Tetrahydrobiopterin restores endothelial function of coronary arteries in patients with hypercholesterolaemia

Heart

Volumn 87, Issue 3, 2002, Pages 264-269

  Fukuda, Yukihiro ^a   Teragawa, H ^a   Matsuda, K ^a   Yamagata, T ^a   Matsuura, H ^a   Chayama, K ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; CHOLESTEROL; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; TETRAHYDROBIOPTERIN;

ADULT; AGED; ANGIOCARDIOGRAPHY; ARTERY DIAMETER; ARTERY ENDOTHELIUM; ARTICLE; BLOOD VESSEL REACTIVITY; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY DISEASE; DOPPLER FLOWMETER; DRUG EFFECT; DRUG MECHANISM; FEMALE; HEMODYNAMICS; HUMAN; HYPERCHOLESTEROLEMIA; MALE; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS; TREATMENT OUTCOME;

EID: 0036182797     PISSN: 13556037     EISSN: None     Source Type: Journal    
DOI: 10.1136/heart.87.3.264     Document Type: Article

References (31)

1. Coronary segmental responses to acetylcholine and bradykinin in patients with atherosclerotic risk factors
2. Nitric oxide production by coronary conductance and resistance vessels in hypercholesterolemia patients
3. Impaired coronary blood flow response to acetylcholine in patients with coronary risk factors and proximal atherosclerotic lesions
4. Endothelium-mediated coronary blood flow modulation in humans effects of age, atherosclerosis, hypercholesterolemia, and hypertension
5. Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease
6. New tetrahydrobiopterin-dependent systems
7. Endothelial nitric-oxide synthase: Expression in Escherichia coli, spectroscopic characterization, and role of tetrahydrobiopterin in dimer formation
8. Ca2+/calmodulin-dependent formation of hydrogen peroxide by brain nitric oxide synthase
9. Tetrahydrobiopterin-dependent formation of endothelium-derived relaxing factor (nitric oxide) in aortic endothelial cells
10. Tetrahydrobiopterin and dysfunction of endothelial nitric oxide synthase in coronary arteries
11. Tetrahydrobiopterin regulates superoxide and nitric oxide generation by recombinant endothelial nitric oxide synthase
12. Tetrahydrobiopterin restores endothelial function in hypercholesterolemia
13. Tetrahydrobiopterin improves endothelium-dependent vasodilation in chronic smokers: Evidence for a dysfunctional nitric oxide synthase
14. Tetrahydrobiopterin improves endothelial function in patients with coronary artery disease
15. Bradykinin induced dilatation of human epicardial and resistance coronary arteries in vivo: Effect of inhibition of nitric oxide synthesis
16. Magnesium causes nitric oxide independent coronary artery vasodilation in humans
17. Hyperpolarization of arterial smooth muscle induced by endothelial humoral substances
18. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
19. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
20. Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine
21. Loss of endothelial pertussis toxin-sensitive G protein function in atherosclerotic porcine coronary arteries
22. Lysophosphatidylcholine modifies G protein-dependent signaling in porcine endothelial cells
23. Effects of native and oxidized low-density lipoproteins on endothelium-dependent and endothelium-independent vasomotion
24. Asymmetric dimethylarginine (ADMA): A novel risk factor for endothelial dysfunction: Its role in hypercholesterolemia
25. Oxidation of tetrahydrobiopterin by peroxynitrite: Implications for vascular endothelial function
26. Coronary atherosclerotic wall thickening and vascular reactivity in humans: Elevate et al d high-density lipoprotein levels ameliorate abnormal vasoconstriction in early atherosclerosis
27. Tetrahydrobiopterin increases myocardial blood flow in healthy volunteers: A double-blind, placebo-controlled study
28. Tetrahydrobiopterin restores endothelial function in long-term smokers
29. Effect of vitamin C on the availability of tetrahydrobiopterin in human endothelial cells
30. In vivo formation of 8-iso-prostaglandin f2alpha and platelet activation in diabetes mellitus: Effects of improved metabolic control and vitamin E supplementation
31. Isoprostanes: Potential markers of oxidant stress in atherothrombotic disease