Tetrahydrobiopterin-free neuronal nitric oxide synthase: Evidence for two identical highly anticooperative pteridine binding sites

Biochemistry

Volumn 35, Issue 51, 1996, Pages 16735-16745

  Gorren, Antonius C F ^a   List, Barbara M ^a   Schrammel, Astrid ^a   Pitters, Eva ^a   Hemmens, Benjamin ^a   Werner, Ernst R ^b   Schmidt, Kurt ^a   Mayer, Bernd ^a  

^a UNIVERSITY OF GRAZ   (Austria)

^b UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CITRULLINE; DIMER; DITHIOTHREITOL; HEME; HYDROGEN PEROXIDE; N(G) NITROARGININE; NITRIC OXIDE SYNTHASE; PTERIDINE; TETRAHYDROBIOPTERIN;

ARTICLE; BINDING SITE; CONTROLLED STUDY; ENZYME ANALYSIS; ENZYME STRUCTURE; LIGAND BINDING; NERVE CELL; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL;

ANIMALS; BINDING SITES; BIOPTERIN; DIMERIZATION; HEME; KINETICS; MOLECULAR STRUCTURE; NEURONS; NITRIC OXIDE SYNTHASE; OXIDATION-REDUCTION; PROTEIN CONFORMATION; PTERIDINES; RATS; RECOMBINANT PROTEINS; SPECTROPHOTOMETRY;

EID: 0030464496     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi961931j     Document Type: Article

References (49)

