Tetrahydrobiopterin improves coronary endothelial function, but does not prevent coronary spasm in patients with vasospastic angina

Circulation Journal

Volumn 66, Issue 1, 2002, Pages 58-62

  Fukuda, Yukihiro ^a   Teragawa, Hiroki ^a   Matsuda, Keiji ^a   Yamagata, Togo ^a   Matsuura, Hideo ^a   Chayama, Kazuaki ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Coronary spasm; Endothelial function; Nitric oxide; Tetrahydrobiopterin

Indexed keywords

ACETYLCHOLINE; TETRAHYDROBIOPTERIN;

ADULT; AGED; ANGINA PECTORIS; ANGIOCARDIOGRAPHY; ARTERY DIAMETER; ARTICLE; BLOOD VESSEL REACTIVITY; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY SPASM; ELECTROCARDIOGRAPHY; FEMALE; HEMODYNAMICS; HUMAN; MALE; PATHOGENESIS; QUANTITATIVE DIAGNOSIS; TREATMENT OUTCOME; VASCULAR ENDOTHELIUM;

ACETYLCHOLINE; ANGINA PECTORIS; ANTIOXIDANTS; BIOPTERIN; CORONARY VASOSPASM; CORONARY VESSELS; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; MALE; MIDDLE AGED; NITRIC OXIDE; REFERENCE VALUES; RESEARCH DESIGN; TREATMENT OUTCOME; VASODILATION;

EID: 0036234279     PISSN: 13469843     EISSN: None     Source Type: Journal    
DOI: 10.1253/circj.66.58     Document Type: Article

References (30)

1. Coronary spam: Clinical features and pathogenesis
2. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries
3. Nitric oxide activity is deficient in spasm arteries of patients with coronary spastic angina
4. Tetrahydrobiopterin synthesis: An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle
5. New tetrahydrobiopterin-dependent systems
6. Endothelial nitric-oxide synthase: Expression in Escherichia coli, spectroscopic characterization, and role of tetrahydrobiopterin in dimer formation
7. Tetrahydrobiopterin regulates superoxide and nitric oxide generation by recombinant endothelial nitric oxide synthase
8. Tetrahydrobiopterin restores endothelial function in hypercholesterolemia
9. Tetrahydrobiopterin improves endothelium-dependent vasodilation in chronic smokers: Evidence for a dysfunctional nitric oxide synthase
10. Tetrahydrobiopterin improves endothelial function in patients with coronary artery disease
11. Tetrahydrobiopterin improves endothelial dysfunction in coronary microcirculation in patients without epicardial coronary artery disease
12. Improvement of coronary vasomotion with eicosapentaenoic acid does not inhibit acetylcholine-induced coronary vasospasm in patients with variant angina
13. Vitamin C attenuates abnormal vasomotor reactivity in spasm coronary arteries in patients with coronary spastic angina
14. Bradykinin induced dilatation of human epicardial and resistance coronary arteries in vivo: Effect of inhibition of nitric oxide synthesis
15. The preventive effect of magnesium on coronary spasm in patients with vasospastic angina
16. Role of abnormal pain sensitivity and behavioral factors in determining chest pain in syndrome X
17. Use of initial ST-segment deviation for prediction of final electrocardiographic size of acute myocardial infarcts
18. Effect of vitamin C on the availability of tetrahydrobiopterin in human endothelial cells
19. Autonomic changes associated with spontaneous coronary spasm in patients with variant angina
20. Changes in autonomic nervous activity prior to spontaneous coronary spasm in patients with variant angina
21. Exertional angina pectoris caused by coronary arterial spasm: Effects of various drugs
22. Magnesium deficiency in patients with recent myocardial infarction and provoked coronary artery spasm
23. Preserved endothelium-dependent vasodilation at the vasospastic site in patients with variant angina
24. Cellular and molecular mechanisms of coronary artery spasm: Lessons from animal models
25. Cysteine 99 of endothelial nitric oxide synthase (NOS-III) is critical for tetrahydrobiopterin-dependent NOS-III stability and activity
26. Role of endothelium in responses of vascular smooth muscle
27. Endothelial control of vascular tone in large and small coronary arteries
28. Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease
29. Modulation of coronary vasomotor tone in humans: Progressive endothelial dysfunction with different early stages of coronary atherosclerosis
30. Nitric oxide production by coronary conductance and resistance vessels in hypercholesterolemia patients