. 2002, 15(4 Pt. 1):326-332.
    • (2002) Am. J. Hypertens. , vol.15 , Issue.4 PART. 1 , pp. 326-332
    • Higashi, Y.1
  • 64
    • 33646402907 scopus 로고    scopus 로고
    • Tetrahydrobiopterin improves aging-related impairment of endothelium-dependent vasodilation through increase in nitric oxide production
    • Higashi Y., et al. Tetrahydrobiopterin improves aging-related impairment of endothelium-dependent vasodilation through increase in nitric oxide production. Atherosclerosis 2006, 186(2):390-395.
    • (2006) Atherosclerosis , vol.186 , Issue.2 , pp. 390-395
    • Higashi, Y.1
  • 65
    • 79953306244 scopus 로고    scopus 로고
    • The N-terminal peptide of mammalian GTP cyclohydrolase I is an autoinhibitory control element and contributes to binding the allosteric regulatory protein GFRP
    • Higgins C.E., Gross S.S. The N-terminal peptide of mammalian GTP cyclohydrolase I is an autoinhibitory control element and contributes to binding the allosteric regulatory protein GFRP. J. Biol. Chem. 2011, 286(14):11919-11928.
    • (2011) J. Biol. Chem. , vol.286 , Issue.14 , pp. 11919-11928
    • Higgins, C.E.1    Gross, S.S.2
  • 66
    • 1642545080 scopus 로고    scopus 로고
    • Vitamin C improves attenuated angiotensin II-induced endothelium-dependent vasodilation in human forearm vessels
    • Hirooka Y., et al. Vitamin C improves attenuated angiotensin II-induced endothelium-dependent vasodilation in human forearm vessels. Hypertens. Res. 2003, 26(12):953-959.
    • (2003) Hypertens. Res. , vol.26 , Issue.12 , pp. 953-959
    • Hirooka, Y.1
  • 67
    • 0035726142 scopus 로고    scopus 로고
    • Supplementation with tetrahydrobiopterin suppresses the development of hypertension in spontaneously hypertensive rats
    • Hong H.J., et al. Supplementation with tetrahydrobiopterin suppresses the development of hypertension in spontaneously hypertensive rats. Hypertension 2001, 38(5):1044-1048.
    • (2001) Hypertension , vol.38 , Issue.5 , pp. 1044-1048
    • Hong, H.J.1
  • 68
    • 0035136699 scopus 로고    scopus 로고
    • Increased plasma tetrahydrobiopterin in septic shock is a possible therapeutic target
    • Hoshiai K., et al. Increased plasma tetrahydrobiopterin in septic shock is a possible therapeutic target. Pathophysiol. 2001, 7(4):275-281.
    • (2001) Pathophysiol. , vol.7 , Issue.4 , pp. 275-281
    • Hoshiai, K.1
  • 69
    • 0034625391 scopus 로고    scopus 로고
    • Ascorbic acid enhances endothelial nitric-oxide synthase activity by increasing intracellular tetrahydrobiopterin
    • Huang A., et al. Ascorbic acid enhances endothelial nitric-oxide synthase activity by increasing intracellular tetrahydrobiopterin. J. Biol. Chem. 2000, 275(23):17399-17406.
    • (2000) J. Biol. Chem. , vol.275 , Issue.23 , pp. 17399-17406
    • Huang, A.1
  • 70
    • 0028151448 scopus 로고
    • Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene
    • Ichinose H., et al. Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene. Nat. Genet. 1994, 8(3):236-242.
    • (1994) Nat. Genet. , vol.8 , Issue.3 , pp. 236-242
    • Ichinose, H.1
  • 71
    • 0028670842 scopus 로고
    • Identification of a rabphilin-3A-interacting protein as GTP cyclohydrolase I in PC12 cells
    • Imazumi K., et al. Identification of a rabphilin-3A-interacting protein as GTP cyclohydrolase I in PC12 cells. Biochem. Biophys. Res. Commun. 1994, 205(2):1409-1416.
    • (1994) Biochem. Biophys. Res. Commun. , vol.205 , Issue.2 , pp. 1409-1416
    • Imazumi, K.1
  • 72
    • 0035129395 scopus 로고    scopus 로고
    • Stimulation of tetrahydrobiopterin synthesis induced by insulin: possible involvement of phosphatidylinositol 3-kinase
    • Ishii M., et al. Stimulation of tetrahydrobiopterin synthesis induced by insulin: possible involvement of phosphatidylinositol 3-kinase. Int. J. Biochem. Cell Biol. 2001, 33(1):65-73.
    • (2001) Int. J. Biochem. Cell Biol. , vol.33 , Issue.1 , pp. 65-73
    • Ishii, M.1
  • 73
    • 84860538154 scopus 로고    scopus 로고
    • Structural biology and drug discovery for protein-protein interactions
    • Jubb, H., et al., Structural biology and drug discovery for protein-protein interactions. Trends Pharmacol Sci. 33(5): p. 241-8.
    • Trends Pharmacol Sci. , vol.33 , Issue.5 , pp. 241-248
    • Jubb, H.1
  • 74
    • 21644454946 scopus 로고    scopus 로고
    • Supplementation with tetrahydrobiopterin prevents the cardiovascular effects of angiotensin II-induced oxidative and nitrosative stress
    • Kase H., et al. Supplementation with tetrahydrobiopterin prevents the cardiovascular effects of angiotensin II-induced oxidative and nitrosative stress. J. Hypertens. 2005, 23(7):1375-1382.
    • (2005) J. Hypertens. , vol.23 , Issue.7 , pp. 1375-1382
    • Kase, H.1
  • 75
    • 0031984389 scopus 로고    scopus 로고
    • Cytokines stimulate GTP cyclohydrolase I gene expression in cultured human umbilical vein endothelial cells
    • Katusic Z.S., Stelter A., Milstien S. Cytokines stimulate GTP cyclohydrolase I gene expression in cultured human umbilical vein endothelial cells. Arterioscler. Thromb. Vasc. Biol. 1998, 18(1):27-32.
    • (1998) Arterioscler. Thromb. Vasc. Biol. , vol.18 , Issue.1 , pp. 27-32
    • Katusic, Z.S.1    Stelter, A.2    Milstien, S.3
  • 76
    • 58149138838 scopus 로고    scopus 로고
    • Vascular protection by tetrahydrobiopterin: progress and therapeutic prospects
    • Katusic Z.S., d'Uscio L.V., Nath K.A. Vascular protection by tetrahydrobiopterin: progress and therapeutic prospects. Trends Pharmacol. Sci. 2009, 30(1):48-54.
    • (2009) Trends Pharmacol. Sci. , vol.30 , Issue.1 , pp. 48-54
    • Katusic, Z.S.1    d'Uscio, L.V.2    Nath, K.A.3
  • 77
    • 78651125086 scopus 로고
    • The structure of the phenylalanine-hydroxylation cofactor
    • Kaufman S. The structure of the phenylalanine-hydroxylation cofactor. Proc. Natl. Acad. Sci. U. S. A. 1963, 50:1085-1093.
    • (1963) Proc. Natl. Acad. Sci. U. S. A. , vol.50 , pp. 1085-1093
    • Kaufman, S.1
  • 78
    • 0018170113 scopus 로고
    • Hyperphenylalaninemia due to a deficiency of biopterin. A variant form of phenylketonuria
    • Kaufman S., et al. Hyperphenylalaninemia due to a deficiency of biopterin. A variant form of phenylketonuria. N. Engl. J. Med. 1978, 299(13):673-679.
    • (1978) N. Engl. J. Med. , vol.299 , Issue.13 , pp. 673-679
    • Kaufman, S.1
  • 79
    • 17744386526 scopus 로고    scopus 로고
    • Pivotal role for endothelial tetrahydrobiopterin in pulmonary hypertension
    • Khoo J.P., et al. Pivotal role for endothelial tetrahydrobiopterin in pulmonary hypertension. Circulation 2005, 111(16):2126-2133.
    • (2005) Circulation , vol.111 , Issue.16 , pp. 2126-2133
    • Khoo, J.P.1
  • 80
    • 0028140141 scopus 로고
    • Inhibitors of brain nitric oxide synthase. Binding kinetics, metabolism, and enzyme inactivation
    • Klatt P., et al. Inhibitors of brain nitric oxide synthase. Binding kinetics, metabolism, and enzyme inactivation. J. Biol. Chem. 1994, 269(3):1674-1680.
