Macrophage microbicidal mechanisms in vivo: Reactive nitrogen versus oxygen intermediates in the killing of intracellular visceral Leishmania donovani

Journal of Experimental Medicine

Volumn 189, Issue 4, 1999, Pages 741-746

  Murray, Henry W ^a   Nathan, F ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Granuloma; Macrophage; Parasite; Protozoan; Visceral leishmaniasis

Indexed keywords

NITRIC OXIDE SYNTHASE; NITROGEN; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GRANULOMA; HOST RESISTANCE; LEISHMANIA DONOVANI; MACROPHAGE; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY BURST; VISCERAL LEISHMANIASIS;

ANIMALS; GENETIC PREDISPOSITION TO DISEASE; GRANULOMA; GRANULOMATOUS DISEASE, CHRONIC; LEISHMANIA DONOVANI; LEISHMANIASIS, VISCERAL; LIVER; MACROPHAGE ACTIVATION; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NADPH OXIDASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; REACTIVE OXYGEN SPECIES;

EID: 0033557291     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.189.4.741     Document Type: Article

References (30)

1. Tumang, M., C. Keogh, L.L. Moldawer, R.F. Teitelbaum, J. Hariprashad, and H.W. Murray. 1994. The role and effect of tumor necrosis factor-alpha in experimental visceral leishmaniasis. J. Immunol. 153:768-775.
2. Taylor, A., and H.W. Murray. 1997. Intracellular antimicrobial activity in the absence of interferon-γ: effect of interleukin 12 in experimental visceral leishmaniasis in interferon-γ gene-disrupted mice. J. Exp. Med. 185:1231-1239.
3. Murray, H.W. 1997. Endogenous interleukin 12 regulates acquired resistance in experimental visceral leishmaniasis. J. Infect. Dis. 175:1477-1479.
4. Murray, H.W. 1999. Granulomatous inflammation: host antimicrobial defense in the tissues in visceral leishmaniasis. In Inflammation: Basic Principles and Clinical Correlates. J.I. Gallin, R. Snyderman, D.T. Fearon, B.F. Haynes, and C.F. Nathan, editors. Lippincott-Raven, Philadelphia. In press.
5. Wilson, M.E., M. Sandor, A.M. Blum, B. Younbag, A. Metwali, D. Elliot, R.G. Lynch, and J.V. Weinstock. 1996. Local suppression of IFN-γ in hepatic granulomas correlates with tissue-specific replication of Leishmania chagasi. J. Immunol. 156:2231-2239.
6. Murray, H.W. 1982. Cell-mediated immune response in experimental visceral leishmaniasis. II. Oxygen-dependent killing of intracellular Leishmania donovani amastigotes. J. Immunol. 129:351-357.
7. Murray, H.W. 1990. Effect of continuous administration of interferon-gamma in experimental visceral leishmaniasis. J. Infect. Dis. 161:992-994.
8. r congenic mouse strains. Infect. Immun. 59:3935-3944.
9. Shiloh, M.U., J.D. MacMicking, S. Nicholoson, J.E. Brause, S. Potter, M. Marino, F. Fang, M. Dinauer, and C. Nathan. 1999. Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase. Immunity. In press.
10. Fang, F.C. 1997. Mechanisms of nitric oxide-related antimicrobial activity. J. Clin. Invest. 99:2818-2825.
11. Murray, H.W., and D.M. Cartelli. 1983. Killing of intracellular Leishmania donovani by human mononuclear phagocytes: evidence for oxygen-dependent and -independent leishmanicidal activity. J. Clin. Invest. 72:32-39.
12. Murray, H.W., and R.F. Teitelbaum. 1992. L-arginine-dependent reactive nitrogen intermediates and the antimicrobial effect of activated human mononuclear phagocytes. J. Infect. Dis. 165:513-517.
13. Murray, H.W., A. Szuro-Sudol, D. Wellner, M.J. Oca, A.M. Granger, D.M. Libby, C.D. Rothermel, and B.Y. Rubin. 1989. Role of tryptophan degradation in respiratory burst-independent antimicrobial activity of gamma interferon-stimulated human macrophages. Infect. Immun. 57:845-849.
