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Volumn 40, Issue 10, 2012, Pages 2833-2840

Administration of tetrahydrobiopterin improves the microcirculation and outcome in an ovine model of septic shock

Author keywords

hemodynamics; microcirculation; pulmonary gas exchange; septic shock; tetrahydrobiopterin

Indexed keywords

LACTIC ACID; PLACEBO; TETRAHYDROBIOPTERIN;

EID: 84866562435     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31825b88ba     Document Type: Article
Times cited : (49)

References (54)
  • 2
    • 27144502125 scopus 로고    scopus 로고
    • Clinical manifestations of disordered microcirculatory perfusion in severe sepsis
    • DOI 10.1186/cc3744
    • Trzeciak S, Rivers EP: Clinical manifestations of disordered microcirculatory perfu-sion in severe sepsis. Crit Care 2005; 9(Suppl 4):S20-S26 (Pubitemid 41498528)
    • (2005) Critical Care , vol.9 , Issue.SUPPL. 4
    • Trzeciak, S.1    Rivers, E.P.2
  • 3
    • 4444233598 scopus 로고    scopus 로고
    • Persistent-microcirculatory alterations are associated with organ failure and death in patients with septic shock
    • DOI 10.1097/01.CCM.0000138558.16257.3F
    • Sakr Y, Dubois MJ, De Backer D, et al: Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock. Crit Care Med 2004; 32:1825-1831 (Pubitemid 39202356)
    • (2004) Critical Care Medicine , vol.32 , Issue.9 , pp. 1825-1831
    • Sakr, Y.1    Dubois, M.-J.2    De Backer, D.3    Creteur, J.4    Vincent, J.-L.5
  • 4
    • 81155137921 scopus 로고    scopus 로고
    • Inhaled nitric oxide improves systemic microcirculation in infants with hypoxemic respiratory failure
    • Top AP, Ince C, Schouwenberg PH, et al: Inhaled nitric oxide improves systemic microcirculation in infants with hypoxemic respiratory failure. Pediatr Crit Care Med 2011; 12:e271-e274
    • (2011) Pediatr Crit Care Med , vol.12
    • Top, A.P.1    Ince, C.2    Schouwenberg, P.H.3
  • 7
    • 77954456169 scopus 로고    scopus 로고
    • Effects of fuids on microvascular perfu-sion in patients with severe sepsis
    • Ospina-Tascon G, Neves AP, Occhipinti G, et al: Effects of fuids on microvascular perfu-sion in patients with severe sepsis. Intensive Care Med 2010; 36:949-955
    • (2010) Intensive Care Med , vol.36 , pp. 949-955
    • Ospina-Tascon, G.1    Neves, A.P.2    Occhipinti, G.3
  • 8
    • 31344453457 scopus 로고    scopus 로고
    • The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects
    • DOI 10.1097/01.CCM.0000198107.61493.5A
    • De Backer D, Creteur J, Dubois MJ, et al: The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects. Crit Care Med 2006; 34:403-408 (Pubitemid 43145619)
    • (2006) Critical Care Medicine , vol.34 , Issue.2 , pp. 403-408
    • De Backer, D.1    Creteur, J.2    Dubois, M.-J.3    Sakr, Y.4    Koch, M.5    Verdant, C.6    Vincent, J.-L.7
  • 9
    • 33745603201 scopus 로고    scopus 로고
    • Effects of drotrecogin alfa activated on microcirculatory alterations in patients with severe sepsis
    • DOI 10.1097/01.CCM.0000220498.48773.3C, PII 0000324620060700000009
    • De Backer D, Verdant C, Chierego M, et al: Effects of drotrecogin alfa activated on micro-circulatory alterations in patients with severe sepsis. Crit Care Med 2006; 34:1918-1924 (Pubitemid 43982468)
    • (2006) Critical Care Medicine , vol.34 , Issue.7 , pp. 1918-1924
    • De Backer, D.1    Verdant, C.2    Chierego, M.3    Koch, M.4    Gullo, A.5    Vincent, J.-L.6
  • 10
    • 4444269296 scopus 로고    scopus 로고
    • Microcirculation in distress: A new resuscitation end point?
