Effects of vitamin C on intracoronary L-arginine dependent coronary vasodilatation in patients with stable angina

Heart

Volumn 91, Issue 10, 2005, Pages 1319-1323

  Tousoulis, Dimitris ^a   Xenakis, C ^a   Tentolouris, C ^a   Davies, G ^b   Antoniades, C ^a   Crake, T ^b   Stefanadis, C ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; ASCORBIC ACID; NITRIC OXIDE; ANTIOXIDANT;

ADULT; ANGIOCARDIOGRAPHY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY; CORONARY ARTERY DILATATION; CORONARY ARTERY DISEASE; DRUG BIOAVAILABILITY; DRUG EFFECT; DRUG MECHANISM; EPICARDIUM; FEMALE; HUMAN; MALE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; STABLE ANGINA PECTORIS; VASOMOTOR REFLEX; ANGINA PECTORIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY BLOOD VESSEL; DRUG COMBINATION; DRUG INTERACTION; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; VASODILATATION;

ANGINA PECTORIS; ANTIOXIDANTS; ARGININE; ASCORBIC ACID; CORONARY ANGIOGRAPHY; CORONARY ARTERIOSCLEROSIS; CORONARY VESSELS; DRUG COMBINATIONS; DRUG INTERACTIONS; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; MALE; MIDDLE AGED; NITRIC OXIDE; VASODILATION;

EID: 25144481421     PISSN: 13556037     EISSN: None     Source Type: Journal    
DOI: 10.1136/hrt.2004.044537     Document Type: Article

References (36)