1. Abu-Soud, H. M., Loftus, M., & Stuehr, D. J. (1995a) Biochemistry 34, 11167-11175.
2. Abu-Soud, H. M., Wang, J., Rousseau, D. L., Fukuto, J. M., Ignarro, L. J., & Stuehr, D. J. (1995b) J. Biol. Chem. 270, 22997-23006.
3. Baek, K. J., Thiel, B. A., Lucas, S., & Stuehr, D. J. (1993) J. Biol. Chem. 268, 21120-21129.
4. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254.
5. Dawson, J. H., & Sono, M. (1987) Chem. Rev. 87, 1255-1276.
6. Degtyarenko, K. N., & Archakov, A. I. (1993) FEBS Lett. 332, 1-8.
7. Fulco, A. J. (1991) Annu. Rev. Pharmacol. Toxicol. 31, 177-203.
8. Gerber, N. C., & Ortiz de Montellano, P. R. (1995) J. Biol. Chem. 270, 17791-17796.
9. Ghosh, D. K., & Stuehr, D. J. (1995) Biochemistry 34, 801-807.
10. Ghosh, D. K., Abu-Soud, H. M., & Stuehr, D. J. (1996) Biochemistry 35, 1444-1449.
11. Griffith, O. W., & Stuehr, D. J. (1995) Annu. Rev. Physiol. 57, 707-736.
12. Harteneck, C., Klatt, P., Schmidt, K., & Mayer, B. (1994) Biochem. J. 304, 683-686.
13. Heinzel, B., John, M., Klatt, P., Böhme, E., & Mayer, B. (1992) Biochem. J. 281, 627-630.
14. Hurshman, A. R., & Marletta, M. A. (1995) Biochemistry 34, 5627-5634.
15. Kaufman, S. (1993) Annu. Rev. Nutr. 13, 261-286.
16. Klatt, P., Schmidt, K., Uray, G., & Mayer, B. (1993) J. Biol. Chem. 268, 14781-14787.
17. Klatt, P., Schmid, M., Leopold, E., Schmidt, K., Werner, E. R., & Mayer, B. (1994a) J. Biol. Chem. 269, 13861-13866.
18. Klatt, P., Schmidt. K., Brunner, F., & Mayer, B. (1994b) J. Biol. Chem. 269, 1674-1680.
19. Klatt, P., Schmidt, K., Lehner, D., Glatter, O., Bächinger, H. P., & Mayer, B. (1995) EMBO J. 14, 3687-3695.
20. Klatt, P., Pfeiffer, S., List, B. M., Lehner, D., Glatter, O., Bächinger, H. P., Werner, E. R., Schmidt, K., & Mayer, B. (1996) J. Biol. Chem. 271, 7336-7342.
21. List, B. M., Klatt, P., Werner, E. R., Schmidt. K., & Mayer, B. (1996) Biochem. J. 315, 57-63.
22. Marietta, M. A. (1993) J. Biol. Chem. 268, 12231-12234.
23. Masters, B. S. S. (1994) Annu. Rev. Nutr. 14, 131-145.
24. Matsuoka, A., Stuehr, D. J., Olson, J. S., Clark, P., & Ikeda-Saito, M. (1994) J. Biol. Chem. 269, 20335-20339.
25. Mayer, B. (1995) in Nitric Oxide in the Nervous System (Vincent, S. R., Ed.) pp 21-42, Academic Press, New York.
26. Mayer, B., & Werner, E. R. (1995) Naunyn-Schmiedebergs Arch. Pharmacol. 351, 453-463.
27. Mayer, B., John, M., Heinzel, B., Werner, E. R., Wachter, H., Schultz, G., & Böhme, E. (1991) FEBS Lett. 288, 187-191.
28. Mayer, B., Klatt, P., Werner, E. R., & Schmidt, K. (1994) Neuropharmacology 33, 1253-1259.
29. Mayer, B., Klatt, P., Harteneck, C., List, B. M., Werner, E. R., & Schmidt, K. (1996) Methods Neurosci. 31, 130-139.
30. McMillan, K., & Masters, B. S. S. (1993) Biochemistry 32, 9875-9880.
31. McMillan, K., & Masters, B. S. S. (1995) Biochemistry 34, 3686-3693.
32. Moncada, S., Palmer, R. M. J., & Higgs, E. A. (1991) Pharmacol. Rev. 43, 109-142.
33. Nakano, R., Sato, H., Watanabe, A., Ito, O., & Shimizu, T. (1996) J. Biol. Chem. 271, 8570-8574.
34. O'Keeffe, D. H., Ebel, R. E., & Peterson, J. A. (1978) J. Biol. Chem. 253, 3509-3516.
35. Poulos, T. L., Finzel, B. C., & Howard, A. J. (1986) Biochemistry 25, 5314-5322.
36. Pufahl, R. A., & Marletta, M. A. (1993) Biochem. Biophys. Res. Commun. 193, 963-970.
37. Rodríguez-Crespo, I., Gerber, N. C., & Ortiz de Montellano, P. R. (1996) J. Biol. Chem. 271, 11462-11467.
38. Roman, L. J., Sheta, E. A., Martasek, P., Gross, S. S., Liu, Q., & Masters, B. S. S. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 8428-8432.
39. Ruf, H. H., & Wende, P. (1977) J. Am. Chem. Soc. 99, 5499-5500.
40. Schenkman, J. B., Remmer, H., & Estabrook, R. W. (1967) Mol. Pharmacol. 3, 113-123.
41. Siddhanta, U., Wu, C., Abu-Soud, H. M., Zhang, J., Ghosh, D. K., & Stuehr, D. J. (1996) J Biol. Chem. 271, 7309-7312.
42. Sono, M., Andersson, L. A., & Dawson, J. H. (1982) J. Biol. Chem. 257, 8308-8320.
43. Sono, M., Dawson, J. H., & Hager, L. P. (1984) J. Biol. Chem. 259, 13209-13216.
44. Tzeng, E., Billiar, T. R., Robbins, P. D., Loftus, M., & Stuehr, D. J. (1995.) Proc. Natl. Acad. Sci. U.S.A. 92, 11771-11775.
45. Ullrich, V., Ruf, H. H., & Wende, P. (1977) Croat. Chem. Acta 49, 213-222.
46. Wang, J., Rousseau, D. L., Abu-Soud, H. M., & Stuehr, D. J. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 10512-10516.
47. Werner, E. R., Schmid, M., Werner-Felmayer, G., Mayer, B., & Wachter, H. (1994) Biochem. J. 304, 189-193.
48. Witteveen, C. F. B., Giovanelli, J., & Kaufman, S. (1996) J. Biol. Chem. 271, 4143-4147.
49. Yu, C-A., Gunsalus, I. C., Katagiri, M., Suhara, K., & Takemori, S. (1974) J. Biol. Chem. 249, 94-101.