    • (1994) J. Biol. Chem. , vol.269 , Issue.3 , pp. 1674-1680
    • Klatt, P.1
  • 81
    • 0029125762 scopus 로고
    • Structural analysis of porcine brain nitric oxide synthase reveals a role for tetrahydrobiopterin and l-arginine in the formation of an SDS-resistant dimer
    • Klatt P., et al. Structural analysis of porcine brain nitric oxide synthase reveals a role for tetrahydrobiopterin and l-arginine in the formation of an SDS-resistant dimer. EMBO J. 1995, 14(15):3687-3695.
    • (1995) EMBO J. , vol.14 , Issue.15 , pp. 3687-3695
    • Klatt, P.1
  • 82
    • 0029081021 scopus 로고
    • Inhibition by N-acetyl-5-hydroxytryptamine of nitric oxide synthase expression in cultured cells and in the anaesthetized rat
    • Klemm P., et al. Inhibition by N-acetyl-5-hydroxytryptamine of nitric oxide synthase expression in cultured cells and in the anaesthetized rat. Br. J. Pharmacol. 1995, 115(7):1175-1181.
    • (1995) Br. J. Pharmacol. , vol.115 , Issue.7 , pp. 1175-1181
    • Klemm, P.1
  • 83
    • 4644347701 scopus 로고    scopus 로고
    • The mechanism of potent GTP cyclohydrolase I inhibition by 2,4-diamino-6-hydroxypyrimidine: requirement of the GTP cyclohydrolase I feedback regulatory protein
    • Kolinsky M.A., Gross S.S. The mechanism of potent GTP cyclohydrolase I inhibition by 2,4-diamino-6-hydroxypyrimidine: requirement of the GTP cyclohydrolase I feedback regulatory protein. J. Biol. Chem. 2004, 279(39):40677-40682.
    • (2004) J. Biol. Chem. , vol.279 , Issue.39 , pp. 40677-40682
    • Kolinsky, M.A.1    Gross, S.S.2
  • 84
    • 68449087481 scopus 로고    scopus 로고
    • Long-term use of short- and long-acting nitrates in stable angina pectoris
    • Kosmicki M.A. Long-term use of short- and long-acting nitrates in stable angina pectoris. Curr. Clin. Pharmacol. 2009, 4(2):132-141.
    • (2009) Curr. Clin. Pharmacol. , vol.4 , Issue.2 , pp. 132-141
    • Kosmicki, M.A.1
  • 85
    • 0034098164 scopus 로고    scopus 로고
    • Functional interactions between GTP cyclohydrolase I and tyrosine hydroxylase in Drosophila
    • Krishnakumar S., et al. Functional interactions between GTP cyclohydrolase I and tyrosine hydroxylase in Drosophila. J. Neurogenet. 2000, 14(1):1-23.
    • (2000) J. Neurogenet. , vol.14 , Issue.1 , pp. 1-23
    • Krishnakumar, S.1
  • 86
    • 0025731835 scopus 로고
    • Nitric oxide: an endogenous modulator of leukocyte adhesion
    • Kubes P., Suzuki M., Granger D.N. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc. Natl. Acad. Sci. U. S. A. 1991, 88(11):4651-4655.
    • (1991) Proc. Natl. Acad. Sci. U. S. A. , vol.88 , Issue.11 , pp. 4651-4655
    • Kubes, P.1    Suzuki, M.2    Granger, D.N.3
  • 87
    • 78649735545 scopus 로고    scopus 로고
    • Tetrahydrobiopterin analogues with NO-dependent pulmonary vasodilator properties
    • Kunuthur S.P., et al. Tetrahydrobiopterin analogues with NO-dependent pulmonary vasodilator properties. Eur. J. Pharmacol. 2011, 650(1):371-377.
    • (2011) Eur. J. Pharmacol. , vol.650 , Issue.1 , pp. 371-377
    • Kunuthur, S.P.1
  • 88
    • 0038604446 scopus 로고    scopus 로고
    • Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase
    • Kuzkaya N., et al. Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase. J. Biol. Chem. 2003, 278(25):22546-22554.
    • (2003) J. Biol. Chem. , vol.278 , Issue.25 , pp. 22546-22554
    • Kuzkaya, N.1
  • 89
    • 0024351625 scopus 로고
    • Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages
    • Kwon N.S., Nathan C.F., Stuehr D.J. Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages. J. Biol. Chem. 1989, 264(34):20496-20501.
    • (1989) J. Biol. Chem. , vol.264 , Issue.34 , pp. 20496-20501
    • Kwon, N.S.1    Nathan, C.F.2    Stuehr, D.J.3
  • 90
    • 0345310078 scopus 로고    scopus 로고
    • Protein kinase C phosphorylates and activates GTP cyclohydrolase I in rat renal mesangial cells
    • Lapize C., et al. Protein kinase C phosphorylates and activates GTP cyclohydrolase I in rat renal mesangial cells. Biochem. Biophys. Res. Commun. 1998, 251(3):802-805.
    • (1998) Biochem. Biophys. Res. Commun. , vol.251 , Issue.3 , pp. 802-805
    • Lapize, C.1
  • 91
    • 0035814951 scopus 로고    scopus 로고
    • Endothelial regulation of vasomotion in ApoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin
    • Laursen J.B., et al. Endothelial regulation of vasomotion in ApoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin. Circulation 2001, 103(9):1282-1288.
    • (2001) Circulation , vol.103 , Issue.9 , pp. 1282-1288
    • Laursen, J.B.1
  • 92
    • 0029951898 scopus 로고    scopus 로고
    • Life-threatening effects of discontinuing inhaled nitric oxide in severe respiratory failure
    • Lavoie A., et al. Life-threatening effects of discontinuing inhaled nitric oxide in severe respiratory failure. Am. J. Respir. Crit. Care Med. 1996, 153(6 Pt. 1):1985-1987.
    • (1996) Am. J. Respir. Crit. Care Med. , vol.153 , Issue.6 PART. 1 , pp. 1985-1987
    • Lavoie, A.1
  • 93
    • 0017180252 scopus 로고
    • Biopterin derivatives in normal and phenylketonuric patients after oral loads of l-phenylalanine, l-tyrosine, and l-tryptophan
    • Leeming R.J., et al. Biopterin derivatives in normal and phenylketonuric patients after oral loads of l-phenylalanine, l-tyrosine, and l-tryptophan. Arch. Dis. Child. 1976, 51(10):771-777.
    • (1976) Arch. Dis. Child. , vol.51 , Issue.10 , pp. 771-777
    • Leeming, R.J.1
  • 94
    • 79953296231 scopus 로고    scopus 로고
    • The therapeutic potential of targeting endogenous inhibitors of nitric oxide synthesis
    • Leiper J., Nandi M. The therapeutic potential of targeting endogenous inhibitors of nitric oxide synthesis. Nat. Rev. Drug Discov. 2011, 10(4):277-291.
    • (2011) Nat. Rev. Drug Discov. , vol.10 , Issue.4 , pp. 277-291
    • Leiper, J.1    Nandi, M.2
  • 95
    • 33847005404 scopus 로고    scopus 로고
    • Disruption of methylarginine metabolism impairs vascular homeostasis
    • Leiper J., et al. Disruption of methylarginine metabolism impairs vascular homeostasis. Nat. Med. 2007, 13(2):198-203.
    • (2007) Nat. Med. , vol.13 , Issue.2 , pp. 198-203
    • Leiper, J.1
  • 96
    • 0032474451 scopus 로고    scopus 로고
    • Long-term l-arginine supplementation improves small-vessel coronary endothelial function in humans
    • Lerman A., et al. Long-term l-arginine supplementation improves small-vessel coronary endothelial function in humans. Circulation 1998, 97(21):2123-2128.
    • (1998) Circulation , vol.97 , Issue.21 , pp. 2123-2128
    • Lerman, A.1
  • 97
    • 0036851140 scopus 로고    scopus 로고
    • Effect of 2,4-diamino-6-hydroxy-pyrimidine on postburn Staphylococcus aureus sepsis in rats
    • Li H.Y., et al. Effect of 2,4-diamino-6-hydroxy-pyrimidine on postburn Staphylococcus aureus sepsis in rats. Crit. Care Med. 2002, 30(11):2520-2527.
