Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice

Clinical Science

Volumn 119, Issue 3, 2010, Pages 131-142

  Schmidt, Tim S ^a   McNeill, Eileen ^a   Douglas, Gillian ^a   Crabtree, Mark J ^a   Hale, Ashley B ^a   Khoo, Jeffrey ^a   O'Neill, Charles A ^b   Cheng, Alphonsus ^b   Channon, Keith M ^a   Alp, Nicholas J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b BIOMARIN PHARMACEUTICAL INC   (United States)

Author keywords

Apolipoprotein E (ApoE); Atherosclerosis; Endothelial nitric oxide synthase (eNOS); Inflammation; Tetrahydrobiopterin (BH4); Vascular disease

Indexed keywords

APOLIPOPROTEIN E; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; KUVAN; MESSENGER RNA; PLACEBO; TETRAHYDROBIOPTERIN; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ADVENTITIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; AORTA ATHEROSCLEROSIS; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DRUG UPTAKE; ENDOTHELIUM CELL; HISTOPATHOLOGY; IMMUNOCOMPETENT CELL; INTRACELLULAR SIGNALING; KNOCKOUT MOUSE; LOW DRUG DOSE; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MALE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE; SUPPLEMENTATION; T LYMPHOCYTE; VASCULITIS;

ADMINISTRATION, ORAL; ANIMALS; AORTIC DISEASES; APOLIPOPROTEINS E; ATHEROSCLEROSIS; BIOPTERIN; CHEMOTAXIS, LEUKOCYTE; DISEASE PROGRESSION; DRUG ADMINISTRATION SCHEDULE; DRUG EVALUATION, PRECLINICAL; ENDOTHELIUM, VASCULAR; HEMODYNAMICS; LIPIDS; MALE; MICE; MICE, KNOCKOUT; RNA, MESSENGER; TISSUE DISTRIBUTION; VASCULAR CELL ADHESION MOLECULE-1;

EID: 77954942970     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20090559     Document Type: Article

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