The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: An EPR spin trapping study

Biochemical Journal

Volumn 362, Issue 3, 2002, Pages 733-739

  Vasquez Vivar, Jeannette ^a   Martasek, Pavel ^a   Whitsett, Jennifer ^a   Joseph, Joy ^a   Kalyanaraman, Balaraman ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

7,8 dihydrobiopterin; Electron paramagnetic resonance; L arginine

Indexed keywords

ESTERS; NITROGEN OXIDES; PROTEINS;

SPIN TRAPPING;

BIOCHEMISTRY;

5 ETHOXYCARBONYL 5 METHYLPYRROLINE N OXIDE; 5 METHYLTETRAHYDROPTERIN; 6 METHYLTETRAHYDROPTERIN; ARGININE; BIOPTERIN; DIHYDROBIOPTERIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PYRROLINE DERIVATIVE; SEPIAPTERIN; SUPEROXIDE; TETRAHYDROBIOPTERIN; TETRAHYDROBIOPTERIN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETES MELLITUS; ELECTRON SPIN RESONANCE; ENZYME RELEASE; HUMAN; HUMAN CELL; HYPERCHOLESTEROLEMIA; HYPERTENSION; OXIDATION; OXIDATION REDUCTION REACTION; PATHOLOGICAL ANATOMY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS;

ARGININE; BIOPTERIN; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENDOTHELIUM, VASCULAR; KINETICS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; OXIDATION-REDUCTION; RECOMBINANT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUPEROXIDES;

EID: 0037086565     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3620733     Document Type: Article

References (37)

1. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide
2. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
3. Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor
4. Mechanisms of abnormal endothelium-dependent vascular relaxation in atherosclerosis: Implications for altered autocrine and paracrine functions of EDRF
5. Role of superoxide anions in the mediation of endothelium-dependent contractions
6. Nitric oxide and oxygen radicals: A question of balance
7. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells
8. Purification and identification of secreted oxidative stress-induced factors from vascular smooth muscle cells
9. Interactions between NO and reactive oxygen species: Pathophysiological importance in atherosclerosis, hypertension, diabetes and heart failure
10. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
11. Oxidative stress as a regulator of gene expression in the vasculature
12. Beneficial effects of peroxynitrite decomposition catalyst in a rat model of splanchnic artery occlusion and reperfusion
13. Tetrahydrobiopterin improves endothelial function in patients with coronary artery disease
14. Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus
15. Tetrahydrobiopterin improves endothelium-dependent vasodilation in chronic smokers
16. Tetrahydrobiopterin restores endothelial function in long-term smokers
17. Endothelial dysfunction of coronary resistance arteries is improved by tetrahydrobiopterin in atherosclerosis
18. Endothelial dysfunction in atherosclerotic mice: Improved relaxation by combined supplementation with L-arginine-tetrahydrobiopterin and enhanced vasoconstriction by endothelin
19. Effects of tetrahydrobiopterin on endothelial dysfunction in rats with ischemic acute renal failure
20. Reaction of tetrahydrobiopterin with superoxide: EPR-kinetic analysis and characterization of the pteridine radical
21. Long-term ascorbic acid administration reverses endothelial vasomotor dysfunction in patients with coronary artery disease
22. Superoxide generation by endothelial nitric oxide synthase: The influence of cofactors
23. Tetrahydrobiopterin-dependent inhibition of superoxide generation from neuronal nitric oxide synthase
24. 2-Ethoxycarbonyl-2-methyl-3,4-dihydro-2H-pyrrole-1-oxide: Evaluation of the spin trapping properties
25. The loop-gap resonator: A new microwave lumped circuit ESR sample structure
26. Simulation of multiple isotropic spin-trap EPR spectra
27. Detection of superoxide anion using an isotopically labeled nitrone spin trap: Potential biological applications
28. Tetrahydrobiopterin binding to macrophage inducible nitric oxide synthase: Heme spin shift and dimer stabilization by the potent pterin antagonist 4-amino-tetrahydrobiopterin
29. Nitric oxide-generated P420 nitric oxide synthase: Characterization and roles for tetrahydrobiopterin and substrate in protecting against or reversing the P420 conversion
30. The inhibition of the constitutive bovine endothelial nitric oxide synthase by imidazole and indazote agents
31. Only fully reduced biopterin attenuate superoxide production from eNOS: An explanation for the tetrahydrobiopterin requirement?
32. Comparative functioning of dihydro- and tetrahydropterins in supporting electron transfer, catalysis, and subunit dimerization in inducible nitric oxide synthase
33. Reaction of neuronal nitric-oxide synthase with oxygen at low temperature. Evidence for reductive activation of the oxy-ferrous complex by tetrahydrobiopterin
34. Formation of a protonated trihydrobiopterin radical cation in the first reaction cycle of neuronal and endothelial nitric oxide synthase detected by electron paramagnetic resonance spectroscopy
35. Restoration of endothelium-dependent vasodilation after reperfusion injury by tetrahydrobiopterin
36. Tetrahydrobiopterin restores endothelial function in hypercholesterolemia
37. Tetrahydrobiopterin, nitric oxide and regulation of cerebral arterial tone