    • DOI 10.1097/01.CCM.0000139617.88704.B9
    • Ince C: Microcirculation in distress: A new resuscitation end point? Crit Care Med 2004; 32:1963-1964 (Pubitemid 39202377)
    • (2004) Critical Care Medicine , vol.32 , Issue.9 , pp. 1963-1964
    • Ince, C.1
  • 12
    • 79955048932 scopus 로고    scopus 로고
    • Oxidative stress and endothelial dysfunction during sepsis
    • Huet O, Dupic L, Harrois A, et al: Oxidative stress and endothelial dysfunction during sepsis. Front Biosci 2011; 16:1986-1995
    • (2011) Front Biosci , vol.16 , pp. 1986-1995
    • Huet, O.1    Dupic, L.2    Harrois, A.3
  • 13
    • 77956258291 scopus 로고    scopus 로고
    • The endothelium: Physiological functions and role in microcirculatory failure during severe sepsis
    • Ait-Oufella H, Maury E, Lehoux S, et al: The endothelium: Physiological functions and role in microcirculatory failure during severe sepsis. Intensive Care Med 2010; 36:1286-1298
    • (2010) Intensive Care Med , vol.36 , pp. 1286-1298
    • Ait-Oufella, H.1    Maury, E.2    Lehoux, S.3
  • 14
    • 79955017821 scopus 로고    scopus 로고
    • Endothelial activation, dysfunction and permeability during severe infections
    • Lee WL, Liles WC: Endothelial activation, dysfunction and permeability during severe infections. Curr Opin Hematol 2011; 18:191-196
    • (2011) Curr Opin Hematol , vol.18 , pp. 191-196
    • Lee, W.L.1    Liles, W.C.2
  • 15
    • 34447536457 scopus 로고    scopus 로고
    • Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease
    • DOI 10.1042/CS20070108
    • Schmidt TS, Alp NJ: Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease. Clin Sci 2007; 113:47-63 (Pubitemid 47066025)
    • (2007) Clinical Science , vol.113 , Issue.1-2 , pp. 47-63
    • Schmidt, T.S.1    Alp, N.J.2
  • 16
    • 0026470180 scopus 로고
    • Generation of superoxide by purifed brain nitric oxide syn-thase
    • Pou S, Pou WS, Bredt DS, et al: Generation of superoxide by purifed brain nitric oxide syn-thase. J Biol Chem 1992; 267:24173-24176
    • (1992) J Biol Chem , vol.267 , pp. 24173-24176
    • Pou, S.1    Pou, W.S.2    Bredt, D.S.3
  • 17
    • 78649471694 scopus 로고    scopus 로고
    • Maintenance of cellular tetrahydrobiopterin homeostasis
    • Kim HL, Park YS: Maintenance of cellular tetrahydrobiopterin homeostasis. BMB Rep 2010; 43:584-592
    • (2010) BMB Rep , vol.43 , pp. 584-592
    • Kim, H.L.1    Park, Y.S.2
  • 18
    • 0344052668 scopus 로고    scopus 로고
    • Tetrahydrobiopterin and endothelial nitric oxide synthase activity
    • DOI 10.1016/S0008-6363(99)00134-0, PII S0008636399001340
    • Cosentino F, Lüscher TF: Tetrahydrobiop-terin and endothelial nitric oxide synthase activity. Cardiovasc Res 1999; 43:274-278 (Pubitemid 29356362)
    • (1999) Cardiovascular Research , vol.43 , Issue.2 , pp. 274-278
    • Cosentino, F.1    Luscher, T.F.2
  • 21
    • 0034890205 scopus 로고    scopus 로고
    • Tetrahydrobiopterin improves endothelial dysfunction in coronary microcirculation in patients without epicardial coronary artery disease
    • DOI 10.1016/S0735-1097(01)01382-1, PII S0735109701013821
    • Setoguchi S, Mohri M, Shimokawa H, et al: Tetrahydrobiopterin improves endothelial dysfunction in coronary microcirculation in patients without epicardial coronary artery disease. J Am Coll Cardiol 2001; 38:493-498 (Pubitemid 32721779)
    • (2001) Journal of the American College of Cardiology , vol.38 , Issue.2 , pp. 493-498
    • Setoguchi, S.1    Mohri, M.2    Shimokawa, H.3    Takeshita, A.4
  • 23
    • 78650414437 scopus 로고    scopus 로고
    • Impaired micro-vascular perfusion in sepsis requires activated coagulation and P-selectin-mediated platelet adhesion in capillaries