    • (2002) Crit. Care Med. , vol.30 , Issue.11 , pp. 2520-2527
    • Li, H.Y.1
  • 98
    • 80054757190 scopus 로고    scopus 로고
    • A novel high-throughput screening assay for discovery of molecules that increase cellular tetrahydrobiopterin
    • Li L., et al. A novel high-throughput screening assay for discovery of molecules that increase cellular tetrahydrobiopterin. J. Biomol. Screen. 2011, 16(8):836-844.
    • (2011) J. Biomol. Screen. , vol.16 , Issue.8 , pp. 836-844
    • Li, L.1
  • 99
    • 76349105015 scopus 로고    scopus 로고
    • GTP cyclohydrolase I phosphorylation and interaction with GTP cyclohydrolase feedback regulatory protein provide novel regulation of endothelial tetrahydrobiopterin and nitric oxide
    • Li, L., et al., GTP cyclohydrolase I phosphorylation and interaction with GTP cyclohydrolase feedback regulatory protein provide novel regulation of endothelial tetrahydrobiopterin and nitric oxide. Circ Res. 106(2): p. 328-36.
    • Circ Res. , vol.106 , Issue.2 , pp. 328-336
    • Li, L.1
  • 100
    • 35548947086 scopus 로고    scopus 로고
    • Endothelium-targeted transgenic GTP-cyclohydrolase I overexpression inhibits neointima formation in mouse carotid artery
    • Liao S.J., et al. Endothelium-targeted transgenic GTP-cyclohydrolase I overexpression inhibits neointima formation in mouse carotid artery. Clin. Exp. Pharmacol. Physiol. 2007, 34(12):1260-1266.
    • (2007) Clin. Exp. Pharmacol. Physiol. , vol.34 , Issue.12 , pp. 1260-1266
    • Liao, S.J.1
  • 101
    • 77956210907 scopus 로고    scopus 로고
    • Association of a functional polymorphism (C59038T) in GTP cyclohydrolase 1 gene and type 2 diabetic macrovascular disease in the Chinese population
    • Liao Y.F., et al. Association of a functional polymorphism (C59038T) in GTP cyclohydrolase 1 gene and type 2 diabetic macrovascular disease in the Chinese population. J. Diabetes Complications 2010, 24(5):313-319.
    • (2010) J. Diabetes Complications , vol.24 , Issue.5 , pp. 313-319
    • Liao, Y.F.1
  • 102
    • 67349085037 scopus 로고    scopus 로고
    • Disorders of biopterin metabolism
    • Longo N. Disorders of biopterin metabolism. J. Inherit. Metab. Dis. 2009, 32(3):333-342.
    • (2009) J. Inherit. Metab. Dis. , vol.32 , Issue.3 , pp. 333-342
    • Longo, N.1
  • 103
    • 4444273012 scopus 로고    scopus 로고
    • Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock
    • Lopez A., et al. Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock. Crit. Care Med. 2004, 32(1):21-30.
    • (2004) Crit. Care Med. , vol.32 , Issue.1 , pp. 21-30
    • Lopez, A.1
  • 104
    • 0029055481 scopus 로고
    • Endothelial injury, vasoconstriction, and its prevention
    • Loscalzo J. Endothelial injury, vasoconstriction, and its prevention. Tex. Heart Inst. J. 1995, 22(2):180-184.
    • (1995) Tex. Heart Inst. J. , vol.22 , Issue.2 , pp. 180-184
    • Loscalzo, J.1
  • 105
    • 0033967254 scopus 로고    scopus 로고
    • Tetrahydrobiopterin improves endothelial function in patients with coronary artery disease
    • Maier W., et al. Tetrahydrobiopterin improves endothelial function in patients with coronary artery disease. J. Cardiovasc. Pharmacol. 2000, 35(2):173-178.
    • (2000) J. Cardiovasc. Pharmacol. , vol.35 , Issue.2 , pp. 173-178
    • Maier, W.1
  • 106
    • 0037022228 scopus 로고    scopus 로고
    • Crystal structure of the stimulatory complex of GTP cyclohydrolase I and its feedback regulatory protein GFRP
    • Maita N., et al. Crystal structure of the stimulatory complex of GTP cyclohydrolase I and its feedback regulatory protein GFRP. Proc. Natl. Acad. Sci. U. S. A. 2002, 99(3):1212-1217.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , Issue.3 , pp. 1212-1217
    • Maita, N.1
  • 107
    • 10944238494 scopus 로고    scopus 로고
    • Structural basis of biopterin-induced inhibition of GTP cyclohydrolase I by GFRP, its feedback regulatory protein
    • Maita N., et al. Structural basis of biopterin-induced inhibition of GTP cyclohydrolase I by GFRP, its feedback regulatory protein. J. Biol. Chem. 2004, 279(49):51534-51540.
    • (2004) J. Biol. Chem. , vol.279 , Issue.49 , pp. 51534-51540
    • Maita, N.1
  • 108
    • 0025049872 scopus 로고
    • Endothelium-derived relaxing factors. A perspective from in vivo data
    • Marshall J.J., Kontos H.A. Endothelium-derived relaxing factors. A perspective from in vivo data. Hypertension 1990, 16(4):371-386.
    • (1990) Hypertension , vol.16 , Issue.4 , pp. 371-386
    • Marshall, J.J.1    Kontos, H.A.2
  • 109
    • 34249282381 scopus 로고    scopus 로고
    • (6R)-5,6,7,8-tetrahydro-l-biopterin and its stereoisomer prevent ischemia reperfusion injury in human forearm
    • Mayahi L., et al. (6R)-5,6,7,8-tetrahydro-l-biopterin and its stereoisomer prevent ischemia reperfusion injury in human forearm. Arterioscler. Thromb. Vasc. Biol. 2007, 27(6):1334-1339.
    • (2007) Arterioscler. Thromb. Vasc. Biol. , vol.27 , Issue.6 , pp. 1334-1339
    • Mayahi, L.1
  • 110
    • 0023838889 scopus 로고
    • Hyperphenylalaninemia in the hph-1 mouse mutant
    • McDonald J.D., Bode V.C. Hyperphenylalaninemia in the hph-1 mouse mutant. Pediatr. Res. 1988, 23(1):63-67.
    • (1988) Pediatr. Res. , vol.23 , Issue.1 , pp. 63-67
    • McDonald, J.D.1    Bode, V.C.2
  • 111
    • 10044245949 scopus 로고    scopus 로고
    • GTP cyclohydrolase I gene transfer reverses tetrahydrobiopterin deficiency and increases nitric oxide synthesis in endothelial cells and isolated vessels from diabetic rats
    • Meininger C.J., et al. GTP cyclohydrolase I gene transfer reverses tetrahydrobiopterin deficiency and increases nitric oxide synthesis in endothelial cells and isolated vessels from diabetic rats. FASEB J. 2004, 18(15):1900-1902.
    • (2004) FASEB J. , vol.18 , Issue.15 , pp. 1900-1902
    • Meininger, C.J.1
  • 112
    • 0021115961 scopus 로고
    • Tetrahydro-sepiapterin is an intermediate in tetrahydrobiopterin biosynthesis
    • Milstien S., Kaufman S. Tetrahydro-sepiapterin is an intermediate in tetrahydrobiopterin biosynthesis. Biochem. Biophys. Res. Commun. 1983, 115(3):888-893.
    • (1983) Biochem. Biophys. Res. Commun. , vol.115 , Issue.3 , pp. 888-893
    • Milstien, S.1    Kaufman, S.2
  • 113
    • 0142232019 scopus 로고    scopus 로고
    • GTP cyclohydrolase 1 inhibition attenuates vasodilation and increases blood pressure in rats
    • Mitchell B.M., Dorrance A.M., Webb R.C. GTP cyclohydrolase 1 inhibition attenuates vasodilation and increases blood pressure in rats. Am. J. Physiol. Heart Circ. Physiol. 2003, 285(5):H2165-H2170.
    • (2003) Am. J. Physiol. Heart Circ. Physiol. , vol.285 , Issue.5
    • Mitchell, B.M.1    Dorrance, A.M.2    Webb, R.C.3
  • 114
    • 2542467793 scopus 로고    scopus 로고
    • Phenylalanine improves dilation and blood pressure in GTP cyclohydrolase inhibition-induced hypertensive rats
    • Mitchell B.M., Dorrance A.M., Webb R.C. Phenylalanine improves dilation and blood pressure in GTP cyclohydrolase inhibition-induced hypertensive rats. J. Cardiovasc. Pharmacol. 2004, 43(6):758-763.
