Biosynthesis of pteridines. Reaction mechanism of GTP cyclohydrolase I

Journal of Molecular Biology

Volumn 326, Issue 2, 2003, Pages 503-516

  Rebelo, Jorge ^a,b   Auerbach, Günter ^a,d   Bader, Gerd ^a   Bracher, Andreas ^c,e   Nar, Herbert ^a,f   Hösl, Cornelia ^c,g   Schramek, Nicholas ^c   Kaiser, Johannes ^c   Bacher, Adelbert ^c   Huber, Robert ^a   Fischer, Markus ^c  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b UNIVERSIDADE NOVA DE LISBOA   (Portugal)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d Antisense Pharma GmbH   (Germany)

^e EUROPEAN MOLECULAR BIOLOGY LABORATORY   (France)

^f BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^g UNIVERSITY OF MUNICH   (Germany)

Author keywords

Biosynthesis; Crystal structure; Folic acid; GTP cyclohydrolase I; Tetrahydrobiopterin

Indexed keywords

AMINO ACID; CARBOXYL GROUP; CYSTEINE; FORMAMIDE DERIVATIVE; GLUTAMIC ACID; GUANOSINE TRIPHOSPHATE; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; HISTIDINE; HYDROGEN; IMIDAZOLE; MUTANT PROTEIN; NUCLEOTIDE; PHOSPHATE; PROTEINASE; PTERIDINE DERIVATIVE; SERINE; WATER; ZINC ION;

ARTICLE; BIOSYNTHESIS; CATALYSIS; CHEMICAL BOND; COMPARATIVE STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; HYDRATION; HYDROGEN BOND; HYDROLYSIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FOLDING; REACTION ANALYSIS;

ANIMALIA; ESCHERICHIA COLI;

EID: 0037436338     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(02)01303-7     Document Type: Article

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