1. Palmer RMJ, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 1988;333:664-6.
2. Casino PR, Kilcoyne CM, Quyyimi AA, et al. Investigation of decreased availability of nitric oxide precursor as the mechanism responsible for impaired endothelium dependent vasodilation in hypercholesterolemic patients. J Am Coll Cardiol 1994;23:844-50.
3. Campisi R, Czernin J, Schoder H, et al. L-Arginine normalizes coronary vasomotion in long term smokers. Circulation 1999;99:491-7.
4. Chauhan A, More RS, Mullins PA, et al. Aging-associated endothelium dysfunction in humans is reversed by L-arginine. J Am Coll Cardiol 1996;28:1796-804.
5. Higashi Y, Oshima T, Sasaki S, et al. Angiotensin-converting enzyme inhibition, but not calcium antagonism, improves a response of the renal vasculature to L-arginine in patients with essential hypertension. Hypertension 1998;32:16-24.
6. Tousoulis D, Tentolouris C, Crake T, et al. Effects of L- and D-arginine on the basal tone of human diseased coronary arteries and their responses to substance P. Heart 1999;81:505-11.
7. Tentolouris C, Tousoulis D, Toutouzas P, et al. Effects of acute L-arginine administration in coronary atherosclerosis response. Circulation 1999;99:1646-9.
8. Tentolouris C, Tousoulis D, Davies G, et al. Serum cholesterol level, cigarette smoking, and vasomotor responses to L-arginine in narrowed epicardial coronary arteries. Am J Cardiol 2000;85:500-3.
9. Tousoulis D, Davies G, Tentolouris C, et al. Coronary stenosis dilation induced by L-arginine. Lancet 1997;349:1812-3.
10. Egashira K, Hirooka Y, Kuga T, et al. Effects of L-arginine supplementation on endothelium dependent coronary vasodilation in patients with angina pectoris and normal coronary angiograms. Circulation 1996;94:130-4.
11. Boger RH, Bode-Boger SM, Thiele W, et al. Restoring vascular nitric oxide formation by L-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease. J Am Coll Cardiol 1998;32:1336-44.
12. 2 Hamon M, Vallet B, Bauters C, et al. Long-term administration of L-arginine reduces intimal thickening and enhances endothelium-dependent acetylcholine-induced relaxation after arterial injury. Circulation 1994;90:1357-62.
13. Szabo G, Bahrle S, Batkai S, et al. L-arginine: effect on reperfusion injury after heart transplantation. World J Surg 1998;32:9-15.
14. Ohara Y, Peterson TE, Harrison DG. Hypercholesterolemia increases endothelial superoxide anion production. J Clin Invest 1993;91:2546-51.
15. Gryglewski RJ, Palmer RM, Moncada S. Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Nature 1986;320:454-6.
16. Frei B, England L, Ames BN. Ascorbate is an outstanding anti-oxidant in human blood plasma. Proc Natl Acad Sci USA 1989;86:6377-81.
17. Ting HH, Timimi FK, Haley EA, et al. Vitamin C improves endothelium-dependent vasodilation in forearm resistance vessels of humans with hypercholesterolemia. Circulation 1997;95:2617-22.
18. Heitzer T, Just H, Munzel T. Antioxidant vitamin C improves endothelial dysfunction in chronic smokers. Circulation 1996;94:6-9.
19. Solzbach U, Hornig B, Jeserich M, et al. Vitamin C improves endothelial dysfunction of epicardial coronary arteries in hypertensive patients. Circulation 1997;96:1513-9.
20. Ting HH, Timimi FK, Boles KS, et al. Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus. J Clin Invest 1996;97:22-8.
21. Chambers JC, McGregor A, Jean-Marie J, et al. Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: an effect reversible with vitamin C therapy. Circulation 1999;99:1156-60.
22. Levine GN, Frei B, Koulouris SN, et al. Ascorbic acid reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation 1996;93:1107-13.
23. Meister A. Glutathione-ascorbic acid antioxidant system in animals. J Biol Chem 1994;269:9397-400.
24. Reiber JH, Serruys PW, Kooijman CJ, et al. Assessment of short-, medium, and long-term variations in arterial dimensions from computer-assisted quantitation of coronary cineangiograms. Circulation 1985;71:280-8.
25. Creager MA, Gallagher SM, Girerd XJ, et al. L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans. J Clin Invest 1992;90:1248-53.
26. Quyyumi A. Does acute improvement of endothelial dysfunction in coronary artery disease improve myocardial ischemia? A double-blind comparison of parenteral D- and L-arginine. J Am Coll Cardiol 1998;32:904-11.
27. Miyazaki H, Matsuoka H, Cooke JP, et al. Endogenous nitric oxide synthase inhibitor: a novel marker of atherosclerosis. Circulation 1999;99:1141-6.
28. Darley-Usmar VM, Hog N, O'Leavy VJ, et al. The simultaneous generation of superoxide and nitric oxide can initiate lipid peroxidation in human low density lipoprotein. Free Radic Res Commun 1992;17:9-20.
29. Myers PR, Wright TF, Tanner MA, et al. The effects of native LDL and oxidized LDL on EDRF bioactivity and nitric oxide production in vascular endothelium. J Lab Clin Med 1994;124:672-83.
30. Keaney JF Jr, Guo Y, Cunningham D, et al. Vascular incorporation of alpha-tocopherol prevents endothelial dysfunction due to oxidized LDL by inhibiting protein kinase C stimulation. J Clin Invest 1996;98:386-94.
31. Vergnani L, Hatrik S, Ricci F, et al. Effect of native and oxidized low-density lipoprotein on endothelial nitric oxide and superoxide production: key role of L-arginine availability. Circulation 2000;101:1261-6.
32. O'Donnell VB, Chumley PH, Hogg N, et al. Nitric oxide inhibition of lipid peroxidation: kinetics of reaction with lipid peroxyl radicals and comparison with alpha-tocopherol. Biochemistry 1997;36:15216-23.
33. Boger RH. The emerging role of asymmetric dimethylarginine as a novel cardiovascular risk factor. Cardiovasc Res 2003;59:824-33.
34. Jackson TS, Xu A, Vita JA, et al. Ascorbate prevents the interaction of superoxide and nitric oxide only at very high physiological concentrations. Circ Res 1998;83:916-22.
35. Heller R, Munscher-Paulig F, Grabner R, et al. L-ascorbic acid potentiates nitric oxide synthesis in endothelial cells. J Biol Chem 1999;274:8254-60.
36. Takahashi S, Mendelsohn ME. Calmodulin-dependent and -independent activation of endothelial nitric-oxide synthase by heat shock protein 90. J Biol Chem 2003;278:9339-44.