    • (2004) J. Cardiovasc. Pharmacol. , vol.43 , Issue.6 , pp. 758-763
    • Mitchell, B.M.1    Dorrance, A.M.2    Webb, R.C.3
  • 115
    • 25444491942 scopus 로고    scopus 로고
    • Tetrahydrobiopterin corrects Escherichia coli endotoxin-induced endothelial dysfunction
    • Mittermayer F., et al. Tetrahydrobiopterin corrects Escherichia coli endotoxin-induced endothelial dysfunction. Am. J. Physiol. Heart Circ. Physiol. 2005, 289(4):H1752-H1757.
    • (2005) Am. J. Physiol. Heart Circ. Physiol. , vol.289 , Issue.4
    • Mittermayer, F.1
  • 116
    • 44949141630 scopus 로고    scopus 로고
    • Mechanisms and potential therapeutic targets for folic acid in cardiovascular disease
    • Moens A.L., et al. Mechanisms and potential therapeutic targets for folic acid in cardiovascular disease. Am. J. Physiol. Heart Circ. Physiol. 2008, 294(5):H1971-H1977.
    • (2008) Am. J. Physiol. Heart Circ. Physiol. , vol.294 , Issue.5
    • Moens, A.L.1
  • 117
    • 80052807512 scopus 로고    scopus 로고
    • Bi-modal dose-dependent cardiac response to tetrahydrobiopterin in pressure-overload induced hypertrophy and heart failure
    • Moens A.L., et al. Bi-modal dose-dependent cardiac response to tetrahydrobiopterin in pressure-overload induced hypertrophy and heart failure. J. Mol. Cell. Cardiol. 2011, 51(4):564-569.
    • (2011) J. Mol. Cell. Cardiol. , vol.51 , Issue.4 , pp. 564-569
    • Moens, A.L.1
  • 118
    • 79960803194 scopus 로고    scopus 로고
    • Targeting endothelial and myocardial dysfunction with tetrahydrobiopterin
    • Moens A.L., et al. Targeting endothelial and myocardial dysfunction with tetrahydrobiopterin. J. Mol. Cell. Cardiol. 2011, 51(4):559-563.
    • (2011) J. Mol. Cell. Cardiol. , vol.51 , Issue.4 , pp. 559-563
    • Moens, A.L.1
  • 119
    • 84859916983 scopus 로고    scopus 로고
    • Tetrahydrobiopterin improves endothelial function and decreases arterial stiffness in estrogen-deficient postmenopausal women
    • Moreau K.L., et al. Tetrahydrobiopterin improves endothelial function and decreases arterial stiffness in estrogen-deficient postmenopausal women. Am. J. Physiol. Heart Circ. Physiol. 2012, 302(5):H1211-H1218.
    • (2012) Am. J. Physiol. Heart Circ. Physiol. , vol.302 , Issue.5
    • Moreau, K.L.1
  • 120
    • 0037180758 scopus 로고    scopus 로고
    • Tetrahydrobiopterin as an alternative treatment for mild phenylketonuria
    • Muntau A.C., et al. Tetrahydrobiopterin as an alternative treatment for mild phenylketonuria. N. Engl. J. Med. 2002, 347(26):2122-2132.
    • (2002) N. Engl. J. Med. , vol.347 , Issue.26 , pp. 2122-2132
    • Muntau, A.C.1
  • 121
    • 0033557291 scopus 로고    scopus 로고
    • Macrophage microbicidal mechanisms in vivo: reactive nitrogen versus oxygen intermediates in the killing of intracellular visceral Leishmania donovani
    • Murray H.W., Nathan C.F. Macrophage microbicidal mechanisms in vivo: reactive nitrogen versus oxygen intermediates in the killing of intracellular visceral Leishmania donovani. J. Exp. Med. 1999, 189(4):741-746.
    • (1999) J. Exp. Med. , vol.189 , Issue.4 , pp. 741-746
    • Murray, H.W.1    Nathan, C.F.2
  • 122
    • 9044252959 scopus 로고
    • Tyrosine hydroxylase. The initial step in norepinephrine biosynthesis
    • Nagatsu T., Levitt M., Udenfriend S. Tyrosine hydroxylase. The initial step in norepinephrine biosynthesis. J. Biol. Chem. 1964, 239:2910-2917.
    • (1964) J. Biol. Chem. , vol.239 , pp. 2910-2917
    • Nagatsu, T.1    Levitt, M.2    Udenfriend, S.3
  • 123
    • 17744381754 scopus 로고    scopus 로고
    • Pulmonary hypertension in a GTP-cyclohydrolase 1-deficient mouse
    • Nandi M., et al. Pulmonary hypertension in a GTP-cyclohydrolase 1-deficient mouse. Circulation 2005, 111(16):2086-2090.
    • (2005) Circulation , vol.111 , Issue.16 , pp. 2086-2090
    • Nandi, M.1
  • 124
    • 33746557602 scopus 로고    scopus 로고
    • Developmental regulation of GTP-CH1 in the porcine lung and its relationship to pulmonary vascular relaxation
    • Nandi M., et al. Developmental regulation of GTP-CH1 in the porcine lung and its relationship to pulmonary vascular relaxation. Pediatr. Res. 2006, 59(6):767-772.
    • (2006) Pediatr. Res. , vol.59 , Issue.6 , pp. 767-772
    • Nandi, M.1
  • 125
    • 42649137529 scopus 로고    scopus 로고
    • Over-expression of GTP-cyclohydrolase 1 feedback regulatory protein attenuates LPS and cytokine-stimulated nitric oxide production
    • Nandi M., et al. Over-expression of GTP-cyclohydrolase 1 feedback regulatory protein attenuates LPS and cytokine-stimulated nitric oxide production. Vasc. Med. 2008, 13(1):29-36.
    • (2008) Vasc. Med. , vol.13 , Issue.1 , pp. 29-36
    • Nandi, M.1
  • 126
    • 74549212539 scopus 로고    scopus 로고
    • The tetrahydrobiopterin pathway and pain
    • Naylor, A.M., et al., The tetrahydrobiopterin pathway and pain. Curr. Opin. Investig. Drugs. 11(1) 19-30.
    • Curr. Opin. Investig. Drugs. , vol.11 , Issue.1 , pp. 19-30
    • Naylor, A.M.1
  • 127
    • 0033612841 scopus 로고    scopus 로고
    • Role of antioxidant vitamins in prevention of cardiovascular diseases. Meta-analysis seems to exclude benefit of vitamin C supplementation
    • Ness A., Egger M., Smith G.D. Role of antioxidant vitamins in prevention of cardiovascular diseases. Meta-analysis seems to exclude benefit of vitamin C supplementation. BMJ 1999, 319(7209):577.
    • (1999) BMJ , vol.319 , Issue.7209 , pp. 577
    • Ness, A.1    Egger, M.2    Smith, G.D.3
  • 128
    • 26044449033 scopus 로고    scopus 로고
    • Sepiapterin reductase deficiency: a congenital dopa-responsive motor and cognitive disorder
    • Neville B.G., et al. Sepiapterin reductase deficiency: a congenital dopa-responsive motor and cognitive disorder. Brain 2005, 128(Pt. 10):2291-2296.
    • (2005) Brain , vol.128 , Issue.PART. 10 , pp. 2291-2296
    • Neville, B.G.1
  • 129
    • 0021344054 scopus 로고
    • GTP cyclohydrolase I deficiency, a new enzyme defect causing hyperphenylalaninemia with neopterin, biopterin, dopamine, and serotonin deficiencies and muscular hypotonia
    • Niederwieser A., et al. GTP cyclohydrolase I deficiency, a new enzyme defect causing hyperphenylalaninemia with neopterin, biopterin, dopamine, and serotonin deficiencies and muscular hypotonia. Eur. J. Pediatr. 1984, 141(4):208-214.
    • (1984) Eur. J. Pediatr. , vol.141 , Issue.4 , pp. 208-214
    • Niederwieser, A.1
  • 130
    • 6044230924 scopus 로고    scopus 로고
    • Tetrahydrobiopterin increases insulin sensitivity in patients with type 2 diabetes and coronary heart disease
    • Nystrom T., Nygren A., Sjoholm A. Tetrahydrobiopterin increases insulin sensitivity in patients with type 2 diabetes and coronary heart disease. Am. J. Physiol. Endocrinol. Metab. 2004, 287(5):E919-E925.