    • Secor D, Li F, Ellis CG, et al: Impaired micro-vascular perfusion in sepsis requires activated coagulation and P-selectin-mediated platelet adhesion in capillaries. Intensive Care Med 2010; 36:1928-1934
    • (2010) Intensive Care Med , vol.36 , pp. 1928-1934
    • Secor, D.1    Li, F.2    Ellis, C.G.3
  • 24
    • 49949105606 scopus 로고    scopus 로고
    • Septic impairment of capillary blood fow requires nicotinamide adenine dinucleotide phosphate oxidase but not nitric oxide synthase and is rapidly reversed by ascorbate through an endothelial nitric oxide synthase-dependent mechanism
    • Tyml K, Li F, Wilson JX: Septic impairment of capillary blood fow requires nicotinamide adenine dinucleotide phosphate oxidase but not nitric oxide synthase and is rapidly reversed by ascorbate through an endothelial nitric oxide synthase-dependent mechanism. Crit Care Med 2008; 36:2355-2362
    • (2008) Crit Care Med , vol.36 , pp. 2355-2362
    • Tyml, K.1    Li, F.2    Wilson, J.X.3
  • 25
    • 0036689831 scopus 로고    scopus 로고
    • A 4-amino analogue of tetrahydrobiopterin attenuates endotoxin-induced hemodynamic alterations and organ injury in rats
    • Fitzal F, Redl H, Strohmaier W, et al: A 4-amino analogue of tetrahydrobiopterin attenuates endotoxin-induced hemodynamic alterations and organ injury in rats. Shock 2002; 18:158-162
    • (2002) Shock , vol.18 , pp. 158-162
    • Fitzal, F.1    Redl, H.2    Strohmaier, W.3
  • 26
    • 0034181284 scopus 로고    scopus 로고
    • Protection against endotoxemia in rats by a novel tetrahydrobiopterin analogue
    • Bahrami S, Fitzal F, Peichl G, et al: Protection against endotoxemia in rats by a novel tetrahydrobiopterin analogue. Shock 2000; 13:386-391
    • (2000) Shock , vol.13 , pp. 386-391
    • Bahrami, S.1    Fitzal, F.2    Peichl, G.3
  • 29
    • 35148888322 scopus 로고    scopus 로고
    • How to evaluate the microcirculation: Report of a round table conference
    • De Backer D, Hollenberg S, Boerma C, et al: How to evaluate the microcirculation: Report of a round table conference. Crit Care 2007; 11:R101
    • (2007) Crit Care , vol.11
    • De Backer, D.1    Hollenberg, S.2    Boerma, C.3
  • 30
    • 77955958738 scopus 로고    scopus 로고
    • Effects of a selective iNOS inhibitor versus norepineph-rine in the treatment of septic shock
    • Su F, Huang H, Akieda K, et al: Effects of a selective iNOS inhibitor versus norepineph-rine in the treatment of septic shock. Shock 2010; 34:243-249
    • (2010) Shock , vol.34 , pp. 243-249
    • Su, F.1    Huang, H.2    Akieda, K.3
  • 31
    • 11344279695 scopus 로고    scopus 로고
    • Bench-to-bedside review: Sepsis is a disease of the microcirculation
    • DOI 10.1186/cc2894
    • Spronk PE, Zandstra DF, Ince C: Bench-to-bedside review: Sepsis is a disease of the microcirculation. Crit Care 2004; 8:462-468 (Pubitemid 40073681)
    • (2004) Critical Care , vol.8 , Issue.6 , pp. 462-468
    • Spronk, P.E.1    Zandstra, D.F.2    Ince, C.3
  • 32
    • 62749206780 scopus 로고    scopus 로고
    • Microcirculatory Alterations in Resuscitation and Shock (MARS) investigators: Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis
    • Trzeciak S, McCoy JV, Phillip Dellinger R, et al; Microcirculatory Alterations in Resuscitation and Shock (MARS) investigators: Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis. Intensive Care Med 2008; 34:2210-2217
    • (2008) Intensive Care Med , vol.34 , pp. 2210-2217
    • Trzeciak, S.1    McCoy, J.V.2    Phillip Dellinger, R.3
  • 34
    • 59849123812 scopus 로고    scopus 로고
    • Regulation of endo-thelial barrier function by reactive oxygen and nitrogen species
