Association of a functional polymorphism (C59038T) in GTP cyclohydrolase 1 gene and Type 2 diabetic macrovascular disease in the Chinese population

Journal of Diabetes and its Complications

Volumn 24, Issue 5, 2010, Pages 313-319

  Liao, Yun Fei ^a   Zeng, Tian Shu ^a   Chen, Lu Lu ^a   Li, Yu Ming ^a   Yu, Fan ^a   Hu, Li Jun ^a   Yue, Ling ^a,b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b WUHAN GENERAL HOSPITAL OF GUANGZHOU COMMAND   (China)

Author keywords

GTP cyclohydrolase 1; Macrovascular disease; Nitric oxide; Polymorphism; Type 2 diabetes

Indexed keywords

C59038T GENE; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; MALONALDEHYDE; NITRIC OXIDE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ADULT; ARTERY DILATATION; ARTICLE; CARDIOVASCULAR RISK; CAROTID ARTERY; CEREBROVASCULAR DISEASE; CHINESE; DNA POLYMORPHISM; ETHNICITY; FEMALE; GENE MUTATION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OXIDATIVE STRESS; PERIPHERAL VASCULAR DISEASE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; VASCULAR DISEASE;

ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; CARDIOVASCULAR DISEASES; CAROTID ARTERIES; CEREBROVASCULAR DISORDERS; CHINA; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GTP CYCLOHYDROLASE; HUMANS; MALE; MALONDIALDEHYDE; MIDDLE AGED; NITRATES; NITRITES; POLYMORPHISM, GENETIC; PREVALENCE; SUPEROXIDE DISMUTASE; TUNICA INTIMA; VASODILATION;

EID: 77956210907     PISSN: 10568727     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdiacomp.2009.04.003     Document Type: Article

References (26)