    • (2004) Am. J. Physiol. Endocrinol. Metab. , vol.287 , Issue.5
    • Nystrom, T.1    Nygren, A.2    Sjoholm, A.3
  • 131
    • 78650857261 scopus 로고    scopus 로고
    • Membrane transport of sepiapterin and dihydrobiopterin by equilibrative nucleoside transporters: a plausible gateway for the salvage pathway of tetrahydrobiopterin biosynthesis
    • Ohashi A., et al. Membrane transport of sepiapterin and dihydrobiopterin by equilibrative nucleoside transporters: a plausible gateway for the salvage pathway of tetrahydrobiopterin biosynthesis. Mol. Genet. Metab. 2011, 102(1):18-28.
    • (2011) Mol. Genet. Metab. , vol.102 , Issue.1 , pp. 18-28
    • Ohashi, A.1
  • 132
    • 0023198721 scopus 로고
    • Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
    • Palmer R.M., Ferrige A.G., Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987, 327(6122):524-526.
    • (1987) Nature , vol.327 , Issue.6122 , pp. 524-526
    • Palmer, R.M.1    Ferrige, A.G.2    Moncada, S.3
  • 133
    • 0037163086 scopus 로고    scopus 로고
    • Distinct dimer interaction and regulation in nitric-oxide synthase types I, II, and III
    • Panda K., et al. Distinct dimer interaction and regulation in nitric-oxide synthase types I, II, and III. J. Biol. Chem. 2002, 277(34):31020-31030.
    • (2002) J. Biol. Chem. , vol.277 , Issue.34 , pp. 31020-31030
    • Panda, K.1
  • 134
    • 0031033321 scopus 로고    scopus 로고
    • Acute amelioration of diabetic endothelial dysfunction with a derivative of the nitric oxide synthase cofactor, tetrahydrobiopterin
    • Pieper G.M. Acute amelioration of diabetic endothelial dysfunction with a derivative of the nitric oxide synthase cofactor, tetrahydrobiopterin. J. Cardiovasc. Pharmacol. 1997, 29(1):8-15.
    • (1997) J. Cardiovasc. Pharmacol. , vol.29 , Issue.1 , pp. 8-15
    • Pieper, G.M.1
  • 135
    • 44049104413 scopus 로고    scopus 로고
    • Tetrahydrobiopterin: a novel antihypertensive therapy
    • Porkert M., et al. Tetrahydrobiopterin: a novel antihypertensive therapy. J. Hum. Hypertens. 2008, 22(6):401-407.
    • (2008) J. Hum. Hypertens. , vol.22 , Issue.6 , pp. 401-407
    • Porkert, M.1
  • 136
    • 0032488596 scopus 로고    scopus 로고
    • Comparative functioning of dihydro- and tetrahydropterins in supporting electron transfer, catalysis, and subunit dimerization in inducible nitric oxide synthase
    • Presta A., et al. Comparative functioning of dihydro- and tetrahydropterins in supporting electron transfer, catalysis, and subunit dimerization in inducible nitric oxide synthase. Biochemistry 1998, 37(1):298-310.
    • (1998) Biochemistry , vol.37 , Issue.1 , pp. 298-310
    • Presta, A.1
  • 137
    • 0037436338 scopus 로고    scopus 로고
    • Biosynthesis of pteridines. Reaction mechanism of GTP cyclohydrolase I
    • Rebelo J., et al. Biosynthesis of pteridines. Reaction mechanism of GTP cyclohydrolase I. J. Mol. Biol. 2003, 326(2):503-516.
    • (2003) J. Mol. Biol. , vol.326 , Issue.2 , pp. 503-516
    • Rebelo, J.1
  • 138
    • 79251493500 scopus 로고    scopus 로고
    • Safety of sapropterin dihydrochloride (6r-bh4) in patients with pulmonary hypertension
    • Robbins I.M., et al. Safety of sapropterin dihydrochloride (6r-bh4) in patients with pulmonary hypertension. Exp. Lung Res. 2011, 37(1):26-34.
    • (2011) Exp. Lung Res. , vol.37 , Issue.1 , pp. 26-34
    • Robbins, I.M.1
  • 139
    • 22244439271 scopus 로고    scopus 로고
    • Selective substrate-based inhibitors of mammalian dimethylarginine dimethylaminohydrolase
    • Rossiter S., et al. Selective substrate-based inhibitors of mammalian dimethylarginine dimethylaminohydrolase. J. Med. Chem. 2005, 48(14):4670-4678.
    • (2005) J. Med. Chem. , vol.48 , Issue.14 , pp. 4670-4678
    • Rossiter, S.1
  • 140
    • 8144220153 scopus 로고    scopus 로고
    • Phenylalanine loading as a diagnostic test for DRD: interpreting the utility of the test
    • Saunders-Pullman R., et al. Phenylalanine loading as a diagnostic test for DRD: interpreting the utility of the test. Mol. Genet. Metab. 2004, 83(3):207-212.
    • (2004) Mol. Genet. Metab. , vol.83 , Issue.3 , pp. 207-212
    • Saunders-Pullman, R.1
  • 141
    • 7944233098 scopus 로고    scopus 로고
    • Tetrahydrobiopterin uptake in supplemental administration: elevation of tissue tetrahydrobiopterin in mice following uptake of the exogenously oxidized product 7,8-dihydrobiopterin and subsequent reduction by an anti-folate-sensitive process
    • Sawabe K., Wakasugi K.O., Hasegawa H. Tetrahydrobiopterin uptake in supplemental administration: elevation of tissue tetrahydrobiopterin in mice following uptake of the exogenously oxidized product 7,8-dihydrobiopterin and subsequent reduction by an anti-folate-sensitive process. J. Pharmacol. Sci. 2004, 96(2):124-133.
    • (2004) J. Pharmacol. Sci. , vol.96 , Issue.2 , pp. 124-133
    • Sawabe, K.1    Wakasugi, K.O.2    Hasegawa, H.3
  • 142
    • 0033556220 scopus 로고    scopus 로고
    • Preferential inhibition of inducible nitric oxide synthase in intact cells by the 4-amino analogue of tetrahydrobiopterin
    • Schmidt K., et al. Preferential inhibition of inducible nitric oxide synthase in intact cells by the 4-amino analogue of tetrahydrobiopterin. Eur. J. Biochem. 1999, 259(1-2):25-31.
    • (1999) Eur. J. Biochem. , vol.259 , Issue.1-2 , pp. 25-31
    • Schmidt, K.1
  • 143
    • 0034852561 scopus 로고    scopus 로고
    • Formation of a protonated trihydrobiopterin radical cation in the first reaction cycle of neuronal and endothelial nitric oxide synthase detected by electron paramagnetic resonance spectroscopy
    • Schmidt P.P., et al. Formation of a protonated trihydrobiopterin radical cation in the first reaction cycle of neuronal and endothelial nitric oxide synthase detected by electron paramagnetic resonance spectroscopy. J. Biol. Inorg. Chem. 2001, 6(2):151-158.
    • (2001) J. Biol. Inorg. Chem. , vol.6 , Issue.2 , pp. 151-158
    • Schmidt, P.P.1
  • 144
    • 77954942970 scopus 로고    scopus 로고
    • Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice
    • Schmidt T.S., et al. Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice. Clin. Sci. (Lond.) 2010, 119(3):131-142.
    • (2010) Clin. Sci. (Lond.) , vol.119 , Issue.3 , pp. 131-142
    • Schmidt, T.S.1
  • 145
    • 0027424890 scopus 로고
    • Modulation of human endothelial cell tetrahydrobiopterin synthesis by activating and deactivating cytokines: new perspectives on endothelium-derived relaxing factor
    • Schoedon G., et al. Modulation of human endothelial cell tetrahydrobiopterin synthesis by activating and deactivating cytokines: new perspectives on endothelium-derived relaxing factor. Biochem. Biophys. Res. Commun. 1993, 196(3):1343-1348.