    • Boueiz A, Hassoun PM: Regulation of endo-thelial barrier function by reactive oxygen and nitrogen species. Microvasc Res 2009; 77:26-34
    • (2009) Microvasc Res , vol.77 , pp. 26-34
    • Boueiz, A.1    Hassoun, P.M.2
  • 37
    • 0038604446 scopus 로고    scopus 로고
    • Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: Implications for uncoupling endothelial nitric-oxide synthase
    • DOI 10.1074/jbc.M302227200
    • Kuzkaya N, Weissmann N, Harrison DG, et al: Interactions of peroxynitrite, tetrahydrobiop-terin, ascorbic acid, and thiols: Implications for uncoupling endothelial nitric-oxide syn-thase. J Biol Chem 2003; 278:22546-22554 (Pubitemid 36830310)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.25 , pp. 22546-22554
    • Kuzkaya, N.1    Weissmann, N.2    Harrison, D.G.3    Dikalov, S.4
  • 38
    • 27644537902 scopus 로고    scopus 로고
    • Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthese (eNOS) activity, and eNOS coupling in vivo: Insights from transgenic mice with endothelial-targeted GTP cyclohydrolase 1 and eNOS overexpression
    • DOI 10.1161/01.RES.0000187447.03525.72
    • Bendall JK, Alp NJ, Warrick N, et al: Stoi-chiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo: Insights from transgenic mice with endothe-lial-targeted GTP cyclohydrolase 1 and eNOS overexpression. Circ Res 2005; 97:864-871 (Pubitemid 41552671)
    • (2005) Circulation Research , vol.97 , Issue.9 , pp. 864-871
    • Bendall, J.K.1    Alp, N.J.2    Warrick, N.3    Cai, S.4    Adlam, D.5    Rockett, K.6    Yokoyama, M.7    Kawashima, S.8    Channon, K.M.9
  • 39
    • 75549090909 scopus 로고    scopus 로고
    • Reactive oxygen and nitrogen species regulate inducible nitric oxide synthase function shifting the balance of nitric oxide and superoxide production
    • Sun J, Druhan LJ, Zweier JL: Reactive oxygen and nitrogen species regulate inducible nitric oxide synthase function shifting the balance of nitric oxide and superoxide production. Arch Biochem Biophys 2010; 494:130-137
    • (2010) Arch Biochem Biophys , vol.494 , pp. 130-137
    • Sun, J.1    Druhan, L.J.2    Zweier, J.L.3
  • 40
    • 33646809398 scopus 로고    scopus 로고
    • The inhibition of inducible nitric oxide synthase in ovine sepsis model
    • Enkhbaatar P, Murakami K, Traber LD, et al: The inhibition of inducible nitric oxide synthase in ovine sepsis model. Shock 2006; 25:522-527
    • (2006) Shock , vol.25 , pp. 522-527
    • Enkhbaatar, P.1    Murakami, K.2    Traber, L.D.3
  • 41
    • 77954156068 scopus 로고    scopus 로고
    • Time course of nitric oxide synthases, nitrosative stress, and poly(ADP ribosylation) in an ovine sepsis model
    • Lange M, Connelly R, Traber DL, et al: Time course of nitric oxide synthases, nitrosative stress, and poly(ADP ribosylation) in an ovine sepsis model. Crit Care 2010; 14:R129
    • (2010) Crit Care , vol.14
    • Lange, M.1    Connelly, R.2    Traber, D.L.3
  • 42
    • 33947492418 scopus 로고    scopus 로고
    • Coagulation and endothelial dysfunction during lonterm hyperdynamic porcine bacteremia - Effects of selective inducible nitric oxide synthase inhibition
    • DOI 10.1160/TH06-09-0498
    • Matejovic M, Krouzecky A, Radej J, et al: Coagulation and endothelial dysfunction during longterm hyperdynamic porcine bactere-mia-effects of selective inducible nitric oxide synthase inhibition. Thromb Haemost 2007; 97:304-309 (Pubitemid 46592152)
    • (2007) Thrombosis and Haemostasis , vol.97 , Issue.2 , pp. 304-309
    • Matejovic, M.1    Krouzecky, A.2    Radej, J.3    Bokyta Jr., R.4    Kralova, H.5    Radermacher, P.6    Novak, I.7
  • 44
    • 77957220423 scopus 로고    scopus 로고
    • Res-veratrol reverses endothelial nitric-oxide synthase uncoupling in apolipoprotein e knockout mice