1. Antoniades C., Shirodaria C., Van A.T., Cunnington C., Tegeder I., Lötsch J., Guzik T.J., Leeson P., Diesch J., Tousoulis D., Stefanadis C., Costigan M., Woolf C.J., Alp N.J., and Channon K.M. GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function Journal of the American College of Cardiology 52 2 2008 158 165
2. Avogaro A., Toffolo G., Kiwanuka E., de Kreutzenberg S.V., Tessari P., and Cobelli C. l-arginine-nitric oxide kinetics in normal and type 2 diabetic subjects: A stable-labelled 15N arginine approach Diabetes 52 3 2003 795 802
3. Bayes-Genis A., Conover C.A., and Schwartz R.S. The insulin-like growth factor axis: A review of atherosclerosis and restenosis Circulation Research 86 2 2000 125 130
4. Beach K.W., and Strandness D.E. Jr Arteriosclerosis obliterans and associated risk factors in insulin-dependent and non-insulin-dependent diabetes Diabetes 29 11 1980 882 888
5. Colao A., Di Somma C., Rota F., Di Maio S., Salerno M., Klain A., Spiezia S., and Lombardi G. Common carotid intima-media thickness in growth hormone (GH)-deficient adolescents: A prospective study after GH withdrawal and restarting GH replacement The Journal of Clinical Endocrinology and Metabolism 90 5 2005 2659 2665
6. Distiller L.A., Joffe B.I., Melville V., Welman T., and Distiller G.B. Carotid artery intima-media complex thickening in patients with relatively long-surviving type 1 diabetes mellitus Journal of Diabetes and Its Complications 20 5 2006 280 284
7. Förstermann U., Closs E.I., Pollock J.S., Nakane M., Schwarz P., Gath I., and Kleinert H. Nitric oxide synthase isozymes: Characterization, purification, molecular cloning, and functions Hypertension 23 6 Pt 2 1994 1121 1131
8. Förstermann U., and Münzel T. Endothelial nitric oxide synthase in vascular disease: From marvel to menace Circulation 113 13 2006 1708 1714
9. Grant E.G., Benson C.B., Moneta G.L., Alexandrov A.V., Baker J.D., Bluth E.I., Carroll B.A., Eliasziw M., Gocke J., Hertzberg B.S., Katanick S., Needleman L., Pellerito J., Polak J.F., Rholl K.S., Wooster D.L., and Zierler R.E. Carotid artery stenosis: Gray-scale and Doppler US diagnosis-Society of Radiologists in Ultrasound Consensus Conference Radiology 229 2 2003 340 346
10. Keenm H., and Jarrett R.J. The WHO multinational study of vascular disease in diabetes Diabetes Care 2 2 1979 187 195
11. Kourembanas S., McQuillan L.P., Leung G.K., and Faller D.V. Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxia and hypoxia Journal of Clinical Investigation 92 1 1993 99 104
12. Meininger C.J, Cai S., Parker J.L., Channon K.M., Kelly K.A., Becker E.J., Wood M.K., Wade L.A., and Wu G. GTP cyclohydrolase I gene transfer reverses tetrahydrobiopterin deficiency and increases nitric oxide synthesis in endothelial cells and isolated vessels from diabetic rats FASEB Journal 18 15 2004 1900 1902
13. Meininger C.J., Marinos R.S., Hatakeyama K., Martinez-Zaguilan R., Rojas J.D., Kelly K.A., and Wu G. Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydrobiopterin deficiency Biochemical Journal 349 Pt 1 2000 353 356
14. Michael T.J., and Eli G. Nitric oxide and its role in diabetes mellitus T.J. Michael, V. Aristidis, Diabetes and cardiovascular disease 2005 Humana press Totowa, NJ 201 224
15. Nichol C.A., Smith G.K., and Duch D.S. Biosynthesis and metabolism of tetrahydrobiopterin and molybdopterin Annual Review of Biochemistry 54 1985 729 764
16. -/-) mice: Role of decreased tetrahydrobiopterin bioavailability British Journal of Pharmacology 136 2 2002 255 263
17. Rittig K., Holder K., Stock J., Tschritter O., Peter A., Stefan N., Fritsche A., Machicao F., Häring H.U., and Balletshofer B. Endothelial NO-synthase intron 4 polymorphism is associated with disturbed in vivo nitric oxide production in individuals prone to type 2 diabetes Hormone and Metabolic Research 40 1 2008 13 17
18. Rutherford R.B., Baker J.D., Ernst C., Johnston K.W., Porter J.M., Ahn S., and Jones D.N. Recommended standards for reports dealing with lower extremity ischemia: Revised version Journal of Vascular Surgery 26 3 1997 517 538
19. Sandrim V.C., de Syllos R.W., Lisboa H.R., Tres G.S., and Tanus-Santos J.E. Influence of eNOS haplotypes on the plasma nitric oxide products concentrations in hypertensive and Type 2 diabetes mellitus patients Nitric Oxide 16 3 2007 348 355
20. Suganthalakshmi B., Anand R., Kim R., Mahalakshmi R., Karthikprakash S., Namperumalsamy P., and Sundaresan P. Association of VEGF and eNOS gene polymorphisms in Type 2 diabetic retinopathy Molecular Vision 11 12 2006 336 341
21. Xiang G.D., Xu L., Zhao L.S., Yue L., and Hou J. The relationship between plasma osteoprotegerin and endothelium-dependent arterial dilation in Type 2 diabetes Diabetes 55 7 2006 2126 2131
22. Xu J., Wu Y., Song P., Zhang M., Wang S., and Zou M.H. Proteasome-dependent degradation of guanosine 5′-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus Circulation 116 8 2007 944 953
23. Zannad F., Visvikis S., Gueguen R., Sass C., Chapet O., Herbeth B., and Siest G. Genetics strongly determines the wall thickness of the left and right carotid arteries Human genetics 103 2 1998 183 188
24. Zhang C., Lopez-Ridaura R., Hunter D.J., Rifai N., and Hu F.B. Common variants of the endothelial nitric oxide synthase gene and the risk of coronary heart disease among U.S. diabetic men Diabetes 55 7 2006 2140 2147
25. Zhang L., Rao F., Zhang K., Khandrika S., Das M., Vaingankar SM., Bao X., Rana B.K., Smith D.W., Wessel J., Salem R.M., Rodriguez-Flores J.L., Mahata S.K., Schork N.J., Ziegler M.G., and O'Connor D.T. Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk The Journal of Clinical Investigation 117 9 2007 2658 2671
26. Zheng J.S., Yang X.Q., Lookingland K.J., Fink G.D., Hesslinger C., Kapatos G., Kovesdi I., and Chen A.F. Gene transfer of human guanosine 5′-triphosphate cyclohydrolase I restores vascular tetrahydrobiopterin level and endothelial function in low renin hypertension Circulation 108 10 2003 1238 1245