    • (1993) Biochem. Biophys. Res. Commun. , vol.196 , Issue.3 , pp. 1343-1348
    • Schoedon, G.1
  • 146
    • 0028231114 scopus 로고
    • Nitric oxide production depends on preceding tetrahydrobiopterin synthesis by endothelial cells: selective suppression of induced nitric oxide production by sepiapterin reductase inhibitors
    • Schoedon G., et al. Nitric oxide production depends on preceding tetrahydrobiopterin synthesis by endothelial cells: selective suppression of induced nitric oxide production by sepiapterin reductase inhibitors. Biochem. Biophys. Res. Commun. 1994, 199(2):504-510.
    • (1994) Biochem. Biophys. Res. Commun. , vol.199 , Issue.2 , pp. 504-510
    • Schoedon, G.1
  • 147
    • 0034890205 scopus 로고    scopus 로고
    • Tetrahydrobiopterin improves endothelial dysfunction in coronary microcirculation in patients without epicardial coronary artery disease
    • Setoguchi S., et al. Tetrahydrobiopterin improves endothelial dysfunction in coronary microcirculation in patients without epicardial coronary artery disease. J. Am. Coll. Cardiol. 2001, 38(2):493-498.
    • (2001) J. Am. Coll. Cardiol. , vol.38 , Issue.2 , pp. 493-498
    • Setoguchi, S.1
  • 148
    • 45149097380 scopus 로고    scopus 로고
    • Role of angiotensin II on dihydrofolate reductase, GTP-cyclohydrolase 1 and nitric oxide synthase expressions in renal ischemia-reperfusion
    • Seujange Y., Eiam-Ong S., Tirawatnapong T. Role of angiotensin II on dihydrofolate reductase, GTP-cyclohydrolase 1 and nitric oxide synthase expressions in renal ischemia-reperfusion. Am. J. Nephrol. 2008, 28(4):692-700.
    • (2008) Am. J. Nephrol. , vol.28 , Issue.4 , pp. 692-700
    • Seujange, Y.1    Eiam-Ong, S.2    Tirawatnapong, T.3
  • 149
    • 77952889385 scopus 로고    scopus 로고
    • Hydrogen peroxide as an endothelium-derived hyperpolarizing factor
    • Shimokawa H. Hydrogen peroxide as an endothelium-derived hyperpolarizing factor. Pflugers Arch. 2010, 459(6):915-922.
    • (2010) Pflugers Arch. , vol.459 , Issue.6 , pp. 915-922
    • Shimokawa, H.1
  • 150
    • 0034730795 scopus 로고    scopus 로고
    • Oral administration of tetrahydrobiopterin prevents endothelial dysfunction and vascular oxidative stress in the aortas of insulin-resistant rats
    • Shinozaki K., et al. Oral administration of tetrahydrobiopterin prevents endothelial dysfunction and vascular oxidative stress in the aortas of insulin-resistant rats. Circ. Res. 2000, 87(7):566-573.
    • (2000) Circ. Res. , vol.87 , Issue.7 , pp. 566-573
    • Shinozaki, K.1
  • 151
    • 0029793534 scopus 로고    scopus 로고
    • Glucocorticoids regulate inducible nitric oxide synthase by inhibiting tetrahydrobiopterin synthesis and l-arginine transport
    • Simmons W.W., et al. Glucocorticoids regulate inducible nitric oxide synthase by inhibiting tetrahydrobiopterin synthesis and l-arginine transport. J. Biol. Chem. 1996, 271(39):23928-23937.
    • (1996) J. Biol. Chem. , vol.271 , Issue.39 , pp. 23928-23937
    • Simmons, W.W.1
  • 152
    • 0014405108 scopus 로고
    • The effect of variation of cofactor and substrate structure on the action of phenylalanine hydroxylase
    • Storm C.B., Kaufman S. The effect of variation of cofactor and substrate structure on the action of phenylalanine hydroxylase. Biochem. Biophys. Res. Commun. 1968, 32(5):788-793.
    • (1968) Biochem. Biophys. Res. Commun. , vol.32 , Issue.5 , pp. 788-793
    • Storm, C.B.1    Kaufman, S.2
  • 153
    • 0031018510 scopus 로고    scopus 로고
    • Tetrahydrobiopterin restores endothelial function in hypercholesterolemia
    • Stroes E., et al. Tetrahydrobiopterin restores endothelial function in hypercholesterolemia. J. Clin. Invest. 1997, 99(1):41-46.
    • (1997) J. Clin. Invest. , vol.99 , Issue.1 , pp. 41-46
    • Stroes, E.1
  • 154
    • 0025892441 scopus 로고
    • N omega-hydroxy-l-arginine is an intermediate in the biosynthesis of nitric oxide from l-arginine
    • Stuehr D.J., et al. N omega-hydroxy-l-arginine is an intermediate in the biosynthesis of nitric oxide from l-arginine. J. Biol. Chem. 1991, 266(10):6259-6263.
    • (1991) J. Biol. Chem. , vol.266 , Issue.10 , pp. 6259-6263
    • Stuehr, D.J.1
  • 155
    • 39849111635 scopus 로고    scopus 로고
    • 6-Acetyl-7,7-dimethyl-5,6,7,8-tetrahydropterin is an activator of nitric oxide synthases
    • Suckling C.J., et al. 6-Acetyl-7,7-dimethyl-5,6,7,8-tetrahydropterin is an activator of nitric oxide synthases. Bioorg. Med. Chem. Lett. 2008, 18(5):1563-1566.
    • (2008) Bioorg. Med. Chem. Lett. , vol.18 , Issue.5 , pp. 1563-1566
    • Suckling, C.J.1
  • 156
    • 73249118905 scopus 로고    scopus 로고
    • Oral l-arginine supplementation in acute myocardial infarction therapy: a meta-analysis of randomized controlled trials
    • Sun T., et al. Oral l-arginine supplementation in acute myocardial infarction therapy: a meta-analysis of randomized controlled trials. Clin. Cardiol. 2009, 32(11):649-652.
    • (2009) Clin. Cardiol. , vol.32 , Issue.11 , pp. 649-652
    • Sun, T.1
  • 157
    • 84875369801 scopus 로고    scopus 로고
    • Estradiol increases GTP cyclohydrolase expression via the nitric oxide mediated activation of camp response element binding protein
    • Sun X., et al. Estradiol increases GTP cyclohydrolase expression via the nitric oxide mediated activation of camp response element binding protein. Endocrinology 2009.
    • (2009) Endocrinology
    • Sun, X.1
  • 158
    • 80051573596 scopus 로고    scopus 로고
    • C-terminus of heat shock protein 70-interacting protein-dependent GTP cyclohydrolase I degradation in lambs with increased pulmonary blood flow
    • Sun X., et al. C-terminus of heat shock protein 70-interacting protein-dependent GTP cyclohydrolase I degradation in lambs with increased pulmonary blood flow. Am. J. Respir. Cell Mol. Biol. 2011, 45(1):163-171.
    • (2011) Am. J. Respir. Cell Mol. Biol. , vol.45 , Issue.1 , pp. 163-171
    • Sun, X.1
  • 159
    • 33646572212 scopus 로고    scopus 로고
    • A yeast 2-hybrid analysis of human GTP cyclohydrolase I protein interactions
    • Swick L., Kapatos G. A yeast 2-hybrid analysis of human GTP cyclohydrolase I protein interactions. J. Neurochem. 2006, 97(5):1447-1455.
    • (2006) J. Neurochem. , vol.97 , Issue.5 , pp. 1447-1455
    • Swick, L.1    Kapatos, G.2
  • 160
    • 65649104427 scopus 로고    scopus 로고
    • Plasma tetrahydrobiopterin/dihydrobiopterin ratio: a possible marker of endothelial dysfunction
    • Takeda M., et al. Plasma tetrahydrobiopterin/dihydrobiopterin ratio: a possible marker of endothelial dysfunction. Circ. J. 2009, 73(5):955-962.
    • (2009) Circ. J. , vol.73 , Issue.5 , pp. 955-962
    • Takeda, M.1
  • 161
    • 67649405068 scopus 로고    scopus 로고
    • GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression
    • Tatham A.L., et al. GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression. J. Biol. Chem. 2009, 284(20):13660-13668.
    • (2009) J. Biol. Chem. , vol.284 , Issue.20 , pp. 13660-13668
    • Tatham, A.L.1
  • 162
    • 0024388901 scopus 로고
    • Macrophage oxidation of l-arginine to nitric oxide, nitrite, and nitrate. Tetrahydrobiopterin is required as a cofactor
    • Tayeh M.A., Marletta M.A. Macrophage oxidation of l-arginine to nitric oxide, nitrite, and nitrate. Tetrahydrobiopterin is required as a cofactor. J. Biol. Chem. 1989, 264(33):19654-19658.
