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Volumn 284, Issue 20, 2009, Pages 13660-13668
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GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression
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Author keywords
[No Author keywords available]
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Indexed keywords
AROMATIC AMINO ACID HYDROXYLASES;
CELL LINES;
COFACTOR;
DOSE-DEPENDENT;
DOXYCYCLINE;
GTP CYCLOHYDROLASE;
GTP CYCLOHYDROLASE I;
HUMAN DISEASE;
INFLAMMATORY STIMULI;
KEY ENZYMES;
LINEAR CORRELATION;
MOUSE LIVER;
MOUSE MODELS;
NITRIC OXIDE SYNTHASES;
OVER-EXPRESSION;
PROTEIN LEVEL;
REGULATORY PROTEIN;
RELATIVE IMPORTANCE;
STRONG CORRELATION;
TETRAHYDROBIOPTERIN;
WILD TYPES;
AMINES;
AMINO ACIDS;
BIOCHEMISTRY;
CELL CULTURE;
COENZYMES;
ENZYMES;
ORGANIC ACIDS;
ENDOTHELIAL CELLS;
DOXYCYCLINE;
GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE FEEDBACK REGULATORY PROTEIN;
GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I;
REGULATOR PROTEIN;
TETRAHYDROBIOPTERIN;
UNCLASSIFIED DRUG;
5,6,7,8-TETRAHYDROBIOPTERIN;
ANTIINFECTIVE AGENT;
BIOPTERIN;
DRUG DERIVATIVE;
SIGNAL PEPTIDE;
ANIMAL CELL;
ANIMAL EXPERIMENT;
ARTICLE;
CELL LEVEL;
CELL STRAIN 3T3;
CONTROLLED STUDY;
ENDOTHELIUM CELL;
ENZYME ACTIVITY;
GENE EXPRESSION;
GENETIC TRANSFECTION;
HETEROZYGOTE;
HOMOZYGOTE;
IMMUNOBLOTTING;
MOUSE;
NONHUMAN;
PRIORITY JOURNAL;
PROTEIN EXPRESSION;
REGULATORY MECHANISM;
WILD TYPE;
ANIMAL;
BIOSYNTHESIS;
DOSE RESPONSE;
DRUG EFFECT;
ENZYMOLOGY;
GENE EXPRESSION REGULATION;
GENE SILENCING;
GENETICS;
HUMAN;
METABOLISM;
PHYSIOLOGY;
MUS;
ANIMALS;
ANTI-BACTERIAL AGENTS;
BIOPTERIN;
DOSE-RESPONSE RELATIONSHIP, DRUG;
DOXYCYCLINE;
ENDOTHELIAL CELLS;
GENE EXPRESSION REGULATION, ENZYMOLOGIC;
GENE KNOCKDOWN TECHNIQUES;
GTP CYCLOHYDROLASE;
HUMANS;
INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS;
MICE;
NIH 3T3 CELLS;
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EID: 67649405068
PISSN: 00219258
EISSN: 1083351X
Source Type: Journal
DOI: 10.1074/jbc.M807959200 Document Type: Article |
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Times cited : (52)
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References (23)
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