Structure of tetrahydrobiopterin tunes its electron transfer to the heme-dioxy intermediate in nitric oxide synthase

Biochemistry

Volumn 42, Issue 7, 2003, Pages 1969-1977

  Wei, Chin Chuan ^a   Wang, Zhi Qiang ^a   Arvai, Andrew S ^b   Hemann, Craig ^c   Hille, Russ ^c   Getzoff, Elizabeth D ^b   Stuehr, Dennis J ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHARGE TRANSFER; CONFORMATIONS; CRYSTAL STRUCTURE; ELECTRONS; HYDROXYLATION; RATE CONSTANTS;

ELECTRON TRANSFER;

ENZYMES;

ARGININE; NITRIC OXIDE SYNTHASE; TETRAHYDROBIOPTERIN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CRYSTALLIZATION; ELECTRON SPIN RESONANCE; ELECTRON TRANSPORT; ENZYME STRUCTURE; HYDROXYLATION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RADICAL REACTION; REACTION ANALYSIS; STOICHIOMETRY; STRUCTURE ANALYSIS;

ANIMALS; ARGININE; BIOPTERIN; CATALYSIS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ELECTRON TRANSPORT; FREE RADICALS; HEME; ISOENZYMES; KINETICS; MICE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; OXIDATION-REDUCTION; OXYGEN; PROTEIN BINDING; PTERINS; SPECTROPHOTOMETRY, ULTRAVIOLET; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037465508     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi026898h     Document Type: Article

References (50)

