Tetrahydrobiopterin and GTP cyclohydrolase I in a rat model of endotoxic shock: Relation to nitric oxide synthesis

Experimental Physiology

Volumn 81, Issue 4, 1996, Pages 665-671

  Hattori, Y ^a   Nakanishi, N ^b   Kasai, K ^a   Murakami, Y ^a   Shimoda, S ^a  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

^b MEIKAI UNIVERSITY SCHOOL OF DENTISTRY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; LIPOPOLYSACCHARIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; TETRAHYDROBIOPTERIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; ENZYME ACTIVITY; HEART; KIDNEY; LIVER; LUNG; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; SEPTIC SHOCK;

EID: 0029759279     PISSN: 09580670     EISSN: None     Source Type: Journal    
DOI: 10.1113/expphysiol.1996.sp003967     Document Type: Article

References (19)

1. FUKUSHIMA, T. & NIXON, J. C. (1980). Analysis of reduced forms of biopterin in biological tissues and fluids. Analytical Biochemistry 102, 176-188.
2. GROSS, S. S. (1995). Tetrahydrobiopterin availability limits LPS-induced killing and NO synthesis in rats. In Fourth International Meeting : Biology of Nitric Oxide. Endothelium 3 (suppl.), s118.
3. GROSS, S. S. & LEVI, R. (1992). Tetrahydrobiopterin synthesis: An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle. Journal of Biological Chemistry 267, 25722-25729.
4. HATTORI, Y. & GROSS, S. S. (1993). GTP cyclohydrolase I mRNA is induced by LPS in vascular smooth muscle: characterization, sequence and relationship to nitric oxide synthase. Biochemical and Biophysical Research Communications 195, 435-441.
5. HATTORI, Y., NAKANISHI, N., KASAI. K., SHIMODA, S. & GROSS, S. S. (1996) Pyrrolidine dithiocarbamate inhibits immunostimulant-induced tetrahydrobiopterin synthesis in rat vascular smooth muscle. European Journal of Pharmacology 296, 107-112.
6. HATTORI, Y., OKA, M., KASAI, K., NAKANISHI, N. & SHIMODA, S. (1995a). Lipopolysaccharide treatment in vivo induces tissue expression of GTP cyclohydrolase I mRNA. FEBS Letters 368, 336-338.
7. HATTORI, Y., SZABO. C., GROSS, S. S., THIEMERMANN, C. & VANE, J. R. (1995b). Lipid A and the lipid A analogue anti-tumour compound ONO-4007 induce nitric oxide synthase in vitro and in vivo. European Journal of Pharmacology 291, 83-90.
8. KNOWLES, R. G., SALTER, M., BROOKS, S. L. & MONCADA, S. (1990). Anti-inflammatory glucocorticoids inhibit the induction by endotoxin of nitric oxide synthase in the lung, liver, and aorta of the rat. Biochemical and Biophysical Research Communications 172, 1042-1048.
9. MUHL, H. & PFEILSCHIFTER, J. (1994). Tetrahydrobiopterin is a limiting factor of nitric oxide generation in interleukin 1β-stimulated rat glomerular mesangial cells. Kidney International 46, 1302-1306.
10. NAKANISHI, N., OZAWA, S., IWANAGA, M., AKATSUKA, I., SAWADA, E., ASAUMI, R., HASEGANVA, H. & YAMADA, S. (1990). Simultaneous determination of GTP cyclohydrolase activity and biopterin content in pheochromocytoma PC12h cells. Journal of Meikai University School of Dentistry 19, 197-203.
11. NAKAVAMA, D. K., GELLER, D. A., DI SILVIO, M., BLOOMGARDEN, G., DAVIES, P., PITT, B. R., HATAKEYAMA, K., KAGIMIYAMA, H., SIMMONS, R. L. & BILLIAR, T. R. (1994). Tetrahydrobiopterin synthesis and inducible nitric oxide production in pulmonary artery smooth muscle. American Journal of Physiology 266, L455-460.
12. NATHAN, C. (1992). Nitric oxide as a secretory product of mammalian cells. FASEB Journal 6, 3051-3064.
13. NICHOL, C. A., SMITH, G. K. & DUCH, D S. (1985). Biosynthesis and metabolism of tetrahydrobtopterin and molybdopterin. Annual Review of Biochemistry 54, 729-764.
14. SCHAFFNER, A., BLAU, N., SCHNEEMANN, M., STEURER, J., EDGELL, C. J. S. & SCHOEDON, G. (1994). Tetrahydrobiopterin as another EDRF in man. Biochemical and Biophysical Research Communications 205, 516-523.
15. SCHOEDON, G., SCHNEEMANN, M., HOFER, S., GUERRERO, L., BLAU, N. & SCHAFFNER, A. (1993). Regulation of the L-arginine-dependent and tetrahydrobiopterin-dependent biosynthesis of nitric oxide in murine macrophages. European Journal of Biochemistry 213, 833-839.
16. SZABO, C., MITCHEL, J. A., THIEMERMANN, C. & VANE, J. R. (1993). Nitric oxide-mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock. British Journal of Pharmacology 108, 786-792.
17. THIEMERMANN, C. & VANE, J. R. (1990). Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo. European Journal of Pharmacology 182, 591-595.
18. WALTER, R., SCHAFFNER, A., BLAU, N., KIERAT, L. & SCHOEDON, G. (1994). Tetrahydrobiopterin is a secretory product of murine vascular endothelial cells. Biochemical and Biophysical Research Communications 203, 1522-1526.
19. WERNER-FELMAYER, G., PRAST, H., WERNER, E. R., PHILIPPU, A. & WACHTER, H. (1993). Induction of GTP cyclohydrolase I by hpopolysaccharide in the rat. FEBS Letters 322, 223-226.