14. Evans, T.G., L. Thai, D.L. Granger, and J.B. Hibbs. 1993. Effect of in vivo inhibition of nitric oxide production in murine leishmaniasis. J. Immunol. 151:907-915.
15. Wei, X.Q., I.G. Charles, A. Smith, J. Ure, G.J. Feng, F.P. Huang, D. Xu, W. Muller, S. Moncada, and F.Y. Liew. 1995. Altered immune responses in mice lacking inducible nitric oxide synthase. Nature. 375:408-411.
16. Stenger, S., H. Thuring, M. Rollinghoff, and C. Bogdan. 1994. Tissue expression of inducible nitric oxide synthase is closely associated with resistance to Leishmania major. J. Exp. Med. 180:783-793.
17. Diefenbach, A., H. Schindler, N. Donhauser, E. Lorenz, T. Laskay, J. McMicking, M. Rollinghoff, I. Gresser, and C. Bogdan. 1998. Type I interferon (IFNα/β) and type 2 nitric oxide synthase regulate the innate immune response to a protozoan parasite. Immunity. 8:77-87.
18. Evans, T.G., S.S. Reed, and J.B. Hibbs. 1996. Nitric oxide production in murine leishmaniasis: correlation of progressive infection with increasing systemic synthesis of nitric oxide. Am. J. Trop. Med. Hyg. 54:486-489.
19. Huang, F.-P., D. Xu, E.-O. Esfandiari, W. Sands, X. Wei, and F.Y. Liew. 1998. Mice defective in Fas are highly susceptible to Leishmania major infection despite elevated IL-12 synthesis, strong ThI responses, and enhanced nitric oxide production. J. Immunol. 160:4143-4147.
20. Melby, P.C., Y.-Z. Yang, J. Cheng, and W. Zhao. 1998. Regional differences in the cellular immune response to experimental cutaneous or visceral leishmaniasis with Leishmania donovani. Infect. Immun. 66:18-27.
21. Bories, C., E. Scherman, and P.N. Bones. 1997. Serum and tissue nitrate levels in murine visceral leishmaniasis correlate with parasite load but not with host protection. Trans. R. Soc. Trop. Med. Hyg. 91:433-436.
22. Nicholson, S., M. da G. Bonecini-Almeida, J.R. Lapa e Silva, C. Nathan, Q.W. Xie, R. Mumford, J.R. Weidner, J. Calaycay, J. Geng, N. Boechat, et al. 1996. Inducible nitric oxide synthase in pulmonary alveolar macrophages from patients with tuberculosis. J. Exp. Med. 183:2293-2302.
23. McMicking, J.D., C. Nathan, G. Horn, N. Chartrain, D.S. Fletcher, M. Trumbauer, K. Stevens, Q. Xie, K. Sokol, N. Hutchinson, et al. 1995. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell. 81:641-650.
24. Pollock, J.D., P.A. Williams, G. Gifford, L.L. Li, X. Du, J. Fisherman, S.H. Orkin, C.M. Doershuck, and M.C. Dinhauer. 1995. Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production. Nat. Genet. 9:202-208.
25. Chan, J., K. Tanaka, D. Carroll, J. Flynn, and B.R. Bloom. 1995. Effect of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis. Infect. Immun. 63:736-740.
26. Nathan, C. 1997. Inducible nitric oxide synthase: what difference does it make? J. Clin. Invest. 100:2417-2423.
27. Hogaboam, C.M., S.W. Chensue, M.L. Steinhauser, G.B. Huffnagle, N.W. Lukacs, R.M. Strieter, and S.L. Kunkel. 1997. Alteration of the cytokine phenotype in an experimental lung granuloma model by inhibiting nitric oxide. J. Immunol. 159:5585-5593.
28. Bogdan, C. 1998. The multiplex function of nitric oxide in (auto)immunity. J. Exp. Med. 187:1361-1365.
29. Morgenstern, D.E., M.A.C. Gifford, L.L. Li, C.M. Doerschuk, and M.C. Dinauer. 1997. Absence of respiratory burst in X-linked chronic granulomatous disease mice leads to abnormalities in both host defense and inflammatory response to Aspergillus fumigatus. J. Exp. Med. 185:207-218.
30. Dinauer, M.C., M.B. Deck, and E.R. Unanue. 1997. Mice lacking reduced nicotinamide adenine dinucleotide phosphate oxidase activity show increased susceptibility to early infection with Listeria monocytogenes. J. Immunol. 158:5581-5583.