    • (1989) J. Biol. Chem. , vol.264 , Issue.33 , pp. 19654-19658
    • Tayeh, M.A.1    Marletta, M.A.2
  • 163
    • 33750683974 scopus 로고    scopus 로고
    • GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence
    • Tegeder I., et al. GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. Nat. Med. 2006, 12(11):1269-1277.
    • (2006) Nat. Med. , vol.12 , Issue.11 , pp. 1269-1277
    • Tegeder, I.1
  • 164
    • 80052381931 scopus 로고    scopus 로고
    • Sepiapterin improves angiogenesis of pulmonary artery endothelial cells with in utero pulmonary hypertension by recoupling endothelial nitric oxide synthase
    • Teng R.J., et al. Sepiapterin improves angiogenesis of pulmonary artery endothelial cells with in utero pulmonary hypertension by recoupling endothelial nitric oxide synthase. Am. J. Physiol. Lung Cell. Mol. Physiol. 2011, 301(3):L334-L345.
    • (2011) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.301 , Issue.3
    • Teng, R.J.1
  • 165
    • 0034176921 scopus 로고    scopus 로고
    • Tetrahydrobiopterin biosynthesis, regeneration and functions
    • Thony B., Auerbach G., Blau N. Tetrahydrobiopterin biosynthesis, regeneration and functions. Biochem. J. 2000, 347(Pt. 1):1-16.
    • (2000) Biochem. J. , vol.347 , Issue.PART. 1 , pp. 1-16
    • Thony, B.1    Auerbach, G.2    Blau, N.3
  • 166
    • 0000456507 scopus 로고
    • A new pteridine-requiring enzyme system for the oxidation of glyceryl ethers
    • Tietz A., Lindberg M., Kennedy E.P. A new pteridine-requiring enzyme system for the oxidation of glyceryl ethers. J. Biol. Chem. 1964, 239:4081-4090.
    • (1964) J. Biol. Chem. , vol.239 , pp. 4081-4090
    • Tietz, A.1    Lindberg, M.2    Kennedy, E.P.3
  • 167
    • 25144481421 scopus 로고    scopus 로고
    • Effects of vitamin C on intracoronary l-arginine dependent coronary vasodilatation in patients with stable angina
    • Tousoulis D., et al. Effects of vitamin C on intracoronary l-arginine dependent coronary vasodilatation in patients with stable angina. Heart 2005, 91(10):1319-1323.
    • (2005) Heart , vol.91 , Issue.10 , pp. 1319-1323
    • Tousoulis, D.1
  • 168
    • 63449107693 scopus 로고    scopus 로고
    • Efficacy of sapropterin dihydrochloride in increasing phenylalanine tolerance in children with phenylketonuria: a phase III, randomized, double-blind, placebo-controlled study
    • Trefz F.K., et al. Efficacy of sapropterin dihydrochloride in increasing phenylalanine tolerance in children with phenylketonuria: a phase III, randomized, double-blind, placebo-controlled study. J. Pediatr. 2009, 154(5):700-707.
    • (2009) J. Pediatr. , vol.154 , Issue.5 , pp. 700-707
    • Trefz, F.K.1
  • 170
    • 0033985197 scopus 로고    scopus 로고
    • Tetrahydrobiopterin restores endothelial function in long-term smokers
    • Ueda S., et al. Tetrahydrobiopterin restores endothelial function in long-term smokers. J. Am. Coll. Cardiol. 2000, 35(1):71-75.
    • (2000) J. Am. Coll. Cardiol. , vol.35 , Issue.1 , pp. 71-75
    • Ueda, S.1
  • 171
    • 0035887885 scopus 로고    scopus 로고
    • Reaction of tetrahydrobiopterin with superoxide: EPR-kinetic analysis and characterization of the pteridine radical
    • Vasquez-Vivar J., et al. Reaction of tetrahydrobiopterin with superoxide: EPR-kinetic analysis and characterization of the pteridine radical. Free Radic. Biol. Med. 2001, 31(8):975-985.
    • (2001) Free Radic. Biol. Med. , vol.31 , Issue.8 , pp. 975-985
    • Vasquez-Vivar, J.1
  • 172
    • 0037086565 scopus 로고    scopus 로고
    • The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study
    • Vasquez-Vivar J., et al. The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study. Biochem. J. 2002, 362(Pt. 3):733-739.
    • (2002) Biochem. J. , vol.362 , Issue.PART. 3 , pp. 733-739
    • Vasquez-Vivar, J.1
  • 173
    • 0036790604 scopus 로고    scopus 로고
    • Altered tetrahydrobiopterin metabolism in atherosclerosis: implications for use of oxidized tetrahydrobiopterin analogues and thiol antioxidants
    • Vasquez-Vivar J., et al. Altered tetrahydrobiopterin metabolism in atherosclerosis: implications for use of oxidized tetrahydrobiopterin analogues and thiol antioxidants. Arterioscler. Thromb. Vasc. Biol. 2002, 22(10):1655-1661.
    • (2002) Arterioscler. Thromb. Vasc. Biol. , vol.22 , Issue.10 , pp. 1655-1661
    • Vasquez-Vivar, J.1
  • 174
    • 0031889756 scopus 로고    scopus 로고
    • Induction of tetrahydrobiopterin synthesis in human umbilical vein smooth muscle cells by inflammatory stimuli
    • Walter R., et al. Induction of tetrahydrobiopterin synthesis in human umbilical vein smooth muscle cells by inflammatory stimuli. Immunol. Lett. 1998, 60(1):13-17.
    • (1998) Immunol. Lett. , vol.60 , Issue.1 , pp. 13-17
    • Walter, R.1
  • 175
    • 52049114150 scopus 로고    scopus 로고
    • Acute inhibition of guanosine triphosphate cyclohydrolase 1 uncouples endothelial nitric oxide synthase and elevates blood pressure
    • Wang S., et al. Acute inhibition of guanosine triphosphate cyclohydrolase 1 uncouples endothelial nitric oxide synthase and elevates blood pressure. Hypertension 2008, 52(3):484-490.
    • (2008) Hypertension , vol.52 , Issue.3 , pp. 484-490
    • Wang, S.1
  • 176
    • 77956385426 scopus 로고    scopus 로고
    • Identification of the gene encoding alkylglycerol monooxygenase defines a third class of tetrahydrobiopterin-dependent enzymes
    • Watschinger K., et al. Identification of the gene encoding alkylglycerol monooxygenase defines a third class of tetrahydrobiopterin-dependent enzymes. Proc. Natl. Acad. Sci. U. S. A. 2010, 107(31):13672-13677.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , Issue.31 , pp. 13672-13677
    • Watschinger, K.1
  • 177
    • 9144268892 scopus 로고    scopus 로고
    • Cardiovascular effects of the nitric oxide synthase inhibitor NG-methyl-l-arginine hydrochloride (546C88) in patients with septic shock: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002)
    • Watson D., et al. Cardiovascular effects of the nitric oxide synthase inhibitor NG-methyl-l-arginine hydrochloride (546C88) in patients with septic shock: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002). Crit. Care Med. 2004, 32(1):13-20.
    • (2004) Crit. Care Med. , vol.32 , Issue.1 , pp. 13-20
    • Watson, D.1
  • 178
    • 0345306661 scopus 로고    scopus 로고
    • A tetrahydrobiopterin radical forms and then becomes reduced during Nomega-hydroxyarginine oxidation by nitric-oxide synthase
    • Wei C.C., et al. A tetrahydrobiopterin radical forms and then becomes reduced during Nomega-hydroxyarginine oxidation by nitric-oxide synthase. J. Biol. Chem. 2003, 278(47):46668-46673.
    • (2003) J. Biol. Chem. , vol.278 , Issue.47 , pp. 46668-46673
    • Wei, C.C.1
  • 179
    • 0037465508 scopus 로고    scopus 로고
    • Structure of tetrahydrobiopterin tunes its electron transfer to the heme-dioxy intermediate in nitric oxide synthase
    • Wei C.C., et al. Structure of tetrahydrobiopterin tunes its electron transfer to the heme-dioxy intermediate in nitric oxide synthase. Biochemistry 2003, 42(7):1969-1977.