1. Alderton, W. K., Cooper, C. E., and Knowles, R. G. (2001) Biochem. J. 357, 593-615.
2. Roman, L. J., Martásek, P., and Masters, B. S. (2002) Chem. Rev. 102, 1179-1190.
3. Stuehr, D. J., and Ghosh, S. (2000) in Handbook of Experimental Pharmacology (Mayer, B., Ed.), pp 33-70, Springer-Verlag, Berlin.
4. Boggs, S., Huang, L., and Stuehr, D. J. (2000) Biochemistry 39, 2332-2339.
5. Bec, N., Gorren, A. C., Voelker, C., Mayer, B., and Lange, R. (1998) J. Biol. Chem. 273, 13502-13508.
6. Hurshman, A. R., and Marletta, M. A. (2002) Biochemistry 41, 3439-3456.
7. Crane, B. R., Arvai, A. S., Ghosh, D. K., Wu, C., Getzoff, E. D., Stuehr, D. J., and Tainer, J. A. (1998) Science, 279, 2121-2126.
8. Raman, C. S., Li, H., Martasek, P., Kral, V., Masters, B. S., and Poulos, T. L. (1998) Cell 95, 939-950.
9. Fischmann, T. O., Hruza, A., Niu, X. D., Fossetta, J. D., Lunn, C. A., Dolphin, E., Prongay, A. J., Reichert, P., Lundell, D. J., Narula, S. K., and Weber, P. C. (1999) Nat. Struct. Biol. 6, 233-242.
10. Gachhui, R., Abu-Soud, H. M., Ghosha, D. K., Presta, A., Blazing, M. A., Mayer, B., George, S. E., and Stuehr, D. J. (1998) J. Biol. Chem. 273, 5451-5454.
11. Adak, S., Santolini, J., Tikunova, S., Wang, Q., Johnson, J. D., and Stuehr, D. J. (2001) J. Biol. Chem. 276, 1244-1252.
12. Miller, R. T., Martasek, P., Omura, T., and Siler Masters, B. S. (1999) Biochem. Biophys, Res. Commun. 265, 184-188.
13. Sato, H., Sagami, I., Daff, S., and Shimizu, T. (1998) Biochem. Biophys. Res. Commun. 53, 845-849.
14. Sono, M., Stuehr, D. J., Ikeda-Saito, M., and Dawson, J. H. (1995) J. Biol. Chem. 270, 19943-19948.
15. Gorren, A. C., Bec, N., Schrammel, A., Werner, E. R., Lange, R., and Mayer, B. (2000) Biochemistry 39, 11763-11708.
16. Couture, M., Stuehr, D. J., and Rousseau, D. L. (2000) J. Biol. Chem. 275, 3201-3205.
17. Adak, S., Wang, Q., and Stuehr, D. J. (2000) J. Biol. Chem. 275, 33554-33561.
18. Rusche, K. M., Spiering, M. M., and Marletta, M. A. (1998) Biochemistry 37, 15503-15512.
19. Wei, C. C., Wang, Z. Q., Wang, Q., Meade, A. L., Hemann, C., Hille, R., and Stuehr, D. J. (2001) J. Biol. Chem. 276, 315-319.
20. Stuehr, D., Pou, S., and Rosen, G. M. (2001) J. Biol. Chem. 276, 14533-14536.
21. Hurshman, A. R., Krebs, C., Edmondson, D. E., Huynh, B. H., and Marletta, M. A. (1999) Biochemistry 38, 15689-15696.
22. Wang, Z. Q., Wei, C. C., Ghosh, S., Meade, A. L., Hemann, C., Hille, R., and Stuehr D. J. (2001) Biochemistry 40, 12819-12825.
23. Schmidt, P. P., Lange, R., Gorren, A. C., Werner, E. R., Mayer, B., and Andersson, K. K. (2001) J. Biol. Inorg. Chem. 6, 151-158.
24. Aoyagi, M., Arvai, A. S., Ghosh, S., Stuehr, D. J., Tainer, J. A., and Getzoff, E. D. (2001) Biochemistry 40, 12826-12832.
25. Werner, E. R., Habisch, H. J., Gorren, A. C., Schmidt, K., Canevari, L., Werner-Felmayer, G., and Mayer, B. (2000) Biochem. J. 348, 579-583.
26. Presta, A., Siddhanta, U., Wu, C., Sennequier, N., Huang, L., Abu-Soud, H. M., Erzurum, S., and Stuehr, D. J. (1998) Biochemistry 37, 298-310.
27. Kotsonis, P., Frohlich, L. G., Raman, C. S., Li, H., Berg, M., Gerwig, R., Groehn, V., Kang, Y., Al-Masoudi, N., Taghavi-Moghadam, S., Mohr, D., Munch, U., Schnabel, J., Martasek, P., Masters, B. S., Strobel, H., Poulos, T., Matter, H., Pfleiderer, W., and Schmidt, H. H. (2001) J. Biol. Chem. 276, 49133-49141.
28. Ghosh, S., Wolan, D., Adak, S., Crane, B. R., Kwon, N. S., Tainer, J. A., Getzoff, E. D., and Stuehr, D. J. (1999) J. Biol. Chem. 274, 24100-24112.
29. Stankovich, M. T. (1980) Anal. Biochem. 109, 295-308.
30. Otwinowski, Z., and Minor, W. (1997) Methods Enzmol. 276, 307.
31. Brunger, A. T., Adams, P. D., Clore, G. M., Delano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, N., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. D54, 905-921.
32. Roussel, A., and Cambillau, C. (1989) Silicon Graphics Geometry Partners Directory 77-78.
33. Ghosh, D. K., Wu, C., Pitters, E., Moloney, M., Werner, E. R., Mayer, B., and Stuehr, D. J. (1997) Biochemistry 36, 10609-10619.
34. Mayer, B., Wu, C., Gorren, A. C., Pfeiffer, S., Schmidt, K., Clark, P., Stuehr, D. J., and Werner, E. R. (1997) Biochemistry 36, 8422-8427.
35. Abu-Soud, H. M., Gachhui, R., Raushel, F. M., and Stuehr, D. J. (1997) J. Biol. Chem. 272, 17349-17353.
36. Ehrenberg, A., Hemmerich, P., Müller, F., and Pfleiderer, W. (1970) Eur. J. Biochem. 16, 584-591.
37. Crane, B. R., Arvai, A. S., Ghosh, S., Getzoff, E. D., Stuehr, D. J., and Tainer, J. A. (2000) Biochemistry 39, 4608-4621.
38. Crane, B. R., Rosenfeld, R. J., Arvai, A. S., Ghosh, D. K., Ghosh, S., Tainer, J. A., Stuehr, D. J., and Getzoff, E. D. (1999) EMBO J. 18, 6271-6281.
39. Rosenfeld, R. J., Garcin, E. D., Panda, K., Andersson, G., Aberg, A., Wallace, A. V., Morris, G. M., Olson, A. J., Stuehr, D. J., Tainer, J. A., and Getzoff, E. D. (2002) Biochemistry 41, 13915-13925.
40. Wang, K., Mei, H., Geren, L., Miller, M. A., Saunders, A., Wang, X., Waldner, J. L., Pielak, G. J., Durham, B., and Millett, F. (1996) Biochemistry 35, 15107-15119.
41. Gorren, A. C., Kungl, A. J., Schmidt, K., Werner, E. R., and Mayer, B. (2001) Nitric Oxide 5, 176-186.
42. Korth, H.-G., Sustmann, R., Thater, C., Butler, A. R., and Ingold, K. U. (1994) J. Biol. Chem. 269, 17776-17779.
43. Groves, J. T., and Wang, C. C-Y. (2000) Curr. Opin. Chem. Biol. 4, 687-695.
44. Zhang, Z., Nassar, A.-E. F., Lu, Z., Shenkman, J. B., and Rusling, J. F. (1997) J. Chem. Soc., Faraday Trans. 93, 1769-1774.
45. Ludwig, M. L., and Luschinsky, C. L. (1992) in Chemistry and Biochemistry of Flavoenzymes (Muller, F., Ed.) Vol. III, p 427-466, CRC Press, Boca Raton, FL.
46. Presta, A., Weber-Main, A. M., Stankovich, M. T., and Stuehr, D. J. (1998) J. Am. Chem. Soc. 120, 9560-9465.
47. Patel, K. B., Stratford, M. R. L., Wardman, P., and Everett, S. A. (2002) Free Radical Biol. Med. 32, 203-211.
48. Vasquez-Vivar, J., Whitsett, J., Martasek, P., Hogg, N., and Kalyanaraman, B. (2001) Free Radical Biol. Med. 31, 975-985.
49. Davydov, R., Ledbetter-Rogers, A., Martasek, P., Larukhin, M., Sono, M., Dawson, J. H., Masters, B. S. S. M., and Hoffman, B. M. (2002) Biochemistry 41, 10375-10381.
50. Eloranta, J. (2000) ftp://EPR.chem.jyu.fi/pub/xemr.