    • Xia N, Daiber A, Habermeier A, et al: Res-veratrol reverses endothelial nitric-oxide synthase uncoupling in apolipoprotein E knockout mice. J Pharmacol Exp Ther 2010; 335:149-154
    • (2010) J Pharmacol Exp Ther , vol.335 , pp. 149-154
    • Xia, N.1    Daiber, A.2    Habermeier, A.3
  • 45
    • 80051978810 scopus 로고    scopus 로고
    • Therapeutic effect of enhancing endothelial nitric oxide syn-thase (eNOS) expression and preventing eNOS uncoupling
    • Förstermann U, Li H: Therapeutic effect of enhancing endothelial nitric oxide syn-thase (eNOS) expression and preventing eNOS uncoupling. Br J Pharmacol 2011; 164:213-223
    • (2011) Br J Pharmacol , vol.164 , pp. 213-223
    • Förstermann, U.1    Li, H.2
  • 46
    • 77955607922 scopus 로고    scopus 로고
    • Tetrahydro-biopterin and the regulation of hypoxic pulmonary vasoconstriction
    • Francis BN, Wilkins MR, Zhao L: Tetrahydro-biopterin and the regulation of hypoxic pulmonary vasoconstriction. Eur Respir J 2010; 36:323-330
    • (2010) Eur Respir J , vol.36 , pp. 323-330
    • Francis, B.N.1    Wilkins, M.R.2    Zhao, L.3
  • 47
    • 77956257800 scopus 로고    scopus 로고
    • Oxidative stress: Acute and progressive lung injury
    • Ward PA: Oxidative stress: Acute and progressive lung injury. Ann N Y Acad Sci 2010; 1203:53-59
    • (2010) Ann N y Acad Sci , vol.1203 , pp. 53-59
    • Ward, P.A.1
  • 48
    • 77955847058 scopus 로고    scopus 로고
    • Role of different nitric oxide synthase isoforms in a murine model of acute lung injury and sepsis
    • Lange M, Nakano Y, Traber DL, et al: Role of different nitric oxide synthase isoforms in a murine model of acute lung injury and sepsis. Biochem Biophys Res Commun 2010; 399:286-291
    • (2010) Biochem Biophys Res Commun , vol.399 , pp. 286-291
    • Lange, M.1    Nakano, Y.2    Traber, D.L.3
  • 49
    • 3142634845 scopus 로고    scopus 로고
    • Acute renal failure and sepsis
    • Schrier RW, Wang W: Acute renal failure and sepsis. N Engl J Med 2004; 351:159-169
    • (2004) N Engl J Med , vol.351 , pp. 159-169
    • Schrier, R.W.1    Wang, W.2
  • 50
    • 0035169143 scopus 로고    scopus 로고
    • A selective inhibitor for inducible nitric oxide synthase improves hypotension and lactic acidosis in canine endotoxic shock
    • Mitaka C, Hirata Y, Yokoyama K, et al: A selective inhibitor for inducible nitric oxide synthase improves hypotension and lactic acidosis in canine endotoxic shock. Crit Care Med 2001; 29:2156-2161 (Pubitemid 33063545)
    • (2001) Critical Care Medicine , vol.29 , Issue.11 , pp. 2156-2161
    • Mitaka, C.1    Hirata, Y.2    Yokoyama, K.3    Makita, K.4    Imai, T.5
  • 52
    • 0022596053 scopus 로고
    • Tetrahydrobiopterin administration to Rhesus macaques: Its appearance in CSF and effect on neurotransmitter synthesis
    • DOI 10.1007/BF00967976
    • Miller L, Insel T, Scheinin M, et al: Tetra-hydrobiopterin administration to rhesus macaques. Its appearance in CSF and effect on neurotransmitter synthesis. Neurochem Res 1986; 11:291-298 (Pubitemid 16161268)
    • (1986) Neurochemical Research , vol.11 , Issue.2 , pp. 291-298
    • Miller, L.1    Insel, T.2    Scheinin, M.3
  • 54
    • 73449092811 scopus 로고    scopus 로고
    • Evaluation of sublingual and gut mucosal microcirculation in sepsis: A quantitative analysis
    • Verdant CL, De Backer D, Bruhn A, et al: Evaluation of sublingual and gut mucosal microcirculation in sepsis: A quantitative analysis. Crit Care Med 2009; 37:2875-2881
    • (2009) Crit Care Med , vol.37 , pp. 2875-2881
    • Verdant, C.L.1    De Backer, D.2    Bruhn, A.3


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