    • (2003) Biochemistry , vol.42 , Issue.7 , pp. 1969-1977
    • Wei, C.C.1
  • 180
    • 45549085992 scopus 로고    scopus 로고
    • Catalytic reduction of a tetrahydrobiopterin radical within nitric-oxide synthase
    • Wei C.C., et al. Catalytic reduction of a tetrahydrobiopterin radical within nitric-oxide synthase. J. Biol. Chem. 2008, 283(17):11734-11742.
    • (2008) J. Biol. Chem. , vol.283 , Issue.17 , pp. 11734-11742
    • Wei, C.C.1
  • 181
    • 37249004920 scopus 로고    scopus 로고
    • Reaching for high-hanging fruit in drug discovery at protein-protein interfaces
    • Wells J.A., McClendon C.L. Reaching for high-hanging fruit in drug discovery at protein-protein interfaces. Nature 2007, 450(7172):1001-1009.
    • (2007) Nature , vol.450 , Issue.7172 , pp. 1001-1009
    • Wells, J.A.1    McClendon, C.L.2
  • 182
    • 0036229130 scopus 로고    scopus 로고
    • Biopterin analogues: novel nitric oxide synthase inhibitors with immunosuppressive action
    • Werner E.R., Werner-Felmayer G. Biopterin analogues: novel nitric oxide synthase inhibitors with immunosuppressive action. Curr. Drug Metab. 2002, 3(2):119-121.
    • (2002) Curr. Drug Metab. , vol.3 , Issue.2 , pp. 119-121
    • Werner, E.R.1    Werner-Felmayer, G.2
  • 183
    • 0037155809 scopus 로고    scopus 로고
    • Bacterial lipopolysaccharide down-regulates expression of GTP cyclohydrolase I feedback regulatory protein
    • Werner E.R., et al. Bacterial lipopolysaccharide down-regulates expression of GTP cyclohydrolase I feedback regulatory protein. J. Biol. Chem. 2002, 277(12):10129-10133.
    • (2002) J. Biol. Chem. , vol.277 , Issue.12 , pp. 10129-10133
    • Werner, E.R.1
  • 184
    • 80051675515 scopus 로고    scopus 로고
    • Tetrahydrobiopterin: biochemistry and pathophysiology
    • Werner E.R., Blau N., Thony B. Tetrahydrobiopterin: biochemistry and pathophysiology. Biochem. J. 2011, 438(3):397-414.
    • (2011) Biochem. J. , vol.438 , Issue.3 , pp. 397-414
    • Werner, E.R.1    Blau, N.2    Thony, B.3
  • 185
    • 0027459585 scopus 로고
    • Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP
    • Werner-Felmayer G., et al. Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP. J. Biol. Chem. 1993, 268(3):1842-1846.
    • (1993) J. Biol. Chem. , vol.268 , Issue.3 , pp. 1842-1846
    • Werner-Felmayer, G.1
  • 186
    • 0036225777 scopus 로고    scopus 로고
    • Tetrahydrobiopterin biosynthesis, utilization and pharmacological effects
    • Werner-Felmayer G., Golderer G., Werner E.R. Tetrahydrobiopterin biosynthesis, utilization and pharmacological effects. Curr. Drug Metab. 2002, 3(2):159-173.
    • (2002) Curr. Drug Metab. , vol.3 , Issue.2 , pp. 159-173
    • Werner-Felmayer, G.1    Golderer, G.2    Werner, E.R.3
  • 187
    • 35448953430 scopus 로고    scopus 로고
    • Regulation of tetrahydrobiopterin biosynthesis by shear stress
    • Widder J.D., et al. Regulation of tetrahydrobiopterin biosynthesis by shear stress. Circ. Res. 2007, 101(8):830-838.
    • (2007) Circ. Res. , vol.101 , Issue.8 , pp. 830-838
    • Widder, J.D.1
  • 188
    • 34447334222 scopus 로고    scopus 로고
    • L-arginine supplementation in peripheral arterial disease: no benefit and possible harm
    • Wilson A.M., et al. l-arginine supplementation in peripheral arterial disease: no benefit and possible harm. Circulation 2007, 116(2):188-195.
    • (2007) Circulation , vol.116 , Issue.2 , pp. 188-195
    • Wilson, A.M.1
  • 189
    • 35548996241 scopus 로고    scopus 로고
    • Effects of tetrahydrobiopterin on coronary vascular reactivity in atherosclerotic human coronary arteries
    • Worthley M.I., et al. Effects of tetrahydrobiopterin on coronary vascular reactivity in atherosclerotic human coronary arteries. Cardiovasc. Res. 2007, 76(3):539-546.
    • (2007) Cardiovasc. Res. , vol.76 , Issue.3 , pp. 539-546
    • Worthley, M.I.1
  • 190
    • 12444293722 scopus 로고    scopus 로고
    • Tetrahydrobiopterin restores impaired coronary microvascular dysfunction in hypercholesterolaemia
    • Wyss C.A., et al. Tetrahydrobiopterin restores impaired coronary microvascular dysfunction in hypercholesterolaemia. Eur. J. Nucl. Med. Mol. Imaging 2005, 32(1):84-91.
    • (2005) Eur. J. Nucl. Med. Mol. Imaging , vol.32 , Issue.1 , pp. 84-91
    • Wyss, C.A.1
  • 191
    • 0028033734 scopus 로고
    • Regulation of rat liver phenylalanine hydroxylase. III. Control of catalysis by (6R)-tetrahydrobiopterin and phenylalanine
    • Xia T., Gray D.W., Shiman R. Regulation of rat liver phenylalanine hydroxylase. III. Control of catalysis by (6R)-tetrahydrobiopterin and phenylalanine. J. Biol. Chem. 1994, 269(40):24657-24665.
    • (1994) J. Biol. Chem. , vol.269 , Issue.40 , pp. 24657-24665
    • Xia, T.1    Gray, D.W.2    Shiman, R.3
  • 192
    • 0038408656 scopus 로고    scopus 로고
    • Role of tetrahydrobiopterin on ischemia-reperfusion injury in isolated perfused rat hearts
    • Yamashiro S., et al. Role of tetrahydrobiopterin on ischemia-reperfusion injury in isolated perfused rat hearts. J. Cardiovasc. Surg. (Torino) 2003, 44(1):37-49.
    • (2003) J. Cardiovasc. Surg. (Torino) , vol.44 , Issue.1 , pp. 37-49
    • Yamashiro, S.1
  • 193
    • 0032493726 scopus 로고    scopus 로고
    • Decameric GTP cyclohydrolase I forms complexes with two pentameric GTP cyclohydrolase I feedback regulatory proteins in the presence of phenylalanine or of a combination of tetrahydrobiopterin and GTP
    • Yoneyama T., Hatakeyama K. Decameric GTP cyclohydrolase I forms complexes with two pentameric GTP cyclohydrolase I feedback regulatory proteins in the presence of phenylalanine or of a combination of tetrahydrobiopterin and GTP. J. Biol. Chem. 1998, 273(32):20102-20108.
    • (1998) J. Biol. Chem. , vol.273 , Issue.32 , pp. 20102-20108
    • Yoneyama, T.1    Hatakeyama, K.2
  • 194
    • 0035082252 scopus 로고    scopus 로고
    • Ligand binding to the inhibitory and stimulatory GTP cyclohydrolase I/GTP cyclohydrolase I feedback regulatory protein complexes
    • Yoneyama T., Hatakeyama K. Ligand binding to the inhibitory and stimulatory GTP cyclohydrolase I/GTP cyclohydrolase I feedback regulatory protein complexes. Protein Sci. 2001, 10(4):871-878.
    • (2001) Protein Sci. , vol.10 , Issue.4 , pp. 871-878
    • Yoneyama, T.1    Hatakeyama, K.2
  • 195
    • 34848928700 scopus 로고    scopus 로고
    • Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk
    • Zhang L., et al. Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk. J. Clin. Invest. 2007, 117(9):2658-2671.
    • (2007) J. Clin. Invest. , vol.117 , Issue.9 , pp. 2658-2671
    • Zhang, L.1
  • 196
    • 0037237526 scopus 로고    scopus 로고
    • Phenylketonuria mutations in Europe
    • Zschocke J. Phenylketonuria mutations in Europe. Hum. Mutat. 2003, 21(4):345-356.
    • (2003) Hum. Mutat. , vol.21 , Issue.4 , pp. 345-356
    • Zschocke, J.1


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