The N-terminal peptide of mammalian GTP cyclohydrolase I is an autoinhibitory control element and contributes to binding the allosteric regulatory protein GFRP

Journal of Biological Chemistry

Volumn 286, Issue 14, 2011, Pages 11919-11928

  Higgins, Christina E ^a   Gross, Steven S ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC AMINO ACID HYDROXYLASES; AUTOREGULATIONS; BINDING PROPERTIES; CATALYTIC ACTIVITY; COFACTORS; COMPLEX FORMATIONS; CONTROL ELEMENTS; GTP CYCLOHYDROLASE I; HEK293 CELLS; HILL COEFFICIENT; INHIBITORY COMPLEX; INHIBITORY PEPTIDES; MOLECULAR MECHANISM; N-TERMINALS; NO SYNTHASES; PENTAMERS; RATE-LIMITING ENZYMES; REGULATORY ACTIONS; REGULATORY PROTEIN; SMALL MOLECULES; TETRAHYDROBIOPTERIN; TRUNCATION MUTANTS; UP-REGULATION; WILD TYPES;

AMINO ACIDS; BINDING ENERGY; BIOCHEMISTRY; IODINE; MAMMALS; PEPTIDES; RAT CONTROL;

CATALYST ACTIVITY;

GT PCH FEEDBACK REGULATORY PROTEIN; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; REGULATOR PROTEIN; TETRAHYDROBIOPTERIN; UNCLASSIFIED DRUG;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ARTICLE; CELL STRAIN HEK293; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME BINDING; ENZYME DEGRADATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; WILD TYPE;

ANIMALS; BLOTTING, WESTERN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GTP CYCLOHYDROLASE; MUTATION; PROTEIN BINDING; PROTEINS; RATS; RECOMBINANT PROTEINS;

MAMMALIA; RATTUS;

EID: 79953306244     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.196204     Document Type: Article

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